Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P54374 (AROE_BACSU)

Last modified November 25, 2008. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25
Gene names
Name: aroD
Ordered Locus Names: BSU25660
OrganismBacillus subtilis [Complete proteome] [HAMAP]
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7.

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Shikimate dehydrogenase
PRO_0000135992

Regions

Nucleotide binding127 – 1315NADP By similarity

Sites

Active site661Proton acceptor Potential

Sequences

Sequence LengthMass (Da)Tools
P54374-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 1EE0CE9C2EDA553F

FASTA28030,642
        10         20         30         40         50         60 
MKKLYGVIGN PIGHSMSPDI HNASLKDLGL DGHYHAFKVE ENDLEDAVKG IRALGVQGIN 

        70         80         90        100        110        120 
VTVPHKVSIM DYLDHIDESA KVLGAVNTVR REGDKLVGYN TDGEGFVKSL MKVLDKPISE 

       130        140        150        160        170        180 
LSFLMIGAGG AARAIFTTFV RNTPKKFDIC NRTLEKAKRL TEATPSFHNK EVLSIKEAEE 

       190        200        210        220        230        240 
RLEQYDVIIH TTSVGMYPNV DDVPLSLQRA ASSAVVCDIV YNPIQTALLK EASQKGLKTL 

       250        260        270        280 
DGVGMFVEQA ALSFQLWTGQ EPNIEKMRSI VIGKLGGTEC 

« Hide

References

« Hide 'large scale' references
[1]"Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes."
Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M., Kobayashi Y.
Microbiology 142:3103-3111(1996) [PubMed: 8969508] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / JH642.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

D84432 Genomic DNA. Translation: BAA12445.1.
Z99117 Genomic DNA. Translation: CAB14508.1.
PIRA69590.
RefSeqNP_390444.1.

3D structure databases

HSSPHSSP built from PDB template 1NVT based on UniProtKB Q58484.
ModBaseSearch...

Genome annotation databases

GeneID937820.
GenomeReviewsGene locus BSU25660 in contig AL009126_GR.
KEGGbsu:BSU25660.
NMPDRfig|224308.1.peg.2569.

Organism-specific databases

SubtiListBG11522. aroD. [Micado]
CMRSearch...

Phylogenomic databases

HOGENOMP54374.

Enzyme and pathway databases

BioCycBSUB224308:BSU2562-MON.

Family and domain databases

HAMAPMF_00222.
[Tree]
InterProIPR016040. NAD(P)-bd.
IPR011342. Quinate/shikimate_5-DHase.
IPR013708. Shikimate_DHase-bd_N.
IPR006151. Shikm_DHase/Glu-tRNA_Rdtase.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00507. aroE. 1 hit.
ProtoNetSearch...

Other Resources

LinkHubP54374.

Entry information

Entry nameAROE_BACSU
AccessionPrimary (citable) accession number: P54374
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents