Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54265

- DMPK_MOUSE

UniProt

P54265 - DMPK_MOUSE

Protein

Myotonin-protein kinase

Gene

Dmpk

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity.5 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G-protein second messengers By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001ATPPROSITE-ProRule annotation
    Active sitei195 – 1951Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi77 – 859ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. myosin phosphatase regulator activity Source: UniProtKB
    4. protein binding Source: MGI
    5. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: UniProtKB
    2. muscle cell apoptotic process Source: UniProtKB
    3. nuclear envelope organization Source: UniProtKB
    4. protein phosphorylation Source: UniProtKB
    5. regulation of catalytic activity Source: GOC
    6. regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Source: MGI
    7. regulation of heart contraction Source: UniProtKB
    8. regulation of myotube differentiation Source: UniProtKB
    9. regulation of skeletal muscle contraction by calcium ion signaling Source: UniProtKB
    10. regulation of sodium ion transport Source: MGI
    11. regulation of synapse structural plasticity Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotonin-protein kinase (EC:2.7.11.1)
    Short name:
    MT-PK
    Alternative name(s):
    DM-kinase
    Short name:
    DMK
    DMPK
    Myotonic dystrophy protein kinase
    Short name:
    MDPK
    Gene namesi
    Name:Dmpk
    Synonyms:Dm15, Mdpk
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:94906. Dmpk.

    Subcellular locationi

    Sarcoplasmic reticulum membrane. Cell membrane
    Note: Localizes to sarcoplasmic reticulum membranes of cardiomyocytes.

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. integral component of mitochondrial outer membrane Source: UniProtKB
    4. nuclear membrane Source: UniProtKB
    5. nuclear outer membrane Source: UniProtKB-SubCell
    6. plasma membrane Source: UniProtKB
    7. sarcoplasmic reticulum membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus, Sarcoplasmic reticulum

    Pathology & Biotechi

    Disruption phenotypei

    Mice are fertile and no negative selection against the absence of the protein is apparent. Newborn do not display hypotonia, respiratory distress or gross anatomical abnormalities. However, a progressive muscle weakness a hall mark of myopathies is observed. Muscles from mature mice show variation in fiber size, increase fiber degeneration and fibrosis. They also display age-related progression in atrioventricular conduction defects that are reminiscent of congenital myotonic dystrophy.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 631631Myotonin-protein kinasePRO_0000085925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161Phosphoserine; by autocatalysisBy similarity
    Modified residuei228 – 2281Phosphoserine; by autocatalysisBy similarity
    Modified residuei234 – 2341Phosphothreonine; by autocatalysisBy similarity

    Post-translational modificationi

    Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK By similarity.By similarity
    Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP54265.
    PaxDbiP54265.
    PRIDEiP54265.

    PTM databases

    PhosphoSiteiP54265.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested, with a predominance in brain, skeletal muscle, heart, and other tissues containing smooth muscle. In the heart, expression is restricted to the cardiomyocytes in the ventricle and atrium.1 Publication

    Developmental stagei

    Primarily detected in striated muscle structures of the 14.5 day embryo, including all major muscles in the skeletal structures, cardiac muscle, diaphragm, and the smooth muscle of the lung and gut.1 Publication

    Gene expression databases

    ArrayExpressiP54265.
    BgeeiP54265.
    CleanExiMM_DMPK.
    GenevestigatoriP54265.

    Interactioni

    Subunit structurei

    Homodimer; homodimerization stimulates the kinase activity. Interacts with HSPB2; may enhance DMPK kinase activity. Interacts with PLN; phosphorylates PLN. May interact with RAC1; may regulate DMPK kinase activity. Interacts with LMNA; may regulate nuclear envelope stability By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032568.

    Structurei

    3D structure databases

    ProteinModelPortaliP54265.
    SMRiP54265. Positions 11-416, 468-531.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 592592CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini614 – 63118LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei593 – 61321Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 339269Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini340 – 41576AGC-kinase C-terminalAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili464 – 53269Sequence AnalysisAdd
    BLAST

    Domaini

    The coiled coil domain is required for homodimerization and regulates the enzymatic activity.By similarity

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117511.
    HOGENOMiHOG000233033.
    HOVERGENiHBG107817.
    InParanoidiP54265.
    KOiK08788.
    OMAiTLSDMQE.
    OrthoDBiEOG7F511X.
    PhylomeDBiP54265.
    TreeFamiTF105337.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR014930. Myotonic_dystrophy_kinase_coil.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF08826. DMPK_coil. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    ProDomiPD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (10)i

    Sequence statusi: Complete.

    This entry describes 10 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P54265-1) [UniParc]FASTAAdd to Basket

    Also known as: DMPK A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAEVRLRQL QQLVLDPGFL GLEPLLDLLL GVHQELGASH LAQDKYVADF    50
    LQWVEPIAAR LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK 100
    IMNKWDMLKR GEVSCFREER DVLVKGDRRW ITQLHFAFQD ENYLYLVMEY 150
    YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG YVHRDIKPDN 200
    ILLDRCGHIR LADFGSCLKL QPDGMVRSLV AVGTPDYLSP EILQAVGGGP 250
    GAGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYAKI VHYREHLSLP 300
    LADTVVPEEA QDLIRGLLCP AEIRLGRGGA GDFQKHPFFF GLDWEGLRDS 350
    VPPFTPDFEG ATDTCNFDVV EDRLTAMVSG GGETLSDMQE DMPLGVRLPF 400
    VGYSYCCMAF RDNQVPDPTP MELEALQLPV SDLQGLDLQP PVSPPDQVAE 450
    EADLVAVPAP VAEAETTVTL QQLQEALEEE VLTRQSLSRE LEAIRTANQN 500
    FSSQLQEAEV RNRDLEAHVR QLQERMEMLQ APGAAAITGV PSPRATDPPS 550
    HLDGPPAVAV GQCPLVGPGP MHRRHLLLPA RIPRPGLSEA RCLLLFAAAL 600
    AAAATLGCTG LVAYTGGLTP VWCFPGATFA P 631
    Length:631
    Mass (Da):69,602
    Last modified:October 1, 1996 - v1
    Checksum:i5EE800A37EA81DF4
    GO
    Isoform 2 (identifier: P54265-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         328-356: Missing.

    Show »
    Length:602
    Mass (Da):66,397
    Checksum:i8A9EBB4E930E5EB0
    GO
    Isoform 3 (identifier: P54265-3) [UniParc]FASTAAdd to Basket

    Also known as: DMPK B

    The sequence of this isoform differs from the canonical sequence as follows:
         378-382: Missing.

    Show »
    Length:626
    Mass (Da):69,244
    Checksum:i84F11B047BB340EF
    GO
    Isoform 4 (identifier: P54265-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         378-382: Missing.
         412-416: DNQVP → LKRPT
         417-631: Missing.

    Show »
    Length:411
    Mass (Da):46,532
    Checksum:i24F3F18634D0131C
    GO
    Isoform 5 (identifier: P54265-5) [UniParc]FASTAAdd to Basket

    Also known as: DMPK E

    The sequence of this isoform differs from the canonical sequence as follows:
         536-537: AI → DP
         538-631: Missing.

    Show »
    Length:537
    Mass (Da):60,161
    Checksum:i21F148D98B3657BB
    GO
    Isoform 6 (identifier: P54265-6) [UniParc]FASTAAdd to Basket

    Also known as: DMPK F

    The sequence of this isoform differs from the canonical sequence as follows:
         378-382: Missing.
         536-537: AI → DP
         538-631: Missing.

    Show »
    Length:532
    Mass (Da):59,803
    Checksum:iA79E9629B958241E
    GO
    Isoform 7 (identifier: P54265-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         536-557: AITGVPSPRATDPPSHLDGPPA → GESLTCFQPRGHWVEMGGMLGV
         558-631: Missing.

    Show »
    Length:557
    Mass (Da):62,322
    Checksum:iD0247256B70FD18C
    GO
    Isoform 8 (identifier: P54265-8) [UniParc]FASTAAdd to Basket

    Also known as: DMPK C

    The sequence of this isoform differs from the canonical sequence as follows:
         552-631: LDGPPAVAVG...WCFPGATFAP → MAPRPWLWAS...SREPPSPPEP

    Show »
    Length:632
    Mass (Da):70,329
    Checksum:iD1576187FFBB8824
    GO
    Isoform 9 (identifier: P54265-9) [UniParc]FASTAAdd to Basket

    Also known as: DMPK D

    The sequence of this isoform differs from the canonical sequence as follows:
         378-382: Missing.
         552-631: LDGPPAVAVG...WCFPGATFAP → MAPRPWLWAS...SREPPSPPEP

    Show »
    Length:627
    Mass (Da):69,972
    Checksum:iC5DD789C58BE9379
    GO
    Isoform 10 (identifier: P54265-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         552-562: LDGPPAVAVGQ → ASRQILPKGTP
         563-631: Missing.

