Reviewed, UniProtKB/Swiss-Prot P54269 (CAUP_DROME)

Names and origin

Protein names

Recommended name:
    Homeobox protein caupolican

Gene names

Name:	caup
ORF Names:	CG10605

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	693 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Controls proneural and vein forming genes. Positive transcriptional controler of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation. Ref.1
Subcellular location	Nucleus Probable.
Miscellaneous	'Caupolican' is named after the Araucanian American-Indian tribe, also called mohawks, who shaved all but a medial stripe of hairs on the head.
Sequence similarities	Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	equator specification Traceable author statement. Source: FlyBase imaginal disc-derived wing vein specification Ref.1 Inferred from genetic interaction. Source: FlyBase phagocytosis, engulfment Inferred from mutant phenotype. Source: FlyBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VG15	1	EBI-111580,EBI-117389
dod	P54353	1	EBI-111580,EBI-194983

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 693	693	Homeobox protein caupolican		PRO_0000048845
Regions
	DNA binding	226 – 288	63	Homeobox; TALE-type
	Compositional bias	300 – 303	4	Poly-Asp
	Compositional bias	405 – 418	14	Poly-Gln
	Compositional bias	501 – 516	16	Poly-Gln
	Compositional bias	517 – 528	12	Poly-His
	Compositional bias	565 – 572	8	Poly-Ser
	Compositional bias	613 – 624	12	Poly-Ser
Experimental info
	Sequence conflict	106	1	C → R in CAA64485. Ref.1
	Sequence conflict	316	1	G → A in CAA64485. Ref.1
	Sequence conflict	518	1	H → N in AAV36871. Ref.4
	Sequence conflict	678	1	G → A in CAA64485. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P54269-1 [UniParc]. Last modified August 14, 2001. Version 2. Checksum: FBEB1616493F7EC9	FASTA	693	73,668
	10 20 30 40 50 60 MAAYAQFGYA GYPTANQLTT ANTDSQSGHG GGSPLSGTNE ASLSPSGGST ATGLTAGPLS 70 80 90 100 110 120 PGAVSQSSHH AGHKGLSTSP AEDVVGGDVP VGLSSAAQDL PSRGSCCENG RPIITDPVSG 130 140 150 160 170 180 QTVCSCQYDP ARLAIGGYSR MALPSGGVGV GVYGGPYPSN EQNPYPSIGV DNSAFYAPLS 190 200 210 220 230 240 NPYGIKDTSP STEMSAWTSA SLQSTTGYYS YDPTLAAYGY GPNYDLAARR KNATRESTAT 250 260 270 280 290 300 LKAWLSEHKK NPYPTKGEKI MLAIITKMTL TQVSTWFANA RRRLKKENKM TWEPKNKTED 310 320 330 340 350 360 DDDGMMSDDE KEKDAGDGGK LSTEAFDPGN QLIKSELGKA EKEVDSSGDQ KLDLDREPHN 370 380 390 400 410 420 LVAMRGLAPY ATPPGAHPMH AAYSSYAQSH NTHTHPHPQQ MQHHQQQQQQ QQNQQQLQHH 430 440 450 460 470 480 QMDQPYYHPG GYGQEESGEF AAQKNPLSRD CGIPVPASKP KIWSVADTAA CKTPPPTAAY 490 500 510 520 530 540 LGQNFYPPSS ADQQLPHQPL QQHQQQQLQQ LQQQQQHHHH PHHHHPHHSM ELGSPLSMMS 550 560 570 580 590 600 SYAGGSPYSR IPTAYTEAMG MHLPSSSSSS SSTGKLPPTH IHPAPQRVGF PEIQPDTPPQ 610 620 630 640 650 660 TPPTMKLNSS GGSSSSSGSS HSSSMHSVTP VTVASMVNIL YSNTDSGYGH GHSHGHGHGH 670 680 690 GHGLGHGHGL GHGHGHMGVT SNAYLTEGGR SGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Araucan and caupolican, two members of the novel iroquois complex, encode homeoproteins that control proneural and vein-forming genes." Gomez-Skarmeta J.-L., del Corral R.D., de la Calle-Mustienes E., Ferres-Marco D., Modolell J. Cell 85:95-105(1996) [PubMed: 8620542] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Larva.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 369-693. Strain: Berkeley. Tissue: Larva and Pupae.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X95178 mRNA. Translation: CAA64485.1. AE014296 Genomic DNA. Translation: AAF49895.1. BT015986 mRNA. Translation: AAV36871.1. BT021246 mRNA. Translation: AAX33394.1. AY122206 mRNA. Translation: AAM52718.1.
RefSeq	NP_524046.2.
UniGene	Dm.2873
3D structure databases
HSSP	HSSP built from PDB template 1LFU based on UniProtKB P41778.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:18539N.
IntAct	P54269. 2 interactions.
Proteomic databases
PRIDE	P54269.
Genome annotation databases
Ensembl	FBgn0015919. Drosophila melanogaster. [Contig view]
GeneID	39440.
KEGG	dme:Dmel_CG10605.
NMPDR	fig|7227.3.peg.9564.
Organism-specific databases
FlyBase	FBgn0015919. caup.
Phylogenomic databases
HOGENOM	P54269.
OMA	P54269. TAYTEAM.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-016427-MON.
Gene expression databases
ArrayExpress	P54269.
GermOnline	CG10605. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. IPR003893. Iroquois_homeo. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. SM00548. IRO. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	813645.

Entry information

Entry name

CAUP_DROME

Accession

Primary (citable) accession number: P54269
Secondary accession number(s): Q5BIH8 , Q5U1A6, Q8MR03, Q9VU00

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	August 14, 2001
Last modified:	June 16, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project