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Protein

Phospholipase A-2-activating protein

Gene

Plaa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance of ubiquitin levels.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A-2-activating protein
Short name:
PLA2P
Short name:
PLAP
Gene namesi
Name:Plaa
Synonyms:Plap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621245. Plaa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511321 – 795Phospholipase A-2-activating proteinAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineCombined sources1
Modified residuei529N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP54319.
PRIDEiP54319.

PTM databases

iPTMnetiP54319.
PhosphoSitePlusiP54319.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007753.
GenevisibleiP54319. RN.

Interactioni

Subunit structurei

Interacts with ubiquitin. Interacts with VCP (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP54319. 1 interactor.
MINTiMINT-4299720.
STRINGi10116.ENSRNOP00000010621.

Structurei

3D structure databases

ProteinModelPortaliP54319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati63 – 107WD 2Add BLAST45
Repeati110 – 148WD 3Add BLAST39
Repeati149 – 188WD 4Add BLAST40
Repeati190 – 227WD 5Add BLAST38
Repeati229 – 268WD 6Add BLAST40
Repeati270 – 307WD 7Add BLAST38
Domaini366 – 465PFUPROSITE-ProRule annotationAdd BLAST100
Domaini533 – 794PULPROSITE-ProRule annotationAdd BLAST262
Repeati546 – 588ARM 1Add BLAST43
Repeati589 – 620ARM 2Add BLAST32
Repeati621 – 669ARM 3Add BLAST49
Repeati670 – 715ARM 4Add BLAST46
Repeati716 – 755ARM 5Add BLAST40
Repeati756 – 795ARM 6Add BLAST40

Domaini

The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus.By similarity
The PFU domain mediates interaction with ubiquitin.By similarity

Sequence similaritiesi

Belongs to the WD repeat PLAP family.Curated
Contains 6 ARM repeats.Curated
Contains 1 PFU domain.PROSITE-ProRule annotation
Contains 1 PUL domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0301. Eukaryota.
ENOG410XS67. LUCA.
GeneTreeiENSGT00550000074944.
HOGENOMiHOG000174247.
HOVERGENiHBG008204.
InParanoidiP54319.
KOiK14018.
OMAiIPSSDMY.
OrthoDBiEOG091G06FX.
PhylomeDBiP54319.
TreeFamiTF105944.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033510. PLAA/Doa1/Lub1.
IPR015155. PLAA_fam_Ub-bd_PFU.
IPR013535. PUL_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19849:SF0. PTHR19849:SF0. 1 hit.
PfamiPF09070. PFU. 1 hit.
PF08324. PUL. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS51394. PFU. 1 hit.
PS51396. PUL. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGAARYRL SCSLPGHELD VRGLVCCLYP PGAFVSVSRD RTTRLWAPDS
60 70 80 90 100
PNRGFTEMHC MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD
110 120 130 140 150
SPMPLYILKG HKDTVCSLSS GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH
160 170 180 190 200
TAAVWAVKIL PEQGLMLTGS ADKTIKLWKA GRCERTFSGH EDCVRGLAIL
210 220 230 240 250
SETEFLSCAN DASIRRWQIT GECLGVYYGH TNYIYSISVF PNCRDFVTTA
260 270 280 290 300
EDRSLRIWKH GECAQTIRLP AQSIWCCCVL DNGDIVVGAS DGIIRVFTEA
310 320 330 340 350
DERTASAEEI KAFERELSQA TIDSKTGDLG DINAEQLPGR EHLNEPGTRE
360 370 380 390 400
GQTRLIRDGE RVEAYQWSVS DGRWIKIGDV VGSSGANQQT SGKVLYEGKE
410 420 430 440 450
FDYVFSIDVN EGGPSYKLPY NVSDDPWLVA YNFLQKNDLN PMFLDQVAKF
460 470 480 490 500
IIDNTKGQTL GLGNTSFSDP FTGGGRYVPG TSGPSNTVQT ADPFTGAGRY
510 520 530 540 550
MPGSAGMDTT MAGVDPFTGN SAYRSAASKT VNIYFPKKEA LTFDQANPTQ
560 570 580 590 600
ILGKLKELNG SAPEEKKLTE DDLVLLEKIL SLICGNASEK PTAQQLQVLW
610 620 630 640 650
KAINWPEDIV FPALDILRLS IKHPSVNENF CNEKEGDQFS SHLINLLNPK
660 670 680 690 700
GKPANQLLAL RTFCNCFVSQ AGQKLMMSQR ESLMSHAIEL KSGSNKNIHI
710 720 730 740 750
ALATLTLNYS VCFHKDHNIE GKAQCLSVIS TILEVVQDLE ATFRLLVALG
760 770 780 790
TLISDDSNAI QLAKSLGVDS QIKKYASVSE PAKVSECCRL ILNLL
Length:795
Mass (Da):87,084
Last modified:June 13, 2006 - v3
Checksum:i648139781B618E32
GO

Sequence cautioni

The sequence AAA79979 differs from that shown. Reason: Frameshift at position 698.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti528S → F (PubMed:7665086).Curated1
Sequence conflicti791I → V (PubMed:7665086).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040245 Genomic DNA. No translation available.
U17901 mRNA. Translation: AAA79979.1. Sequence problems.
PIRiJC4239.
RefSeqiNP_446318.3. NM_053866.3.
UniGeneiRn.7441.

Genome annotation databases

EnsembliENSRNOT00000010621; ENSRNOP00000010621; ENSRNOG00000007753.
GeneIDi116645.
KEGGirno:116645.
UCSCiRGD:621245. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03040245 Genomic DNA. No translation available.
U17901 mRNA. Translation: AAA79979.1. Sequence problems.
PIRiJC4239.
RefSeqiNP_446318.3. NM_053866.3.
UniGeneiRn.7441.

3D structure databases

ProteinModelPortaliP54319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP54319. 1 interactor.
MINTiMINT-4299720.
STRINGi10116.ENSRNOP00000010621.

PTM databases

iPTMnetiP54319.
PhosphoSitePlusiP54319.

Proteomic databases

PaxDbiP54319.
PRIDEiP54319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010621; ENSRNOP00000010621; ENSRNOG00000007753.
GeneIDi116645.
KEGGirno:116645.
UCSCiRGD:621245. rat.

Organism-specific databases

CTDi9373.
RGDi621245. Plaa.

Phylogenomic databases

eggNOGiKOG0301. Eukaryota.
ENOG410XS67. LUCA.
GeneTreeiENSGT00550000074944.
HOGENOMiHOG000174247.
HOVERGENiHBG008204.
InParanoidiP54319.
KOiK14018.
OMAiIPSSDMY.
OrthoDBiEOG091G06FX.
PhylomeDBiP54319.
TreeFamiTF105944.

Miscellaneous databases

PROiP54319.

Gene expression databases

BgeeiENSRNOG00000007753.
GenevisibleiP54319. RN.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR033510. PLAA/Doa1/Lub1.
IPR015155. PLAA_fam_Ub-bd_PFU.
IPR013535. PUL_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR19849:SF0. PTHR19849:SF0. 1 hit.
PfamiPF09070. PFU. 1 hit.
PF08324. PUL. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS51394. PFU. 1 hit.
PS51396. PUL. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLAP_RAT
AccessioniPrimary (citable) accession number: P54319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 13, 2006
Last modified: November 30, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.