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Protein

Voltage-dependent L-type calcium channel subunit beta-3

Gene

Cacnb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.By similarity

GO - Molecular functioni

  • high voltage-gated calcium channel activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-112308 Presynaptic depolarization and calcium channel opening
R-MMU-422356 Regulation of insulin secretion
R-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit beta-3
Short name:
CAB3
Alternative name(s):
Calcium channel voltage-dependent subunit beta 3
Short name:
CCHB3
Gene namesi
Name:Cacnb3
Synonyms:Cacnlb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:103307 Cacnb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440571 – 484Voltage-dependent L-type calcium channel subunit beta-3Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54285
PRIDEiP54285

PTM databases

iPTMnetiP54285
PhosphoSitePlusiP54285

Expressioni

Gene expression databases

BgeeiENSMUSG00000003352
ExpressionAtlasiP54285 baseline and differential
GenevisibleiP54285 MM

Interactioni

Subunit structurei

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma (By similarity). Interacts with CACNA2D4. Interacts with FASLG (By similarity). Interacts with CBARP; prevents the interaction of CACNB3 with the alpha subunit CACNA1C thereby negatively regulating the activity of the corresponding calcium channel (PubMed:24751537).By similarity1 Publication

Protein-protein interaction databases

BioGridi198441, 4 interactors
IntActiP54285, 2 interactors
STRINGi10090.ENSMUSP00000003442

Structurei

3D structure databases

ProteinModelPortaliP54285
SMRiP54285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 128SH3PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 345Mediates interaction with the alpha subunitBy similarityAdd BLAST151

Sequence similaritiesi

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3812 Eukaryota
ENOG410XRDI LUCA
GeneTreeiENSGT00390000002740
HOGENOMiHOG000230979
HOVERGENiHBG050765
InParanoidiP54285
KOiK04864
OMAiKQKQTEH
OrthoDBiEOG091G09C1
TreeFamiTF316195

Family and domain databases

CDDicd12042 SH3_CACNB3, 1 hit
InterProiView protein in InterPro
IPR035760 CACNB3_SH3
IPR008145 GK/Ca_channel_bsu
IPR027417 P-loop_NTPase
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008079 VDCC_L_b3su
IPR000584 VDCC_L_bsu
PANTHERiPTHR11824 PTHR11824, 1 hit
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF12052 VGCC_beta4Aa_N, 1 hit
PRINTSiPR01626 LCACHANNELB
PR01696 LCACHANNELB3
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3A (identifier: P54285-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ
60 70 80 90 100
QLERAKHKPV AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS
110 120 130 140 150
NDWWIGRLVK EGGDIAFIPS PQRLESIRLK QEQKARRSGN PSSLGDIGNR
160 170 180 190 200
RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV VLVGPSLKGY EVTDMMQKAL
210 220 230 240 250
FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER SSARSSIAEV
260 270 280 290 300
QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL
310 320 330 340 350
QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA
360 370 380 390 400
EYLEVYWRAT HHPAPGPGLL GPPSAIPGLQ NQQLLGERVE EHSPLERDSL
410 420 430 440 450
MPSDEASESS RQAWTGSSQR SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA
460 470 480
NGHDPQDRLL AQDSEHDHND RNWQRNRPWP KDSY
Length:484
Mass (Da):54,572
Last modified:October 3, 2012 - v2
Checksum:i56871A0B563A567E
GO
Isoform 3B (identifier: P54285-2)
Sequence is not available
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82G → A in AAA91105 (PubMed:7490102).Curated1
Sequence conflicti114D → A in AAA91105 (PubMed:7490102).Curated1
Sequence conflicti149N → F in AAA91105 (PubMed:7490102).Curated1
Sequence conflicti335V → A in AAA91105 (PubMed:7490102).Curated1
Sequence conflicti384L → Q in AAA91105 (PubMed:7490102).Curated1
Sequence conflicti409S → T in CAB61648 (PubMed:8617257).Curated1
Sequence conflicti421S → T in CAB61648 (PubMed:8617257).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20372 mRNA Translation: AAA91105.1
X94404, X94406, X94405 Genomic DNA Translation: CAB61648.1
AC156543 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04179.1
CCDSiCCDS27800.1 [P54285-1]
PIRiS62185
RefSeqiNP_031607.2, NM_007581.3 [P54285-1]
UniGeneiMm.3544

Genome annotation databases

EnsembliENSMUST00000003442; ENSMUSP00000003442; ENSMUSG00000003352 [P54285-1]
GeneIDi12297
KEGGimmu:12297
UCSCiuc007xnc.2 mouse [P54285-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCACB3_MOUSE
AccessioniPrimary (citable) accession number: P54285
Secondary accession number(s): G5E821
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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