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Reviewed, UniProtKB/Swiss-Prot P54296 (MYOM2_HUMAN)

Last modified November 25, 2008. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Myomesin-2
Alternative name(s):
    Myomesin family member 2
      Short name=M-protein
    165 kDa titin-associated protein
    165 kDa connectin-associated protein
Gene names
Name: MYOM2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length1465 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

Subunit structure

Interacts with TTN/titin By similarity.

Sequence similarities

Contains 5 fibronectin type-III domains.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

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Ontologies

Keywords

   Cellular componentThick filament
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
   Molecular functionMuscle protein

Gene Ontology (GO)

   Biological processstriated muscle contraction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrion

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

striated muscle thick filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionstructural constituent of muscle Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14651465Myomesin-2
PRO_0000072686

Regions

Domain154 – 24592Ig-like C2-type 1
Domain266 – 371106Ig-like C2-type 2
Domain383 – 47593Fibronectin type-III 1
Domain511 – 60393Fibronectin type-III 2
Domain612 – 70291Fibronectin type-III 3
Domain711 – 80393Fibronectin type-III 4
Domain813 – 90593Fibronectin type-III 5
Domain904 – 100299Ig-like C2-type 3
Domain1130 – 121182Ig-like C2-type 4
Domain1345 – 143490Ig-like C2-type 5

Natural variations

Natural variant811E → K: dbSNP rs35985218.
VAR_033613
Natural variant1821T → M: dbSNP rs17064618.
VAR_033614
Natural variant3211L → V: dbSNP rs2272720.
VAR_033615
Natural variant3631V → I: dbSNP rs34316994.
VAR_033616
Natural variant6011S → Y: dbSNP rs36089594.
VAR_033617
Natural variant7011V → I: dbSNP rs35335787.
VAR_033618
Natural variant7761T → M: dbSNP rs2294066.
VAR_020083
Natural variant10221L → F: dbSNP rs2280896.
VAR_020084
Natural variant12841E → D: dbSNP rs34735757.
VAR_033619

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Sequences

Sequence LengthMass (Da)Tools
P54296-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6F2927B5A1E69F2D

FASTA1,465164,794
        10         20         30         40         50         60 
MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ RSSSQRASSQ 

        70         80         90        100        110        120 
TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK RHGFLSELAH LEEDVHLARS 

       130        140        150        160        170        180 
QARDKLDKYA IQQMMEDKLA WERHTFEERI SRAPEILVRL RSHTVWERMS VKLCFTVQGF 

       190        200        210        220        230        240 
PTPVVQWYKD GSLICQAAEP GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST 

       250        260        270        280        290        300 
NAAVVVRRFR GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT 

       310        320        330        340        350        360 
MLVTPDLKRV QPRAEWYRDD LLLKESKWTK MFFGEGQASL SFSHLHKDDE GLYTLRIVSR 

       370        380        390        400        410        420 
GGVTDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI VTWKPPNTTT ESPVMGYFVD 

       430        440        450        460        470        480 
RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG RSYIFRVRAV NSAGISRPSR VSDAVAALDP 

       490        500        510        520        530        540 
LDLRRLQAVH LEGEKEIAIY QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD 

       550        560        570        580        590        600 
PLMYFIEKSV VGSGTWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT 

       610        620        630        640        650        660 
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV AGTNLWEPCN 

       670        680        690        700        710        720 
HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD VIKVQAALTV PSHPYGITLL 

       730        740        750        760        770        780 
NCDGHSMTLG WKVPKFSGGS PILGYYLDKR EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL 

       790        800        810        820        830        840 
YEFKIAAVNL AGIGEPSDPS EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG 

       850        860        870        880        890        900 
SSPVSGYFVD FREEDAGEWI TVDQTTTASR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD 

       910        920        930        940        950        960 
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI SDDERFKIET 

       970        980        990       1000       1010       1020 
VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE LERLMALSNE IKNPTIPLKS 

      1030       1040       1050       1060       1070       1080 
ELAYEIFDKG RVRFWLQAEH LSPDASYRFI INDREVSDSE IHRIKCDKAT GIIEMVMDRF 

      1090       1100       1110       1120       1130       1140 
SIENEGTYTV QIHDGKAKSQ SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV 

      1150       1160       1170       1180       1190       1200 
TEECEVRLVC KVANTKKETV FKWLKDDALY ETETLPNLER GICELLIPKL SKKDHGEYKA 

      1210       1220       1230       1240       1250       1260 
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ CFMKYFTDEM 

      1270       1280       1290       1300       1310       1320 
KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK YTFEIFDGKD NHQRSLDLSG 

      1330       1340       1350       1360       1370       1380 
QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK 

      1390       1400       1410       1420       1430       1440 
NDQDIQLSEH FSVKVEQAKY VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE 

      1450       1460 
KIPDMAPPQQ AKPKLIPASA SAAGQ

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References

[1]"The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins."
Vinkemeier U., Obermann W., Weber K., Fuerst D.O.
J. Cell Sci. 106:319-330(1993) [PubMed: 7505783] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X69089 mRNA. Translation: CAA48832.1.
PIRS43529.
UniGeneHs.443683

3D structure databases

HSSPHSSP built from PDB template 1BPV based on UniProtKB Q10466.
ModBaseSearch...

PTM databases

PhosphoSiteP54296.

Genome annotation databases

EnsemblENSG00000036448. Homo sapiens. [Contig view]

Organism-specific databases

H-InvDBHIX0025666.
HGNCHGNC:7614. MYOM2.
HPAHPA001765.
HPA005953.
MIM603509. gene.
PharmGKBPA31419.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP54296.
HOVERGENP54296.

Gene expression databases

ArrayExpressP54296.
CleanExHS_MYOM2.
GermOnlineENSG00000036448. Homo sapiens.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003962. FnIII_subd.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 5 hits.
G3DSA:2.60.40.10. Ig-like_fold. 4 hits.
PfamPF00041. fn3. 5 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSPR00014. FNTYPEIII.
SMARTSM00060. FN3. 5 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameMYOM2_HUMAN
AccessionPrimary (citable) accession number: P54296
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 25, 2008
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents