Reviewed, UniProtKB/Swiss-Prot P54285 (CACB3_MOUSE)

Names and origin

Protein names

Recommended name:
    Voltage-dependent L-type calcium channel subunit beta-3
      Short name=CAB3
Alternative name(s):
    Calcium channel voltage-dependent subunit beta 3
      Short name=CCHB3

Gene names

Name:	Cacnb3
Synonyms:	Cacnlb3

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subunit structure	The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4 By similarity.
Sequence similarities	Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Coding sequence diversity	Alternative splicing
Domain	SH3 domain
Ligand	Calcium
Molecular function	Calcium channel Ionic channel Voltage-gated channel
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	T cell receptor signaling pathway Inferred from mutant phenotype. Source: MGI calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	voltage-gated calcium channel complex Inferred from direct assay. Source: MGI
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW high voltage-gated calcium channel activity Traceable author statement. Source: MGI protein binding Inferred from physical interaction. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]

Isoform 3A (identifier: P54285-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 3B (identifier: P54285-2)

The sequence of this isoform is not available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	Voltage-dependent L-type calcium channel subunit beta-3		PRO_0000144057
Regions
	Domain	59 – 120	62	SH3
Amino acid modifications
	Modified residue	171	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3A [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 730B1C2057230EB1	FASTA	484	54,562
	10 20 30 40 50 60 MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV 70 80 90 100 110 120 AFAVRTNVSY CGVLDEECPV QASGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGAIAFIPS 130 140 150 160 170 180 PQRLESIRLK QEQKARRSGN PSSLGDIGFR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV 190 200 210 220 230 240 VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER 250 260 270 280 290 300 SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL 310 320 330 340 350 360 QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDAILDEN QLEDACEHLA EYLEVYWRAT 370 380 390 400 410 420 HHPAPGPGLL GPPSAIPGLQ NQQQLGERVE EHSPLERDSL MPSDEASESS RQAWTGSSQR 430 440 450 460 470 480 SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHDHND RNWQRNRPWP KDSY
	Isoform 3B (Sequence not available).	FASTA	–	–

References

[1]	"Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits." Chin H., Kwon O.-J., Jung H.H., Kim D.S., Kozak C.A. Genomics 28:592-595(1995) [PubMed: 7490102] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products." Murakami M., Wissenbach U., Flockerzi V. Eur. J. Biochem. 236:138-143(1996) [PubMed: 8617257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U20372 mRNA. Translation: AAA91105.1. X94404, X94406, X94405 Genomic DNA. Translation: CAB61648.1. Sequence problems.
IPI	IPI00133518.
PIR	S62185.
UniGene	Mm.3544
3D structure databases
HSSP	HSSP built from PDB template 1KJW based on UniProtKB P31016.
SMR	P54285. Positions 38-362.
ModBase	Search...
PTM databases
PhosphoSite	P54285.
Proteomic databases
PRIDE	P54285.
Genome annotation databases
Ensembl	ENSMUSG00000003352. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:103307. Cacnb3.
Phylogenomic databases
HOGENOM	P54285.
HOVERGEN	P54285.
Gene expression databases
Bgee	P54285.
GermOnline	ENSMUSG00000003352. Mus musculus.
Family and domain databases
InterPro	IPR008145. Guanylt/Ca. IPR001452. SH3_domain. IPR008079. VDCC_L_b3su. IPR000584. VDCC_L_bsu. [Graphical view]
PANTHER	PTHR11824. Ca_channel_B. 1 hit.
Pfam	PF00774. Ca_channel_B. 1 hit. [Graphical view]
PRINTS	PR01626. LCACHANNELB. PR01696. LCACHANNELB3.
ProDom	PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00072. GuKc. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50002. SH3. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CACB3_MOUSE

Accession

Primary (citable) accession number: P54285

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)