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P54273

- XYLA_GEOSE

UniProt

P54273 - XYLA_GEOSE

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Protein
Xylose isomerase
Gene
xylA
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Binds 2 manganese ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei99 – 991
Active sitei102 – 1021 By similarity
Metal bindingi230 – 2301Manganese 1
Metal bindingi266 – 2661Manganese 1
Metal bindingi266 – 2661Manganese 2
Metal bindingi294 – 2941Manganese 1
Metal bindingi305 – 3051Manganese 2
Metal bindingi307 – 3071Manganese 2
Metal bindingi337 – 3371Manganese 1

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Xylose isomeraseUniRule annotation
PRO_0000195766Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi22 – 254
Helixi37 – 415
Beta strandi43 – 464
Helixi47 – 526
Helixi67 – 704
Helixi73 – 9119
Beta strandi94 – 996
Helixi100 – 1034
Helixi110 – 12819
Beta strandi134 – 1396
Beta strandi143 – 1453
Helixi146 – 1483
Helixi158 – 17821
Beta strandi181 – 1855
Beta strandi190 – 1934
Helixi195 – 1973
Helixi200 – 22021
Beta strandi225 – 2295
Beta strandi235 – 2428
Helixi245 – 25410
Helixi258 – 2603
Beta strandi261 – 2666
Helixi267 – 2726
Helixi277 – 28610
Beta strandi290 – 2945
Beta strandi302 – 3043
Helixi313 – 32513
Beta strandi334 – 3363
Helixi348 – 37326
Helixi376 – 3849
Helixi386 – 3883
Helixi391 – 3988
Helixi403 – 4119
Helixi423 – 43513

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A0DX-ray3.00A/B/C/D2-441[»]
ProteinModelPortaliP54273.
SMRiP54273. Positions 2-438.

Miscellaneous databases

EvolutionaryTraceiP54273.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54273-1 [UniParc]FASTAAdd to Basket

« Hide

MPYFDNISTI AYEGPASKNP LAFKFYNPEE KVGDKTMEEH LRFSVAYWHT    50
FTGDGSDPFG AGNMIRPWNK YSGMDLAKAR VEAAFEFFEK LNIPFFCFHD 100
VDIAPEGETL KETYKNLDII VDMIEEYMKT SKTKLLWNTA NLFTHPRFVH 150
GAATSCNADV FAYAAAKVKK GLEIAKRLGA ENYVFWGGRE GYETLLNTDM 200
KLELDNLARF LHMAVDYAKE IGFDGQFLIE PKPKEPTKHQ YDFDVATALA 250
FLQTYGLKDY FKFNIEANHA TLAGHTFEHE LRVARIHGML GSVDANQGDM 300
LLGWDTDEFP TDLYSTTLAM YEILKNGGLG RGGLNFDAKV RRGSFEPEDL 350
FYAHIAGMDS FAVGLKVAHR LIEDRVFDEF IEERYKSYTE GIGREIVEGT 400
ADFHKLEAHA LQLGEIQNQS GRQERLKTLL NQYLLEVCAA R 441
Length:441
Mass (Da):50,142
Last modified:July 15, 1998 - v2
Checksum:i78BB39852919D017
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481A → R in CAA66715. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98088 Genomic DNA. Translation: CAA66715.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98088 Genomic DNA. Translation: CAA66715.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A0D X-ray 3.00 A/B/C/D 2-441 [» ]
ProteinModelPortali P54273.
SMRi P54273. Positions 2-438.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P54273.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Jackson R., Brannigan J., Taylor M.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCIMB 12403 / LLD-R.
  2. "Crystal structures of class II xylose isomerases from two thermophiles and a hyperthermophile."
    Gallay O., Chopra R., Conti E., Brick P., Jackson R., Hartley B., Vieille C., Zeikus J.G., Blow D.
    Submitted (NOV-1997) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), SEQUENCE REVISION TO 248.
    Strain: NCIMB 12403 / LLD-R.

Entry informationi

Entry nameiXYLA_GEOSE
AccessioniPrimary (citable) accession number: P54273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: February 19, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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