    Show »
    Length:562
    Mass (Da):62,682
    Checksum:iC8D00A5C40223DBD
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei328 – 35629Missing in isoform 2. 1 PublicationVSP_004819Add
    BLAST
    Alternative sequencei378 – 3825Missing in isoform 3, isoform 4, isoform 6 and isoform 9. 1 PublicationVSP_004820
    Alternative sequencei412 – 4165DNQVP → LKRPT in isoform 4. 1 PublicationVSP_004821
    Alternative sequencei417 – 631215Missing in isoform 4. 1 PublicationVSP_004822Add
    BLAST
    Alternative sequencei536 – 55722AITGV…DGPPA → GESLTCFQPRGHWVEMGGML GV in isoform 7. CuratedVSP_004825Add
    BLAST
    Alternative sequencei536 – 5372AI → DP in isoform 5 and isoform 6. 1 PublicationVSP_004823
    Alternative sequencei538 – 63194Missing in isoform 5 and isoform 6. 1 PublicationVSP_004824Add
    BLAST
    Alternative sequencei552 – 63180LDGPP…ATFAP → MAPRPWLWASARWWGQAPCT AVTCCSLPGSLGLAYPRRVA CSCSPLLWLLPPHWAALGWW PIPAVSPQSGVSREPPSPPE P in isoform 8 and isoform 9. 1 PublicationVSP_004827Add
    BLAST
    Alternative sequencei552 – 56211LDGPPAVAVGQ → ASRQILPKGTP in isoform 10. CuratedVSP_004828Add
    BLAST
    Alternative sequencei558 – 63174Missing in isoform 7. CuratedVSP_004826Add
    BLAST
    Alternative sequencei563 – 63169Missing in isoform 10. CuratedVSP_004829Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21503
    , Z21504, Z21505, Z21506 Genomic DNA. Translation: CAA79715.1.
    Z38015 Genomic DNA. Translation: CAA86113.1.
    S60313 mRNA. Translation: AAC60667.1.
    S60314 mRNA. Translation: AAC60666.1.
    S60315 mRNA. Translation: AAC60665.1.
    S60316 mRNA. Translation: AAC60664.1.
    CCDSiCCDS39794.1. [P54265-1]
    CCDS52054.1. [P54265-5]
    PIRiI78393.
    I78394.
    I78395.
    I78396.
    S71829.
    RefSeqiNP_001177420.1. NM_001190491.1. [P54265-5]
    NP_115794.1. NM_032418.2. [P54265-1]
    XP_006539581.1. XM_006539518.1. [P54265-9]
    XP_006539582.1. XM_006539519.1. [P54265-3]
    UniGeneiMm.6529.

    Genome annotation databases

    EnsembliENSMUST00000032568; ENSMUSP00000032568; ENSMUSG00000030409. [P54265-1]
    ENSMUST00000108473; ENSMUSP00000104113; ENSMUSG00000030409. [P54265-5]
    GeneIDi13400.
    KEGGimmu:13400.
    UCSCiuc009fkn.2. mouse. [P54265-1]
    uc009fkp.2. mouse. [P54265-5]
    uc009fkq.2. mouse. [P54265-8]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21503
    , Z21504 , Z21505 , Z21506 Genomic DNA. Translation: CAA79715.1 .
    Z38015 Genomic DNA. Translation: CAA86113.1 .
    S60313 mRNA. Translation: AAC60667.1 .
    S60314 mRNA. Translation: AAC60666.1 .
    S60315 mRNA. Translation: AAC60665.1 .
    S60316 mRNA. Translation: AAC60664.1 .
    CCDSi CCDS39794.1. [P54265-1 ]
    CCDS52054.1. [P54265-5 ]
    PIRi I78393.
    I78394.
    I78395.
    I78396.
    S71829.
    RefSeqi NP_001177420.1. NM_001190491.1. [P54265-5 ]
    NP_115794.1. NM_032418.2. [P54265-1 ]
    XP_006539581.1. XM_006539518.1. [P54265-9 ]
    XP_006539582.1. XM_006539519.1. [P54265-3 ]
    UniGenei Mm.6529.

    3D structure databases

    ProteinModelPortali P54265.
    SMRi P54265. Positions 11-416, 468-531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032568.

    PTM databases

    PhosphoSitei P54265.

