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P54290 (CA2D1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Alternative name(s):
Voltage-gated calcium channel subunit alpha-2/delta-1

Cleaved into the following 2 chains:

  1. Voltage-dependent calcium channel subunit alpha-2-1
  2. Voltage-dependent calcium channel subunit delta-1
Gene names
Name:Cacna2d1
Synonyms:Cacnl2a, Cchl2a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length1091 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling By similarity.

Subunit structure

Dimer formed of alpha-2-1 and delta-1 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Domain

The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch By similarity.

Post-translational modification

Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked By similarity.

Miscellaneous

Binds gabapentin, an antiepileptic drug By similarity.

Sequence similarities

Belongs to the calcium channel subunit alpha-2/delta family.

Contains 1 cache domain.

Contains 1 VWFA domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

THBS2P354422EBI-2466294,EBI-2466249From a different organism.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: 2 isoforms are produced.
Isoform 1 (identifier: P54290-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 10911067Voltage-dependent calcium channel subunit alpha-2/delta-1
PRO_0000304635
Chain25 – 944920Voltage-dependent calcium channel subunit alpha-2-1 By similarity
PRO_0000005005
Chain945 – 1091147Voltage-dependent calcium channel subunit delta-1 By similarity
PRO_0000005006

Regions

Topological domain25 – 10611037Extracellular Potential
Transmembrane1062 – 108221Helical; Potential
Topological domain1083 – 10919Cytoplasmic Potential
Domain252 – 429178VWFA
Domain445 – 53692Cache
Motif258 – 2625MIDAS-like motif

Sites

Metal binding2581Divalent metal cation By similarity
Metal binding2601Divalent metal cation By similarity
Metal binding2621Divalent metal cation By similarity

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation1361N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation3231N-linked (GlcNAc...) Potential
Glycosylation3471N-linked (GlcNAc...) Potential
Glycosylation5931N-linked (GlcNAc...) Potential
Glycosylation7691N-linked (GlcNAc...) Potential
Glycosylation8761N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7054907D9D343B34

FASTA1,091123,823
        10         20         30         40         50         60 
MAAGCLLALT LTLFQSWLIG PSSEEPFPSP VTIKSWVDKM QEDLVTLAKT ASGVTQLADI 

        70         80         90        100        110        120 
YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL AMEAEKVQAA HQWREDFASN 

       130        140        150        160        170        180 
EVVYYNAKDD LDPERNESES GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 

       190        200        210        220        230        240 
NELNWTSALD EVFKRNRDED PTLLWQVFAA DRLARYYPAS PWVDNSRTPN KIDLYDVRRR 

       250        260        270        280        290        300 
PWYIQGAASP KDMLILVDVS GSVSGLTLKL IRTSVSEMLE TLSDDDFVNV ASFNSNAQDV 

       310        320        330        340        350        360 
SCFQHLVQAN VRNKKVLKDA VNNITAKGIT DYKKGFTFAF EQLLNYNVSR ANCNKIIMLF 

       370        380        390        400        410        420 
TDGGEERAQE IFAKYNKDKK VRVFTFSVGQ HNYDRGPIQW MACENKGYYY EIPSIGAIRI 

       430        440        450        460        470        480 
NTQEYLDVLG RPMVLAGDKA KQVQWTNVYL DALELGLVIT GTLPVFNVTG QSENKTNLKN 

       490        500        510        520        530        540 
QLILGVMGVD VSLEDIKRLT PRFTLCPNGY YFAIDPNGYV LLHPNLQPKN PKSQEPVTLD 

       550        560        570        580        590        600 
FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI DKGNRTYTWT PVNGTDYRYL 

       610        620        630        640        650        660 
ALVLPTYSFY YIKAKIEETI TQARSKKGKM KDSETLKPDN FEESGYTFIA PREYCNDLKP 

       670        680        690        700        710        720 
SDNNTEFLLN FNEFIDRKTP NNPSCNTDLI NRILLDAGFT NELVQNYWSK QKNIKGVKAR 

       730        740        750        760        770        780 
FVVTDGGITR VYPKEAGENW QENPETYEDS FYKRSLDNDN YVFTAPYFNK SGPGAYESGI 

       790        800        810        820        830        840 
MVSKAVELYI QGKLLKPAVV GIKIDVNSWI ENFTKTSIRD PCAGPVCDCK RNSDVMDCVI 

       850        860        870        880        890        900 
LDDGGFLLMA NHDDYTNQIG RFFGEIDPRM MRHLVNISLY AFNKSYDYQS VCDPGAAPKQ 

       910        920        930        940        950        960 
GAGHRSAYVP SITDILQIGW WATAAAWSIL QQLLLSLTFP RLLEAVEMEE DDFTASLSKQ 

       970        980        990       1000       1010       1020 
SCITEQTQYF FKNDTKSFSG LLDCGNCSRI FHVEKLMNTN LVFIMVESKG TCPCDTRLLM 

      1030       1040       1050       1060       1070       1080 
QAEQTSDGPD PCDMVKQPRY RKGPDVCFDN NVLEDYTDCG GVSGLNPSLW SIFGLQFILL 

      1090 
WLVSGSRHYL W

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References

[1]"Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit."
Kim H.L., Kim H., Lee P., King R.G., Chin H.
Proc. Natl. Acad. Sci. U.S.A. 89:3251-3255(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M86621 mRNA. Translation: AAA41088.1.
IPIIPI00777578.
PIRA44147.
UniGeneRn.11276.

3D structure databases

ProteinModelPortalP54290.
ModBaseSearch...

Protein-protein interaction databases

IntActP54290. 1 interaction.

PTM databases

PhosphoSiteP54290.

Proteomic databases

PaxDbP54290.
PRIDEP54290.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD2247. Cacna2d1.

Phylogenomic databases

eggNOGNOG307080.
HOGENOMHOG000004860.
HOVERGENHBG057779.
InParanoidP54290.

Enzyme and pathway databases

ReactomeREACT_113568. Metabolism.

Gene expression databases

ArrayExpressP54290.
GenevestigatorP54290.
GermOnlineENSRNOG00000033531. Rattus norvegicus.

Family and domain databases

InterProIPR004010. Cache_domain.
IPR013680. VDCC_a2/dsu.
IPR013608. VWA_N.
IPR002035. VWF_A.
[Graphical view]
PfamPF02743. Cache_1. 1 hit.
PF08473. VGCC_alpha2. 1 hit.
PF00092. VWA. 1 hit.
PF08399. VWA_N. 1 hit.
[Graphical view]
SMARTSM00327. VWA. 1 hit.
[Graphical view]
PROSITEPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP54290.
ChEMBLCHEMBL3420.

Entry information

Entry nameCA2D1_RAT
AccessionPrimary (citable) accession number: P54290
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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