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Protein

Myosin-2 essential light chain

Gene

Mlc-c

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi93 – 104PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • myosin binding Source: FlyBase
  • myosin heavy chain binding Source: FlyBase

GO - Biological processi

  • actin filament-based movement Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-445355. Smooth Muscle Contraction.
R-DME-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-2 essential light chain
Alternative name(s):
Myosin II essential light chain
Non-muscle myosin essential light chain
Gene namesi
Name:Mlc-c
ORF Names:CG3201
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004687. Mlc-c.

Subcellular locationi

GO - Cellular componenti

  • myosin complex Source: FlyBase
  • myosin II complex Source: FlyBase
  • myosin V complex Source: FlyBase
  • myosin VI complex Source: FlyBase
  • myosin VII complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987171 – 147Myosin-2 essential light chainAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54357.
PRIDEiP54357.

PTM databases

iPTMnetiP54357.

Expressioni

Gene expression databases

BgeeiFBgn0004687.
ExpressionAtlasiP54357. baseline.
GenevisibleiP54357. DM.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.By similarity

GO - Molecular functioni

  • myosin binding Source: FlyBase
  • myosin heavy chain binding Source: FlyBase

Protein-protein interaction databases

BioGridi57980. 16 interactors.
DIPiDIP-19766N.
IntActiP54357. 1 interactor.
MINTiMINT-323736.
STRINGi7227.FBpp0300803.

Structurei

3D structure databases

ProteinModelPortaliP54357.
SMRiP54357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini80 – 115EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini115 – 147EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000035937.
InParanoidiP54357.
KOiK12751.
OrthoDBiEOG091G0TQL.
PhylomeDBiP54357.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYTEDQLA EFQEAFNLFD NRGDGKIQLS QVGECLRALG QNPTESDVKK
60 70 80 90 100
CTHQLKPDER ISFEVFLPIY QAISKARSGD TADDFIEGLR HFDKDASGYI
110 120 130 140
SSAELRHLLT TLGEKLTDEE VEQLLANMED QQGNINYEEF VRMVMSG
Length:147
Mass (Da):16,613
Last modified:October 1, 1996 - v1
Checksum:iA37FA3C9DE942B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25057 mRNA. Translation: AAA84897.1.
AE014298 Genomic DNA. Translation: AAF46048.1.
BT082023 mRNA. Translation: ACO72860.1.
RefSeqiNP_511049.1. NM_078494.4.
UniGeneiDm.3980.

Genome annotation databases

EnsemblMetazoaiFBtr0070783; FBpp0070749; FBgn0004687.
GeneIDi31474.
KEGGidme:Dmel_CG3201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25057 mRNA. Translation: AAA84897.1.
AE014298 Genomic DNA. Translation: AAF46048.1.
BT082023 mRNA. Translation: ACO72860.1.
RefSeqiNP_511049.1. NM_078494.4.
UniGeneiDm.3980.

3D structure databases

ProteinModelPortaliP54357.
SMRiP54357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57980. 16 interactors.
DIPiDIP-19766N.
IntActiP54357. 1 interactor.
MINTiMINT-323736.
STRINGi7227.FBpp0300803.

PTM databases

iPTMnetiP54357.

Proteomic databases

PaxDbiP54357.
PRIDEiP54357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070783; FBpp0070749; FBgn0004687.
GeneIDi31474.
KEGGidme:Dmel_CG3201.

Organism-specific databases

CTDi31474.
FlyBaseiFBgn0004687. Mlc-c.

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000035937.
InParanoidiP54357.
KOiK12751.
OrthoDBiEOG091G0TQL.
PhylomeDBiP54357.

Enzyme and pathway databases

ReactomeiR-DME-445355. Smooth Muscle Contraction.
R-DME-5627123. RHO GTPases activate PAKs.

Miscellaneous databases

GenomeRNAii31474.
PROiP54357.

Gene expression databases

BgeeiFBgn0004687.
ExpressionAtlasiP54357. baseline.
GenevisibleiP54357. DM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLC2_DROME
AccessioniPrimary (citable) accession number: P54357
Secondary accession number(s): C1C594, Q9W4A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.