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Protein

Septin-2

Gene

Sep2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in cytokinesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79GTPBy similarity1
Binding sitei105GTP; via amide nitrogenBy similarity1
Binding sitei240GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei255GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 57GTPBy similarity8
Nucleotide bindingi186 – 194GTPBy similarity9

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • cellularization Source: FlyBase
  • growth of a germarium-derived egg chamber Source: FlyBase
  • imaginal disc development Source: FlyBase
  • mitotic cytokinesis Source: FlyBase
  • mitotic nuclear division Source: UniProtKB-KW
  • neurogenesis Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-2
Gene namesi
Name:Sep2
ORF Names:CG4173
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0014029. Sep2.

Subcellular locationi

GO - Cellular componenti

  • germline ring canal Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • septin complex Source: FlyBase
  • septin ring Source: FlyBase
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735121 – 419Septin-2Add BLAST419

Proteomic databases

PaxDbiP54359.
PRIDEiP54359.

Expressioni

Gene expression databases

BgeeiFBgn0014029.
ExpressionAtlasiP54359. baseline.
GenevisibleiP54359. DM.

Interactioni

Subunit structurei

May assemble into a multicomponent structure.

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi67416. 8 interactors.
DIPiDIP-20060N.
IntActiP54359. 3 interactors.
MINTiMINT-912734.
STRINGi7227.FBpp0083352.

Structurei

3D structure databases

ProteinModelPortaliP54359.
SMRiP54359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 306Septin-type GAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 269Important for dimerizationBy similarityAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133721.
InParanoidiP54359.
KOiK16939.
OMAiDHLKRTH.
OrthoDBiEOG091G0IKM.
PhylomeDBiP54359.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVEVDFVDK KEVHLRTLKQ SGHVGFDSLP DQLVNKSVQN GFVFNVMCIG
60 70 80 90 100
ETGLGKSTLM DTLFNTSFES TPSPHTLPSV KLKAHTYELQ ESNVRLKLTI
110 120 130 140 150
CDTVGYGDQI NKDDSFKAVV DYIDAQFENY LQEELKIKRS LVTCHDSRIH
160 170 180 190 200
ICLYFICPTG HGLKSLDLVC MKKLDSKVNI IPVIAKADTI SKVELQRFKA
210 220 230 240 250
KIIQELNANG VHIYQFPTDD ETVAETNTSM NSHIPFAVVG STEFIKVGNK
260 270 280 290 300
LIRARQYPWG TVQVENETHC DFVKLREMLI RTNMEDMREK THTRHYELYR
310 320 330 340 350
QKRLEQMGFS DVDSDNKPIS FQQTFEAKRS NHLAELQSKE EEVRQMFVQR
360 370 380 390 400
VKEKEAELKE SEKDLHAKFE KLKRDHAEEK RKLEESRKAL EEDYLDFQRR
410
KQQLATAHHT LTLGKSKKK
Length:419
Mass (Da):48,474
Last modified:November 1, 1997 - v2
Checksum:i00D65B757C7DD0D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28966 mRNA. Translation: AAB52512.1.
AE014297 Genomic DNA. Translation: AAF55783.1.
AY061281 mRNA. Translation: AAL28829.1.
RefSeqiNP_524417.1. NM_079693.4.
UniGeneiDm.3659.

Genome annotation databases

EnsemblMetazoaiFBtr0083945; FBpp0083352; FBgn0014029.
GeneIDi42438.
KEGGidme:Dmel_CG4173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28966 mRNA. Translation: AAB52512.1.
AE014297 Genomic DNA. Translation: AAF55783.1.
AY061281 mRNA. Translation: AAL28829.1.
RefSeqiNP_524417.1. NM_079693.4.
UniGeneiDm.3659.

3D structure databases

ProteinModelPortaliP54359.
SMRiP54359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi67416. 8 interactors.
DIPiDIP-20060N.
IntActiP54359. 3 interactors.
MINTiMINT-912734.
STRINGi7227.FBpp0083352.

Proteomic databases

PaxDbiP54359.
PRIDEiP54359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0083945; FBpp0083352; FBgn0014029.
GeneIDi42438.
KEGGidme:Dmel_CG4173.

Organism-specific databases

CTDi42438.
FlyBaseiFBgn0014029. Sep2.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133721.
InParanoidiP54359.
KOiK16939.
OMAiDHLKRTH.
OrthoDBiEOG091G0IKM.
PhylomeDBiP54359.

Miscellaneous databases

GenomeRNAii42438.
PROiP54359.

Gene expression databases

BgeeiFBgn0014029.
ExpressionAtlasiP54359. baseline.
GenevisibleiP54359. DM.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT2_DROME
AccessioniPrimary (citable) accession number: P54359
Secondary accession number(s): Q24092, Q9VDK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.