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Protein

Voltage-dependent L-type calcium channel subunit beta-3

Gene

Cacnb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

GO - Molecular functioni

  • high voltage-gated calcium channel activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-MMU-419037. NCAM1 interactions.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit beta-3
Short name:
CAB3
Alternative name(s):
Calcium channel voltage-dependent subunit beta 3
Short name:
CCHB3
Gene namesi
Name:Cacnb3
Synonyms:Cacnlb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:103307. Cacnb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Voltage-dependent L-type calcium channel subunit beta-3PRO_0000144057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521PhosphoserineBy similarity
Modified residuei393 – 3931PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54285.
PaxDbiP54285.
PRIDEiP54285.

PTM databases

iPTMnetiP54285.
PhosphoSiteiP54285.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003352.
ExpressionAtlasiP54285. baseline and differential.
GenevisibleiP54285. MM.

Interactioni

Subunit structurei

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4. Interacts with FASLG (By similarity). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel.By similarity1 Publication

Protein-protein interaction databases

BioGridi198441. 3 interactions.
IntActiP54285. 1 interaction.
STRINGi10090.ENSMUSP00000003442.

Structurei

3D structure databases

ProteinModelPortaliP54285.
SMRiP54285. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 12062SH3Add
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
GeneTreeiENSGT00390000002740.
HOGENOMiHOG000230979.
HOVERGENiHBG050765.
InParanoidiP54285.
KOiK04864.
OMAiNERNWQR.
OrthoDBiEOG091G09C1.
TreeFamiTF316195.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR008079. VDCC_L_b3su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
[Graphical view]
PRINTSiPR01626. LCACHANNELB.
PR01696. LCACHANNELB3.
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3A (identifier: P54285-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ
60 70 80 90 100
QLERAKHKPV AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS
110 120 130 140 150
NDWWIGRLVK EGGDIAFIPS PQRLESIRLK QEQKARRSGN PSSLGDIGNR
160 170 180 190 200
RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL
210 220 230 240 250
FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER SSARSSIAEV
260 270 280 290 300
QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL
310 320 330 340 350
QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA
360 370 380 390 400
EYLEVYWRAT HHPAPGPGLL GPPSAIPGLQ NQQLLGERVE EHSPLERDSL
410 420 430 440 450
MPSDEASESS RQAWTGSSQR SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA
460 470 480
NGHDPQDRLL AQDSEHDHND RNWQRNRPWP KDSY
Length:484
Mass (Da):54,572
Last modified:October 3, 2012 - v2
Checksum:i56871A0B563A567E
GO
Isoform 3B (identifier: P54285-2)
Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821G → A in AAA91105 (PubMed:7490102).Curated
Sequence conflicti114 – 1141D → A in AAA91105 (PubMed:7490102).Curated
Sequence conflicti149 – 1491N → F in AAA91105 (PubMed:7490102).Curated
Sequence conflicti335 – 3351V → A in AAA91105 (PubMed:7490102).Curated
Sequence conflicti384 – 3841L → Q in AAA91105 (PubMed:7490102).Curated
Sequence conflicti409 – 4091S → T in CAB61648 (PubMed:8617257).Curated
Sequence conflicti421 – 4211S → T in CAB61648 (PubMed:8617257).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20372 mRNA. Translation: AAA91105.1.
X94404, X94406, X94405 Genomic DNA. Translation: CAB61648.1.
AC156543 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04179.1.
CCDSiCCDS27800.1. [P54285-1]
PIRiS62185.
RefSeqiNP_031607.2. NM_007581.3. [P54285-1]
UniGeneiMm.3544.

Genome annotation databases

EnsembliENSMUST00000003442; ENSMUSP00000003442; ENSMUSG00000003352. [P54285-1]
GeneIDi12297.
KEGGimmu:12297.
UCSCiuc007xnc.2. mouse. [P54285-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20372 mRNA. Translation: AAA91105.1.
X94404, X94406, X94405 Genomic DNA. Translation: CAB61648.1.
AC156543 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04179.1.
CCDSiCCDS27800.1. [P54285-1]
PIRiS62185.
RefSeqiNP_031607.2. NM_007581.3. [P54285-1]
UniGeneiMm.3544.

3D structure databases

ProteinModelPortaliP54285.
SMRiP54285. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198441. 3 interactions.
IntActiP54285. 1 interaction.
STRINGi10090.ENSMUSP00000003442.

PTM databases

iPTMnetiP54285.
PhosphoSiteiP54285.

Proteomic databases

MaxQBiP54285.
PaxDbiP54285.
PRIDEiP54285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003442; ENSMUSP00000003442; ENSMUSG00000003352. [P54285-1]
GeneIDi12297.
KEGGimmu:12297.
UCSCiuc007xnc.2. mouse. [P54285-1]

Organism-specific databases

CTDi784.
MGIiMGI:103307. Cacnb3.

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
GeneTreeiENSGT00390000002740.
HOGENOMiHOG000230979.
HOVERGENiHBG050765.
InParanoidiP54285.
KOiK04864.
OMAiNERNWQR.
OrthoDBiEOG091G09C1.
TreeFamiTF316195.

Enzyme and pathway databases

ReactomeiR-MMU-112308. Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels.
R-MMU-419037. NCAM1 interactions.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

PROiP54285.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003352.
ExpressionAtlasiP54285. baseline and differential.
GenevisibleiP54285. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR008079. VDCC_L_b3su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
[Graphical view]
PRINTSiPR01626. LCACHANNELB.
PR01696. LCACHANNELB3.
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCACB3_MOUSE
AccessioniPrimary (citable) accession number: P54285
Secondary accession number(s): G5E821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.