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P54281 (ECLC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Epithelial chloride channel protein
Alternative name(s):
Calcium-activated chloride channel
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length903 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Trachea.

Post-translational modification

Phosphorylated by CaM-kinase II.

Sequence similarities

Belongs to the CLCR family.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 903903Epithelial chloride channel protein
PRO_0000054105

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane331 – 35121Helical; Potential
Transmembrane617 – 63721Helical; Potential
Transmembrane883 – 90321Helical; Potential
Domain308 – 476169VWFA

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation5041N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation6881N-linked (GlcNAc...) Potential
Glycosylation8111N-linked (GlcNAc...) Potential
Glycosylation8161N-linked (GlcNAc...) Potential
Glycosylation8421N-linked (GlcNAc...) Potential
Glycosylation8571N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P54281 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 9742AB1590908AEC

FASTA903100,306
        10         20         30         40         50         60 
MVPRLTVILF LTLHLLPGMK SSMVNLINNG YDGIVIAINP SVPEDEKLIQ NIKEMVTEAS 

        70         80         90        100        110        120 
TYLFHATKRR VYFRNVSILI PMTWKSKSEY LMPKQESYDQ AEVIVANPYL KHGDDPYTLQ 

       130        140        150        160        170        180 
YGRCGEKGQY IHFTPNFLLT NNLPIYGSRG RAFVHEWAHL RWGIFDEYNG DQPFYISRRN 

       190        200        210        220        230        240 
TIEATRCSTH ITGTNVIVKC QGGSCITRPC RRDSQTGLYE AKCTFIPEKS QTARESIMFM 

       250        260        270        280        290        300 
QSLHSVTEFC TEKTHNVEAP NLQNKMCNGK STWDVIMNST DFQNTSPMTE MNPPTQPTFS 

       310        320        330        340        350        360 
LLKSKQRVVC LVLDKSGSMS SEDRLFRMNQ AAELFLIQII EKGSLVGMVT FDSVAEIRNN 

       370        380        390        400        410        420 
LTKITDDNVY ENITANLPQE ANGGTSICRG LKAGFQAIIQ SQQSTSGSEI ILLTDGEDNE 

       430        440        450        460        470        480 
IHSCIEEVKQ SGVIIHTIAL GPSAAKELET LSDMTGGHRF YANKDINGLT NAFSRISSRS 

       490        500        510        520        530        540 
GSITQQTIQL ESKALAITEK KWVNGTVPVD STIGNDTFFV VTWTIKKPEI LLQDPKGKKY 

       550        560        570        580        590        600 
KTSDFKEDKL NIHSARLRIP GIAETGTWTY SLLNNHASPQ ILTVTVTTRA RSPTTPPVTA 

       610        620        630        640        650        660 
TAHMSQNTAH YPSPVIVYAQ VSQGFLPVLG INVTAIIETE DGHQVTLELW DNGAGADTVK 

       670        680        690        700        710        720 
NDGIYSRYFT DYRGNGRYSL KVHAEARNNT ARLSLRQPQN KALYIPGYIE NGKIILNPPR 

       730        740        750        760        770        780 
PEVKDDLAKA EIEDFSRLTS GGSFTVSGAP PGNHPSVLPP NKIIDLEAKF KEDHIQLSWT 

       790        800        810        820        830        840 
APANVLDKGK ANSYIIRISK SFLDLQKDFD NATLVNTSSL KPKEAGSDEN FEFKPEPFRI 

       850        860        870        880        890        900 
ENGTNFYIAV QAINEANLTS EVSNIAQAIK FIPMPEDSVP ALGTKISAIN LAIFALAMIL 


SIV 

« Hide

References

[1]"Cloning of an epithelial chloride channel from bovine trachea."
Cunningham S.A., Awayda M.S., Bubien J.K., Ismailov I.I., Arrate M.P., Berdiev B.K., Benos D.J., Fuller C.M.
J. Biol. Chem. 270:31016-31026(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Trachea.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36445 mRNA. Translation: AAC48511.1.
RefSeqNP_001229512.1. NM_001242583.1.
UniGeneBt.66156.

3D structure databases

ProteinModelPortalP54281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000028657.

Protein family/group databases

TCDB1.A.13.1.1. the epithelial chloride channel (e-clc) family.

Proteomic databases

PRIDEP54281.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID784768.
KEGGbta:784768.

Phylogenomic databases

eggNOGNOG42884.
HOGENOMHOG000015107.
HOVERGENHBG005560.
InParanoidP54281.
KOK05030.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view]
PfamPF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view]
SMARTSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
TIGRFAMsTIGR00868. hCaCC. 1 hit.
PROSITEPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20926889.

Entry information

Entry nameECLC_BOVIN
AccessionPrimary (citable) accession number: P54281
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families