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Protein

Myosin-2 essential light chain

Gene

Mlc-c

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi93 – 104PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • myosin binding Source: FlyBase
  • myosin heavy chain binding Source: FlyBase

GO - Biological processi

  • actin filament-based movement Source: FlyBase

Keywordsi

Molecular functionMotor protein, Myosin
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-350480 Activation of non-muscle Myosin II
R-DME-445355 Smooth Muscle Contraction
R-DME-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-2 essential light chain
Alternative name(s):
Myosin II essential light chain
Non-muscle myosin essential light chain
Gene namesi
Name:Mlc-c
ORF Names:CG3201
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004687 Mlc-c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001987171 – 147Myosin-2 essential light chainAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54357
PRIDEiP54357

PTM databases

iPTMnetiP54357

Expressioni

Gene expression databases

BgeeiFBgn0004687
ExpressionAtlasiP54357 baseline and differential
GenevisibleiP54357 DM

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.By similarity

GO - Molecular functioni

  • myosin binding Source: FlyBase
  • myosin heavy chain binding Source: FlyBase

Protein-protein interaction databases

BioGridi57980, 20 interactors
DIPiDIP-19766N
IntActiP54357, 1 interactor
STRINGi7227.FBpp0300803

Structurei

3D structure databases

ProteinModelPortaliP54357
SMRiP54357
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini80 – 115EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini115 – 147EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000035937
InParanoidiP54357
KOiK12751
OMAiQGNVNYE
OrthoDBiEOG091G0TQL
PhylomeDBiP54357

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

P54357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYTEDQLA EFQEAFNLFD NRGDGKIQLS QVGECLRALG QNPTESDVKK
60 70 80 90 100
CTHQLKPDER ISFEVFLPIY QAISKARSGD TADDFIEGLR HFDKDASGYI
110 120 130 140
SSAELRHLLT TLGEKLTDEE VEQLLANMED QQGNINYEEF VRMVMSG
Length:147
Mass (Da):16,613
Last modified:October 1, 1996 - v1
Checksum:iA37FA3C9DE942B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25057 mRNA Translation: AAA84897.1
AE014298 Genomic DNA Translation: AAF46048.1
BT082023 mRNA Translation: ACO72860.1
RefSeqiNP_511049.1, NM_078494.4
UniGeneiDm.3980

Genome annotation databases

EnsemblMetazoaiFBtr0070783; FBpp0070749; FBgn0004687
GeneIDi31474
KEGGidme:Dmel_CG3201

Similar proteinsi

Entry informationi

Entry nameiMLC2_DROME
AccessioniPrimary (citable) accession number: P54357
Secondary accession number(s): C1C594, Q9W4A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health