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Protein

Inactive pancreatic lipase-related protein 1

Gene

Pnliprp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711NucleophileBy similarity
Active sitei194 – 1941Charge relay systemPROSITE-ProRule annotation
Metal bindingi205 – 2051Calcium; via carbonyl oxygenBy similarity
Metal bindingi208 – 2081Calcium; via carbonyl oxygenBy similarity
Metal bindingi210 – 2101CalciumBy similarity
Metal bindingi213 – 2131CalciumBy similarity
Active sitei281 – 2811Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • lipase activity Source: RGD
  • triglyceride lipase activity Source: InterPro

GO - Biological processi

  • lipid metabolic process Source: InterPro
  • pancreas development Source: RGD
  • response to glucocorticoid Source: RGD
  • response to peptide hormone Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.26. 5301.

Protein family/group databases

ESTHERiratno-3plip. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive pancreatic lipase-related protein 1
Short name:
PL-RP1
Gene namesi
Name:Pnliprp1
Synonyms:Plrp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620792. Pnliprp1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 473456Inactive pancreatic lipase-related protein 1PRO_0000017792Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi255 ↔ 279PROSITE-ProRule annotation
Disulfide bondi303 ↔ 314PROSITE-ProRule annotation
Disulfide bondi317 ↔ 322PROSITE-ProRule annotation
Disulfide bondi451 ↔ 467PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54316.
PRIDEiP54316.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024164.

Structurei

3D structure databases

ProteinModelPortaliP54316.
SMRiP54316. Positions 18-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini356 – 470115PLATPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP54316.
KOiK14074.
PhylomeDBiP54316.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLWTVSLF LLGAAQGKEV CYDNLGCFSD AEPWAGTAIR PLKLLPWSPE
60 70 80 90 100
KINTRFLLYT NENPTAFQTL QLSDPLTIGA SNFQVARKTR FIIHGFIDKG
110 120 130 140 150
EENWVVDMCK NMFQVEEVNC ICVDWKKGSQ TTYTQAANNV RVVGAQVAQM
160 170 180 190 200
IDILVKNYSY SPSKVHLIGH SLGAHVAGEA GSRTPGLGRI TGLDPVEANF
210 220 230 240 250
EGTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQMSG HLDFFPNGGQ
260 270 280 290 300
SMPGCKKNAL SQIVDIDGIW SGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCASYKDFE SNKCFPCPDQ GCPQMGHYAD KFAGKSGDEP QKFFLNTGEA
360 370 380 390 400
KNFARWRYRV SLILSGRMVT GQVKVALFGS KGNTRQYDIF RGIIKPGATH
410 420 430 440 450
SSEFDAKLDV GTIEKVKFLW NNQVINPSFP KVGAAKITVQ KGEERTEYNF
460 470
CSEETVREDT LLTLLPCETS DTV
Length:473
Mass (Da):52,378
Last modified:October 1, 1996 - v1
Checksum:iCE03D1E021F30723
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61925 mRNA. Translation: CAA43927.1.
PIRiS20612.
RefSeqiNP_114470.1. NM_032081.1.
UniGeneiRn.6696.

Genome annotation databases

GeneIDi84028.
KEGGirno:84028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61925 mRNA. Translation: CAA43927.1.
PIRiS20612.
RefSeqiNP_114470.1. NM_032081.1.
UniGeneiRn.6696.

3D structure databases

ProteinModelPortaliP54316.
SMRiP54316. Positions 18-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024164.

Protein family/group databases

ESTHERiratno-3plip. Pancreatic_lipase.

Proteomic databases

PaxDbiP54316.
PRIDEiP54316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84028.
KEGGirno:84028.

Organism-specific databases

CTDi5407.
RGDi620792. Pnliprp1.

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP54316.
KOiK14074.
PhylomeDBiP54316.

Enzyme and pathway databases

BRENDAi3.1.1.26. 5301.

Miscellaneous databases

NextBioi616607.
PROiP54316.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR016272. Lipase_LIPH.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of rat pancreatic lipase mRNA."
    Wicker-Planquart C., Puigserver A.
    FEBS Lett. 296:61-66(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pancreas.

Entry informationi

Entry nameiLIPR1_RAT
AccessioniPrimary (citable) accession number: P54316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 11, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be the pancreatic lipase.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.