Reviewed,
UniProtKB/Swiss-Prot P54296 (MYOM2_HUMAN)
Last modified
November 25, 2008.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Myomesin-2 Alternative name(s): Myomesin family member 2 Short name=M-protein 165 kDa titin-associated protein 165 kDa connectin-associated protein | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1465 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. |
| Subunit structure | Interacts with TTN/titin By similarity. |
| Sequence similarities | Contains 5 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Thick filament |
| Coding sequence diversity | Polymorphism |
| Domain | Immunoglobulin domain Repeat |
| Molecular function | Muscle protein |
Gene Ontology (GO) | |
| Biological process | striated muscle contraction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrion Inferred from direct assay. Source: HPA nucleusInferred from direct assay. Source: HPA striated muscle thick filamentInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | structural constituent of muscle Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1465 | 1465 | Myomesin-2 | PRO_0000072686 | |||||
Regions | |||||||||
| Domain | 154 – 245 | 92 | Ig-like C2-type 1 | ||||||
| Domain | 266 – 371 | 106 | Ig-like C2-type 2 | ||||||
| Domain | 383 – 475 | 93 | Fibronectin type-III 1 | ||||||
| Domain | 511 – 603 | 93 | Fibronectin type-III 2 | ||||||
| Domain | 612 – 702 | 91 | Fibronectin type-III 3 | ||||||
| Domain | 711 – 803 | 93 | Fibronectin type-III 4 | ||||||
| Domain | 813 – 905 | 93 | Fibronectin type-III 5 | ||||||
| Domain | 904 – 1002 | 99 | Ig-like C2-type 3 | ||||||
| Domain | 1130 – 1211 | 82 | Ig-like C2-type 4 | ||||||
| Domain | 1345 – 1434 | 90 | Ig-like C2-type 5 | ||||||
Natural variations | |||||||||
| Natural variant | 81 | 1 | E → K: dbSNP rs35985218. | VAR_033613 | |||||
| Natural variant | 182 | 1 | T → M: dbSNP rs17064618. | VAR_033614 | |||||
| Natural variant | 321 | 1 | L → V: dbSNP rs2272720. | VAR_033615 | |||||
| Natural variant | 363 | 1 | V → I: dbSNP rs34316994. | VAR_033616 | |||||
| Natural variant | 601 | 1 | S → Y: dbSNP rs36089594. | VAR_033617 | |||||
| Natural variant | 701 | 1 | V → I: dbSNP rs35335787. | VAR_033618 | |||||
| Natural variant | 776 | 1 | T → M: dbSNP rs2294066. | VAR_020083 | |||||
| Natural variant | 1022 | 1 | L → F: dbSNP rs2280896. | VAR_020084 | |||||
| Natural variant | 1284 | 1 | E → D: dbSNP rs34735757. | VAR_033619 | |||||
Sequences
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References
| [1] | "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins." Vinkemeier U., Obermann W., Weber K., Fuerst D.O. J. Cell Sci. 106:319-330(1993) [PubMed: 7505783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X69089 mRNA. Translation: CAA48832.1. | |
| PIR | S43529. |
| UniGene | Hs.443683 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BPV based on UniProtKB Q10466. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P54296. |
Genome annotation databases | |
| Ensembl | ENSG00000036448. Homo sapiens. [Contig view] |
Organism-specific databases | |
| H-InvDB | HIX0025666. |
| HGNC | HGNC:7614. MYOM2. |
| HPA | HPA001765. HPA005953. |
| MIM | 603509. gene. |
| PharmGKB | PA31419. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P54296. |
| HOVERGEN | P54296. |
Gene expression databases | |
| ArrayExpress | P54296. |
| CleanEx | HS_MYOM2. |
| GermOnline | ENSG00000036448. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 5 hits. G3DSA:2.60.40.10. Ig-like_fold. 4 hits. |
| Pfam | PF00041. fn3. 5 hits. PF07679. I-set. 3 hits. [Graphical view] |
| PRINTS | PR00014. FNTYPEIII. |
| SMART | SM00060. FN3. 5 hits. SM00409. IG. 2 hits. SM00408. IGc2. 1 hit. [Graphical view] |
| PROSITE | PS50853. FN3. 5 hits. PS50835. IG_LIKE. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | MYOM2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P54296 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


