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Protein

Calcium-activated chloride channel regulator 1

Gene
N/A
Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in mediating calcium-activated chloride conductance (PubMed:8537359). May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi155Zinc; catalyticBy similarity1
Active sitei156By similarity1
Metal bindingi159Zinc; catalyticBy similarity1
Metal bindingi166Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Chloride, Metal-binding

Protein family/group databases

TCDBi1.A.13.1.1. the epithelial chloride channel (e-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated chloride channel regulator 1Curated (EC:3.4.-.-By similarity)
Alternative name(s):
Calcium-activated chloride channel
Epithelial chloride channel protein1 Publication
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei883 – 903HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000005410522 – 903Calcium-activated chloride channel regulator 1Add BLAST882

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi842N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP54281.
PRIDEiP54281.

Expressioni

Tissue specificityi

Trachea.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028657.

Structurei

3D structure databases

ProteinModelPortaliP54281.
SMRiP54281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini308 – 476VWFAPROSITE-ProRule annotationAdd BLAST169

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 199Metalloprotease domainBy similarityAdd BLAST155

Domaini

The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates.By similarity

Sequence similaritiesi

Belongs to the CLCR family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEPS. Eukaryota.
ENOG410XPSZ. LUCA.
HOGENOMiHOG000015107.
HOVERGENiHBG005560.
KOiK05030.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.390.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR004727. CLCA_chordata.
IPR013642. CLCA_N.
IPR013783. Ig-like_fold.
IPR024079. MetalloPept_cat_dom.
IPR002035. VWF_A.
PfamiView protein in Pfam
PF08434. CLCA. 1 hit.
PF00092. VWA. 1 hit.
SMARTiView protein in SMART
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00868. hCaCC. 1 hit.
PROSITEiView protein in PROSITE
PS50234. VWFA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRLTVILF LTLHLLPGMK SSMVNLINNG YDGIVIAINP SVPEDEKLIQ
60 70 80 90 100
NIKEMVTEAS TYLFHATKRR VYFRNVSILI PMTWKSKSEY LMPKQESYDQ
110 120 130 140 150
AEVIVANPYL KHGDDPYTLQ YGRCGEKGQY IHFTPNFLLT NNLPIYGSRG
160 170 180 190 200
RAFVHEWAHL RWGIFDEYNG DQPFYISRRN TIEATRCSTH ITGTNVIVKC
210 220 230 240 250
QGGSCITRPC RRDSQTGLYE AKCTFIPEKS QTARESIMFM QSLHSVTEFC
260 270 280 290 300
TEKTHNVEAP NLQNKMCNGK STWDVIMNST DFQNTSPMTE MNPPTQPTFS
310 320 330 340 350
LLKSKQRVVC LVLDKSGSMS SEDRLFRMNQ AAELFLIQII EKGSLVGMVT
360 370 380 390 400
FDSVAEIRNN LTKITDDNVY ENITANLPQE ANGGTSICRG LKAGFQAIIQ
410 420 430 440 450
SQQSTSGSEI ILLTDGEDNE IHSCIEEVKQ SGVIIHTIAL GPSAAKELET
460 470 480 490 500
LSDMTGGHRF YANKDINGLT NAFSRISSRS GSITQQTIQL ESKALAITEK
510 520 530 540 550
KWVNGTVPVD STIGNDTFFV VTWTIKKPEI LLQDPKGKKY KTSDFKEDKL
560 570 580 590 600
NIHSARLRIP GIAETGTWTY SLLNNHASPQ ILTVTVTTRA RSPTTPPVTA
610 620 630 640 650
TAHMSQNTAH YPSPVIVYAQ VSQGFLPVLG INVTAIIETE DGHQVTLELW
660 670 680 690 700
DNGAGADTVK NDGIYSRYFT DYRGNGRYSL KVHAEARNNT ARLSLRQPQN
710 720 730 740 750
KALYIPGYIE NGKIILNPPR PEVKDDLAKA EIEDFSRLTS GGSFTVSGAP
760 770 780 790 800
PGNHPSVLPP NKIIDLEAKF KEDHIQLSWT APANVLDKGK ANSYIIRISK
810 820 830 840 850
SFLDLQKDFD NATLVNTSSL KPKEAGSDEN FEFKPEPFRI ENGTNFYIAV
860 870 880 890 900
QAINEANLTS EVSNIAQAIK FIPMPEDSVP ALGTKISAIN LAIFALAMIL

SIV
Length:903
Mass (Da):100,306
Last modified:October 1, 1996 - v1
Checksum:i9742AB1590908AEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36445 mRNA. Translation: AAC48511.1.
RefSeqiNP_001229512.1. NM_001242583.1.
UniGeneiBt.66156.

Genome annotation databases

GeneIDi784768.
KEGGibta:784768.

Similar proteinsi

Entry informationi

Entry nameiCLCA1_BOVIN
AccessioniPrimary (citable) accession number: P54281
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was initially characterized as chloride channel, but such a function is difficult to reconcile with the single predicted transmembrane region. Other family members have been shown to stimulate channel activity.Curated1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families