P54283 (CACB1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent L-type calcium channel subunit beta-1
Short name=CAB1

Alternative name(s):
Calcium channel voltage-dependent subunit beta 1

Gene names

Name:	Cacnb1
Synonyms:	Cacnlb1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subunit structure	The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 By similarity.
Subcellular location	Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Sequence similarities	Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	SH3 domain
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	sarcolemma Inferred from electronic annotation. Source: UniProtKB-SubCell voltage-gated calcium channel complex Inferred from direct assay PubMed 16049183PubMed 16554304PubMed 19840220. Source: RGD
Molecular_function	protein kinase binding Inferred from direct assay PubMed 18205403. Source: RGD voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 597	597	Voltage-dependent L-type calcium channel subunit beta-1		PRO_0000144049
Regions
	Domain	100 – 161	62	SH3
Amino acid modifications
	Modified residue	186	1	Phosphoserine By similarity
	Modified residue	499	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54283 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: D95BF4982AF1FD5E	FASTA	597	65,680
	10 20 30 40 50 60 MVQKSGMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 70 80 90 100 110 120 ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 130 140 150 160 170 180 VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQTLRQNR 190 200 210 220 230 240 LSSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK 250 260 270 280 290 300 GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA 310 320 330 340 350 360 EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG 370 380 390 400 410 420 KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSRTPP 430 440 450 460 470 480 NPLLNRTMAT AALAVSPAPV SNLQGPYLVS GDQPLDRATG EHASVHEYPG ELGQPPGLYP 490 500 510 520 530 540 SNHPPGRAGT LWALSRQDTF DADTPGSRNS VYTEPGDSCV DMETDPSEGP GPGDPAGGGT 550 560 570 580 590 PPARQGSWEE EEDYEEEMTD NRNRGRNKAR YCAEGGGPVL GRNKNELEGW GQGVYIR

References

[1]	"Cloning and tissue-specific expression of the brain calcium channel beta-subunit." Pragnell M., Sakamoto J., Jay S.D., Campbell K.P. FEBS Lett. 291:253-258(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61394 mRNA. Translation: CAA43665.1.
IPI	IPI00211872.
PIR	S18304.
RefSeq	NP_059042.1. NM_017346.1.
UniGene	Rn.9417.
3D structure databases
ProteinModelPortal	P54283.
SMR	P54283. Positions 74-416.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-33255N.
IntAct	P54283. 1 interaction.
STRING	10116.ENSRNOP00000030299.
PTM databases
PhosphoSite	P54283.
Proteomic databases
PaxDb	P54283.
PRIDE	P54283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	50688.
KEGG	rno:50688.
UCSC	RGD:68382. rat.
Organism-specific databases
CTD	782.
RGD	68382. Cacnb1.
Phylogenomic databases
eggNOG	NOG326500.
HOGENOM	HOG000230979.
HOVERGEN	HBG050765.
KO	K04862.
Enzyme and pathway databases
Reactome	REACT_113568. Metabolism.
Gene expression databases
ArrayExpress	P54283.
Genevestigator	P54283.
GermOnline	ENSRNOG00000004518. Rattus norvegicus.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR001452. SH3_domain. IPR005443. VDCC_L_b1su. IPR000584. VDCC_L_bsu. [Graphical view]
PANTHER	PTHR11824. PTHR11824. 1 hit.
Pfam	PF00625. Guanylate_kin. 1 hit. PF12052. VGCC_beta4Aa_N. 1 hit. [Graphical view]
PRINTS	PR01626. LCACHANNELB. PR01627. LCACHANNELB1.
SMART	SM00072. GuKc. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P54283.
ChEMBL	CHEMBL1075136.
NextBio	610546.

Entry information

Entry name

CACB1_RAT

Accession

Primary (citable) accession number: P54283

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program