Reviewed, UniProtKB/Swiss-Prot P54359 (SEPT2_DROME)

Names and origin

Protein names

Recommended name:
    Septin-2

Gene names

Name:	Sep2
ORF Names:	CG4173

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in cytokinesis By similarity.
Subunit structure	May assemble into a multicomponent structure.
Subcellular location	Cytoplasm. Spindle By similarity.
Sequence similarities	Belongs to the septin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellularization Traceable author statement. Source: FlyBase cytokinesis Inferred from mutant phenotype. Source: FlyBase mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	germline ring canal Non-traceable author statement. Source: FlyBase septin complex Inferred from electronic annotation. Source: InterPro spindle Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CG9699	Q9VXD0	1	EBI-188936,EBI-118172
lectin-30A	Q6GV06	1	EBI-188936,EBI-118476

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Septin-2		PRO_0000173512
Regions
	Nucleotide binding	50 – 57	8	GTP By similarity
	Nucleotide binding	188 – 194	7	GTP By similarity
	Region	259 – 269	11	Important for dimerization By similarity
Sites
	Binding site	240	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	257	1	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54359-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 00D65B757C7DD0D4	FASTA	419	48,474
	10 20 30 40 50 60 MSVEVDFVDK KEVHLRTLKQ SGHVGFDSLP DQLVNKSVQN GFVFNVMCIG ETGLGKSTLM 70 80 90 100 110 120 DTLFNTSFES TPSPHTLPSV KLKAHTYELQ ESNVRLKLTI CDTVGYGDQI NKDDSFKAVV 130 140 150 160 170 180 DYIDAQFENY LQEELKIKRS LVTCHDSRIH ICLYFICPTG HGLKSLDLVC MKKLDSKVNI 190 200 210 220 230 240 IPVIAKADTI SKVELQRFKA KIIQELNANG VHIYQFPTDD ETVAETNTSM NSHIPFAVVG 250 260 270 280 290 300 STEFIKVGNK LIRARQYPWG TVQVENETHC DFVKLREMLI RTNMEDMREK THTRHYELYR 310 320 330 340 350 360 QKRLEQMGFS DVDSDNKPIS FQQTFEAKRS NHLAELQSKE EEVRQMFVQR VKEKEAELKE 370 380 390 400 410 SEKDLHAKFE KLKRDHAEEK RKLEESRKAL EEDYLDFQRR KQQLATAHHT LTLGKSKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Al-Awar O.S., Peifer M., Pringle J.R. Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U28966 mRNA. Translation: AAB52512.1. AE014297 Genomic DNA. Translation: AAF55783.1. AY061281 mRNA. Translation: AAL28829.1.
RefSeq	NP_524417.1.
UniGene	Dm.3659
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:20060N.
IntAct	P54359. 10 interactions.
Genome annotation databases
Ensembl	FBgn0014029. Drosophila melanogaster. [Contig view]
GeneID	42438.
KEGG	dme:Dmel_CG4173.
NMPDR	fig|7227.3.peg.13746.
Organism-specific databases
FlyBase	FBgn0014029. Sep2.
Phylogenomic databases
HOGENOM	P54359.
OMA	P54359. LDLVCMK.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-012507-MON.
Gene expression databases
ArrayExpress	P54359.
GermOnline	CG4173. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000038. Cell_Div_GTP_bd. IPR016491. Septin. [Graphical view]
PANTHER	PTHR18884. Cell_Div_GTP_bd. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
ProDom	PD002565. GTP_Cell_Div. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	828789.

Entry information

Entry name

SEPT2_DROME

Accession

Primary (citable) accession number: P54359
Secondary accession number(s): Q24092, Q9VDK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project