Myomesin-2 - Homo sapiens (Human)

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P54296 (MYOM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 112. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Myomesin-2

Alternative name(s):
165 kDa connectin-associated protein
165 kDa titin-associated protein
M-protein
Myomesin family member 2

Gene names

Name:

MYOM2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1465 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Subunit structure	Interacts with TTN/titin By similarity.
Subcellular location	Cytoplasm › myofibril › sarcomere › M line By similarity.
Sequence similarities	Contains 5 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cytoplasm Thick filament
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat
Molecular function	Muscle protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	muscle contraction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	M band Inferred from electronic annotation. Source: UniProtKB-SubCell myosin filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of muscle Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
ACTN2	P35609	2	EBI-5357134,EBI-77797
DYSF	O75923	3	EBI-5357134,EBI-2799016
RYR1	P21817	2	EBI-5357134,EBI-1221290
TTN	Q8WZ42	2	EBI-5357134,EBI-681210

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1465

1465

Myomesin-2

PRO_0000072686

Regions

Domain

154 – 245

Ig-like C2-type 1

Domain

266 – 371

106

Ig-like C2-type 2

Domain

383 – 475

Fibronectin type-III 1

Domain

511 – 603

Fibronectin type-III 2

Domain

612 – 702

Fibronectin type-III 3

Domain

711 – 803

Fibronectin type-III 4

Domain

813 – 905

Fibronectin type-III 5

Domain

904 – 1002

Ig-like C2-type 3

Domain

1130 – 1211

Ig-like C2-type 4

Domain

1345 – 1434

Ig-like C2-type 5

Natural variations

Natural variant

E → K.
Corresponds to variant rs35985218 [ dbSNP | Ensembl ].

VAR_033613

Natural variant

182

T → M.
Corresponds to variant rs17064618 [ dbSNP | Ensembl ].

VAR_033614

Natural variant

321

V → L. Ref.1
Corresponds to variant rs2272720 [ dbSNP | Ensembl ].

VAR_033615

Natural variant

363

V → I.
Corresponds to variant rs34316994 [ dbSNP | Ensembl ].

VAR_033616

Natural variant

601

S → Y.
Corresponds to variant rs36089594 [ dbSNP | Ensembl ].

VAR_033617

Natural variant

701

V → I.
Corresponds to variant rs35335787 [ dbSNP | Ensembl ].

VAR_033618

Natural variant

776

T → M. Ref.3
Corresponds to variant rs2294066 [ dbSNP | Ensembl ].

VAR_020083

Natural variant

869

N → S. Ref.1 Ref.3
Corresponds to variant rs968381 [ dbSNP | Ensembl ].

VAR_054501

Natural variant

1022

L → F.
Corresponds to variant rs2280896 [ dbSNP | Ensembl ].

VAR_020084

Natural variant

1168

V → A. Ref.1 Ref.3
Corresponds to variant rs17854780 [ dbSNP | Ensembl ].

VAR_061320

Natural variant

1284

E → D.
Corresponds to variant rs34735757 [ dbSNP | Ensembl ].

VAR_033619

Experimental info

Sequence conflict

102 – 103

QR → HG in CAA48832. Ref.1

Sequence conflict

364

S → T in CAA48832. Ref.1

Sequence conflict

555

S → T in CAA48832. Ref.1

Sequence conflict

863

N → D in CAA48832. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P54296 [UniParc].

Last modified March 3, 2009. Version 2.
Checksum: 71C6B11FCB066A8B
Show »

FASTA

1,465

164,896

        10         20         30         40         50         60 
MSLVTVPFYQ KRHRHFDQSY RNIQTRYLLD EYASKKRAST QASSQKSLSQ RSSSQRASSQ 

        70         80         90        100        110        120 
TSLGGTICRV CAKRVSTQED EEQENRSRYQ SLVAAYGEAK RQRFLSELAH LEEDVHLARS 

       130        140        150        160        170        180 
QARDKLDKYA IQQMMEDKLA WERHTFEERI SRAPEILVRL RSHTVWERMS VKLCFTVQGF 

       190        200        210        220        230        240 
PTPVVQWYKD GSLICQAAEP GKYRIESNYG VHTLEINRAD FDDTATYSAV ATNAHGQVST 

       250        260        270        280        290        300 
NAAVVVRRFR GDEEPFRSVG LPIGLPLSSM IPYTHFDVQF LEKFGVTFRR EGETVTLKCT 

       310        320        330        340        350        360 
MLVTPDLKRV QPRAEWYRDD VLLKESKWTK MFFGEGQASL SFSHLHKDDE GLYTLRIVSR 

       370        380        390        400        410        420 
GGVSDHSAFL FVRDADPLVT GAPGAPMDLQ CHDANRDYVI VTWKPPNTTT ESPVMGYFVD 

       430        440        450        460        470        480 
RCEVGTNNWV QCNDAPVKIC KYPVTGLFEG RSYIFRVRAV NSAGISRPSR VSDAVAALDP 

       490        500        510        520        530        540 
LDLRRLQAVH LEGEKEIAIY QDDLEGDAQV PGPPTGVHAS EISRNYVVLS WEPPTPRGKD 

       550        560        570        580        590        600 
PLMYFIEKSV VGSGSWQRVN AQTAVRSPRY AVFDLMEGKS YVFRVLSANR HGLSEPSEIT 

       610        620        630        640        650        660 
SPIQAQDVTV VPSAPGRVLA SRNTKTSVVV QWDRPKHEED LLGYYVDCCV AGTNLWEPCN 

       670        680        690        700        710        720 
HKPIGYNRFV VHGLTTGEQY IFRVKAVNAV GMSENSQESD VIKVQAALTV PSHPYGITLL 

       730        740        750        760        770        780 
NCDGHSMTLG WKVPKFSGGS PILGYYLDKR EVHHKNWHEV NSSPSKPTIL TVDGLTEGSL 

       790        800        810        820        830        840 
YEFKIAAVNL AGIGEPSDPS EHFKCEAWTM PEPGPAYDLT FCEVRDTSLV MLWKAPVYSG 

       850        860        870        880        890        900 
SSPVSGYFVD FREEDAGEWI TVNQTTTANR YLKVSDLQQG KTYVFRVRAV NANGVGKPSD 

       910        920        930        940        950        960 
TSEPVLVEAR PGTKEISAGV DEQGNIYLGF DCQEMTDASQ FTWCKSYEEI SDDERFKIET 

       970        980        990       1000       1010       1020 
VGDHSKLYLK NPDKEDLGTY SVSVSDTDGV SSSFVLDPEE LERLMALSNE IKNPTIPLKS 

      1030       1040       1050       1060       1070       1080 
ELAYEIFDKG RVRFWLQAEH LSPDASYRFI INDREVSDSE IHRIKCDKAT GIIEMVMDRF 

      1090       1100       1110       1120       1130       1140 
SIENEGTYTV QIHDGKAKSQ SSLVLIGDAF KTVLEEAEFQ RKEFLRKQGP HFAEYLHWDV 

      1150       1160       1170       1180       1190       1200 
TEECEVRLVC KVANTKKETV FKWLKDDVLY ETETLPNLER GICELLIPKL SKKDHGEYKA 

      1210       1220       1230       1240       1250       1260 
TLKDDRGQDV SILEIAGKVY DDMILAMSRV CGKSASPLKV LCTPEGIRLQ CFMKYFTDEM 

      1270       1280       1290       1300       1310       1320 
KVNWCHKDAK ISSSEHMRIG GSEEMAWLQI CEPTEKDKGK YTFEIFDGKD NHQRSLDLSG 

      1330       1340       1350       1360       1370       1380 
QAFDEAFAEF QQFKAAAFAE KNRGRLIGGL PDVVTIMEGK TLNLTCTVFG NPDPEVIWFK 

      1390       1400       1410       1420       1430       1440 
NDQDIQLSEH FSVKVEQAKY VSMTIKGVTS EDSGKYSINI KNKYGGEKID VTVSVYKHGE 

      1450       1460 
KIPDMAPPQQ AKPKLIPASA SAAGQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins." Vinkemeier U., Obermann W., Weber K., Fuerst D.O. J. Cell Sci. 106:319-330(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-321; SER-869 AND ALA-1168. Tissue: Skeletal muscle.
[2]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-776; SER-869 AND ALA-1168. Tissue: PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69089 mRNA. Translation: CAA48832.1. AC125453 Genomic DNA. No translation available. BC052969 mRNA. Translation: AAH52969.1.
IPI	IPI00005587.
PIR	S43529.
RefSeq	NP_003961.2. NM_003970.2.
UniGene	Hs.443683.
3D structure databases
ProteinModelPortal	P54296.
ModBase	Search...
Protein-protein interaction databases
IntAct	P54296. 13 interactions.
STRING	9606.ENSP00000262113.
PTM databases
PhosphoSite	P54296.
Polymorphism databases
DMDM	224471842.
Proteomic databases
PaxDb	P54296.
PRIDE	P54296.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262113; ENSP00000262113; ENSG00000036448. ENST00000566299; ENSP00000454232; ENSG00000260130.
GeneID	9172.
KEGG	hsa:9172.
UCSC	uc003wpx.4. human.
Organism-specific databases
CTD	9172.
GeneCards	GC08P001993.
H-InvDB	HIX0025666.
HGNC	HGNC:7614. MYOM2.
HPA	HPA001765. HPA005953.
MIM	603509. gene.
neXtProt	NX_P54296.
PharmGKB	PA31419.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147025.
HOGENOM	HOG000293283.
HOVERGEN	HBG004977.
InParanoid	P54296.
OMA	DHSKLYF.
OrthoDB	EOG4HQDHF.
Gene expression databases
ArrayExpress	P54296.
Bgee	P54296.
CleanEx	HS_MYOM2.
Genevestigator	P54296.
GermOnline	ENSG00000036448. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 11 hits.
InterPro	IPR003961. Fibronectin_type3. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Pfam	PF00041. fn3. 5 hits. PF07679. I-set. 3 hits. [Graphical view]
SMART	SM00060. FN3. 5 hits. SM00409. IG. 2 hits. SM00408. IGc2. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 5 hits.
PROSITE	PS50853. FN3. 5 hits. PS50835. IG_LIKE. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MYOM2. human.
GenomeRNAi	9172.
NextBio	34395.
SOURCE	Search...

Entry information

Entry name

MYOM2_HUMAN

Accession

Primary (citable) accession number: P54296
Secondary accession number(s): Q7Z3Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents