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Protein

Homeobox protein goosecoid

Gene

Gsc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Appears to regulate regional development of specific tissues. Can rescue axis polarity in UV-radiated Xenopus embryos.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi282 – 341HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • sequence-specific DNA binding Source: InterPro
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein goosecoid
Gene namesi
Name:Gsc
ORF Names:CG2851
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0010323 Gsc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488931 – 415Homeobox protein goosecoidAdd BLAST415

Proteomic databases

PaxDbiP54366
PRIDEiP54366

Expressioni

Tissue specificityi

In early embryo development, expression confined to two regions; a horseshoe-like pattern across the dorsal side which is destined to form the brain hemispheres and a second domain which invaginates inside the stomodeum and which, is fated to form the foregut, ring gland and stomatogastric nervous system (SNS).

Gene expression databases

BgeeiFBgn0010323
ExpressionAtlasiP54366 baseline and differential
GenevisibleiP54366 DM

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi59496, 20 interactors
IntActiP54366, 1 interactor
STRINGi7227.FBpp0113060

Structurei

3D structure databases

ProteinModelPortaliP54366
SMRiP54366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 77Gln-richPROSITE-ProRule annotationAdd BLAST27
Compositional biasi191 – 239Ala-richPROSITE-ProRule annotationAdd BLAST49
Compositional biasi244 – 275His-richPROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
HOGENOMiHOG000276707
InParanoidiP54366
KOiK09324
OrthoDBiEOG091G0OQ6

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P54366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVETNSPPAG YTLKRSPSDL GEQQQPPRQI SRSPGNTAAY HLTTAMLLNS
60 70 80 90 100
QQCGYLGQRL QSVLQQQHAQ HQQSQSQTPS SDDGSQSGVT ILEEERRGGA
110 120 130 140 150
AAASLFTIDS ILGSRQQGGG TAPSQGSHIS SNGNQNGLTS NGISLGLKRS
160 170 180 190 200
GAESPASPNS NSSSSAAASP IRPQRVPAML QHPGLHLGHL AAAAASGFAA
210 220 230 240 250
SPSDFLVAYP NFYPNYMHAA AVAHVAAAQM QAHVSGAAAG LSGHGHHPHH
260 270 280 290 300
PHGHPHHPHL GAHHHGQHHL SHLGHGPPPK RKRRHRTIFT EEQLEQLEAT
310 320 330 340 350
FDKTHYPDVV LREQLALKVD LKEERVEVWF KNRRAKWRKQ KREEQERLRK
360 370 380 390 400
LQEEQCGSTT NGTTNSSSGT TSSTGNGSLT VKCPGSDHYS AQLVHIKSDA
410
NGYSDADESS DLEVA
Length:415
Mass (Da):44,506
Last modified:March 16, 2016 - v2
Checksum:i9646621754668657
GO

Sequence cautioni

The sequence AAB17948 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA64699 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95420 mRNA Translation: CAA64699.1 Different initiation.
U52968 mRNA Translation: AAB17948.1 Different initiation.
AE014134 Genomic DNA Translation: AAF51473.2
PIRiS70617
RefSeqiNP_476949.2, NM_057601.3

Genome annotation databases

EnsemblMetazoaiFBtr0343220; FBpp0309909; FBgn0010323
GeneIDi33240
KEGGidme:Dmel_CG2851

Similar proteinsi

Entry informationi

Entry nameiGSC_DROME
AccessioniPrimary (citable) accession number: P54366
Secondary accession number(s): Q9VPR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 16, 2016
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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