P54261 (GCST_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	sll0171

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Aminomethyltransferase HAMAP MF_00259		PRO_0000122609

Sequences

	Sequence		Length	Mass (Da)
	P54261 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 751D3E1BA65DE2DA	FASTA	372	41,036
	10 20 30 40 50 60 MANLFPALRT PLYNLITEQT TKLTTFGGWE MPVQFAGLKQ EHQAVREKVG MFDISHMGKF 70 80 90 100 110 120 VLTGQKVLAA LQSLVPSDLD RLTPGKAQYT VLLNAQGGII DDIIVYDQGK NPEGQERVTL 130 140 150 160 170 180 IVNAATTVKD KQWLLEHLPE EIDFQDLSRE KVLIALQGPE ALTILQPLVD QNLGELPAFG 190 200 210 220 230 240 HLEAEFLREK AFIARTGYTG EDGFEIMVSP EVGKQLWQTF GSKGVTPCGL GARDTLRLEA 250 260 270 280 290 300 GMGLYGQDMN DETTPLEAGL GWLVHLDSKG DFIGRAVLTE QKANGVEKRL VGLEMLAKQI 310 320 330 340 350 360 ARHDYPILHN GEIMGIVTSG TLSPTLQKAI ALGYVPTELA KVGQELEVEV RGKTYGIKVV 370 KKLFYRSEQK PR

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10058.1.
PIR	S76080.
RefSeq	NP_441988.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P54261.
ModBase	Search...
Protein-protein interaction databases
STRING	P54261.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952774.
GenomeReviews	Gene locus sll0171 in contig BA000022_GR.
KEGG	syn:sll0171.
NMPDR	fig|1148.1.peg.2089.
PATRIC	23841542. VBISynSp132158_2319.
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	P54261.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0171-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_SYNY3

Accession

Primary (citable) accession number: P54261

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program