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P54281

- ECLC_BOVIN

UniProt

P54281 - ECLC_BOVIN

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Protein
Epithelial chloride channel protein
Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. chloride channel activity Source: UniProtKB-KW
  3. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Protein family/group databases

TCDBi1.A.13.1.1. the epithelial chloride channel (e-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial chloride channel protein
Alternative name(s):
Calcium-activated chloride channel
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei331 – 35121Helical; Reviewed prediction
Add
BLAST
Transmembranei617 – 63721Helical; Reviewed prediction
Add
BLAST
Transmembranei883 – 90321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. chloride channel complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 903903Epithelial chloride channel protein
PRO_0000054105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi372 – 3721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi504 – 5041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi688 – 6881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi811 – 8111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi816 – 8161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi842 – 8421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi857 – 8571N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated by CaM-kinase II.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP54281.

Expressioni

Tissue specificityi

Trachea.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028657.

Structurei

3D structure databases

ProteinModelPortaliP54281.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini308 – 476169VWFA
Add
BLAST

Sequence similaritiesi

Belongs to the CLCR family.
Contains 1 VWFA domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42884.
HOGENOMiHOG000015107.
HOVERGENiHBG005560.
InParanoidiP54281.
KOiK05030.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view]
PfamiPF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00868. hCaCC. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54281-1 [UniParc]FASTAAdd to Basket

« Hide

MVPRLTVILF LTLHLLPGMK SSMVNLINNG YDGIVIAINP SVPEDEKLIQ    50
NIKEMVTEAS TYLFHATKRR VYFRNVSILI PMTWKSKSEY LMPKQESYDQ 100
AEVIVANPYL KHGDDPYTLQ YGRCGEKGQY IHFTPNFLLT NNLPIYGSRG 150
RAFVHEWAHL RWGIFDEYNG DQPFYISRRN TIEATRCSTH ITGTNVIVKC 200
QGGSCITRPC RRDSQTGLYE AKCTFIPEKS QTARESIMFM QSLHSVTEFC 250
TEKTHNVEAP NLQNKMCNGK STWDVIMNST DFQNTSPMTE MNPPTQPTFS 300
LLKSKQRVVC LVLDKSGSMS SEDRLFRMNQ AAELFLIQII EKGSLVGMVT 350
FDSVAEIRNN LTKITDDNVY ENITANLPQE ANGGTSICRG LKAGFQAIIQ 400
SQQSTSGSEI ILLTDGEDNE IHSCIEEVKQ SGVIIHTIAL GPSAAKELET 450
LSDMTGGHRF YANKDINGLT NAFSRISSRS GSITQQTIQL ESKALAITEK 500
KWVNGTVPVD STIGNDTFFV VTWTIKKPEI LLQDPKGKKY KTSDFKEDKL 550
NIHSARLRIP GIAETGTWTY SLLNNHASPQ ILTVTVTTRA RSPTTPPVTA 600
TAHMSQNTAH YPSPVIVYAQ VSQGFLPVLG INVTAIIETE DGHQVTLELW 650
DNGAGADTVK NDGIYSRYFT DYRGNGRYSL KVHAEARNNT ARLSLRQPQN 700
KALYIPGYIE NGKIILNPPR PEVKDDLAKA EIEDFSRLTS GGSFTVSGAP 750
PGNHPSVLPP NKIIDLEAKF KEDHIQLSWT APANVLDKGK ANSYIIRISK 800
SFLDLQKDFD NATLVNTSSL KPKEAGSDEN FEFKPEPFRI ENGTNFYIAV 850
QAINEANLTS EVSNIAQAIK FIPMPEDSVP ALGTKISAIN LAIFALAMIL 900
SIV 903
Length:903
Mass (Da):100,306
Last modified:October 1, 1996 - v1
Checksum:i9742AB1590908AEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36445 mRNA. Translation: AAC48511.1.
RefSeqiNP_001229512.1. NM_001242583.1.
UniGeneiBt.66156.

Genome annotation databases

GeneIDi784768.
KEGGibta:784768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36445 mRNA. Translation: AAC48511.1 .
RefSeqi NP_001229512.1. NM_001242583.1.
UniGenei Bt.66156.

3D structure databases

ProteinModelPortali P54281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000028657.

Protein family/group databases

TCDBi 1.A.13.1.1. the epithelial chloride channel (e-clc) family.

Proteomic databases

PRIDEi P54281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 784768.
KEGGi bta:784768.

Phylogenomic databases

eggNOGi NOG42884.
HOGENOMi HOG000015107.
HOVERGENi HBG005560.
InParanoidi P54281.
KOi K05030.

Miscellaneous databases

NextBioi 20926889.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR004727. CaCC_prot.
IPR013642. Cl_channel_Ca.
IPR015394. DUF1973.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF08434. CLCA_N. 1 hit.
PF09315. DUF1973. 1 hit.
[Graphical view ]
SMARTi SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
TIGRFAMsi TIGR00868. hCaCC. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Trachea.

Entry informationi

Entry nameiECLC_BOVIN
AccessioniPrimary (citable) accession number: P54281
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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