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Protein

Ornithine decarboxylase antizyme 1

Gene

Oaz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:16916800, PubMed:18508777). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338).By similarity4 Publications

GO - Molecular functioni

  • ornithine decarboxylase inhibitor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of polyamine transmembrane transport Source: UniProtKB
  • polyamine biosynthetic process Source: UniProtKB-KW
  • polyamine metabolic process Source: MGI
  • positive regulation of intracellular protein transport Source: UniProtKB
  • positive regulation of protein catabolic process Source: UniProtKB
  • transport Source: UniProtKB-KW

Keywordsi

Biological processPolyamine biosynthesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 1
Short name:
ODC-Az
Gene namesi
Name:Oaz1
Synonyms:Oaz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109433. Oaz1.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208511 – 227Ornithine decarboxylase antizyme 1Add BLAST227

Proteomic databases

PaxDbiP54369.
PRIDEiP54369.

PTM databases

iPTMnetiP54369.
PhosphoSitePlusiP54369.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035242.
CleanExiMM_OAZ1.
ExpressionAtlasiP54369. baseline and differential.
GenevisibleiP54369. MM.

Interactioni

Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:16916800, PubMed:18062773, PubMed:24967154).By similarity3 Publications

Protein-protein interaction databases

IntActiP54369. 1 interactor.
STRINGi10090.ENSMUSP00000137400.

Structurei

3D structure databases

ProteinModelPortaliP54369.
SMRiP54369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387. Eukaryota.
ENOG4112791. LUCA.
GeneTreeiENSGT00390000009476.
HOGENOMiHOG000115253.
HOVERGENiHBG007857.
InParanoidiP54369.
KOiK16548.
OMAiCDVPHPP.
OrthoDBiEOG091G0SR0.
PhylomeDBiP54369.
TreeFamiTF314741.

Family and domain databases

InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR029914. ODC-AZ_1.
IPR002993. ODC_AZ.
PANTHERiPTHR10279. PTHR10279. 1 hit.
PTHR10279:SF15. PTHR10279:SF15. 1 hit.
PfamiView protein in Pfam
PF02100. ODC_AZ. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiView protein in PROSITE
PS01337. ODC_AZ. 1 hit.

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket

Note: A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Isoform 1 (identifier: P54369-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKSSLQRIL NSHCFAREKE GDKRSATLHA SRTMPLLSQH SRGGCSSESS
60 70 80 90 100
RVALNCCSNL GPGPRWCSDV PHPPLKIPGG RGNSQRDHSL SASILYSDER
110 120 130 140 150
LNVTEEPTSN DKTRVLSIQS TLTEAKQVTW RAVWSGGGLY IELPAGPLPE
160 170 180 190 200
GSKDSFAALL EFAEEQLQAD HVFICFPKNR EDRAALLRTF SFLGFEIVRP
210 220
GHPLVPKRPD ACFMVYTLER EDPGEED
Length:227
Mass (Da):25,133
Last modified:January 23, 2007 - v3
Checksum:iC2D0E1614C5F28A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69D → C in AAB96330 (PubMed:9428668).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52822 mRNA. Translation: AAB96329.1.
U52823 Genomic DNA. Translation: AAB96330.1.
U84291 Genomic DNA. Translation: AAC53307.1.
CCDSiCCDS56736.1. [P54369-1]
PIRiPC4378.
RefSeqiNP_032779.2. NM_008753.4. [P54369-1]
UniGeneiMm.398119.

Genome annotation databases

EnsembliENSMUST00000180036; ENSMUSP00000137400; ENSMUSG00000035242. [P54369-1]
GeneIDi18245.
KEGGimmu:18245.
UCSCiuc033frg.1. mouse. [P54369-1]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Entry informationi

Entry nameiOAZ1_MOUSE
AccessioniPrimary (citable) accession number: P54369
Secondary accession number(s): O08610
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families