P54368 (OAZ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase antizyme 1
Short name=ODC-Az

Gene names

Name:	OAZ1
Synonyms:	OAZ

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Ref.7
Subunit structure	Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.
Sequence similarities	Belongs to the ODC antizyme family.
Sequence caution	The sequence BAA11374.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism Ribosomal frameshifting
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	polyamine biosynthetic process Traceable author statement. Source: ProtInc regulation of cellular amino acid metabolic process Traceable author statement. Source: Reactome
Cellular component	cytosol Traceable author statement. Source: Reactome
Molecular function	ornithine decarboxylase inhibitor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by ribosomal frameshifting. [Select]

Note: A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.

Isoform 1 (identifier: P54368-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 228	227	Ornithine decarboxylase antizyme 1		PRO_0000220849
Natural variations
	Natural variant	32	1	R → L. Ref.5 Corresponds to variant rs4667 [ dbSNP | Ensembl ].		VAR_022215
	Natural variant	44	1	G → D. Ref.5 Corresponds to variant rs28359762 [ dbSNP | Ensembl ].		VAR_022216
	Natural variant	50	1	S → F. Ref.5 Corresponds to variant rs28384673 [ dbSNP | Ensembl ].		VAR_022217
	Natural variant	53	1	S → F. Ref.5 Corresponds to variant rs2230749 [ dbSNP | Ensembl ].		VAR_022218
	Natural variant	147	1	A → V. Ref.5		VAR_022219
Experimental info
	Sequence conflict	69	1	D → C in BAA13497. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: DA43B74DF030BD9D	FASTA	228	25,406
	10 20 30 40 50 60 MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSESS RVSLHCCSNP 70 80 90 100 110 120 GPGPRWCSDA PHPPLKIPGG RGNSQRDHNL SANLFYSDDR LNVTEELTSN DKTRILNVQS 130 140 150 160 170 180 RLTDAKRINW RTVLSGGSLY IEIPGGALPE GSKDSFAVLL EFAEEQLRAD HVFICFHKNR 190 200 210 220 EDRAALLRTF SFLGFEIVRP GHPLVPKRPD ACFMAYTFER ESSGEEEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme." Tewari D.S., Qian Y., Thornton R.D., Pieringer J., Taub R., Mochan E., Tewari M. Biochim. Biophys. Acta 1209:293-295(1994) [PubMed: 7811704] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fibroblast.
[2]	"Molecular cloning of human antizyme from brain library." Hideyama T., Nisiyama M., Hayashi S. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Molecular cloning of human antizyme cDNA." Yang D., Takii T., Hayashi H., Itoh S., Hayashi M., Onozaki K. Biochem. Mol. Biol. Int. 38:957-964(1996) [PubMed: 9132164] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoma.
[4]	"Characterization of the human antizyme gene." Hayashi T., Matsufuji S., Hayashi S. Gene 203:131-139(1997) [PubMed: 9426243] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	NIEHS SNPs program Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-32; ASP-44; PHE-50; PHE-53 AND VAL-147.
[6]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)." Lin Y., Martin J., Gruendler C., Farley J., Meng X., Li B.-Y., Lechleider R., Huff C., Kim R.H., Grasser W.A., Paralkar V., Wang T. BMC Cell Biol. 3:15-15(2002) [PubMed: 12097147] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH PSMB4 AND SMAD1, FUNCTION.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09202 mRNA. Translation: AAA82155.1. Sequence problems. U09202 mRNA. Translation: AAA82154.1. Sequence problems. D87914 mRNA. Translation: BAA13497.1. D78361 mRNA. Translation: BAA11373.1. D78361 mRNA. Translation: BAA11374.1. Different initiation. D89870 Genomic DNA. Translation: BAA23101.1. AY865622 Genomic DNA. Translation: AAW56074.1. AC004152 Genomic DNA. Translation: AAC02802.1. AC004152 Genomic DNA. Translation: AAC02803.1.
IPI	IPI00219773.
PIR	I38591.
RefSeq	NP_004143.1. NM_004152.2.
UniGene	Hs.446427.
3D structure databases
ProteinModelPortal	P54368.
SMR	P54368. Positions 94-219.
ModBase	Search...
Protein-protein interaction databases
IntAct	P54368. 3 interactions.
MINT	MINT-2861418.
STRING	P54368.
Polymorphism databases
DMDM	1709427.
Proteomic databases
PRIDE	P54368.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322297; ENSP00000314813; ENSG00000104904.
GeneID	4946.
KEGG	hsa:4946.
Organism-specific databases
CTD	4946.
GeneCards	GC19P002269.
H-InvDB	HIX0040080.
HGNC	HGNC:8095. OAZ1.
HPA	HPA009291.
MIM	601579. gene.
neXtProt	NX_P54368.
PharmGKB	PA31884.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19306.
HOGENOM	HBG445846.
HOVERGEN	HBG007857.
InParanoid	P54368.
OrthoDB	EOG4GF3G3.
Enzyme and pathway databases
Pathway_Interaction_DB	aurora_a_pathway. Aurora A signaling.
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	P54368.
Bgee	P54368.
CleanEx	HS_OAZ1.
Genevestigator	P54368.
GermOnline	ENSG00000104904. Homo sapiens.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR002993. ODC_AZ. [Graphical view]
PANTHER	PTHR10279. ODC_AZ. 1 hit.
Pfam	PF02100. ODC_AZ. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS01337. ODC_AZ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00129. L-Ornithine.
NextBio	19053.
SOURCE	Search...

Entry information

Entry name

OAZ1_HUMAN

Accession

Primary (citable) accession number: P54368
Secondary accession number(s): O43382 , Q14989, Q92595, Q9UPL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.