P54374 (AROE_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 95.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Shikimate dehydrogenase EC=1.1.1.25 | ||||
| Gene names |
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| Organism | Bacillus subtilis | ||||
| Taxonomic identifier | 1423 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 280 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 |
| Sequence similarities | Belongs to the shikimate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 280 | 280 | Shikimate dehydrogenase HAMAP MF_00222 | PRO_0000135992 | |||||
Regions | |||||||||
| Nucleotide binding | 127 – 131 | 5 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 66 | 1 | Proton acceptor Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 139 | 1 | I → F in BAA12445. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes." Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y. Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / JH642. |
| [2] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.  Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| [3] | "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed: 19383706] [Abstract] Cited for: SEQUENCE REVISION TO 139. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D84432 Genomic DNA. Translation: BAA12445.1. AL009126 Genomic DNA. Translation: CAB14508.2. |
| PIR | A69590. |
| RefSeq | NP_390444.2. NC_000964.3. |
3D structure databases | |
| ProteinModelPortal | P54374. |
| SMR | P54374. Positions 1-276. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000001857; EBBACP00000001857; EBBACG00000001854. |
| GeneID | 937820. |
| GenomeReviews | Gene locus BSU25660 in contig AL009126_GR. |
| KEGG | bsu:BSU25660. |
| NMPDR | fig|224308.1.peg.2569. |
| PATRIC | 18976974. VBIBacSub10457_2676. |
Organism-specific databases | |
| GenoList | BSU25660. [Micado] |
Phylogenomic databases | |
| GeneTree | EBGT00050000000826. |
| HOGENOM | HBG553408. |
| PhylomeDB | P54374. |
| ProtClustDB | PRK00258. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU25660-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00222. Shikimate_DH_AroE. [Tree] |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00014. |
| Pfam | PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00507. AroE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AROE_BACSU | ||||||||
| Accession | Primary (citable) accession number: P54374 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |