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P54273

- XYLA_GEOSE

UniProt

P54273 - XYLA_GEOSE

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Protein

Xylose isomerase

Gene

xylA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mn2+Note: Binds 2 manganese ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991
Active sitei102 – 1021By similarity
Metal bindingi230 – 2301Manganese 1
Metal bindingi266 – 2661Manganese 1
Metal bindingi266 – 2661Manganese 2
Metal bindingi294 – 2941Manganese 1
Metal bindingi305 – 3051Manganese 2
Metal bindingi307 – 3071Manganese 2
Metal bindingi337 – 3371Manganese 1

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Xylose isomerasePRO_0000195766Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
441
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254Combined sources
Helixi37 – 415Combined sources
Beta strandi43 – 464Combined sources
Helixi47 – 526Combined sources
Helixi67 – 704Combined sources
Helixi73 – 9119Combined sources
Beta strandi94 – 996Combined sources
Helixi100 – 1034Combined sources
Helixi110 – 12819Combined sources
Beta strandi134 – 1396Combined sources
Beta strandi143 – 1453Combined sources
Helixi146 – 1483Combined sources
Helixi158 – 17821Combined sources
Beta strandi181 – 1855Combined sources
Beta strandi190 – 1934Combined sources
Helixi195 – 1973Combined sources
Helixi200 – 22021Combined sources
Beta strandi225 – 2295Combined sources
Beta strandi235 – 2428Combined sources
Helixi245 – 25410Combined sources
Helixi258 – 2603Combined sources
Beta strandi261 – 2666Combined sources
Helixi267 – 2726Combined sources
Helixi277 – 28610Combined sources
Beta strandi290 – 2945Combined sources
Beta strandi302 – 3043Combined sources
Helixi313 – 32513Combined sources
Beta strandi334 – 3363Combined sources
Helixi348 – 37326Combined sources
Helixi376 – 3849Combined sources
Helixi386 – 3883Combined sources
Helixi391 – 3988Combined sources
Helixi403 – 4119Combined sources
Helixi423 – 43513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A0DX-ray3.00A/B/C/D2-441[»]
ProteinModelPortaliP54273.
SMRiP54273. Positions 2-438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54273.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYFDNISTI AYEGPASKNP LAFKFYNPEE KVGDKTMEEH LRFSVAYWHT
60 70 80 90 100
FTGDGSDPFG AGNMIRPWNK YSGMDLAKAR VEAAFEFFEK LNIPFFCFHD
110 120 130 140 150
VDIAPEGETL KETYKNLDII VDMIEEYMKT SKTKLLWNTA NLFTHPRFVH
160 170 180 190 200
GAATSCNADV FAYAAAKVKK GLEIAKRLGA ENYVFWGGRE GYETLLNTDM
210 220 230 240 250
KLELDNLARF LHMAVDYAKE IGFDGQFLIE PKPKEPTKHQ YDFDVATALA
260 270 280 290 300
FLQTYGLKDY FKFNIEANHA TLAGHTFEHE LRVARIHGML GSVDANQGDM
310 320 330 340 350
LLGWDTDEFP TDLYSTTLAM YEILKNGGLG RGGLNFDAKV RRGSFEPEDL
360 370 380 390 400
FYAHIAGMDS FAVGLKVAHR LIEDRVFDEF IEERYKSYTE GIGREIVEGT
410 420 430 440
ADFHKLEAHA LQLGEIQNQS GRQERLKTLL NQYLLEVCAA R
Length:441
Mass (Da):50,142
Last modified:July 15, 1998 - v2
Checksum:i78BB39852919D017
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481A → R in CAA66715. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98088 Genomic DNA. Translation: CAA66715.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98088 Genomic DNA. Translation: CAA66715.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A0D X-ray 3.00 A/B/C/D 2-441 [» ]
ProteinModelPortali P54273.
SMRi P54273. Positions 2-438.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P54273.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Jackson R., Brannigan J., Taylor M.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCIMB 12403 / LLD-R.
  2. "Crystal structures of class II xylose isomerases from two thermophiles and a hyperthermophile."
    Gallay O., Chopra R., Conti E., Brick P., Jackson R., Hartley B., Vieille C., Zeikus J.G., Blow D.
    Submitted (NOV-1997) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), SEQUENCE REVISION TO 248.
    Strain: NCIMB 12403 / LLD-R.

Entry informationi

Entry nameiXYLA_GEOSE
AccessioniPrimary (citable) accession number: P54273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 26, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3