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Protein

Putative peptidyl-prolyl cis-trans isomerase dodo

Gene

dod

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: FlyBase

GO - Biological processi

  • epidermal growth factor receptor signaling pathway Source: FlyBase
  • regulation of locomotor rhythm Source: FlyBase

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-DME-6811555. PI5P Regulates TP53 Acetylation.
SignaLinkiP54353.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peptidyl-prolyl cis-trans isomerase dodo (EC:5.2.1.8)
Short name:
PPIase dodo
Alternative name(s):
Rotamase dodo
Gene namesi
Name:dod
ORF Names:CG17051
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0015379. dod.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934321 – 166Putative peptidyl-prolyl cis-trans isomerase dodoAdd BLAST166

Proteomic databases

PaxDbiP54353.
PRIDEiP54353.

Expressioni

Gene expression databases

BgeeiFBgn0015379.
GenevisibleiP54353. DM.

Interactioni

Protein-protein interaction databases

BioGridi59389. 42 interactors.
DIPiDIP-18540N.
IntActiP54353. 2 interactors.
MINTiMINT-770073.
STRINGi7227.FBpp0076894.

Structurei

3D structure databases

ProteinModelPortaliP54353.
SMRiP54353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 39WWPROSITE-ProRule annotationAdd BLAST35
Domaini55 – 166PpiCPROSITE-ProRule annotationAdd BLAST112

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00640000091578.
InParanoidiP54353.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG091G0RO7.
PhylomeDBiP54353.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00456. WW. 1 hit.
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P54353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDAEQLPDG WEKRTSRSTG MSYYLNMYTK ESQWDQPTEP AKKAGGGSAG
60 70 80 90 100
GGDAPDEVHC LHLLVKHKGS RRPSSWREAN ITRTKEEAQL LLEVYRNKIV
110 120 130 140 150
QQEATFDELA RSYSDCSSAK RGGDLGKFGR GQMQAAFEDA AFKLNVNQLS
160
GIVDSDSGLH IILRKA
Length:166
Mass (Da):18,377
Last modified:December 1, 2000 - v3
Checksum:i3B4306FA930E7259
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44A → T in AAC28408 (PubMed:9520435).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35140 mRNA. Translation: AAC46958.1.
AF017777 Genomic DNA. Translation: AAC28408.1.
AE014298 Genomic DNA. Translation: AAF50829.1.
BT099557 mRNA. Translation: ACU32641.1.
PIRiT08426.
RefSeqiNP_523428.1. NM_078704.4.
UniGeneiDm.19749.

Genome annotation databases

EnsemblMetazoaiFBtr0077193; FBpp0076894; FBgn0015379.
GeneIDi33111.
KEGGidme:Dmel_CG17051.
UCSCiCG17051-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiDOD_DROME
AccessioniPrimary (citable) accession number: P54353
Secondary accession number(s): C6TP71, O61344, Q9VRH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: August 30, 2017
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase