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Protein

Myomesin-2

Gene

MYOM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.

GO - Molecular functioni

  1. structural constituent of muscle Source: ProtInc

GO - Biological processi

  1. muscle contraction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Myomesin-2
Alternative name(s):
165 kDa connectin-associated protein
165 kDa titin-associated protein
M-protein
Myomesin family member 2
Gene namesi
Name:MYOM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 8, Unplaced

Organism-specific databases

HGNCiHGNC:7614. MYOM2.

Subcellular locationi

CytoplasmmyofibrilsarcomereM line By similarity

GO - Cellular componenti

  1. M band Source: UniProtKB-SubCell
  2. mitochondrion Source: UniProtKB
  3. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14651465Myomesin-2PRO_0000072686Add
BLAST

Proteomic databases

MaxQBiP54296.
PaxDbiP54296.
PRIDEiP54296.

PTM databases

PhosphoSiteiP54296.

Expressioni

Gene expression databases

BgeeiP54296.
CleanExiHS_MYOM2.
GenevestigatoriP54296.

Organism-specific databases

HPAiHPA001765.
HPA005953.

Interactioni

Subunit structurei

Interacts with TTN/titin.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTN2P356092EBI-5357134,EBI-77797
DYSFO759233EBI-5357134,EBI-2799016
RYR1P218172EBI-5357134,EBI-1221290
TTNQ8WZ422EBI-5357134,EBI-681210

Protein-protein interaction databases

BioGridi114612. 1 interaction.
IntActiP54296. 13 interactions.
STRINGi9606.ENSP00000262113.

Structurei

3D structure databases

ProteinModelPortaliP54296.
SMRiP54296. Positions 150-1436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini154 – 24592Ig-like C2-type 1Add
BLAST
Domaini266 – 371106Ig-like C2-type 2Add
BLAST
Domaini385 – 48096Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini513 – 60896Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini614 – 70794Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini710 – 812103Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini815 – 91298Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini904 – 100299Ig-like C2-type 3Add
BLAST
Domaini1130 – 121182Ig-like C2-type 4Add
BLAST
Domaini1345 – 143490Ig-like C2-type 5Add
BLAST

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG147025.
HOGENOMiHOG000293283.
HOVERGENiHBG004977.
InParanoidiP54296.
OMAiHSKLYFK.
PhylomeDBiP54296.
TreeFamiTF331825.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ
60 70 80 90 100
RSSSQRASSQ TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK
110 120 130 140 150
RQRFLSELAH LEEDVHLARS QARDKLDKYA IQQMMEDKLA WERHTFEERI
160 170 180 190 200
SRAPEILVRL RSHTVWERMS VKLCFTVQGF PTPVVQWYKD GSLICQAAEP
210 220 230 240 250
GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST NAAVVVRRFR
260 270 280 290 300
GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT
310 320 330 340 350
MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE
360 370 380 390 400
GLYTLRIVSR GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI
410 420 430 440 450
VTWKPPNTTT ESPVMGYFVD RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG
460 470 480 490 500
RSYIFRVRAV NSAGISRPSR VSDAVAALDP LDLRRLQAVH LEGEKEIAIY
510 520 530 540 550
QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD PLMYFIEKSV
560 570 580 590 600
VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT
610 620 630 640 650
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV
660 670 680 690 700
AGTNLWEPCN HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD
710 720 730 740 750
VIKVQAALTV PSHPYGITLL NCDGHSMTLG WKVPKFSGGS PILGYYLDKR
760 770 780 790 800
EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL YEFKIAAVNL AGIGEPSDPS
810 820 830 840 850
EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG SSPVSGYFVD
860 870 880 890 900
FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD
910 920 930 940 950
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI
960 970 980 990 1000
SDDERFKIET VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE
1010 1020 1030 1040 1050
LERLMALSNE IKNPTIPLKS ELAYEIFDKG RVRFWLQAEH LSPDASYRFI
1060 1070 1080 1090 1100
INDREVSDSE IHRIKCDKAT GIIEMVMDRF SIENEGTYTV QIHDGKAKSQ
1110 1120 1130 1140 1150
SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV TEECEVRLVC
1160 1170 1180 1190 1200
KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA
1210 1220 1230 1240 1250
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ
1260 1270 1280 1290 1300
CFMKYFTDEM KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK
1310 1320 1330 1340 1350
YTFEIFDGKD NHQRSLDLSG QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL
1360 1370 1380 1390 1400
PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK NDQDIQLSEH FSVKVEQAKY
1410 1420 1430 1440 1450
VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE KIPDMAPPQQ
1460
AKPKLIPASA SAAGQ
Length:1,465
Mass (Da):164,896
Last modified:March 3, 2009 - v2
Checksum:i71C6B11FCB066A8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1032QR → HG in CAA48832 (PubMed:7505783).Curated
Sequence conflicti364 – 3641S → T in CAA48832 (PubMed:7505783).Curated
Sequence conflicti555 – 5551S → T in CAA48832 (PubMed:7505783).Curated
Sequence conflicti863 – 8631N → D in CAA48832 (PubMed:7505783).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti81 – 811E → K.
Corresponds to variant rs35985218 [ dbSNP | Ensembl ].
VAR_033613
Natural varianti182 – 1821T → M.
Corresponds to variant rs17064618 [ dbSNP | Ensembl ].
VAR_033614
Natural varianti321 – 3211V → L.1 Publication
Corresponds to variant rs2272720 [ dbSNP | Ensembl ].
VAR_033615
Natural varianti363 – 3631V → I.
Corresponds to variant rs34316994 [ dbSNP | Ensembl ].
VAR_033616
Natural varianti601 – 6011S → Y.
Corresponds to variant rs36089594 [ dbSNP | Ensembl ].
VAR_033617
Natural varianti701 – 7011V → I.
Corresponds to variant rs35335787 [ dbSNP | Ensembl ].
VAR_033618
Natural varianti776 – 7761T → M.1 Publication
Corresponds to variant rs2294066 [ dbSNP | Ensembl ].
VAR_020083
Natural varianti869 – 8691N → S.2 Publications
Corresponds to variant rs968381 [ dbSNP | Ensembl ].
VAR_054501
Natural varianti1022 – 10221L → F.
Corresponds to variant rs2280896 [ dbSNP | Ensembl ].
VAR_020084
Natural varianti1168 – 11681V → A.2 Publications
Corresponds to variant rs17854780 [ dbSNP | Ensembl ].
VAR_061320
Natural varianti1284 – 12841E → D.
Corresponds to variant rs34735757 [ dbSNP | Ensembl ].
VAR_033619

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69089 mRNA. Translation: CAA48832.1.
AC125453 Genomic DNA. No translation available.
BC052969 mRNA. Translation: AAH52969.1.
CCDSiCCDS5957.1.
PIRiS43529.
RefSeqiNP_003961.3. NM_003970.3.
UniGeneiHs.443683.

Genome annotation databases

EnsembliENST00000262113; ENSP00000262113; ENSG00000036448.
ENST00000616680; ENSP00000478322; ENSG00000274137.
GeneIDi9172.
KEGGihsa:9172.
UCSCiuc003wpx.4. human.

Polymorphism databases

DMDMi224471842.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69089 mRNA. Translation: CAA48832.1.
AC125453 Genomic DNA. No translation available.
BC052969 mRNA. Translation: AAH52969.1.
CCDSiCCDS5957.1.
PIRiS43529.
RefSeqiNP_003961.3. NM_003970.3.
UniGeneiHs.443683.

3D structure databases

ProteinModelPortaliP54296.
SMRiP54296. Positions 150-1436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114612. 1 interaction.
IntActiP54296. 13 interactions.
STRINGi9606.ENSP00000262113.

PTM databases

PhosphoSiteiP54296.

Polymorphism databases

DMDMi224471842.

Proteomic databases

MaxQBiP54296.
PaxDbiP54296.
PRIDEiP54296.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262113; ENSP00000262113; ENSG00000036448.
ENST00000616680; ENSP00000478322; ENSG00000274137.
GeneIDi9172.
KEGGihsa:9172.
UCSCiuc003wpx.4. human.

Organism-specific databases

CTDi9172.
GeneCardsiGC08P001993.
H-InvDBHIX0025666.
HGNCiHGNC:7614. MYOM2.
HPAiHPA001765.
HPA005953.
MIMi603509. gene.
neXtProtiNX_P54296.
PharmGKBiPA31419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG147025.
HOGENOMiHOG000293283.
HOVERGENiHBG004977.
InParanoidiP54296.
OMAiHSKLYFK.
PhylomeDBiP54296.
TreeFamiTF331825.

Miscellaneous databases

ChiTaRSiMYOM2. human.
GeneWikiiMYOM2.
GenomeRNAii9172.
NextBioi34395.
PROiP54296.
SOURCEiSearch...

Gene expression databases

BgeeiP54296.
CleanExiHS_MYOM2.
GenevestigatoriP54296.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 5 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins."
    Vinkemeier U., Obermann W., Weber K., Fuerst D.O.
    J. Cell Sci. 106:319-330(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-321; SER-869 AND ALA-1168.
    Tissue: Skeletal muscle.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-776; SER-869 AND ALA-1168.
    Tissue: PNS.

Entry informationi

Entry nameiMYOM2_HUMAN
AccessioniPrimary (citable) accession number: P54296
Secondary accession number(s): Q7Z3Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 3, 2009
Last modified: January 7, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.