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Reviewed, UniProtKB/Swiss-Prot P54359 (SEPT2_DROME)

Last modified June 16, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Septin-2
Gene names
Name: Sep2
ORF Names: CG4173
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in cytokinesis By similarity.

Subunit structure

May assemble into a multicomponent structure.

Subcellular location

Cytoplasm. Spindle By similarity.

Sequence similarities

Belongs to the septin family.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcellularization

Traceable author statement. Source: FlyBase

cytokinesis

Inferred from mutant phenotype. Source: FlyBase

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentgermline ring canal

Non-traceable author statement. Source: FlyBase

septin complex

Inferred from electronic annotation. Source: InterPro

spindle

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CG9699Q9VXD01EBI-188936,EBI-118172
lectin-30AQ6GV061EBI-188936,EBI-118476

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Septin-2
PRO_0000173512

Regions

Nucleotide binding50 – 578GTP By similarity
Nucleotide binding188 – 1947GTP By similarity
Region259 – 26911Important for dimerization By similarity

Sites

Binding site2401GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2571GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
P54359-1 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 00D65B757C7DD0D4

FASTA41948,474
        10         20         30         40         50         60 
MSVEVDFVDK KEVHLRTLKQ SGHVGFDSLP DQLVNKSVQN GFVFNVMCIG ETGLGKSTLM 

        70         80         90        100        110        120 
DTLFNTSFES TPSPHTLPSV KLKAHTYELQ ESNVRLKLTI CDTVGYGDQI NKDDSFKAVV 

       130        140        150        160        170        180 
DYIDAQFENY LQEELKIKRS LVTCHDSRIH ICLYFICPTG HGLKSLDLVC MKKLDSKVNI 

       190        200        210        220        230        240 
IPVIAKADTI SKVELQRFKA KIIQELNANG VHIYQFPTDD ETVAETNTSM NSHIPFAVVG 

       250        260        270        280        290        300 
STEFIKVGNK LIRARQYPWG TVQVENETHC DFVKLREMLI RTNMEDMREK THTRHYELYR 

       310        320        330        340        350        360 
QKRLEQMGFS DVDSDNKPIS FQQTFEAKRS NHLAELQSKE EEVRQMFVQR VKEKEAELKE 

       370        380        390        400        410 
SEKDLHAKFE KLKRDHAEEK RKLEESRKAL EEDYLDFQRR KQQLATAHHT LTLGKSKKK 

« Hide

References

« Hide 'large scale' references
[1]Al-Awar O.S., Peifer M., Pringle J.R.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.

Cross-references

Sequence databases

U28966 mRNA. Translation: AAB52512.1.
AE014297 Genomic DNA. Translation: AAF55783.1.
AY061281 mRNA. Translation: AAL28829.1.
RefSeqNP_524417.1.
UniGeneDm.3659

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:20060N.
IntActP54359. 10 interactions.

Genome annotation databases

EnsemblFBgn0014029. Drosophila melanogaster. [Contig view]
GeneID42438.
KEGGdme:Dmel_CG4173.
NMPDRfig|7227.3.peg.13746.

Organism-specific databases

FlyBaseFBgn0014029. Sep2.

Phylogenomic databases

HOGENOMP54359.
OMAP54359. LDLVCMK.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-012507-MON.

Gene expression databases

ArrayExpressP54359.
GermOnlineCG4173. Drosophila melanogaster.

Family and domain databases

InterProIPR000038. Cell_Div_GTP_bd.
IPR016491. Septin.
[Graphical view]
PANTHERPTHR18884. Cell_Div_GTP_bd. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
ProDomPD002565. GTP_Cell_Div. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

NextBio828789.

Entry information

Entry nameSEPT2_DROME
AccessionPrimary (citable) accession number: P54359
Secondary accession number(s): Q24092, Q9VDK8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents