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Protein

Inactive pancreatic lipase-related protein 1

Gene

PNLIPRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Nucleophile1
Active sitei194Charge relay system1
Metal bindingi205Calcium; via carbonyl oxygen1
Metal bindingi208Calcium; via carbonyl oxygen1
Metal bindingi210Calcium1
Metal bindingi213Calcium1
Active sitei281Charge relay system1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • triglyceride lipase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.26. 2681.
ReactomeiR-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-PNLIPRP1. Pancreatic_lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive pancreatic lipase-related protein 1
Short name:
PL-RP1
Gene namesi
Name:PNLIPRP1
Synonyms:PLRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9156. PNLIPRP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187021.
PharmGKBiPA33479.

Polymorphism and mutation databases

BioMutaiPNLIPRP1.
DMDMi1708837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001779018 – 467Inactive pancreatic lipase-related protein 1Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation1 Publication
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation1 Publication
Disulfide bondi255 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi303 ↔ 314PROSITE-ProRule annotation1 Publication
Disulfide bondi317 ↔ 322PROSITE-ProRule annotation1 Publication
Disulfide bondi451 ↔ 467PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP54315.
PeptideAtlasiP54315.
PRIDEiP54315.

Expressioni

Tissue specificityi

Pancreas.1 Publication

Gene expression databases

BgeeiENSG00000187021.
CleanExiHS_PNLIPRP1.
ExpressionAtlasiP54315. baseline and differential.
GenevisibleiP54315. HS.

Interactioni

Protein-protein interaction databases

BioGridi111408. 9 interactors.
IntActiP54315. 3 interactors.
STRINGi9606.ENSP00000351695.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 22Combined sources4
Turni23 – 25Combined sources3
Beta strandi26 – 30Combined sources5
Turni32 – 34Combined sources3
Beta strandi35 – 40Combined sources6
Helixi49 – 52Combined sources4
Beta strandi55 – 63Combined sources9
Beta strandi68 – 71Combined sources4
Helixi76 – 80Combined sources5
Beta strandi87 – 93Combined sources7
Helixi104 – 115Combined sources12
Beta strandi118 – 124Combined sources7
Helixi126 – 129Combined sources4
Helixi133 – 158Combined sources26
Helixi162 – 164Combined sources3
Beta strandi165 – 170Combined sources6
Helixi173 – 182Combined sources10
Beta strandi189 – 194Combined sources6
Turni198 – 202Combined sources5
Turni205 – 207Combined sources3
Helixi211 – 213Combined sources3
Beta strandi214 – 220Combined sources7
Helixi227 – 230Combined sources4
Beta strandi240 – 246Combined sources7
Beta strandi249 – 251Combined sources3
Helixi266 – 270Combined sources5
Helixi279 – 293Combined sources15
Turni295 – 298Combined sources4
Helixi306 – 310Combined sources5
Beta strandi324 – 326Combined sources3
Helixi327 – 331Combined sources5
Beta strandi341 – 345Combined sources5
Beta strandi349 – 352Combined sources4
Beta strandi356 – 367Combined sources12
Beta strandi369 – 379Combined sources11
Beta strandi387 – 394Combined sources8
Beta strandi399 – 408Combined sources10
Beta strandi412 – 421Combined sources10
Beta strandi432 – 441Combined sources10
Beta strandi447 – 451Combined sources5
Beta strandi462 – 466Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PPLX-ray2.20A18-467[»]
ProteinModelPortaliP54315.
SMRiP54315.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 467PLATPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP54315.
KOiK14074.
OMAiLGFGTNQ.
PhylomeDBiP54315.
TreeFamiTF324997.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P54315-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE
60 70 80 90 100
KIGTRFLLYT NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG
110 120 130 140 150
DESWVTDMCK KLFEVEEVNC ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM
160 170 180 190 200
LDILLTEYSY PPSKVHLIGH SLGAHVAGEA GSKTPGLSRI TGLDPVEASF
210 220 230 240 250
ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG HLDFFPNGGE
260 270 280 290 300
SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA
360 370 380 390 400
SNFARWRYGV SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH
410 420 430 440 450
SYEFDAKLDV GTIEKVKFLW NNNVINPTLP KVGATKITVQ KGEEKTVYNF
460
CSEDTVREDT LLTLTPC
Length:467
Mass (Da):51,848
Last modified:October 1, 1996 - v1
Checksum:i2781EA1E22E39E78
GO
Isoform 2 (identifier: P54315-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-186: KLFEVEEVNC...AGEAGSKTPG → VGASSDPCGQ...EKYSYYLISG
     187-467: Missing.

Show »
Length:186
Mass (Da):21,354
Checksum:i00AA562CC980CDF0
GO
Isoform 3 (identifier: P54315-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-117: KLFEVEE → PGASPRA
     118-467: Missing.

Show »
Length:117
Mass (Da):13,245
Checksum:i24E13DBDF751B557
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04982061N → D.Corresponds to variant rs11197744dbSNPEnsembl.1
Natural variantiVAR_036379129S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_022082271A → V.Corresponds to variant rs2305205dbSNPEnsembl.1
Natural variantiVAR_022659414E → D.1 PublicationCorresponds to variant rs2305204dbSNPEnsembl.1
Natural variantiVAR_014915461L → P.Corresponds to variant rs1049125dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014097111 – 186KLFEV…SKTPG → VGASSDPCGQLRPTLLLTSL HHFMHSRNLYILGNFMQLKC FSSQKLKCLSMFPHYICTLK QPHLLLEKYSYYLISG in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_014098111 – 117KLFEVEE → PGASPRA in isoform 3. 1 Publication7
Alternative sequenceiVSP_014099118 – 467Missing in isoform 3. 1 PublicationAdd BLAST350
Alternative sequenceiVSP_014100187 – 467Missing in isoform 2. 1 PublicationAdd BLAST281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93283 mRNA. Translation: AAA59532.1.
CR749299 mRNA. Translation: CAH18154.1.
CR749524 mRNA. Translation: CAH18337.1.
BC005233 mRNA. Translation: AAH05233.1.
BC025784 mRNA. Translation: AAH25784.1.
CCDSiCCDS7595.1. [P54315-1]
PIRiA43357.
RefSeqiNP_001290064.1. NM_001303135.1. [P54315-1]
NP_006220.1. NM_006229.3. [P54315-1]
XP_011538170.1. XM_011539868.1. [P54315-1]
UniGeneiHs.73923.

Genome annotation databases

EnsembliENST00000358834; ENSP00000351695; ENSG00000187021. [P54315-1]
ENST00000528052; ENSP00000433933; ENSG00000187021. [P54315-1]
GeneIDi5407.
KEGGihsa:5407.
UCSCiuc001lco.2. human. [P54315-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93283 mRNA. Translation: AAA59532.1.
CR749299 mRNA. Translation: CAH18154.1.
CR749524 mRNA. Translation: CAH18337.1.
BC005233 mRNA. Translation: AAH05233.1.
BC025784 mRNA. Translation: AAH25784.1.
CCDSiCCDS7595.1. [P54315-1]
PIRiA43357.
RefSeqiNP_001290064.1. NM_001303135.1. [P54315-1]
NP_006220.1. NM_006229.3. [P54315-1]
XP_011538170.1. XM_011539868.1. [P54315-1]
UniGeneiHs.73923.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PPLX-ray2.20A18-467[»]
ProteinModelPortaliP54315.
SMRiP54315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111408. 9 interactors.
IntActiP54315. 3 interactors.
STRINGi9606.ENSP00000351695.

Protein family/group databases

ESTHERihuman-PNLIPRP1. Pancreatic_lipase.

Polymorphism and mutation databases

BioMutaiPNLIPRP1.
DMDMi1708837.

Proteomic databases

PaxDbiP54315.
PeptideAtlasiP54315.
PRIDEiP54315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358834; ENSP00000351695; ENSG00000187021. [P54315-1]
ENST00000528052; ENSP00000433933; ENSG00000187021. [P54315-1]
GeneIDi5407.
KEGGihsa:5407.
UCSCiuc001lco.2. human. [P54315-1]

Organism-specific databases

CTDi5407.
GeneCardsiPNLIPRP1.
HGNCiHGNC:9156. PNLIPRP1.
MIMi604422. gene.
neXtProtiNX_P54315.
OpenTargetsiENSG00000187021.
PharmGKBiPA33479.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHRX. Eukaryota.
ENOG410Y92X. LUCA.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP54315.
KOiK14074.
OMAiLGFGTNQ.
PhylomeDBiP54315.
TreeFamiTF324997.

Enzyme and pathway databases

BRENDAi3.1.1.26. 2681.
ReactomeiR-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

EvolutionaryTraceiP54315.
GenomeRNAii5407.
PROiP54315.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187021.
CleanExiHS_PNLIPRP1.
ExpressionAtlasiP54315. baseline and differential.
GenevisibleiP54315. HS.

Family and domain databases

CDDicd00707. Pancreat_lipase_like. 1 hit.
Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR016272. Lipase_LIPH.
IPR033906. Lipase_N.
IPR002331. Lipase_panc.
IPR001024. PLAT/LH2_dom.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPR1_HUMAN
AccessioniPrimary (citable) accession number: P54315
Secondary accession number(s): Q68D83
, Q68DR6, Q8TAU2, Q9BS82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.