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Protein

Voltage-dependent L-type calcium channel subunit beta-1

Gene

Cacnb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

GO - Molecular functioni

  • high voltage-gated calcium channel activity Source: GO_Central
  • phosphoprotein binding Source: RGD
  • protein domain specific binding Source: RGD
  • protein kinase binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-400042. Adrenaline,noradrenaline inhibits insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit beta-1
Short name:
CAB1
Alternative name(s):
Calcium channel voltage-dependent subunit beta 1
Gene namesi
Name:Cacnb1
Synonyms:Cacnlb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68382. Cacnb1.

Subcellular locationi

GO - Cellular componenti

  • sarcolemma Source: UniProtKB-SubCell
  • voltage-gated calcium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440491 – 597Voltage-dependent L-type calcium channel subunit beta-1Add BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei499PhosphothreonineBy similarity1
Modified residuei547PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54283.
PRIDEiP54283.

PTM databases

iPTMnetiP54283.
PhosphoSitePlusiP54283.

Interactioni

Subunit structurei

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 (By similarity). Interacts with CBARP.By similarity1 Publication

GO - Molecular functioni

  • phosphoprotein binding Source: RGD
  • protein domain specific binding Source: RGD
  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi248426. 2 interactors.
DIPiDIP-33255N.
IntActiP54283. 1 interactor.
STRINGi10116.ENSRNOP00000006098.

Structurei

3D structure databases

ProteinModelPortaliP54283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 161SH3PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
HOGENOMiHOG000230979.
HOVERGENiHBG050765.
InParanoidiP54283.
KOiK04862.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR005443. VDCC_L_b1su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
[Graphical view]
PRINTSiPR01626. LCACHANNELB.
PR01627. LCACHANNELB1.
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT
60 70 80 90 100
SNSFVRQGSA ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP
110 120 130 140 150
VAFAVRTNVG YNPSPGDEVP VQGVAITFEP KDFLHIKEKY NNDWWIGRLV
160 170 180 190 200
KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR LSSSKSGDNS SSSLGDVVTG
210 220 230 240 250
TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK GYEVTDMMQK
260 270 280 290 300
ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA
310 320 330 340 350
EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK
360 370 380 390 400
VLQRLIKSRG KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH
410 420 430 440 450
LAEYLEAYWK ATHPPSRTPP NPLLNRTMAT AALAVSPAPV SNLQGPYLVS
460 470 480 490 500
GDQPLDRATG EHASVHEYPG ELGQPPGLYP SNHPPGRAGT LWALSRQDTF
510 520 530 540 550
DADTPGSRNS VYTEPGDSCV DMETDPSEGP GPGDPAGGGT PPARQGSWEE
560 570 580 590
EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYIR
Length:597
Mass (Da):65,680
Last modified:October 1, 1996 - v1
Checksum:iD95BF4982AF1FD5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61394 mRNA. Translation: CAA43665.1.
PIRiS18304.
RefSeqiNP_059042.1. NM_017346.1.
UniGeneiRn.9417.

Genome annotation databases

GeneIDi50688.
KEGGirno:50688.
UCSCiRGD:68382. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61394 mRNA. Translation: CAA43665.1.
PIRiS18304.
RefSeqiNP_059042.1. NM_017346.1.
UniGeneiRn.9417.

3D structure databases

ProteinModelPortaliP54283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248426. 2 interactors.
DIPiDIP-33255N.
IntActiP54283. 1 interactor.
STRINGi10116.ENSRNOP00000006098.

PTM databases

iPTMnetiP54283.
PhosphoSitePlusiP54283.

Proteomic databases

PaxDbiP54283.
PRIDEiP54283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi50688.
KEGGirno:50688.
UCSCiRGD:68382. rat.

Organism-specific databases

CTDi782.
RGDi68382. Cacnb1.

Phylogenomic databases

eggNOGiKOG3812. Eukaryota.
ENOG410XRDI. LUCA.
HOGENOMiHOG000230979.
HOVERGENiHBG050765.
InParanoidiP54283.
KOiK04862.

Enzyme and pathway databases

ReactomeiR-RNO-400042. Adrenaline,noradrenaline inhibits insulin secretion.

Miscellaneous databases

PROiP54283.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
IPR005443. VDCC_L_b1su.
IPR000584. VDCC_L_bsu.
[Graphical view]
PANTHERiPTHR11824. PTHR11824. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF12052. VGCC_beta4Aa_N. 1 hit.
[Graphical view]
PRINTSiPR01626. LCACHANNELB.
PR01627. LCACHANNELB1.
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCACB1_RAT
AccessioniPrimary (citable) accession number: P54283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.