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Reviewed, UniProtKB/Swiss-Prot P54318 (LIPR2_RAT)

Last modified June 16, 2009. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pancreatic lipase-related protein 2
      Short name=PL-RP2
    EC=3.1.1.3
Alternative name(s):
    Secretory glycoprotein GP-3
Gene names
Name: Pnliprp2
Synonyms: Plrp2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted. Membrane.

Tissue specificity

Pancreatic secretory (zymogen) granule.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Contains 1 PLAT domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Ref.1
Chain17 – 468452Pancreatic lipase-related protein 2
PRO_0000017796

Regions

Domain356 – 468113PLAT

Sites

Active site1701Nucleophile
Active site1941Charge relay system
Active site2811Charge relay system

Amino acid modifications

Glycosylation3521N-linked (GlcNAc...) Potential
Disulfide bond20 ↔ 26
Disulfide bond108 ↔ 119
Disulfide bond255 ↔ 279
Disulfide bond303 ↔ 314
Disulfide bond317 ↔ 322
Disulfide bond452 ↔ 468

Secondary structure

1 ............................................................................... 468
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P54318-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B41FB0B339BA9A6F

FASTA46852,535
        10         20         30         40         50         60 
MLLCWIVSLL LATVGGKEVC YGHLGCFSND KPWAGMLQRP LKIFPWSPED IDTRFLLYTN 

        70         80         90        100        110        120 
ENPNNYQKIS ATEPDTIKFS NFQLDRKTRF IVHGFIDKGE DGWLLDMCKK MFQVEKVNCI 

       130        140        150        160        170        180 
CVDWRRGSRT EYTQASYNTR VVGAEIAFLV QVLSTEMGYS PENVHLIGHS LGAHVVGEAG 

       190        200        210        220        230        240 
RRLEGHVGRI TGLDPAEPCF QGLPEEVRLD PSDAMFVDVI HTDSAPIIPY LGFGMSQKVG 

       250        260        270        280        290        300 
HLDFFPNGGK EMPGCQKNIL STIVDINGIW EGTQNFVACN HLRSYKYYAS SILNPDGFLG 

       310        320        330        340        350        360 
YPCSSYEKFQ QNDCFPCPEE GCPKMGHYAD QFEGKTATVE QTVYLNTGDS GNFTRWRYKV 

       370        380        390        400        410        420 
SVTLSGAKKL SGYILVALYG NNGNSKQYEI FKGSLKPEAR HVRDIDVDIN VGEIQKVKFL 

       430        440        450        460 
WNNKVINLFR PTLGASQITV QSGVDGKEYN FCSSDTVRED VLQSLYPC

« Hide

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References

[1]"Identification and cloning of GP-3 from rat pancreatic acinar zymogen granules as a glycosylated membrane-associated lipase."
Wishart M.J., Andrews P.C., Nichols R., Blevins G.T. Jr., Logsdon C.D., Williams J.A.
J. Biol. Chem. 268:10303-10311(1993) [PubMed: 8486693] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-46.
Strain: Sprague-Dawley.
Tissue: Pancreas.
[2]"Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development."
Payne R.M., Sims H.F., Jennens M.L., Lowe M.E.
Am. J. Physiol. 266:G914-G921(1994) [PubMed: 8203536] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structure and activity of rat pancreatic lipase-related protein 2."
Roussel A., Yang Y., Ferrato F., Verger R., Cambillau C., Lowe M.
J. Biol. Chem. 273:32121-32128(1998) [PubMed: 9822688] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 17-468.
Tissue: Pancreas.

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Cross-references

Sequence databases

L09216 mRNA. Translation: AAA41250.1. Different initiation.
IPIIPI00231487.
PIRA46696.
RefSeqNP_476554.1.
UniGeneRn.87688

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1BU8X-ray1.80A17-468[»]
ModBaseSearch...

Genome annotation databases

GeneID117554.
KEGGrno:117554.

Organism-specific databases

RGD620793. Pnliprp2.

Phylogenomic databases

HOVERGENP54318.

Enzyme and pathway databases

BRENDA3.1.1.3. 248.

Gene expression databases

ArrayExpressP54318.

Family and domain databases

InterProIPR000734. Lipase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. LipOase_LH2.
IPR016272. Lipoprotein_lipase_LIPH.
[Graphical view]
Gene3DG3DSA:2.60.60.20. Lipase_LipOase. 1 hit.
PANTHERPTHR11610. Lipase. 1 hit.
PTHR11610:SF8. Lipase_panc. 1 hit.
PfamPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTSM00308. LH2. 1 hit.
[Graphical view]
PROSITEPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio620403.

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Entry information

Entry nameLIPR2_RAT
AccessionPrimary (citable) accession number: P54318
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents