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P54290

- CA2D1_RAT

UniProt

P54290 - CA2D1_RAT

Protein

Voltage-dependent calcium channel subunit alpha-2/delta-1

Gene

Cacna2d1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi258 – 2581Divalent metal cationBy similarity
    Metal bindingi260 – 2601Divalent metal cationBy similarity
    Metal bindingi262 – 2621Divalent metal cationBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. voltage-gated calcium channel activity Source: RGD

    GO - Biological processi

    1. calcium ion transport Source: RGD

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel subunit alpha-2/delta-1
    Alternative name(s):
    Voltage-gated calcium channel subunit alpha-2/delta-1
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Cacna2d1
    Synonyms:Cacnl2a, Cchl2a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2247. Cacna2d1.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated calcium channel complex Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 10911067Voltage-dependent calcium channel subunit alpha-2/delta-1PRO_0000304635Add
    BLAST
    Chaini25 – 944920Voltage-dependent calcium channel subunit alpha-2-1By similarityPRO_0000005005Add
    BLAST
    Chaini945 – 1091147Voltage-dependent calcium channel subunit delta-1By similarityPRO_0000005006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi403 ↔ 1047Interchain (between alpha-2-1 and delta-1 chains)By similarity
    Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi769 – 7691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi876 – 8761N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP54290.
    PRIDEiP54290.

    PTM databases

    PhosphoSiteiP54290.

    Expressioni

    Gene expression databases

    GenevestigatoriP54290.

    Interactioni

    Subunit structurei

    Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    THBS2P354422EBI-2466294,EBI-2466249From a different organism.

    Protein-protein interaction databases

    IntActiP54290. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP54290.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 10611037ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1083 – 10919CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1062 – 108221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini252 – 429178VWFAPROSITE-ProRule annotationAdd
    BLAST
    Domaini445 – 53692CacheAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi258 – 2625MIDAS-like motif

    Domaini

    The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch.By similarity

    Sequence similaritiesi

    Contains 1 cache domain.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG307080.
    HOGENOMiHOG000004860.
    HOVERGENiHBG057779.
    InParanoidiP54290.
    PhylomeDBiP54290.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR004010. Cache_domain.
    IPR013680. VDCC_a2/dsu.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF02743. Cache_1. 1 hit.
    PF08473. VGCC_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view]
    SMARTiSM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: 2 isoforms are produced.

    Isoform 1 (identifier: P54290-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGCLLALT LTLFQSWLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT     50
    ASGVTQLADI YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL 100
    AMEAEKVQAA HQWREDFASN EVVYYNAKDD LDPERNESES GSQRIKPVFI 150
    EDANFGRQIS YQHAAVHIPT DIYEGSTIVL NELNWTSALD EVFKRNRDED 200
    PTLLWQVFAA DRLARYYPAS PWVDNSRTPN KIDLYDVRRR PWYIQGAASP 250
    KDMLILVDVS GSVSGLTLKL IRTSVSEMLE TLSDDDFVNV ASFNSNAQDV 300
    SCFQHLVQAN VRNKKVLKDA VNNITAKGIT DYKKGFTFAF EQLLNYNVSR 350
    ANCNKIIMLF TDGGEERAQE IFAKYNKDKK VRVFTFSVGQ HNYDRGPIQW 400
    MACENKGYYY EIPSIGAIRI NTQEYLDVLG RPMVLAGDKA KQVQWTNVYL 450
    DALELGLVIT GTLPVFNVTG QSENKTNLKN QLILGVMGVD VSLEDIKRLT 500
    PRFTLCPNGY YFAIDPNGYV LLHPNLQPKN PKSQEPVTLD FLDAELENDI 550
    KVEIRNKMID GESGEKTFRT LVKSQDERYI DKGNRTYTWT PVNGTDYRYL 600
    ALVLPTYSFY YIKAKIEETI TQARSKKGKM KDSETLKPDN FEESGYTFIA 650
    PREYCNDLKP SDNNTEFLLN FNEFIDRKTP NNPSCNTDLI NRILLDAGFT 700
    NELVQNYWSK QKNIKGVKAR FVVTDGGITR VYPKEAGENW QENPETYEDS 750
    FYKRSLDNDN YVFTAPYFNK SGPGAYESGI MVSKAVELYI QGKLLKPAVV 800
    GIKIDVNSWI ENFTKTSIRD PCAGPVCDCK RNSDVMDCVI LDDGGFLLMA 850
    NHDDYTNQIG RFFGEIDPRM MRHLVNISLY AFNKSYDYQS VCDPGAAPKQ 900
    GAGHRSAYVP SITDILQIGW WATAAAWSIL QQLLLSLTFP RLLEAVEMEE 950
    DDFTASLSKQ SCITEQTQYF FKNDTKSFSG LLDCGNCSRI FHVEKLMNTN 1000
    LVFIMVESKG TCPCDTRLLM QAEQTSDGPD PCDMVKQPRY RKGPDVCFDN 1050
    NVLEDYTDCG GVSGLNPSLW SIFGLQFILL WLVSGSRHYL W 1091
    Length:1,091
    Mass (Da):123,823
    Last modified:October 1, 1996 - v1
    Checksum:i7054907D9D343B34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86621 mRNA. Translation: AAA41088.1.
    PIRiA44147.
    UniGeneiRn.1110.
    Rn.11276.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86621 mRNA. Translation: AAA41088.1 .
    PIRi A44147.
    UniGenei Rn.1110.
    Rn.11276.

    3D structure databases

    ProteinModelPortali P54290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P54290. 1 interaction.

    Chemistry

    BindingDBi P54290.
    ChEMBLi CHEMBL3420.

    PTM databases

    PhosphoSitei P54290.

    Proteomic databases

    PaxDbi P54290.
    PRIDEi P54290.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2247. Cacna2d1.

    Phylogenomic databases

    eggNOGi NOG307080.
    HOGENOMi HOG000004860.
    HOVERGENi HBG057779.
    InParanoidi P54290.
    PhylomeDBi P54290.

    Miscellaneous databases

    PROi P54290.

    Gene expression databases

    Genevestigatori P54290.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR004010. Cache_domain.
    IPR013680. VDCC_a2/dsu.
    IPR013608. VWA_N.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF02743. Cache_1. 1 hit.
    PF08473. VGCC_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    PF08399. VWA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit."
      Kim H.L., Kim H., Lee P., King R.G., Chin H.
      Proc. Natl. Acad. Sci. U.S.A. 89:3251-3255(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCA2D1_RAT
    AccessioniPrimary (citable) accession number: P54290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds gabapentin, an antiepileptic drug.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3