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P54281

- ECLC_BOVIN

UniProt

P54281 - ECLC_BOVIN

Protein

Epithelial chloride channel protein

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. chloride channel activity Source: UniProtKB-KW
    3. voltage-gated ion channel activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Calcium channel, Chloride channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Chloride

    Protein family/group databases

    TCDBi1.A.13.1.1. the epithelial chloride channel (e-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Epithelial chloride channel protein
    Alternative name(s):
    Calcium-activated chloride channel
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. chloride channel complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 903903Epithelial chloride channel proteinPRO_0000054105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi688 – 6881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi816 – 8161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by CaM-kinase II.

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP54281.

    Expressioni

    Tissue specificityi

    Trachea.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000028657.

    Structurei

    3D structure databases

    ProteinModelPortaliP54281.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei331 – 35121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei883 – 90321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini308 – 476169VWFAPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CLCR family.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42884.
    HOGENOMiHOG000015107.
    HOVERGENiHBG005560.
    InParanoidiP54281.
    KOiK05030.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR004727. CaCC_prot.
    IPR013642. Cl_channel_Ca.
    IPR015394. DUF1973.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF08434. CLCA_N. 1 hit.
    PF09315. DUF1973. 1 hit.
    [Graphical view]
    SMARTiSM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    TIGRFAMsiTIGR00868. hCaCC. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54281-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPRLTVILF LTLHLLPGMK SSMVNLINNG YDGIVIAINP SVPEDEKLIQ    50
    NIKEMVTEAS TYLFHATKRR VYFRNVSILI PMTWKSKSEY LMPKQESYDQ 100
    AEVIVANPYL KHGDDPYTLQ YGRCGEKGQY IHFTPNFLLT NNLPIYGSRG 150
    RAFVHEWAHL RWGIFDEYNG DQPFYISRRN TIEATRCSTH ITGTNVIVKC 200
    QGGSCITRPC RRDSQTGLYE AKCTFIPEKS QTARESIMFM QSLHSVTEFC 250
    TEKTHNVEAP NLQNKMCNGK STWDVIMNST DFQNTSPMTE MNPPTQPTFS 300
    LLKSKQRVVC LVLDKSGSMS SEDRLFRMNQ AAELFLIQII EKGSLVGMVT 350
    FDSVAEIRNN LTKITDDNVY ENITANLPQE ANGGTSICRG LKAGFQAIIQ 400
    SQQSTSGSEI ILLTDGEDNE IHSCIEEVKQ SGVIIHTIAL GPSAAKELET 450
    LSDMTGGHRF YANKDINGLT NAFSRISSRS GSITQQTIQL ESKALAITEK 500
    KWVNGTVPVD STIGNDTFFV VTWTIKKPEI LLQDPKGKKY KTSDFKEDKL 550
    NIHSARLRIP GIAETGTWTY SLLNNHASPQ ILTVTVTTRA RSPTTPPVTA 600
    TAHMSQNTAH YPSPVIVYAQ VSQGFLPVLG INVTAIIETE DGHQVTLELW 650
    DNGAGADTVK NDGIYSRYFT DYRGNGRYSL KVHAEARNNT ARLSLRQPQN 700
    KALYIPGYIE NGKIILNPPR PEVKDDLAKA EIEDFSRLTS GGSFTVSGAP 750
    PGNHPSVLPP NKIIDLEAKF KEDHIQLSWT APANVLDKGK ANSYIIRISK 800
    SFLDLQKDFD NATLVNTSSL KPKEAGSDEN FEFKPEPFRI ENGTNFYIAV 850
    QAINEANLTS EVSNIAQAIK FIPMPEDSVP ALGTKISAIN LAIFALAMIL 900
    SIV 903
    Length:903
    Mass (Da):100,306
    Last modified:October 1, 1996 - v1
    Checksum:i9742AB1590908AEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36445 mRNA. Translation: AAC48511.1.
    RefSeqiNP_001229512.1. NM_001242583.1.
    UniGeneiBt.66156.

    Genome annotation databases

    GeneIDi784768.
    KEGGibta:784768.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36445 mRNA. Translation: AAC48511.1 .
    RefSeqi NP_001229512.1. NM_001242583.1.
    UniGenei Bt.66156.

    3D structure databases

    ProteinModelPortali P54281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000028657.

    Protein family/group databases

    TCDBi 1.A.13.1.1. the epithelial chloride channel (e-clc) family.

    Proteomic databases

    PRIDEi P54281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 784768.
    KEGGi bta:784768.

    Phylogenomic databases

    eggNOGi NOG42884.
    HOGENOMi HOG000015107.
    HOVERGENi HBG005560.
    InParanoidi P54281.
    KOi K05030.

    Miscellaneous databases

    NextBioi 20926889.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR004727. CaCC_prot.
    IPR013642. Cl_channel_Ca.
    IPR015394. DUF1973.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF08434. CLCA_N. 1 hit.
    PF09315. DUF1973. 1 hit.
    [Graphical view ]
    SMARTi SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    TIGRFAMsi TIGR00868. hCaCC. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Trachea.

    Entry informationi

    Entry nameiECLC_BOVIN
    AccessioniPrimary (citable) accession number: P54281
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3