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Protein

Epithelial chloride channel protein

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. chloride channel activity Source: UniProtKB-KW
  3. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Protein family/group databases

TCDBi1.A.13.1.1. the epithelial chloride channel (e-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial chloride channel protein
Alternative name(s):
Calcium-activated chloride channel
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei331 – 35121HelicalSequence AnalysisAdd
BLAST
Transmembranei617 – 63721HelicalSequence AnalysisAdd
BLAST
Transmembranei883 – 90321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Epithelial chloride channel proteinPRO_0000054105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi688 – 6881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi816 – 8161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi842 – 8421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi857 – 8571N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by CaM-kinase II.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP54281.

Expressioni

Tissue specificityi

Trachea.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028657.

Structurei

3D structure databases

ProteinModelPortaliP54281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 476169VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CLCR family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42884.
HOGENOMiHOG000015107.
HOVERGENiHBG005560.
KOiK05030.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00868. hCaCC. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRLTVILF LTLHLLPGMK SSMVNLINNG YDGIVIAINP SVPEDEKLIQ
60 70 80 90 100
NIKEMVTEAS TYLFHATKRR VYFRNVSILI PMTWKSKSEY LMPKQESYDQ
110 120 130 140 150
AEVIVANPYL KHGDDPYTLQ YGRCGEKGQY IHFTPNFLLT NNLPIYGSRG
160 170 180 190 200
RAFVHEWAHL RWGIFDEYNG DQPFYISRRN TIEATRCSTH ITGTNVIVKC
210 220 230 240 250
QGGSCITRPC RRDSQTGLYE AKCTFIPEKS QTARESIMFM QSLHSVTEFC
260 270 280 290 300
TEKTHNVEAP NLQNKMCNGK STWDVIMNST DFQNTSPMTE MNPPTQPTFS
310 320 330 340 350
LLKSKQRVVC LVLDKSGSMS SEDRLFRMNQ AAELFLIQII EKGSLVGMVT
360 370 380 390 400
FDSVAEIRNN LTKITDDNVY ENITANLPQE ANGGTSICRG LKAGFQAIIQ
410 420 430 440 450
SQQSTSGSEI ILLTDGEDNE IHSCIEEVKQ SGVIIHTIAL GPSAAKELET
460 470 480 490 500
LSDMTGGHRF YANKDINGLT NAFSRISSRS GSITQQTIQL ESKALAITEK
510 520 530 540 550
KWVNGTVPVD STIGNDTFFV VTWTIKKPEI LLQDPKGKKY KTSDFKEDKL
560 570 580 590 600
NIHSARLRIP GIAETGTWTY SLLNNHASPQ ILTVTVTTRA RSPTTPPVTA
610 620 630 640 650
TAHMSQNTAH YPSPVIVYAQ VSQGFLPVLG INVTAIIETE DGHQVTLELW
660 670 680 690 700
DNGAGADTVK NDGIYSRYFT DYRGNGRYSL KVHAEARNNT ARLSLRQPQN
710 720 730 740 750
KALYIPGYIE NGKIILNPPR PEVKDDLAKA EIEDFSRLTS GGSFTVSGAP
760 770 780 790 800
PGNHPSVLPP NKIIDLEAKF KEDHIQLSWT APANVLDKGK ANSYIIRISK
810 820 830 840 850
SFLDLQKDFD NATLVNTSSL KPKEAGSDEN FEFKPEPFRI ENGTNFYIAV
860 870 880 890 900
QAINEANLTS EVSNIAQAIK FIPMPEDSVP ALGTKISAIN LAIFALAMIL

SIV
Length:903
Mass (Da):100,306
Last modified:October 1, 1996 - v1
Checksum:i9742AB1590908AEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36445 mRNA. Translation: AAC48511.1.
RefSeqiNP_001229512.1. NM_001242583.1.
UniGeneiBt.66156.

Genome annotation databases

GeneIDi784768.
KEGGibta:784768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36445 mRNA. Translation: AAC48511.1.
RefSeqiNP_001229512.1. NM_001242583.1.
UniGeneiBt.66156.

3D structure databases

ProteinModelPortaliP54281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028657.

Protein family/group databases

TCDBi1.A.13.1.1. the epithelial chloride channel (e-clc) family.

Proteomic databases

PRIDEiP54281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi784768.
KEGGibta:784768.

Phylogenomic databases

eggNOGiNOG42884.
HOGENOMiHOG000015107.
HOVERGENiHBG005560.
KOiK05030.

Miscellaneous databases

NextBioi20926889.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00868. hCaCC. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.

Entry informationi

Entry nameiECLC_BOVIN
AccessioniPrimary (citable) accession number: P54281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.