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Protein

Inactive pancreatic lipase-related protein 1

Gene

Pnliprp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity).By similarity

Caution

Was originally thought to be the pancreatic lipase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171NucleophileBy similarity1
Active sitei194Charge relay systemPROSITE-ProRule annotation1
Metal bindingi205Calcium; via carbonyl oxygenBy similarity1
Metal bindingi208Calcium; via carbonyl oxygenBy similarity1
Metal bindingi210CalciumBy similarity1
Metal bindingi213CalciumBy similarity1
Active sitei281Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • carboxylic ester hydrolase activity Source: InterPro
  • lipase activity Source: RGD

GO - Biological processi

  • lipid metabolic process Source: InterPro
  • pancreas development Source: RGD
  • response to glucocorticoid Source: RGD
  • response to peptide hormone Source: RGD

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.26 5301

Protein family/group databases

ESTHERiratno-3plip Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive pancreatic lipase-related protein 1
Short name:
PL-RP1
Gene namesi
Name:Pnliprp1
Synonyms:Plrp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620792 Pnliprp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001779218 – 473Inactive pancreatic lipase-related protein 1Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 279PROSITE-ProRule annotation
Disulfide bondi303 ↔ 314PROSITE-ProRule annotation
Disulfide bondi317 ↔ 322PROSITE-ProRule annotation
Disulfide bondi451 ↔ 467PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54316
PRIDEiP54316

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024164

Structurei

3D structure databases

ProteinModelPortaliP54316
SMRiP54316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 470PLATPROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiP54316
KOiK14074
PhylomeDBiP54316

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLWTVSLF LLGAAQGKEV CYDNLGCFSD AEPWAGTAIR PLKLLPWSPE
60 70 80 90 100
KINTRFLLYT NENPTAFQTL QLSDPLTIGA SNFQVARKTR FIIHGFIDKG
110 120 130 140 150
EENWVVDMCK NMFQVEEVNC ICVDWKKGSQ TTYTQAANNV RVVGAQVAQM
160 170 180 190 200
IDILVKNYSY SPSKVHLIGH SLGAHVAGEA GSRTPGLGRI TGLDPVEANF
210 220 230 240 250
EGTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQMSG HLDFFPNGGQ
260 270 280 290 300
SMPGCKKNAL SQIVDIDGIW SGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCASYKDFE SNKCFPCPDQ GCPQMGHYAD KFAGKSGDEP QKFFLNTGEA
360 370 380 390 400
KNFARWRYRV SLILSGRMVT GQVKVALFGS KGNTRQYDIF RGIIKPGATH
410 420 430 440 450
SSEFDAKLDV GTIEKVKFLW NNQVINPSFP KVGAAKITVQ KGEERTEYNF
460 470
CSEETVREDT LLTLLPCETS DTV
Length:473
Mass (Da):52,378
Last modified:October 1, 1996 - v1
Checksum:iCE03D1E021F30723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61925 mRNA Translation: CAA43927.1
PIRiS20612
RefSeqiNP_114470.1, NM_032081.1
UniGeneiRn.6696

Genome annotation databases

GeneIDi84028
KEGGirno:84028

Similar proteinsi

Entry informationi

Entry nameiLIPR1_RAT
AccessioniPrimary (citable) accession number: P54316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health