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P54315

- LIPR1_HUMAN

UniProt

P54315 - LIPR1_HUMAN

Protein

Inactive pancreatic lipase-related protein 1

Gene

PNLIPRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei171 – 1711Nucleophile
    Active sitei194 – 1941Charge relay system
    Metal bindingi205 – 2051Calcium; via carbonyl oxygen
    Metal bindingi208 – 2081Calcium; via carbonyl oxygen
    Metal bindingi210 – 2101Calcium
    Metal bindingi213 – 2131Calcium
    Active sitei281 – 2811Charge relay system

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. triglyceride lipase activity Source: ProtInc

    GO - Biological processi

    1. lipid metabolic process Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_9518. Digestion of dietary lipid.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive pancreatic lipase-related protein 1
    Short name:
    PL-RP1
    Gene namesi
    Name:PNLIPRP1
    Synonyms:PLRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:9156. PNLIPRP1.

    Subcellular locationi

    Secreted 2 Publications

    GO - Cellular componenti

    1. extracellular region Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33479.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 467450Inactive pancreatic lipase-related protein 1PRO_0000017790Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi21 ↔ 271 PublicationPROSITE-ProRule annotation
    Disulfide bondi109 ↔ 1201 PublicationPROSITE-ProRule annotation
    Disulfide bondi255 ↔ 2791 PublicationPROSITE-ProRule annotation
    Disulfide bondi303 ↔ 3141 PublicationPROSITE-ProRule annotation
    Disulfide bondi317 ↔ 3221 PublicationPROSITE-ProRule annotation
    Disulfide bondi451 ↔ 4671 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP54315.
    PRIDEiP54315.

    PTM databases

    PhosphoSiteiP54315.

    Expressioni

    Tissue specificityi

    Pancreas.1 Publication

    Gene expression databases

    ArrayExpressiP54315.
    BgeeiP54315.
    CleanExiHS_PNLIPRP1.
    GenevestigatoriP54315.

    Interactioni

    Protein-protein interaction databases

    IntActiP54315. 1 interaction.
    STRINGi9606.ENSP00000351695.

    Structurei

    Secondary structure

    1
    467
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi19 – 224
    Turni23 – 253
    Beta strandi26 – 305
    Turni32 – 343
    Beta strandi35 – 406
    Helixi49 – 524
    Beta strandi55 – 639
    Beta strandi68 – 714
    Helixi76 – 805
    Beta strandi87 – 937
    Helixi104 – 11512
    Beta strandi118 – 1247
    Helixi126 – 1294
    Helixi133 – 15826
    Helixi162 – 1643
    Beta strandi165 – 1706
    Helixi173 – 18210
    Beta strandi189 – 1946
    Turni198 – 2025
    Turni205 – 2073
    Helixi211 – 2133
    Beta strandi214 – 2207
    Helixi227 – 2304
    Beta strandi240 – 2467
    Beta strandi249 – 2513
    Helixi266 – 2705
    Helixi279 – 29315
    Turni295 – 2984
    Helixi306 – 3105
    Beta strandi324 – 3263
    Helixi327 – 3315
    Beta strandi341 – 3455
    Beta strandi349 – 3524
    Beta strandi356 – 36712
    Beta strandi369 – 37911
    Beta strandi387 – 3948
    Beta strandi399 – 40810
    Beta strandi412 – 42110
    Beta strandi432 – 44110
    Beta strandi447 – 4515
    Beta strandi462 – 4665

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PPLX-ray2.20A18-467[»]
    ProteinModelPortaliP54315.
    SMRiP54315. Positions 18-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP54315.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini356 – 467112PLATPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated
    Contains 1 PLAT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40923.
    HOGENOMiHOG000038552.
    HOVERGENiHBG003243.
    InParanoidiP54315.
    KOiK14074.
    OMAiKGDESWV.
    PhylomeDBiP54315.
    TreeFamiTF324997.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR002331. Lipase_panc.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSiPR00823. PANCLIPASE.
    PR00821. TAGLIPASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P54315-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE    50
    KIGTRFLLYT NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG 100
    DESWVTDMCK KLFEVEEVNC ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM 150
    LDILLTEYSY PPSKVHLIGH SLGAHVAGEA GSKTPGLSRI TGLDPVEASF 200
    ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG HLDFFPNGGE 250
    SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA 300
    YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA 350
    SNFARWRYGV SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH 400
    SYEFDAKLDV GTIEKVKFLW NNNVINPTLP KVGATKITVQ KGEEKTVYNF 450
    CSEDTVREDT LLTLTPC 467
    Length:467
    Mass (Da):51,848
    Last modified:October 1, 1996 - v1
    Checksum:i2781EA1E22E39E78
    GO
    Isoform 2 (identifier: P54315-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         111-186: KLFEVEEVNC...AGEAGSKTPG → VGASSDPCGQ...EKYSYYLISG
         187-467: Missing.

    Show »
    Length:186
    Mass (Da):21,354
    Checksum:i00AA562CC980CDF0
    GO
    Isoform 3 (identifier: P54315-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         111-117: KLFEVEE → PGASPRA
         118-467: Missing.

