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Protein

Ornithine decarboxylase antizyme 1

Gene

Oaz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:16916800, PubMed:18508777). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:18062773). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338).By similarity4 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of polyamine transmembrane transport Source: UniProtKB
  • polyamine biosynthetic process Source: UniProtKB-KW
  • polyamine metabolic process Source: MGI
  • positive regulation of intracellular protein transport Source: UniProtKB
  • positive regulation of protein catabolic process Source: UniProtKB

Keywordsi

Biological processPolyamine biosynthesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-350562 Regulation of ornithine decarboxylase (ODC)

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase antizyme 1
Short name:
ODC-Az
Gene namesi
Name:Oaz1
Synonyms:Oaz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109433 Oaz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002208511 – 227Ornithine decarboxylase antizyme 1Add BLAST227

Proteomic databases

PaxDbiP54369
PRIDEiP54369

PTM databases

iPTMnetiP54369
PhosphoSitePlusiP54369

Expressioni

Gene expression databases

BgeeiENSMUSG00000035242
CleanExiMM_OAZ1
ExpressionAtlasiP54369 baseline and differential
GenevisibleiP54369 MM

Interactioni

Subunit structurei

Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:16916800, PubMed:18062773, PubMed:24967154).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiP54369, 1 interactor
STRINGi10090.ENSMUSP00000137400

Structurei

3D structure databases

ProteinModelPortaliP54369
SMRiP54369
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ODC antizyme family.Curated

Phylogenomic databases

eggNOGiKOG4387 Eukaryota
ENOG4112791 LUCA
GeneTreeiENSGT00390000009476
HOGENOMiHOG000115253
HOVERGENiHBG007857
InParanoidiP54369
KOiK16548
OMAiCDVPHPP
OrthoDBiEOG091G0SR0
PhylomeDBiP54369
TreeFamiTF314741

Family and domain databases

Gene3Di3.40.630.60, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR029914 ODC-AZ_1
IPR002993 ODC_AZ
IPR038581 ODC_AZ_sf
PANTHERiPTHR10279 PTHR10279, 1 hit
PTHR10279:SF8 PTHR10279:SF8, 1 hit
PfamiView protein in Pfam
PF02100 ODC_AZ, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS01337 ODC_AZ, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by ribosomal frameshifting. AlignAdd to basket

Note: A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.
Isoform 1 (identifier: P54369-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKSSLQRIL NSHCFAREKE GDKRSATLHA SRTMPLLSQH SRGGCSSESS
60 70 80 90 100
RVALNCCSNL GPGPRWCSDV PHPPLKIPGG RGNSQRDHSL SASILYSDER
110 120 130 140 150
LNVTEEPTSN DKTRVLSIQS TLTEAKQVTW RAVWSGGGLY IELPAGPLPE
160 170 180 190 200
GSKDSFAALL EFAEEQLQAD HVFICFPKNR EDRAALLRTF SFLGFEIVRP
210 220
GHPLVPKRPD ACFMVYTLER EDPGEED
Length:227
Mass (Da):25,133
Last modified:January 23, 2007 - v3
Checksum:iC2D0E1614C5F28A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69D → C in AAB96330 (PubMed:9428668).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52822 mRNA Translation: AAB96329.1
U52823 Genomic DNA Translation: AAB96330.1
U84291 Genomic DNA Translation: AAC53307.1
CCDSiCCDS56736.1 [P54369-1]
PIRiPC4378
RefSeqiNP_032779.2, NM_008753.4 [P54369-1]
UniGeneiMm.398119

Genome annotation databases

EnsembliENSMUST00000180036; ENSMUSP00000137400; ENSMUSG00000035242 [P54369-1]
GeneIDi18245
KEGGimmu:18245
UCSCiuc033frg.1 mouse [P54369-1]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Entry informationi

Entry nameiOAZ1_MOUSE
AccessioniPrimary (citable) accession number: P54369
Secondary accession number(s): O08610
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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