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P54315 (LIPR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive pancreatic lipase-related protein 1

Short name=PL-RP1
Gene names
Name:PNLIPRP1
Synonyms:PLRP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) By similarity. Ref.4

Subcellular location

Secreted Ref.1 Ref.4.

Tissue specificity

Pancreas. Ref.1

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Contains 1 PLAT domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   LigandCalcium
Metal-binding
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functioncalcium ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

triglyceride lipase activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P54315-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P54315-2)

The sequence of this isoform differs from the canonical sequence as follows:
     111-186: KLFEVEEVNC...AGEAGSKTPG → VGASSDPCGQ...EKYSYYLISG
     187-467: Missing.
Isoform 3 (identifier: P54315-3)

The sequence of this isoform differs from the canonical sequence as follows:
     111-117: KLFEVEE → PGASPRA
     118-467: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 467450Inactive pancreatic lipase-related protein 1
PRO_0000017790

Regions

Domain356 – 467112PLAT

Sites

Active site1711Nucleophile
Active site1941Charge relay system
Active site2811Charge relay system
Metal binding2051Calcium; via carbonyl oxygen
Metal binding2081Calcium; via carbonyl oxygen
Metal binding2101Calcium
Metal binding2131Calcium

Amino acid modifications

Disulfide bond21 ↔ 27 Ref.5
Disulfide bond109 ↔ 120 Ref.5
Disulfide bond255 ↔ 279 Ref.5
Disulfide bond303 ↔ 314 Ref.5
Disulfide bond317 ↔ 322 Ref.5
Disulfide bond451 ↔ 467 Ref.5

Natural variations

Alternative sequence111 – 18676KLFEV…SKTPG → VGASSDPCGQLRPTLLLTSL HHFMHSRNLYILGNFMQLKC FSSQKLKCLSMFPHYICTLK QPHLLLEKYSYYLISG in isoform 2.
VSP_014097
Alternative sequence111 – 1177KLFEVEE → PGASPRA in isoform 3.
VSP_014098
Alternative sequence118 – 467350Missing in isoform 3.
VSP_014099
Alternative sequence187 – 467281Missing in isoform 2.
VSP_014100
Natural variant611N → D.
Corresponds to variant rs11197744 [ dbSNP | Ensembl ].
VAR_049820
Natural variant1291S → C in a breast cancer sample; somatic mutation. Ref.6
VAR_036379
Natural variant2711A → V.
Corresponds to variant rs2305205 [ dbSNP | Ensembl ].
VAR_022082
Natural variant4141E → D. Ref.3
Corresponds to variant rs2305204 [ dbSNP | Ensembl ].
VAR_022659
Natural variant4611L → P.
Corresponds to variant rs1049125 [ dbSNP | Ensembl ].
VAR_014915

Secondary structure

............................................................................. 467
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2781EA1E22E39E78

FASTA46751,848
        10         20         30         40         50         60 
MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE KIGTRFLLYT 

        70         80         90        100        110        120 
NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG DESWVTDMCK KLFEVEEVNC 

       130        140        150        160        170        180 
ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM LDILLTEYSY PPSKVHLIGH SLGAHVAGEA 

       190        200        210        220        230        240 
GSKTPGLSRI TGLDPVEASF ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG 

       250        260        270        280        290        300 
HLDFFPNGGE SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA 

       310        320        330        340        350        360 
YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA SNFARWRYGV 

       370        380        390        400        410        420 
SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH SYEFDAKLDV GTIEKVKFLW 

       430        440        450        460 
NNNVINPTLP KVGATKITVQ KGEEKTVYNF CSEDTVREDT LLTLTPC 

« Hide

Isoform 2 [UniParc].

Checksum: 00AA562CC980CDF0
Show »

FASTA18621,354
Isoform 3 [UniParc].

Checksum: 24E13DBDF751B557
Show »

FASTA11713,245

References

« Hide 'large scale' references
[1]"Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity."
Giller T., Buchwald P., Blum-Kaelin D., Hunziker W.
J. Biol. Chem. 267:16509-16516(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ABSENCE OF LIPASE ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Pancreas.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-414.
Tissue: Pancreas.
[4]"Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules."
Berton A., Sebban-Kreuzer C., Rouvellac S., Lopez C., Crenon I.
Mol. Nutr. Food Res. 53:1592-1602(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, ABSENCE OF CATALYTIC ACTIVITY.
[5]"Structure of the human pancreatic lipase-related protein 1."
Structural genomics consortium (SGC)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 18-467 IN COMPLEX WITH CALCIUM IONS, DISULFIDE BONDS.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M93283 mRNA. Translation: AAA59532.1.
CR749299 mRNA. Translation: CAH18154.1.
CR749524 mRNA. Translation: CAH18337.1.
BC005233 mRNA. Translation: AAH05233.1.
BC025784 mRNA. Translation: AAH25784.1.
PIRA43357.
RefSeqNP_006220.1. NM_006229.2.
XP_005269960.1. XM_005269903.2.
UniGeneHs.73923.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2PPLX-ray2.20A18-467[»]
ProteinModelPortalP54315.
SMRP54315. Positions 18-467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP54315. 1 interaction.
STRING9606.ENSP00000351695.

PTM databases

PhosphoSiteP54315.

Polymorphism databases

DMDM1708837.

Proteomic databases

PaxDbP54315.
PRIDEP54315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358834; ENSP00000351695; ENSG00000187021. [P54315-1]
ENST00000442761; ENSP00000400963; ENSG00000187021. [P54315-3]
ENST00000528052; ENSP00000433933; ENSG00000187021. [P54315-1]
ENST00000572596; ENSP00000458759; ENSG00000262273. [P54315-1]
ENST00000572926; ENSP00000461234; ENSG00000262273. [P54315-1]
GeneID5407.
KEGGhsa:5407.
UCSCuc001lcn.3. human. [P54315-2]
uc001lco.1. human. [P54315-1]

Organism-specific databases

CTD5407.
GeneCardsGC10P118340.
HGNCHGNC:9156. PNLIPRP1.
MIM604422. gene.
neXtProtNX_P54315.
PharmGKBPA33479.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40923.
HOGENOMHOG000038552.
HOVERGENHBG003243.
InParanoidP54315.
KOK14074.
OMAKGDESWV.
PhylomeDBP54315.
TreeFamTF324997.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP54315.
BgeeP54315.
CleanExHS_PNLIPRP1.
GenevestigatorP54315.

Family and domain databases

Gene3D2.60.60.20. 1 hit.
InterProIPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERPTHR11610. PTHR11610. 1 hit.
PTHR11610:SF8. PTHR11610:SF8. 1 hit.
PfamPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMSSF49723. SSF49723. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP54315.
GenomeRNAi5407.
NextBio20935.
PROP54315.
SOURCESearch...

Entry information

Entry nameLIPR1_HUMAN
AccessionPrimary (citable) accession number: P54315
Secondary accession number(s): Q68D83 expand/collapse secondary AC list , Q68DR6, Q8TAU2, Q9BS82
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM