Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative peptidyl-prolyl cis-trans isomerase dodo

Gene

dod

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: FlyBase

GO - Biological processi

  • epidermal growth factor receptor signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

SignaLinkiP54353.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptidyl-prolyl cis-trans isomerase dodo (EC:5.2.1.8)
Short name:
PPIase dodo
Alternative name(s):
Rotamase dodo
Gene namesi
Name:dod
ORF Names:CG17051
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015379. dod.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Putative peptidyl-prolyl cis-trans isomerase dodoPRO_0000193432Add
BLAST

Proteomic databases

PaxDbiP54353.
PRIDEiP54353.

Expressioni

Gene expression databases

BgeeiP54353.
GenevisibleiP54353. DM.

Interactioni

Protein-protein interaction databases

BioGridi59389. 42 interactions.
DIPiDIP-18540N.
IntActiP54353. 2 interactions.
MINTiMINT-770073.
STRINGi7227.FBpp0076894.

Structurei

3D structure databases

ProteinModelPortaliP54353.
SMRiP54353. Positions 6-164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 3935WWPROSITE-ProRule annotationAdd
BLAST
Domaini55 – 166112PpiCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PpiC domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00640000091578.
InParanoidiP54353.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG7S4X82.
PhylomeDBiP54353.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDAEQLPDG WEKRTSRSTG MSYYLNMYTK ESQWDQPTEP AKKAGGGSAG
60 70 80 90 100
GGDAPDEVHC LHLLVKHKGS RRPSSWREAN ITRTKEEAQL LLEVYRNKIV
110 120 130 140 150
QQEATFDELA RSYSDCSSAK RGGDLGKFGR GQMQAAFEDA AFKLNVNQLS
160
GIVDSDSGLH IILRKA
Length:166
Mass (Da):18,377
Last modified:December 1, 2000 - v3
Checksum:i3B4306FA930E7259
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441A → T in AAC28408 (PubMed:9520435).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35140 mRNA. Translation: AAC46958.1.
AF017777 Genomic DNA. Translation: AAC28408.1.
AE014298 Genomic DNA. Translation: AAF50829.1.
BT099557 mRNA. Translation: ACU32641.1.
PIRiT08426.
RefSeqiNP_523428.1. NM_078704.4.
UniGeneiDm.19749.

Genome annotation databases

EnsemblMetazoaiFBtr0077193; FBpp0076894; FBgn0015379.
GeneIDi33111.
KEGGidme:Dmel_CG17051.
UCSCiCG17051-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35140 mRNA. Translation: AAC46958.1.
AF017777 Genomic DNA. Translation: AAC28408.1.
AE014298 Genomic DNA. Translation: AAF50829.1.
BT099557 mRNA. Translation: ACU32641.1.
PIRiT08426.
RefSeqiNP_523428.1. NM_078704.4.
UniGeneiDm.19749.

3D structure databases

ProteinModelPortaliP54353.
SMRiP54353. Positions 6-164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59389. 42 interactions.
DIPiDIP-18540N.
IntActiP54353. 2 interactions.
MINTiMINT-770073.
STRINGi7227.FBpp0076894.

Proteomic databases

PaxDbiP54353.
PRIDEiP54353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0077193; FBpp0076894; FBgn0015379.
GeneIDi33111.
KEGGidme:Dmel_CG17051.
UCSCiCG17051-RA. d. melanogaster.

Organism-specific databases

CTDi33111.
FlyBaseiFBgn0015379. dod.

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00640000091578.
InParanoidiP54353.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG7S4X82.
PhylomeDBiP54353.

Enzyme and pathway databases

SignaLinkiP54353.

Miscellaneous databases

GenomeRNAii33111.
PROiP54353.

Gene expression databases

BgeeiP54353.
GenevisibleiP54353. DM.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae."
    Maleszka R., Hanes S.D., Hackett R.L., de Couet H.G., Miklos G.L.G.
    Proc. Natl. Acad. Sci. U.S.A. 93:447-451(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Oregon-R.
    Tissue: Larva and Pupae.
  2. "Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila."
    Maleszka R., de Couet H.G., Miklos G.L.G.
    Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Canton-S.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.

Entry informationi

Entry nameiDOD_DROME
AccessioniPrimary (citable) accession number: P54353
Secondary accession number(s): C6TP71, O61344, Q9VRH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: July 6, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.