Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54296

- MYOM2_HUMAN

UniProt

P54296 - MYOM2_HUMAN

Protein

Myomesin-2

Gene

MYOM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural constituent of muscle Source: ProtInc

    GO - Biological processi

    1. muscle contraction Source: ProtInc

    Keywords - Molecular functioni

    Muscle protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myomesin-2
    Alternative name(s):
    165 kDa connectin-associated protein
    165 kDa titin-associated protein
    M-protein
    Myomesin family member 2
    Gene namesi
    Name:MYOM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7614. MYOM2.

    Subcellular locationi

    CytoplasmmyofibrilsarcomereM line By similarity

    GO - Cellular componenti

    1. M band Source: UniProtKB-SubCell
    2. mitochondrion Source: UniProt
    3. myosin filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31419.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14651465Myomesin-2PRO_0000072686Add
    BLAST

    Proteomic databases

    MaxQBiP54296.
    PaxDbiP54296.
    PRIDEiP54296.

    PTM databases

    PhosphoSiteiP54296.

    Expressioni

    Gene expression databases

    ArrayExpressiP54296.
    BgeeiP54296.
    CleanExiHS_MYOM2.
    GenevestigatoriP54296.

    Organism-specific databases

    HPAiHPA001765.
    HPA005953.

    Interactioni

    Subunit structurei

    Interacts with TTN/titin.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ACTN2P356092EBI-5357134,EBI-77797
    DYSFO759233EBI-5357134,EBI-2799016
    RYR1P218172EBI-5357134,EBI-1221290
    TTNQ8WZ422EBI-5357134,EBI-681210

    Protein-protein interaction databases

    BioGridi114612. 1 interaction.
    IntActiP54296. 13 interactions.
    STRINGi9606.ENSP00000262113.

    Structurei

    3D structure databases

    ProteinModelPortaliP54296.
    SMRiP54296. Positions 150-1436.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini154 – 24592Ig-like C2-type 1Add
    BLAST
    Domaini266 – 371106Ig-like C2-type 2Add
    BLAST
    Domaini385 – 48096Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini513 – 60896Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini614 – 70794Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini710 – 812103Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini815 – 91298Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini904 – 100299Ig-like C2-type 3Add
    BLAST
    Domaini1130 – 121182Ig-like C2-type 4Add
    BLAST
    Domaini1345 – 143490Ig-like C2-type 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG147025.
    HOGENOMiHOG000293283.
    HOVERGENiHBG004977.
    InParanoidiP54296.
    OMAiHSKLYFK.
    PhylomeDBiP54296.
    TreeFamiTF331825.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 5 hits.
    PF07679. I-set. 3 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 5 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54296-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ     50
    RSSSQRASSQ TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK 100
    RQRFLSELAH LEEDVHLARS QARDKLDKYA IQQMMEDKLA WERHTFEERI 150
    SRAPEILVRL RSHTVWERMS VKLCFTVQGF PTPVVQWYKD GSLICQAAEP 200
    GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST NAAVVVRRFR 250
    GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT 300
    MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE 350
    GLYTLRIVSR GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI 400
    VTWKPPNTTT ESPVMGYFVD RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG 450
    RSYIFRVRAV NSAGISRPSR VSDAVAALDP LDLRRLQAVH LEGEKEIAIY 500
    QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD PLMYFIEKSV 550
    VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT 600
    SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV 650
    AGTNLWEPCN HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD 700
    VIKVQAALTV PSHPYGITLL NCDGHSMTLG WKVPKFSGGS PILGYYLDKR 750
    EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL YEFKIAAVNL AGIGEPSDPS 800
    EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG SSPVSGYFVD 850
    FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD 900
    TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI 950
    SDDERFKIET VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE 1000
    LERLMALSNE IKNPTIPLKS ELAYEIFDKG RVRFWLQAEH LSPDASYRFI 1050
    INDREVSDSE IHRIKCDKAT GIIEMVMDRF SIENEGTYTV QIHDGKAKSQ 1100
    SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV TEECEVRLVC 1150
    KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA 1200
    TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ 1250
    CFMKYFTDEM KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK 1300
    YTFEIFDGKD NHQRSLDLSG QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL 1350
    PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK NDQDIQLSEH FSVKVEQAKY 1400
    VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE KIPDMAPPQQ 1450
    AKPKLIPASA SAAGQ 1465
    Length:1,465
    Mass (Da):164,896
    Last modified:March 3, 2009 - v2
    Checksum:i71C6B11FCB066A8B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1032QR → HG in CAA48832. (PubMed:7505783)Curated
    Sequence conflicti364 – 3641S → T in CAA48832. (PubMed:7505783)Curated
    Sequence conflicti555 – 5551S → T in CAA48832. (PubMed:7505783)Curated
    Sequence conflicti863 – 8631N → D in CAA48832. (PubMed:7505783)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811E → K.
    Corresponds to variant rs35985218 [ dbSNP | Ensembl ].
    VAR_033613
    Natural varianti182 – 1821T → M.
    Corresponds to variant rs17064618 [ dbSNP | Ensembl ].
    VAR_033614
    Natural varianti321 – 3211V → L.1 Publication
    Corresponds to variant rs2272720 [ dbSNP | Ensembl ].
    VAR_033615
    Natural varianti363 – 3631V → I.
    Corresponds to variant rs34316994 [ dbSNP | Ensembl ].
    VAR_033616
    Natural varianti601 – 6011S → Y.
    Corresponds to variant rs36089594 [ dbSNP | Ensembl ].
    VAR_033617
    Natural varianti701 – 7011V → I.
    Corresponds to variant rs35335787 [ dbSNP | Ensembl ].
    VAR_033618
    Natural varianti776 – 7761T → M.1 Publication
    Corresponds to variant rs2294066 [ dbSNP | Ensembl ].
    VAR_020083
    Natural varianti869 – 8691N → S.2 Publications
    Corresponds to variant rs968381 [ dbSNP | Ensembl ].
    VAR_054501
    Natural varianti1022 – 10221L → F.
    Corresponds to variant rs2280896 [ dbSNP | Ensembl ].
    VAR_020084
    Natural varianti1168 – 11681V → A.2 Publications
    Corresponds to variant rs17854780 [ dbSNP | Ensembl ].
    VAR_061320
    Natural varianti1284 – 12841E → D.
    Corresponds to variant rs34735757 [ dbSNP | Ensembl ].
    VAR_033619

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69089 mRNA. Translation: CAA48832.1.
    AC125453 Genomic DNA. No translation available.
    BC052969 mRNA. Translation: AAH52969.1.
    CCDSiCCDS5957.1.
    PIRiS43529.
    RefSeqiNP_003961.3. NM_003970.3.
    UniGeneiHs.443683.

    Genome annotation databases

    EnsembliENST00000262113; ENSP00000262113; ENSG00000036448.
    GeneIDi9172.
    KEGGihsa:9172.
    UCSCiuc003wpx.4. human.

    Polymorphism databases

    DMDMi224471842.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69089 mRNA. Translation: CAA48832.1 .
    AC125453 Genomic DNA. No translation available.
    BC052969 mRNA. Translation: AAH52969.1 .
    CCDSi CCDS5957.1.
    PIRi S43529.
    RefSeqi NP_003961.3. NM_003970.3.
    UniGenei Hs.443683.

    3D structure databases

    ProteinModelPortali P54296.
    SMRi P54296. Positions 150-1436.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114612. 1 interaction.
    IntActi P54296. 13 interactions.
    STRINGi 9606.ENSP00000262113.

    PTM databases

    PhosphoSitei P54296.

    Polymorphism databases

    DMDMi 224471842.

    Proteomic databases

    MaxQBi P54296.
    PaxDbi P54296.
    PRIDEi P54296.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262113 ; ENSP00000262113 ; ENSG00000036448 .
    GeneIDi 9172.
    KEGGi hsa:9172.
    UCSCi uc003wpx.4. human.

    Organism-specific databases

    GeneCardsi GC08P001993.
    H-InvDB HIX0025666.
    HGNCi HGNC:7614. MYOM2.
    HPAi HPA001765.
    HPA005953.
    MIMi 603509. gene.
    neXtProti NX_P54296.
    PharmGKBi PA31419.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147025.
    HOGENOMi HOG000293283.
    HOVERGENi HBG004977.
    InParanoidi P54296.
    OMAi HSKLYFK.
    PhylomeDBi P54296.
    TreeFami TF331825.

    Miscellaneous databases

    ChiTaRSi MYOM2. human.
    GeneWikii MYOM2.
    GenomeRNAii 9172.
    NextBioi 34395.
    PROi P54296.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P54296.
    Bgeei P54296.
    CleanExi HS_MYOM2.
    Genevestigatori P54296.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 5 hits.
    PF07679. I-set. 3 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 5 hits.
    SM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins."
      Vinkemeier U., Obermann W., Weber K., Fuerst D.O.
      J. Cell Sci. 106:319-330(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-321; SER-869 AND ALA-1168.
      Tissue: Skeletal muscle.
    2. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-776; SER-869 AND ALA-1168.
      Tissue: PNS.

    Entry informationi

    Entry nameiMYOM2_HUMAN
    AccessioniPrimary (citable) accession number: P54296
    Secondary accession number(s): Q7Z3Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3