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Protein

Ornithine decarboxylase antizyme 1

Gene

Oaz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:16916800, PubMed:18508777). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338).4 Publications

GO - Molecular functioni

  • ornithine decarboxylase inhibitor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of polyamine transmembrane transport Source: UniProtKB
  • polyamine biosynthetic process Source: UniProtKB-KW
  • polyamine metabolic process Source: MGI
  • positive regulation of intracellular protein transport Source: UniProtKB
  • positive regulation of protein catabolic process Source: UniProtKB
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 1
Short name:
ODC-Az
Gene namesi
Name:Oaz1
Synonyms:Oaz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109433. Oaz1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002208512 – 227Ornithine decarboxylase antizyme 1Add BLAST226

Proteomic databases

PaxDbiP54369.
PRIDEiP54369.

PTM databases

iPTMnetiP54369.
PhosphoSitePlusiP54369.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035242.
CleanExiMM_OAZ1.
ExpressionAtlasiP54369. baseline and differential.
GenevisibleiP54369. MM.

Interactioni

Subunit structurei

Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Interacts with AZIN2; the interaction stabilizes the complex by inhibiting AZIN2 ubiquitination and degradation and leads to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation.By similarity3 Publications

Protein-protein interaction databases

IntActiP54369. 1 interactor.
STRINGi10090.ENSMUSP00000137400.

Structurei

3D structure databases

ProteinModelPortaliP54369.
SMRiP54369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
GeneTreeiENSGT00390000009476.
HOGENOMiHOG000115253.
HOVERGENiHBG007857.
InParanoidiP54369.
KOiK16548.
OMAiAKHITWR.
OrthoDBiEOG091G0SR0.
PhylomeDBiP54369.
TreeFamiTF314741.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR029914. ODC-AZ_1.
IPR002993. ODC_AZ.
[Graphical view]
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF8. PTHR10279:SF8. 1 hit.
PfamiPF02100. ODC_AZ. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS01337. ODC_AZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket

Note: A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Isoform 1 (identifier: P54369-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKSSLQRIL NSHCFAREKE GDKRSATLHA SRTMPLLSQH SRGGCSSESS
60 70 80 90 100
RVALNCCSNL GPGPRWCSDV PHPPLKIPGG RGNSQRDHSL SASILYSDER
110 120 130 140 150
LNVTEEPTSN DKTRVLSIQS TLTEAKQVTW RAVWSGGGLY IELPAGPLPE
160 170 180 190 200
GSKDSFAALL EFAEEQLQAD HVFICFPKNR EDRAALLRTF SFLGFEIVRP
210 220
GHPLVPKRPD ACFMVYTLER EDPGEED
Length:227
Mass (Da):25,133
Last modified:January 23, 2007 - v3
Checksum:iC2D0E1614C5F28A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69D → C in AAB96330 (PubMed:9428668).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52822 mRNA. Translation: AAB96329.1.
U52823 Genomic DNA. Translation: AAB96330.1.
U84291 Genomic DNA. Translation: AAC53307.1.
CCDSiCCDS56736.1. [P54369-1]
PIRiPC4378.
RefSeqiNP_032779.2. NM_008753.4. [P54369-1]
UniGeneiMm.398119.

Genome annotation databases

EnsembliENSMUST00000180036; ENSMUSP00000137400; ENSMUSG00000035242. [P54369-1]
GeneIDi18245.
KEGGimmu:18245.
UCSCiuc033frg.1. mouse. [P54369-1]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52822 mRNA. Translation: AAB96329.1.
U52823 Genomic DNA. Translation: AAB96330.1.
U84291 Genomic DNA. Translation: AAC53307.1.
CCDSiCCDS56736.1. [P54369-1]
PIRiPC4378.
RefSeqiNP_032779.2. NM_008753.4. [P54369-1]
UniGeneiMm.398119.

3D structure databases

ProteinModelPortaliP54369.
SMRiP54369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP54369. 1 interactor.
STRINGi10090.ENSMUSP00000137400.

PTM databases

iPTMnetiP54369.
PhosphoSitePlusiP54369.

Proteomic databases

PaxDbiP54369.
PRIDEiP54369.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180036; ENSMUSP00000137400; ENSMUSG00000035242. [P54369-1]
GeneIDi18245.
KEGGimmu:18245.
UCSCiuc033frg.1. mouse. [P54369-1]

Organism-specific databases

CTDi4946.
MGIiMGI:109433. Oaz1.

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
GeneTreeiENSGT00390000009476.
HOGENOMiHOG000115253.
HOVERGENiHBG007857.
InParanoidiP54369.
KOiK16548.
OMAiAKHITWR.
OrthoDBiEOG091G0SR0.
PhylomeDBiP54369.
TreeFamiTF314741.

Enzyme and pathway databases

ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).

Miscellaneous databases

PROiP54369.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035242.
CleanExiMM_OAZ1.
ExpressionAtlasiP54369. baseline and differential.
GenevisibleiP54369. MM.

Family and domain databases

InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR029914. ODC-AZ_1.
IPR002993. ODC_AZ.
[Graphical view]
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF8. PTHR10279:SF8. 1 hit.
PfamiPF02100. ODC_AZ. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS01337. ODC_AZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOAZ1_MOUSE
AccessioniPrimary (citable) accession number: P54369
Secondary accession number(s): O08610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.