Reviewed, UniProtKB/Swiss-Prot P54353 (DOD_DROME)

Names and origin

Protein names

Recommended name:
    Protein dodo

Gene names

Name:	dod
ORF Names:	CG17051

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 PpiC domain. Contains 1 WW domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	epidermal growth factor receptor signaling pathway Inferred from mutant phenotype. Source: FlyBase protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: FlyBase
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q8T0D9	1	EBI-194983,EBI-89145
	Q9VJF9	1	EBI-194983,EBI-91191
caup	P54269	1	EBI-194983,EBI-111580

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Protein dodo		PRO_0000193432
Regions
	Domain	5 – 39	35	WW
	Domain	55 – 166	112	PpiC
Experimental info
	Sequence conflict	44	1	A → T in AAC28408. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P54353-1 [UniParc]. Last modified December 1, 2000. Version 3. Checksum: 3B4306FA930E7259	FASTA	166	18,377
	10 20 30 40 50 60 MPDAEQLPDG WEKRTSRSTG MSYYLNMYTK ESQWDQPTEP AKKAGGGSAG GGDAPDEVHC 70 80 90 100 110 120 LHLLVKHKGS RRPSSWREAN ITRTKEEAQL LLEVYRNKIV QQEATFDELA RSYSDCSSAK 130 140 150 160 RGGDLGKFGR GQMQAAFEDA AFKLNVNQLS GIVDSDSGLH IILRKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae." Maleszka R., Hanes S.D., Hackett R.L., de Couet H.G., Miklos G.L.G. Proc. Natl. Acad. Sci. U.S.A. 93:447-451(1996) [PubMed: 8552658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Oregon-R. Tissue: Larva and Pupae.
[2]	"Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila." Maleszka R., de Couet H.G., Miklos G.L.G. Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998) [PubMed: 9520435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U35140 mRNA. Translation: AAC46958.1. AF017777 Genomic DNA. Translation: AAC28408.1. AE014298 Genomic DNA. Translation: AAF50829.1.
PIR	T08426.
RefSeq	NP_523428.1.
UniGene	Dm.19749
3D structure databases
HSSP	HSSP built from PDB template 1PIN based on UniProtKB Q13526.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:18540N.
IntAct	P54353. 12 interactions.
Proteomic databases
PRIDE	P54353.
Genome annotation databases
Ensembl	FBgn0015379. Drosophila melanogaster. [Contig view]
GeneID	33111.
KEGG	dme:Dmel_CG17051.
NMPDR	fig|7227.3.peg.18888.
Organism-specific databases
FlyBase	FBgn0015379. dod.
Phylogenomic databases
HOGENOM	P54353.
OMA	P54353. NGQGEPT.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-002856-MON.
Gene expression databases
GermOnline	CG17051. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000297. PPIase_PpiC. IPR001202. WW_Rsp5_WWP. [Graphical view]
Pfam	PF00639. Rotamase. 1 hit. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00456. WW. 1 hit. [Graphical view]
PROSITE	PS01096. PPIC_PPIASE_1. 1 hit. PS50198. PPIC_PPIASE_2. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	781962.

Entry information

Entry name

DOD_DROME

Accession

Primary (citable) accession number: P54353
Secondary accession number(s): O61344, Q9VRH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project