UniProtKB - P54315 (LIPR1_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Inactive pancreatic lipase-related protein 1
Gene
PNLIPRP1
Organism
Homo sapiens (Human)
Status
Functioni
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | Nucleophile | 1 | |
Active sitei | 194 | Charge relay system | 1 | |
Metal bindingi | 205 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 208 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 210 | Calcium | 1 | |
Metal bindingi | 213 | Calcium | 1 | |
Active sitei | 281 | Charge relay system | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- triglyceride lipase activity Source: ProtInc
GO - Biological processi
- lipid metabolic process Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.1.26. 2681. |
Reactomei | R-HSA-192456. Digestion of dietary lipid. |
Protein family/group databases
ESTHERi | human-PNLIPRP1. Pancreatic_lipase. |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive pancreatic lipase-related protein 1Short name: PL-RP1 |
Gene namesi | Name:PNLIPRP1 Synonyms:PLRP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187021.14. |
HGNCi | HGNC:9156. PNLIPRP1. |
MIMi | 604422. gene. |
neXtProti | NX_P54315. |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000187021. |
PharmGKBi | PA33479. |
Polymorphism and mutation databases
BioMutai | PNLIPRP1. |
DMDMi | 1708837. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000017790 | 18 – 467 | Inactive pancreatic lipase-related protein 1Add BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 27 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 109 ↔ 120 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 255 ↔ 279 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 303 ↔ 314 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 317 ↔ 322 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 451 ↔ 467 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P54315. |
PeptideAtlasi | P54315. |
PRIDEi | P54315. |
Expressioni
Tissue specificityi
Pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000187021. |
CleanExi | HS_PNLIPRP1. |
ExpressionAtlasi | P54315. baseline and differential. |
Genevisiblei | P54315. HS. |
Interactioni
Protein-protein interaction databases
BioGridi | 111408. 9 interactors. |
IntActi | P54315. 7 interactors. |
MINTi | P54315. |
STRINGi | 9606.ENSP00000351695. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 19 – 22 | Combined sources | 4 | |
Turni | 23 – 25 | Combined sources | 3 | |
Beta strandi | 26 – 30 | Combined sources | 5 | |
Turni | 32 – 34 | Combined sources | 3 | |
Beta strandi | 35 – 40 | Combined sources | 6 | |
Helixi | 49 – 52 | Combined sources | 4 | |
Beta strandi | 55 – 63 | Combined sources | 9 | |
Beta strandi | 68 – 71 | Combined sources | 4 | |
Helixi | 76 – 80 | Combined sources | 5 | |
Beta strandi | 87 – 93 | Combined sources | 7 | |
Helixi | 104 – 115 | Combined sources | 12 | |
Beta strandi | 118 – 124 | Combined sources | 7 | |
Helixi | 126 – 129 | Combined sources | 4 | |
Helixi | 133 – 158 | Combined sources | 26 | |
Helixi | 162 – 164 | Combined sources | 3 | |
Beta strandi | 165 – 170 | Combined sources | 6 | |
Helixi | 173 – 182 | Combined sources | 10 | |
Beta strandi | 189 – 194 | Combined sources | 6 | |
Turni | 198 – 202 | Combined sources | 5 | |
Turni | 205 – 207 | Combined sources | 3 | |
Helixi | 211 – 213 | Combined sources | 3 | |
Beta strandi | 214 – 220 | Combined sources | 7 | |
Helixi | 227 – 230 | Combined sources | 4 | |
Beta strandi | 240 – 246 | Combined sources | 7 | |
Beta strandi | 249 – 251 | Combined sources | 3 | |
Helixi | 266 – 270 | Combined sources | 5 | |
Helixi | 279 – 293 | Combined sources | 15 | |
Turni | 295 – 298 | Combined sources | 4 | |
Helixi | 306 – 310 | Combined sources | 5 | |
Beta strandi | 324 – 326 | Combined sources | 3 | |
Helixi | 327 – 331 | Combined sources | 5 | |
Beta strandi | 341 – 345 | Combined sources | 5 | |
Beta strandi | 349 – 352 | Combined sources | 4 | |
Beta strandi | 356 – 367 | Combined sources | 12 | |
Beta strandi | 369 – 379 | Combined sources | 11 | |
Beta strandi | 387 – 394 | Combined sources | 8 | |
Beta strandi | 399 – 408 | Combined sources | 10 | |
Beta strandi | 412 – 421 | Combined sources | 10 | |