    Proteomic databases

    MaxQBi P54265.
    PaxDbi P54265.
    PRIDEi P54265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032568 ; ENSMUSP00000032568 ; ENSMUSG00000030409 . [P54265-1 ]
    ENSMUST00000108473 ; ENSMUSP00000104113 ; ENSMUSG00000030409 . [P54265-5 ]
    GeneIDi 13400.
    KEGGi mmu:13400.
    UCSCi uc009fkn.2. mouse. [P54265-1 ]
    uc009fkp.2. mouse. [P54265-5 ]
    uc009fkq.2. mouse. [P54265-8 ]

    Organism-specific databases

    CTDi 1760.
    MGIi MGI:94906. Dmpk.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117511.
    HOGENOMi HOG000233033.
    HOVERGENi HBG107817.
    InParanoidi P54265.
    KOi K08788.
    OMAi TLSDMQE.
    OrthoDBi EOG7F511X.
    PhylomeDBi P54265.
    TreeFami TF105337.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 3474.

    Miscellaneous databases

    NextBioi 283791.
    PROi P54265.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P54265.
    Bgeei P54265.
    CleanExi MM_DMPK.
    Genevestigatori P54265.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR014930. Myotonic_dystrophy_kinase_coil.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF08826. DMPK_coil. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    ProDomi PD011252. Myotonic_dystrophy_kinase_coil. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "No imprinting involved in the expression of DM-kinase mRNAs in mouse and human tissues."
      Jansen G., Bartolomei M., Kalscheuer V., Merkx G., Wormskamp N., Mariman E., Smeets D., Ropers H.-H., Wieringa B.
      Hum. Mol. Genet. 2:1221-1227(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 117-631 (ISOFORMS 2; 4; 5 AND 8).
      Tissue: Brain.
    4. "Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy."
      Reddy S., Smith D.B., Rich M.M., Leferovich J.M., Reilly P., Davis B.M., Tran K., Rayburn H., Bronson R., Cros D., Balice-Gordon R.J., Housman D.
      Nat. Genet. 13:325-335(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    5. "Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells."
      Benders A.A., Groenen P.J., Oerlemans F.T., Veerkamp J.H., Wieringa B.
      J. Clin. Invest. 100:1440-1447(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELLULAR CALCIUM HOMEOSTASIS.
    6. "Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties."
      Groenen P.J.T.A., Wansink D.G., Coerwinkel M., van den Broek W., Jansen G., Wieringa B.
      Hum. Mol. Genet. 9:605-616(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 1; 3; 5; 6; 8 AND 9).
    7. "Progressive atrioventricular conduction block in a mouse myotonic dystrophy model."
      Berul C.I., Maguire C.T., Gehrmann J., Reddy S.
      J. Interv. Card. Electrophysiol. 4:351-358(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    8. "A role for myotonic dystrophy protein kinase in synaptic plasticity."
      Schulz P.E., McIntosh A.D., Kasten M.R., Wieringa B., Epstein H.F.
      J. Neurophysiol. 89:1177-1186(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SYNAPTIC PLASTICITY.
    9. "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum."
      Kaliman P., Catalucci D., Lam J.T., Kondo R., Gutierrez J.C., Reddy S., Palacin M., Zorzano A., Chien K.R., Ruiz-Lozano P.
      J. Biol. Chem. 280:8016-8021(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CALCIUM UPTAKE BY CARDIAC SARCOPLASMIC RETICULUM, FUNCTION IN PHOSPHORYLATION OF PLN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    10. "Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors."
      van Herpen R.E., Oude Ophuis R.J., Wijers M., Bennink M.B., van de Loo F.A., Fransen J., Wieringa B., Wansink D.G.
      Mol. Cell. Biol. 25:1402-1414(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TOPOLOGY, AUTOPHOSPHORYLATION.
    11. "Myotonic dystrophy protein kinase is expressed in embryonic myocytes and is required for myotube formation."
      Harmon E.B., Harmon M.L., Larsen T.D., Paulson A.F., Perryman M.B.
      Dev. Dyn. 237:2353-2366(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN MYOGENESIS, SUBCELLULAR LOCATION.
    12. "Myotonic dystrophy protein kinase is critical for nuclear envelope integrity."
      Harmon E.B., Harmon M.L., Larsen T.D., Yang J., Glasford J.W., Perryman M.B.
      J. Biol. Chem. 286:40296-40306(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NUCLEAR ENVELOPE STABILITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDMPK_MOUSE
    AccessioniPrimary (citable) accession number: P54265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3