    Show »
    Length:117
    Mass (Da):13,245
    Checksum:i24E13DBDF751B557
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611N → D.
    Corresponds to variant rs11197744 [ dbSNP | Ensembl ].
    VAR_049820
    Natural varianti129 – 1291S → C in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036379
    Natural varianti271 – 2711A → V.
    Corresponds to variant rs2305205 [ dbSNP | Ensembl ].
    VAR_022082
    Natural varianti414 – 4141E → D.1 Publication
    Corresponds to variant rs2305204 [ dbSNP | Ensembl ].
    VAR_022659
    Natural varianti461 – 4611L → P.
    Corresponds to variant rs1049125 [ dbSNP | Ensembl ].
    VAR_014915

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei111 – 18676KLFEV…SKTPG → VGASSDPCGQLRPTLLLTSL HHFMHSRNLYILGNFMQLKC FSSQKLKCLSMFPHYICTLK QPHLLLEKYSYYLISG in isoform 2. 1 PublicationVSP_014097Add
    BLAST
    Alternative sequencei111 – 1177KLFEVEE → PGASPRA in isoform 3. 1 PublicationVSP_014098
    Alternative sequencei118 – 467350Missing in isoform 3. 1 PublicationVSP_014099Add
    BLAST
    Alternative sequencei187 – 467281Missing in isoform 2. 1 PublicationVSP_014100Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93283 mRNA. Translation: AAA59532.1.
    CR749299 mRNA. Translation: CAH18154.1.
    CR749524 mRNA. Translation: CAH18337.1.
    BC005233 mRNA. Translation: AAH05233.1.
    BC025784 mRNA. Translation: AAH25784.1.
    CCDSiCCDS7595.1. [P54315-1]
    PIRiA43357.
    RefSeqiNP_006220.1. NM_006229.2. [P54315-1]
    XP_005269960.1. XM_005269903.2. [P54315-1]
    UniGeneiHs.73923.

    Genome annotation databases

    EnsembliENST00000358834; ENSP00000351695; ENSG00000187021. [P54315-1]
    ENST00000528052; ENSP00000433933; ENSG00000187021. [P54315-1]
    GeneIDi5407.
    KEGGihsa:5407.
    UCSCiuc001lcn.3. human. [P54315-2]
    uc001lco.1. human. [P54315-1]

    Polymorphism databases

    DMDMi1708837.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93283 mRNA. Translation: AAA59532.1 .
    CR749299 mRNA. Translation: CAH18154.1 .
    CR749524 mRNA. Translation: CAH18337.1 .
    BC005233 mRNA. Translation: AAH05233.1 .
    BC025784 mRNA. Translation: AAH25784.1 .
    CCDSi CCDS7595.1. [P54315-1 ]
    PIRi A43357.
    RefSeqi NP_006220.1. NM_006229.2. [P54315-1 ]
    XP_005269960.1. XM_005269903.2. [P54315-1 ]
    UniGenei Hs.73923.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PPL X-ray 2.20 A 18-467 [» ]
    ProteinModelPortali P54315.
    SMRi P54315. Positions 18-467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P54315. 1 interaction.
    STRINGi 9606.ENSP00000351695.

    PTM databases

    PhosphoSitei P54315.

    Polymorphism databases

    DMDMi 1708837.

    Proteomic databases

    PaxDbi P54315.
    PRIDEi P54315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358834 ; ENSP00000351695 ; ENSG00000187021 . [P54315-1 ]
    ENST00000528052 ; ENSP00000433933 ; ENSG00000187021 . [P54315-1 ]
    GeneIDi 5407.
    KEGGi hsa:5407.
    UCSCi uc001lcn.3. human. [P54315-2 ]
    uc001lco.1. human. [P54315-1 ]

    Organism-specific databases

    CTDi 5407.
    GeneCardsi GC10P118340.
    HGNCi HGNC:9156. PNLIPRP1.
    MIMi 604422. gene.
    neXtProti NX_P54315.
    PharmGKBi PA33479.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40923.
    HOGENOMi HOG000038552.
    HOVERGENi HBG003243.
    InParanoidi P54315.
    KOi K14074.
    OMAi KGDESWV.
    PhylomeDBi P54315.
    TreeFami TF324997.

    Enzyme and pathway databases

    Reactomei REACT_9518. Digestion of dietary lipid.

    Miscellaneous databases

    EvolutionaryTracei P54315.
    GenomeRNAii 5407.
    NextBioi 20935.
    PROi P54315.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P54315.
    Bgeei P54315.
    CleanExi HS_PNLIPRP1.
    Genevestigatori P54315.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR002331. Lipase_panc.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSi PR00823. PANCLIPASE.
    PR00821. TAGLIPASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity."
      Giller T., Buchwald P., Blum-Kaelin D., Hunziker W.
      J. Biol. Chem. 267:16509-16516(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ABSENCE OF LIPASE ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Pancreas.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-414.
      Tissue: Pancreas.
    4. "Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules."
      Berton A., Sebban-Kreuzer C., Rouvellac S., Lopez C., Crenon I.
      Mol. Nutr. Food Res. 53:1592-1602(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ABSENCE OF CATALYTIC ACTIVITY.
    5. "Structure of the human pancreatic lipase-related protein 1."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 18-467 IN COMPLEX WITH CALCIUM IONS, DISULFIDE BONDS.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-129.

    Entry informationi

    Entry nameiLIPR1_HUMAN
    AccessioniPrimary (citable) accession number: P54315
    Secondary accession number(s): Q68D83
    , Q68DR6, Q8TAU2, Q9BS82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3