Beta strandi | 432 – 441 | Combined sources | 10 | |
Beta strandi | 447 – 451 | Combined sources | 5 | |
Beta strandi | 462 – 466 | Combined sources | 5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PPL | X-ray | 2.20 | A | 18-467 | [»] | |
ProteinModelPortali | P54315. | |||||
SMRi | P54315. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P54315. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 467 | PLATPROSITE-ProRule annotationAdd BLAST | 112 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410IHRX. Eukaryota. ENOG410Y92X. LUCA. |
GeneTreei | ENSGT00760000119069. |
HOGENOMi | HOG000038552. |
HOVERGENi | HBG003243. |
InParanoidi | P54315. |
KOi | K14074. |
OMAi | DQGCPQM. |
PhylomeDBi | P54315. |
TreeFami | TF324997. |
Family and domain databases
CDDi | cd00707. Pancreat_lipase_like. 1 hit. |
Gene3Di | 3.40.50.1820. 1 hit. |
InterProi | View protein in InterPro IPR029058. AB_hydrolase. IPR013818. Lipase/vitellogenin. IPR016272. Lipase_LIPH. IPR033906. Lipase_N. IPR002331. Lipase_panc. IPR001024. PLAT/LH2_dom. IPR036392. PLAT/LH2_dom_sf. IPR000734. TAG_lipase. |
PANTHERi | PTHR11610. PTHR11610. 1 hit. |
Pfami | View protein in Pfam PF00151. Lipase. 1 hit. PF01477. PLAT. 1 hit. |
PIRSFi | PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit. |
PRINTSi | PR00823. PANCLIPASE. PR00821. TAGLIPASE. |
SMARTi | View protein in SMART SM00308. LH2. 1 hit. |
SUPFAMi | SSF49723. SSF49723. 1 hit. SSF53474. SSF53474. 1 hit. |
PROSITEi | View protein in PROSITE PS00120. LIPASE_SER. 1 hit. PS50095. PLAT. 1 hit. |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: P54315-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE
60 70 80 90 100
KIGTRFLLYT NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG
110 120 130 140 150
DESWVTDMCK KLFEVEEVNC ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM
160 170 180 190 200
LDILLTEYSY PPSKVHLIGH SLGAHVAGEA GSKTPGLSRI TGLDPVEASF
210 220 230 240 250
ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG HLDFFPNGGE
260 270 280 290 300
SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA
360 370 380 390 400
SNFARWRYGV SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH
410 420 430 440 450
SYEFDAKLDV GTIEKVKFLW NNNVINPTLP KVGATKITVQ KGEEKTVYNF
460
CSEDTVREDT LLTLTPC
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049820 | 61 | N → D. Corresponds to variant dbSNP:rs11197744Ensembl. | 1 | |
Natural variantiVAR_036379 | 129 | S → C in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_022082 | 271 | A → V. Corresponds to variant dbSNP:rs2305205Ensembl. | 1 | |
Natural variantiVAR_022659 | 414 | E → D1 PublicationCorresponds to variant dbSNP:rs2305204Ensembl. | 1 | |
Natural variantiVAR_014915 | 461 | L → P. Corresponds to variant dbSNP:rs1049125Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_014097 | 111 – 186 | KLFEV…SKTPG → VGASSDPCGQLRPTLLLTSL HHFMHSRNLYILGNFMQLKC FSSQKLKCLSMFPHYICTLK QPHLLLEKYSYYLISG in isoform 2. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_014098 | 111 – 117 | KLFEVEE → PGASPRA in isoform 3. 1 Publication | 7 | |
Alternative sequenceiVSP_014099 | 118 – 467 | Missing in isoform 3. 1 PublicationAdd BLAST | 350 | |
Alternative sequenceiVSP_014100 | 187 – 467 | Missing in isoform 2. 1 PublicationAdd BLAST | 281 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93283 mRNA. Translation: AAA59532.1. CR749299 mRNA. Translation: CAH18154.1. CR749524 mRNA. Translation: CAH18337.1. BC005233 mRNA. Translation: AAH05233.1. BC025784 mRNA. Translation: AAH25784.1. |
CCDSi | CCDS7595.1. [P54315-1] |
PIRi | A43357. |
RefSeqi | NP_001290064.1. NM_001303135.1. [P54315-1] NP_006220.1. NM_006229.3. [P54315-1] XP_011538170.1. XM_011539868.1. [P54315-1] |
UniGenei | Hs.73923. |
Genome annotation databases
Ensembli | ENST00000358834; ENSP00000351695; ENSG00000187021. [P54315-1] ENST00000528052; ENSP00000433933; ENSG00000187021. [P54315-1] |
GeneIDi | 5407. |
KEGGi | hsa:5407. |
UCSCi | uc001lco.2. human. [P54315-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | LIPR1_HUMAN | |
Accessioni | P54315Primary (citable) accession number: P54315 Secondary accession number(s): Q68D83 Q9BS82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |