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P54315

- LIPR1_HUMAN

UniProt

P54315 - LIPR1_HUMAN

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Protein

Inactive pancreatic lipase-related protein 1

Gene

PNLIPRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei171 – 1711Nucleophile
Active sitei194 – 1941Charge relay system
Metal bindingi205 – 2051Calcium; via carbonyl oxygen
Metal bindingi208 – 2081Calcium; via carbonyl oxygen
Metal bindingi210 – 2101Calcium
Metal bindingi213 – 2131Calcium
Active sitei281 – 2811Charge relay system

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. triglyceride lipase activity Source: ProtInc

GO - Biological processi

  1. lipid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_9518. Digestion of dietary lipid.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive pancreatic lipase-related protein 1
Short name:
PL-RP1
Gene namesi
Name:PNLIPRP1
Synonyms:PLRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:9156. PNLIPRP1.

Subcellular locationi

Secreted 2 Publications

GO - Cellular componenti

  1. extracellular region Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33479.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 467450Inactive pancreatic lipase-related protein 1PRO_0000017790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 271 PublicationPROSITE-ProRule annotation
Disulfide bondi109 ↔ 1201 PublicationPROSITE-ProRule annotation
Disulfide bondi255 ↔ 2791 PublicationPROSITE-ProRule annotation
Disulfide bondi303 ↔ 3141 PublicationPROSITE-ProRule annotation
Disulfide bondi317 ↔ 3221 PublicationPROSITE-ProRule annotation
Disulfide bondi451 ↔ 4671 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP54315.
PRIDEiP54315.

PTM databases

PhosphoSiteiP54315.

Expressioni

Tissue specificityi

Pancreas.1 Publication

Gene expression databases

BgeeiP54315.
CleanExiHS_PNLIPRP1.
ExpressionAtlasiP54315. baseline and differential.
GenevestigatoriP54315.

Interactioni

Protein-protein interaction databases

IntActiP54315. 1 interaction.
STRINGi9606.ENSP00000351695.

Structurei

Secondary structure

1
467
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 224Combined sources
Turni23 – 253Combined sources
Beta strandi26 – 305Combined sources
Turni32 – 343Combined sources
Beta strandi35 – 406Combined sources
Helixi49 – 524Combined sources
Beta strandi55 – 639Combined sources
Beta strandi68 – 714Combined sources
Helixi76 – 805Combined sources
Beta strandi87 – 937Combined sources
Helixi104 – 11512Combined sources
Beta strandi118 – 1247Combined sources
Helixi126 – 1294Combined sources
Helixi133 – 15826Combined sources
Helixi162 – 1643Combined sources
Beta strandi165 – 1706Combined sources
Helixi173 – 18210Combined sources
Beta strandi189 – 1946Combined sources
Turni198 – 2025Combined sources
Turni205 – 2073Combined sources
Helixi211 – 2133Combined sources
Beta strandi214 – 2207Combined sources
Helixi227 – 2304Combined sources
Beta strandi240 – 2467Combined sources
Beta strandi249 – 2513Combined sources
Helixi266 – 2705Combined sources
Helixi279 – 29315Combined sources
Turni295 – 2984Combined sources
Helixi306 – 3105Combined sources
Beta strandi324 – 3263Combined sources
Helixi327 – 3315Combined sources
Beta strandi341 – 3455Combined sources
Beta strandi349 – 3524Combined sources
Beta strandi356 – 36712Combined sources
Beta strandi369 – 37911Combined sources
Beta strandi387 – 3948Combined sources
Beta strandi399 – 40810Combined sources
Beta strandi412 – 42110Combined sources
Beta strandi432 – 44110Combined sources
Beta strandi447 – 4515Combined sources
Beta strandi462 – 4665Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PPLX-ray2.20A18-467[»]
ProteinModelPortaliP54315.
SMRiP54315. Positions 18-467.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini356 – 467112PLATPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40923.
GeneTreeiENSGT00760000119069.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP54315.
KOiK14074.
OMAiKGDESWV.
PhylomeDBiP54315.
TreeFamiTF324997.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P54315-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLIFWTITLF LLGAAKGKEV CYEDLGCFSD TEPWGGTAIR PLKILPWSPE
60 70 80 90 100
KIGTRFLLYT NENPNNFQIL LLSDPSTIEA SNFQMDRKTR FIIHGFIDKG
110 120 130 140 150
DESWVTDMCK KLFEVEEVNC ICVDWKKGSQ ATYTQAANNV RVVGAQVAQM
160 170 180 190 200
LDILLTEYSY PPSKVHLIGH SLGAHVAGEA GSKTPGLSRI TGLDPVEASF
210 220 230 240 250
ESTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQQMG HLDFFPNGGE
260 270 280 290 300
SMPGCKKNAL SQIVDLDGIW AGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCTSYKSFE SDKCFPCPDQ GCPQMGHYAD KFAGRTSEEQ QKFFLNTGEA
360 370 380 390 400
SNFARWRYGV SITLSGRTAT GQIKVALFGN KGNTHQYSIF RGILKPGSTH
410 420 430 440 450
SYEFDAKLDV GTIEKVKFLW NNNVINPTLP KVGATKITVQ KGEEKTVYNF
460
CSEDTVREDT LLTLTPC
Length:467
Mass (Da):51,848
Last modified:October 1, 1996 - v1
Checksum:i2781EA1E22E39E78
GO
Isoform 2 (identifier: P54315-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-186: KLFEVEEVNC...AGEAGSKTPG → VGASSDPCGQ...EKYSYYLISG
     187-467: Missing.

Show »
Length:186
Mass (Da):21,354
Checksum:i00AA562CC980CDF0
GO
Isoform 3 (identifier: P54315-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-117: KLFEVEE → PGASPRA
     118-467: Missing.

Show »
Length:117
Mass (Da):13,245
Checksum:i24E13DBDF751B557
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti61 – 611N → D.
Corresponds to variant rs11197744 [ dbSNP | Ensembl ].
VAR_049820
Natural varianti129 – 1291S → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_036379
Natural varianti271 – 2711A → V.
Corresponds to variant rs2305205 [ dbSNP | Ensembl ].
VAR_022082
Natural varianti414 – 4141E → D.1 Publication
Corresponds to variant rs2305204 [ dbSNP | Ensembl ].
VAR_022659
Natural varianti461 – 4611L → P.
Corresponds to variant rs1049125 [ dbSNP | Ensembl ].
VAR_014915

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei111 – 18676KLFEV…SKTPG → VGASSDPCGQLRPTLLLTSL HHFMHSRNLYILGNFMQLKC FSSQKLKCLSMFPHYICTLK QPHLLLEKYSYYLISG in isoform 2. 1 PublicationVSP_014097Add
BLAST
Alternative sequencei111 – 1177KLFEVEE → PGASPRA in isoform 3. 1 PublicationVSP_014098
Alternative sequencei118 – 467350Missing in isoform 3. 1 PublicationVSP_014099Add
BLAST
Alternative sequencei187 – 467281Missing in isoform 2. 1 PublicationVSP_014100Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93283 mRNA. Translation: AAA59532.1.
CR749299 mRNA. Translation: CAH18154.1.
CR749524 mRNA. Translation: CAH18337.1.
BC005233 mRNA. Translation: AAH05233.1.
BC025784 mRNA. Translation: AAH25784.1.
CCDSiCCDS7595.1. [P54315-1]
PIRiA43357.
RefSeqiNP_006220.1. NM_006229.2. [P54315-1]
XP_005269960.1. XM_005269903.2. [P54315-1]
UniGeneiHs.73923.

Genome annotation databases

EnsembliENST00000358834; ENSP00000351695; ENSG00000187021. [P54315-1]
ENST00000528052; ENSP00000433933; ENSG00000187021. [P54315-1]
GeneIDi5407.
KEGGihsa:5407.
UCSCiuc001lcn.3. human. [P54315-2]
uc001lco.1. human. [P54315-1]

Polymorphism databases

DMDMi1708837.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93283 mRNA. Translation: AAA59532.1 .
CR749299 mRNA. Translation: CAH18154.1 .
CR749524 mRNA. Translation: CAH18337.1 .
BC005233 mRNA. Translation: AAH05233.1 .
BC025784 mRNA. Translation: AAH25784.1 .
CCDSi CCDS7595.1. [P54315-1 ]
PIRi A43357.
RefSeqi NP_006220.1. NM_006229.2. [P54315-1 ]
XP_005269960.1. XM_005269903.2. [P54315-1 ]
UniGenei Hs.73923.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PPL X-ray 2.20 A 18-467 [» ]
ProteinModelPortali P54315.
SMRi P54315. Positions 18-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P54315. 1 interaction.
STRINGi 9606.ENSP00000351695.

PTM databases

PhosphoSitei P54315.

Polymorphism databases

DMDMi 1708837.

Proteomic databases

PaxDbi P54315.
PRIDEi P54315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358834 ; ENSP00000351695 ; ENSG00000187021 . [P54315-1 ]
ENST00000528052 ; ENSP00000433933 ; ENSG00000187021 . [P54315-1 ]
GeneIDi 5407.
KEGGi hsa:5407.
UCSCi uc001lcn.3. human. [P54315-2 ]
uc001lco.1. human. [P54315-1 ]

Organism-specific databases

CTDi 5407.
GeneCardsi GC10P118340.
HGNCi HGNC:9156. PNLIPRP1.
MIMi 604422. gene.
neXtProti NX_P54315.
PharmGKBi PA33479.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40923.
GeneTreei ENSGT00760000119069.
HOGENOMi HOG000038552.
HOVERGENi HBG003243.
InParanoidi P54315.
KOi K14074.
OMAi KGDESWV.
PhylomeDBi P54315.
TreeFami TF324997.

Enzyme and pathway databases

Reactomei REACT_9518. Digestion of dietary lipid.

Miscellaneous databases

EvolutionaryTracei P54315.
GenomeRNAii 5407.
NextBioi 20935.
PROi P54315.
SOURCEi Search...

Gene expression databases

Bgeei P54315.
CleanExi HS_PNLIPRP1.
ExpressionAtlasi P54315. baseline and differential.
Genevestigatori P54315.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
Pfami PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity."
    Giller T., Buchwald P., Blum-Kaelin D., Hunziker W.
    J. Biol. Chem. 267:16509-16516(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ABSENCE OF LIPASE ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-414.
    Tissue: Pancreas.
  4. "Individual and combined action of pancreatic lipase and pancreatic lipase-related proteins 1 and 2 on native versus homogenized milk fat globules."
    Berton A., Sebban-Kreuzer C., Rouvellac S., Lopez C., Crenon I.
    Mol. Nutr. Food Res. 53:1592-1602(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, ABSENCE OF CATALYTIC ACTIVITY.
  5. "Structure of the human pancreatic lipase-related protein 1."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 18-467 IN COMPLEX WITH CALCIUM IONS, DISULFIDE BONDS.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-129.

Entry informationi

Entry nameiLIPR1_HUMAN
AccessioniPrimary (citable) accession number: P54315
Secondary accession number(s): Q68D83
, Q68DR6, Q8TAU2, Q9BS82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3