Reviewed, UniProtKB/Swiss-Prot P54296 (MYOM2_HUMAN)

Names and origin

Protein names

Recommended name:
    Myomesin-2
Alternative name(s):
    Myomesin family member 2
      Short name=M-protein
    165 kDa titin-associated protein
    165 kDa connectin-associated protein

Gene names

Name:

MYOM2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1465 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subunit structure	Interacts with TTN/titin By similarity.
Sequence similarities	Contains 5 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Thick filament
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat
Molecular function	Muscle protein
Gene Ontology (GO)
Biological process	striated muscle contraction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA striated muscle thick filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of muscle Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1465	1465	Myomesin-2		PRO_0000072686
Regions
	Domain	154 – 245	92	Ig-like C2-type 1
	Domain	266 – 371	106	Ig-like C2-type 2
	Domain	383 – 475	93	Fibronectin type-III 1
	Domain	511 – 603	93	Fibronectin type-III 2
	Domain	612 – 702	91	Fibronectin type-III 3
	Domain	711 – 803	93	Fibronectin type-III 4
	Domain	813 – 905	93	Fibronectin type-III 5
	Domain	904 – 1002	99	Ig-like C2-type 3
	Domain	1130 – 1211	82	Ig-like C2-type 4
	Domain	1345 – 1434	90	Ig-like C2-type 5
Natural variations
	Natural variant	81	1	E → K: dbSNP rs35985218.		VAR_033613
	Natural variant	182	1	T → M: dbSNP rs17064618.		VAR_033614
	Natural variant	321	1	V → L: dbSNP rs2272720. Ref.1		VAR_033615
	Natural variant	363	1	V → I: dbSNP rs34316994.		VAR_033616
	Natural variant	601	1	S → Y: dbSNP rs36089594.		VAR_033617
	Natural variant	701	1	V → I: dbSNP rs35335787.		VAR_033618
	Natural variant	776	1	T → M: dbSNP rs2294066. Ref.3		VAR_020083
	Natural variant	869	1	N → S: dbSNP rs968381. Ref.1 Ref.3		VAR_054501
	Natural variant	1022	1	L → F: dbSNP rs2280896.		VAR_020084
	Natural variant	1284	1	E → D: dbSNP rs34735757.		VAR_033619
Experimental info
	Sequence conflict	102 – 103	2	QR → HG in CAA48832. Ref.1
	Sequence conflict	364	1	S → T in CAA48832. Ref.1
	Sequence conflict	555	1	S → T in CAA48832. Ref.1
	Sequence conflict	863	1	N → D in CAA48832. Ref.1
	Sequence conflict	1168	1	V → A in CAA48832. Ref.1
	Sequence conflict	1168	1	V → A in AAH52969. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P54296-1 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: 71C6B11FCB066A8B	FASTA	1,465	164,896
	10 20 30 40 50 60 MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ RSSSQRASSQ 70 80 90 100 110 120 TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK RQRFLSELAH LEEDVHLARS 130 140 150 160 170 180 QARDKLDKYA IQQMMEDKLA WERHTFEERI SRAPEILVRL RSHTVWERMS VKLCFTVQGF 190 200 210 220 230 240 PTPVVQWYKD GSLICQAAEP GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST 250 260 270 280 290 300 NAAVVVRRFR GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT 310 320 330 340 350 360 MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE GLYTLRIVSR 370 380 390 400 410 420 GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI VTWKPPNTTT ESPVMGYFVD 430 440 450 460 470 480 RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG RSYIFRVRAV NSAGISRPSR VSDAVAALDP 490 500 510 520 530 540 LDLRRLQAVH LEGEKEIAIY QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD 550 560 570 580 590 600 PLMYFIEKSV VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT 610 620 630 640 650 660 SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV AGTNLWEPCN 670 680 690 700 710 720 HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD VIKVQAALTV PSHPYGITLL 730 740 750 760 770 780 NCDGHSMTLG WKVPKFSGGS PILGYYLDKR EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL 790 800 810 820 830 840 YEFKIAAVNL AGIGEPSDPS EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG 850 860 870 880 890 900 SSPVSGYFVD FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD 910 920 930 940 950 960 TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI SDDERFKIET 970 980 990 1000 1010 1020 VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE LERLMALSNE IKNPTIPLKS 1030 1040 1050 1060 1070 1080 ELAYEIFDKG RVRFWLQAEH LSPDASYRFI INDREVSDSE IHRIKCDKAT GIIEMVMDRF 1090 1100 1110 1120 1130 1140 SIENEGTYTV QIHDGKAKSQ SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV 1150 1160 1170 1180 1190 1200 TEECEVRLVC KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA 1210 1220 1230 1240 1250 1260 TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ CFMKYFTDEM 1270 1280 1290 1300 1310 1320 KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK YTFEIFDGKD NHQRSLDLSG 1330 1340 1350 1360 1370 1380 QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK 1390 1400 1410 1420 1430 1440 NDQDIQLSEH FSVKVEQAKY VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE 1450 1460 KIPDMAPPQQ AKPKLIPASA SAAGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins." Vinkemeier U., Obermann W., Weber K., Fuerst D.O. J. Cell Sci. 106:319-330(1993) [PubMed: 7505783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-321 AND SER-869. Tissue: Skeletal muscle.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed: 16421571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-776 AND SER-869. Tissue: PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X69089 mRNA. Translation: CAA48832.1. AC125453 Genomic DNA. No translation available. BC052969 mRNA. Translation: AAH52969.1.
IPI	IPI00005587.
PIR	S43529.
RefSeq	NP_003961.2.
UniGene	Hs.443683
3D structure databases
HSSP	HSSP built from PDB template 1BPV based on UniProtKB Q10466.
ModBase	Search...
PTM databases
PhosphoSite	P54296.
Proteomic databases
PRIDE	P54296.
Genome annotation databases
Ensembl	ENSG00000036448. Homo sapiens. [Contig view]
GeneID	9172.
Organism-specific databases
GeneCards	GC08P001980.
H-InvDB	HIX0025666.
HGNC	HGNC:7614. MYOM2.
HPA	HPA001765. HPA005953.
MIM	603509. gene.
PharmGKB	PA31419.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P54296.
HOVERGEN	P54296.
OMA	P54296. ESKWTKM.
Gene expression databases
ArrayExpress	P54296.
Bgee	P54296.
CleanEx	HS_MYOM2.
GermOnline	ENSG00000036448. Homo sapiens.
Family and domain databases
InterPro	IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 5 hits. G3DSA:2.60.40.10. Ig-like_fold. 4 hits.
Pfam	PF00041. fn3. 5 hits. PF07679. I-set. 3 hits. PF00047. ig. 1 hit. [Graphical view]
PRINTS	PR00014. FNTYPEIII.
SMART	SM00060. FN3. 5 hits. SM00409. IG. 2 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50853. FN3. 5 hits. PS50835. IG_LIKE. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	34395.
SOURCE	Search...

Entry information

Entry name

MYOM2_HUMAN

Accession

Primary (citable) accession number: P54296
Secondary accession number(s): Q7Z3Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	March 3, 2009
Last modified:	June 16, 2009
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)