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P54359 (SEPT2_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Septin-2
Gene names
Name:Sep2
ORF Names:CG4173
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in cytokinesis By similarity.

Subunit structure

May assemble into a multicomponent structure.

Subcellular location

Cytoplasm. Cytoplasm › cytoskeleton › spindle By similarity.

Sequence similarities

Belongs to the septin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Septin-2
PRO_0000173512

Regions

Nucleotide binding50 – 578GTP By similarity
Nucleotide binding186 – 1949GTP By similarity
Region259 – 26911Important for dimerization By similarity

Sites

Binding site791GTP By similarity
Binding site1051GTP; via amide nitrogen By similarity
Binding site2401GTP; via amide nitrogen and carbonyl oxygen By similarity
Binding site2551GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
P54359 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 00D65B757C7DD0D4

FASTA41948,474
        10         20         30         40         50         60 
MSVEVDFVDK KEVHLRTLKQ SGHVGFDSLP DQLVNKSVQN GFVFNVMCIG ETGLGKSTLM 

        70         80         90        100        110        120 
DTLFNTSFES TPSPHTLPSV KLKAHTYELQ ESNVRLKLTI CDTVGYGDQI NKDDSFKAVV 

       130        140        150        160        170        180 
DYIDAQFENY LQEELKIKRS LVTCHDSRIH ICLYFICPTG HGLKSLDLVC MKKLDSKVNI 

       190        200        210        220        230        240 
IPVIAKADTI SKVELQRFKA KIIQELNANG VHIYQFPTDD ETVAETNTSM NSHIPFAVVG 

       250        260        270        280        290        300 
STEFIKVGNK LIRARQYPWG TVQVENETHC DFVKLREMLI RTNMEDMREK THTRHYELYR 

       310        320        330        340        350        360 
QKRLEQMGFS DVDSDNKPIS FQQTFEAKRS NHLAELQSKE EEVRQMFVQR VKEKEAELKE 

       370        380        390        400        410 
SEKDLHAKFE KLKRDHAEEK RKLEESRKAL EEDYLDFQRR KQQLATAHHT LTLGKSKKK

« Hide

References

« Hide 'large scale' references
[1]Al-Awar O.S., Peifer M., Pringle J.R.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U28966 mRNA. Translation: AAB52512.1.
AE014297 Genomic DNA. Translation: AAF55783.1.
AY061281 mRNA. Translation: AAL28829.1.
RefSeqNP_524417.1. NM_079693.3.
UniGeneDm.3659.

3D structure databases

ProteinModelPortalP54359.
SMRP54359. Positions 21-308.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-20060N.
IntActP54359. 2 interactions.
MINTMINT-912734.
STRINGP54359.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0083945; FBpp0083352; FBgn0014029.
GeneID42438.
KEGGdme:Dmel_CG4173.
NMPDRfig|7227.3.peg.13746.

Organism-specific databases

CTD42438.
FlyBaseFBgn0014029. Sep2.

Phylogenomic databases

eggNOGinNOG04585.
GeneTreeEMGT00050000002763.
InParanoidP54359.
OMALVNKSVN.
OrthoDBEOG48932X.
PhylomeDBP54359.

Gene expression databases

BgeeP54359.
GermOnlineCG4173. Drosophila melanogaster.

Family and domain databases

InterProIPR000038. Cell_div_GTP-bd.
IPR016491. Septin.
[Graphical view]
PANTHERPTHR18884. Cell_Div_GTP_bd. 1 hit.
PfamPF00735. Septin. 1 hit.
[Graphical view]
PIRSFPIRSF006698. Septin. 1 hit.
ProtoNetSearch...

Other

NextBio828789.

Entry information

Entry nameSEPT2_DROME
AccessionPrimary (citable) accession number: P54359
Secondary accession number(s): Q24092, Q9VDK8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents