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P54290

- CA2D1_RAT

UniProt

P54290 - CA2D1_RAT

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Protein

Voltage-dependent calcium channel subunit alpha-2/delta-1

Gene

Cacna2d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi258 – 2581Divalent metal cationBy similarity
Metal bindingi260 – 2601Divalent metal cationBy similarity
Metal bindingi262 – 2621Divalent metal cationBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. voltage-gated calcium channel activity Source: RGD

GO - Biological processi

  1. calcium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-1
Cleaved into the following 2 chains:
Gene namesi
Name:Cacna2d1
Synonyms:Cacnl2a, Cchl2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2247. Cacna2d1.

Subcellular locationi

GO - Cellular componenti

  1. voltage-gated calcium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 10911067Voltage-dependent calcium channel subunit alpha-2/delta-1PRO_0000304635Add
BLAST
Chaini25 – 944920Voltage-dependent calcium channel subunit alpha-2-1By similarityPRO_0000005005Add
BLAST
Chaini945 – 1091147Voltage-dependent calcium channel subunit delta-1By similarityPRO_0000005006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi403 ↔ 1047Interchain (between alpha-2-1 and delta-1 chains)By similarity
Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi769 – 7691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi876 – 8761N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54290.
PRIDEiP54290.

PTM databases

PhosphoSiteiP54290.

Expressioni

Gene expression databases

GenevestigatoriP54290.

Interactioni

Subunit structurei

Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
THBS2P354422EBI-2466294,EBI-2466249From a different organism.

Protein-protein interaction databases

IntActiP54290. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP54290.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 10611037ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1083 – 10919CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1062 – 108221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini252 – 429178VWFAPROSITE-ProRule annotationAdd
BLAST
Domaini445 – 53692CacheAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi258 – 2625MIDAS-like motif

Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity

Sequence similaritiesi

Contains 1 cache domain.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG307080.
HOGENOMiHOG000004860.
HOVERGENiHBG057779.
InParanoidiP54290.
PhylomeDBiP54290.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamiPF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: 2 isoforms are produced.

Isoform 1 (identifier: P54290-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGCLLALT LTLFQSWLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT
60 70 80 90 100
ASGVTQLADI YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL
110 120 130 140 150
AMEAEKVQAA HQWREDFASN EVVYYNAKDD LDPERNESES GSQRIKPVFI
160 170 180 190 200
EDANFGRQIS YQHAAVHIPT DIYEGSTIVL NELNWTSALD EVFKRNRDED
210 220 230 240 250
PTLLWQVFAA DRLARYYPAS PWVDNSRTPN KIDLYDVRRR PWYIQGAASP
260 270 280 290 300
KDMLILVDVS GSVSGLTLKL IRTSVSEMLE TLSDDDFVNV ASFNSNAQDV
310 320 330 340 350
SCFQHLVQAN VRNKKVLKDA VNNITAKGIT DYKKGFTFAF EQLLNYNVSR
360 370 380 390 400
ANCNKIIMLF TDGGEERAQE IFAKYNKDKK VRVFTFSVGQ HNYDRGPIQW
410 420 430 440 450
MACENKGYYY EIPSIGAIRI NTQEYLDVLG RPMVLAGDKA KQVQWTNVYL
460 470 480 490 500
DALELGLVIT GTLPVFNVTG QSENKTNLKN QLILGVMGVD VSLEDIKRLT
510 520 530 540 550
PRFTLCPNGY YFAIDPNGYV LLHPNLQPKN PKSQEPVTLD FLDAELENDI
560 570 580 590 600
KVEIRNKMID GESGEKTFRT LVKSQDERYI DKGNRTYTWT PVNGTDYRYL
610 620 630 640 650
ALVLPTYSFY YIKAKIEETI TQARSKKGKM KDSETLKPDN FEESGYTFIA
660 670 680 690 700
PREYCNDLKP SDNNTEFLLN FNEFIDRKTP NNPSCNTDLI NRILLDAGFT
710 720 730 740 750
NELVQNYWSK QKNIKGVKAR FVVTDGGITR VYPKEAGENW QENPETYEDS
760 770 780 790 800
FYKRSLDNDN YVFTAPYFNK SGPGAYESGI MVSKAVELYI QGKLLKPAVV
810 820 830 840 850
GIKIDVNSWI ENFTKTSIRD PCAGPVCDCK RNSDVMDCVI LDDGGFLLMA
860 870 880 890 900
NHDDYTNQIG RFFGEIDPRM MRHLVNISLY AFNKSYDYQS VCDPGAAPKQ
910 920 930 940 950
GAGHRSAYVP SITDILQIGW WATAAAWSIL QQLLLSLTFP RLLEAVEMEE
960 970 980 990 1000
DDFTASLSKQ SCITEQTQYF FKNDTKSFSG LLDCGNCSRI FHVEKLMNTN
1010 1020 1030 1040 1050
LVFIMVESKG TCPCDTRLLM QAEQTSDGPD PCDMVKQPRY RKGPDVCFDN
1060 1070 1080 1090
NVLEDYTDCG GVSGLNPSLW SIFGLQFILL WLVSGSRHYL W
Length:1,091
Mass (Da):123,823
Last modified:October 1, 1996 - v1
Checksum:i7054907D9D343B34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86621 mRNA. Translation: AAA41088.1.
PIRiA44147.
UniGeneiRn.1110.
Rn.11276.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86621 mRNA. Translation: AAA41088.1 .
PIRi A44147.
UniGenei Rn.1110.
Rn.11276.

3D structure databases

ProteinModelPortali P54290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P54290. 1 interaction.

Chemistry

BindingDBi P54290.
ChEMBLi CHEMBL3137270.

PTM databases

PhosphoSitei P54290.

Proteomic databases

PaxDbi P54290.
PRIDEi P54290.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2247. Cacna2d1.

Phylogenomic databases

eggNOGi NOG307080.
HOGENOMi HOG000004860.
HOVERGENi HBG057779.
InParanoidi P54290.
PhylomeDBi P54290.

Miscellaneous databases

PROi P54290.

Gene expression databases

Genevestigatori P54290.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view ]
SMARTi SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit."
    Kim H.L., Kim H., Lee P., King R.G., Chin H.
    Proc. Natl. Acad. Sci. U.S.A. 89:3251-3255(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCA2D1_RAT
AccessioniPrimary (citable) accession number: P54290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds gabapentin, an antiepileptic drug.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3