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P54290

- CA2D1_RAT

UniProt

P54290 - CA2D1_RAT

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Protein
Voltage-dependent calcium channel subunit alpha-2/delta-1
Gene
Cacna2d1, Cacnl2a, Cchl2a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Divalent metal cation By similarity
Metal bindingi260 – 2601Divalent metal cation By similarity
Metal bindingi262 – 2621Divalent metal cation By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. voltage-gated calcium channel activity Source: RGD

GO - Biological processi

  1. calcium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-1
Cleaved into the following 2 chains:
Gene namesi
Name:Cacna2d1
Synonyms:Cacnl2a, Cchl2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2247. Cacna2d1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 10611037Extracellular Reviewed prediction
Add
BLAST
Transmembranei1062 – 108221Helical; Reviewed prediction
Add
BLAST
Topological domaini1083 – 10919Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. voltage-gated calcium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Chaini25 – 10911067Voltage-dependent calcium channel subunit alpha-2/delta-1
PRO_0000304635Add
BLAST
Chaini25 – 944920Voltage-dependent calcium channel subunit alpha-2-1 By similarity
PRO_0000005005Add
BLAST
Chaini945 – 1091147Voltage-dependent calcium channel subunit delta-1 By similarity
PRO_0000005006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi136 – 1361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi403 ↔ 1047Interchain (between alpha-2-1 and delta-1 chains) By similarity
Glycosylationi593 – 5931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi769 – 7691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi876 – 8761N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54290.
PRIDEiP54290.

PTM databases

PhosphoSiteiP54290.

Expressioni

Gene expression databases

GenevestigatoriP54290.

Interactioni

Subunit structurei

Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
THBS2P354422EBI-2466294,EBI-2466249From a different organism.

Protein-protein interaction databases

IntActiP54290. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP54290.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini252 – 429178VWFA
Add
BLAST
Domaini445 – 53692Cache
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi258 – 2625MIDAS-like motif

Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch By similarity.

Sequence similaritiesi

Contains 1 cache domain.
Contains 1 VWFA domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307080.
HOGENOMiHOG000004860.
HOVERGENiHBG057779.
InParanoidiP54290.
PhylomeDBiP54290.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: 2 isoforms are produced.

Isoform 1 (identifier: P54290-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAGCLLALT LTLFQSWLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT     50
ASGVTQLADI YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL 100
AMEAEKVQAA HQWREDFASN EVVYYNAKDD LDPERNESES GSQRIKPVFI 150
EDANFGRQIS YQHAAVHIPT DIYEGSTIVL NELNWTSALD EVFKRNRDED 200
PTLLWQVFAA DRLARYYPAS PWVDNSRTPN KIDLYDVRRR PWYIQGAASP 250
KDMLILVDVS GSVSGLTLKL IRTSVSEMLE TLSDDDFVNV ASFNSNAQDV 300
SCFQHLVQAN VRNKKVLKDA VNNITAKGIT DYKKGFTFAF EQLLNYNVSR 350
ANCNKIIMLF TDGGEERAQE IFAKYNKDKK VRVFTFSVGQ HNYDRGPIQW 400
MACENKGYYY EIPSIGAIRI NTQEYLDVLG RPMVLAGDKA KQVQWTNVYL 450
DALELGLVIT GTLPVFNVTG QSENKTNLKN QLILGVMGVD VSLEDIKRLT 500
PRFTLCPNGY YFAIDPNGYV LLHPNLQPKN PKSQEPVTLD FLDAELENDI 550
KVEIRNKMID GESGEKTFRT LVKSQDERYI DKGNRTYTWT PVNGTDYRYL 600
ALVLPTYSFY YIKAKIEETI TQARSKKGKM KDSETLKPDN FEESGYTFIA 650
PREYCNDLKP SDNNTEFLLN FNEFIDRKTP NNPSCNTDLI NRILLDAGFT 700
NELVQNYWSK QKNIKGVKAR FVVTDGGITR VYPKEAGENW QENPETYEDS 750
FYKRSLDNDN YVFTAPYFNK SGPGAYESGI MVSKAVELYI QGKLLKPAVV 800
GIKIDVNSWI ENFTKTSIRD PCAGPVCDCK RNSDVMDCVI LDDGGFLLMA 850
NHDDYTNQIG RFFGEIDPRM MRHLVNISLY AFNKSYDYQS VCDPGAAPKQ 900
GAGHRSAYVP SITDILQIGW WATAAAWSIL QQLLLSLTFP RLLEAVEMEE 950
DDFTASLSKQ SCITEQTQYF FKNDTKSFSG LLDCGNCSRI FHVEKLMNTN 1000
LVFIMVESKG TCPCDTRLLM QAEQTSDGPD PCDMVKQPRY RKGPDVCFDN 1050
NVLEDYTDCG GVSGLNPSLW SIFGLQFILL WLVSGSRHYL W 1091
Length:1,091
Mass (Da):123,823
Last modified:October 1, 1996 - v1
Checksum:i7054907D9D343B34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86621 mRNA. Translation: AAA41088.1.
PIRiA44147.
UniGeneiRn.1110.
Rn.11276.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86621 mRNA. Translation: AAA41088.1 .
PIRi A44147.
UniGenei Rn.1110.
Rn.11276.

3D structure databases

ProteinModelPortali P54290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P54290. 1 interaction.

Chemistry

BindingDBi P54290.
ChEMBLi CHEMBL3420.

PTM databases

PhosphoSitei P54290.

Proteomic databases

PaxDbi P54290.
PRIDEi P54290.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2247. Cacna2d1.

Phylogenomic databases

eggNOGi NOG307080.
HOGENOMi HOG000004860.
HOVERGENi HBG057779.
InParanoidi P54290.
PhylomeDBi P54290.

Miscellaneous databases

PROi P54290.

Gene expression databases

Genevestigatori P54290.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view ]
SMARTi SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit."
    Kim H.L., Kim H., Lee P., King R.G., Chin H.
    Proc. Natl. Acad. Sci. U.S.A. 89:3251-3255(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCA2D1_RAT
AccessioniPrimary (citable) accession number: P54290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds gabapentin, an antiepileptic drug By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi