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P54273

- XYLA_GEOSE

UniProt

P54273 - XYLA_GEOSE

Protein

Xylose isomerase

Gene

xylA

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.

    Cofactori

    Binds 2 manganese ions per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei99 – 991
    Active sitei102 – 1021By similarity
    Metal bindingi230 – 2301Manganese 1
    Metal bindingi266 – 2661Manganese 1
    Metal bindingi266 – 2661Manganese 2
    Metal bindingi294 – 2941Manganese 1
    Metal bindingi305 – 3051Manganese 2
    Metal bindingi307 – 3071Manganese 2
    Metal bindingi337 – 3371Manganese 1

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomerase (EC:5.3.1.5)
    Gene namesi
    Name:xylA
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Xylose isomerasePRO_0000195766Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    Secondary structure

    1
    441
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi22 – 254
    Helixi37 – 415
    Beta strandi43 – 464
    Helixi47 – 526
    Helixi67 – 704
    Helixi73 – 9119
    Beta strandi94 – 996
    Helixi100 – 1034
    Helixi110 – 12819
    Beta strandi134 – 1396
    Beta strandi143 – 1453
    Helixi146 – 1483
    Helixi158 – 17821
    Beta strandi181 – 1855
    Beta strandi190 – 1934
    Helixi195 – 1973
    Helixi200 – 22021
    Beta strandi225 – 2295
    Beta strandi235 – 2428
    Helixi245 – 25410
    Helixi258 – 2603
    Beta strandi261 – 2666
    Helixi267 – 2726
    Helixi277 – 28610
    Beta strandi290 – 2945
    Beta strandi302 – 3043
    Helixi313 – 32513
    Beta strandi334 – 3363
    Helixi348 – 37326
    Helixi376 – 3849
    Helixi386 – 3883
    Helixi391 – 3988
    Helixi403 – 4119
    Helixi423 – 43513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A0DX-ray3.00A/B/C/D2-441[»]
    ProteinModelPortaliP54273.
    SMRiP54273. Positions 2-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP54273.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.Curated

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYFDNISTI AYEGPASKNP LAFKFYNPEE KVGDKTMEEH LRFSVAYWHT    50
    FTGDGSDPFG AGNMIRPWNK YSGMDLAKAR VEAAFEFFEK LNIPFFCFHD 100
    VDIAPEGETL KETYKNLDII VDMIEEYMKT SKTKLLWNTA NLFTHPRFVH 150
    GAATSCNADV FAYAAAKVKK GLEIAKRLGA ENYVFWGGRE GYETLLNTDM 200
    KLELDNLARF LHMAVDYAKE IGFDGQFLIE PKPKEPTKHQ YDFDVATALA 250
    FLQTYGLKDY FKFNIEANHA TLAGHTFEHE LRVARIHGML GSVDANQGDM 300
    LLGWDTDEFP TDLYSTTLAM YEILKNGGLG RGGLNFDAKV RRGSFEPEDL 350
    FYAHIAGMDS FAVGLKVAHR LIEDRVFDEF IEERYKSYTE GIGREIVEGT 400
    ADFHKLEAHA LQLGEIQNQS GRQERLKTLL NQYLLEVCAA R 441
    Length:441
    Mass (Da):50,142
    Last modified:July 15, 1998 - v2
    Checksum:i78BB39852919D017
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti248 – 2481A → R in CAA66715. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98088 Genomic DNA. Translation: CAA66715.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98088 Genomic DNA. Translation: CAA66715.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A0D X-ray 3.00 A/B/C/D 2-441 [» ]
    ProteinModelPortali P54273.
    SMRi P54273. Positions 2-438.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P54273.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jackson R., Brannigan J., Taylor M.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NCIMB 12403 / LLD-R.
    2. "Crystal structures of class II xylose isomerases from two thermophiles and a hyperthermophile."
      Gallay O., Chopra R., Conti E., Brick P., Jackson R., Hartley B., Vieille C., Zeikus J.G., Blow D.
      Submitted (NOV-1997) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), SEQUENCE REVISION TO 248.
      Strain: NCIMB 12403 / LLD-R.

    Entry informationi

    Entry nameiXYLA_GEOSE
    AccessioniPrimary (citable) accession number: P54273
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3