ID   HAP1_RAT                Reviewed;         629 AA.
AC   P54256;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-NOV-2011, entry version 69.
DE   RecName: Full=Huntingtin-associated protein 1;
DE            Short=HAP-1;
GN   Name=Hap1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RC   TISSUE=Brain;
RX   MEDLINE=96077112; PubMed=7477378; DOI=10.1038/378398a0;
RA   Li X.-J., Li S.-H., Sharp A.H., Nucifora F.C. Jr., Schilling G.,
RA   Lanahan A., Worley P., Snyder S.H., Ross C.A.;
RT   "A huntingtin-associated protein enriched in brain with implications
RT   for pathology.";
RL   Nature 378:398-402(1995).
CC   -!- FUNCTION: Associates specifically with huntingtin. This binding is
CC       enhanced by an expanded polyglutamine repeat.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B; Synonyms=Long;
CC         IsoId=P54256-1; Sequence=Displayed;
CC       Name=A; Synonyms=Short;
CC         IsoId=P54256-2; Sequence=VSP_004280;
CC   -!- TISSUE SPECIFICITY: In the brain, especially in the olfactory bulb
CC       and in the brain stem. No detectable expression in peripheral
CC       tissues such as lung, testis, spleen, and small intestine.
CC   -!- SIMILARITY: Contains 1 HAP1 N-terminal domain.
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DR   EMBL; U38370; AAC52326.1; -; mRNA.
DR   EMBL; U38373; AAC52327.1; -; mRNA.
DR   IPI; IPI00211805; -.
DR   IPI; IPI00231413; -.
DR   PIR; S67492; S67492.
DR   PIR; S67495; S67495.
DR   RefSeq; NP_077047.1; NM_024133.2.
DR   RefSeq; NP_817091.1; NM_177982.1.
DR   UniGene; Rn.37430; -.
DR   ProteinModelPortal; P54256; -.
DR   IntAct; P54256; 4.
DR   MINT; MINT-421542; -.
DR   STRING; P54256; -.
DR   PRIDE; P54256; -.
DR   GeneID; 29430; -.
DR   KEGG; rno:29430; -.
DR   UCSC; NM_024133; rat.
DR   CTD; 9001; -.
DR   RGD; 68327; Hap1.
DR   eggNOG; maNOG19164; -.
DR   GeneTree; ENSGT00390000003132; -.
DR   HOVERGEN; HBG031599; -.
DR   InParanoid; P54256; -.
DR   NextBio; 609148; -.
DR   ArrayExpress; P54256; -.
DR   Genevestigator; P54256; -.
DR   GermOnline; ENSRNOG00000014819; Rattus norvegicus.
DR   GO; GO:0043679; C:axon terminus; IDA:RGD.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0005769; C:early endosome; TAS:RGD.
DR   GO; GO:0030426; C:growth cone; IDA:RGD.
DR   GO; GO:0005770; C:late endosome; TAS:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0005515; F:protein binding; IPI:RGD.
DR   GO; GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
DR   GO; GO:0045022; P:early endosome to late endosome transport; TAS:RGD.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IDA:RGD.
DR   InterPro; IPR006933; HAP1_N.
DR   KO; K04647; -.
DR   Pfam; PF04849; HAP1_N; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Reference proteome.
FT   CHAIN         1    629       Huntingtin-associated protein 1.
FT                                /FTId=PRO_0000083896.
FT   DOMAIN       80    404       HAP1 N-terminal.
FT   COMPBIAS    220    529       Glu-rich.
FT   COMPBIAS    220    237       Poly-Glu.
FT   COMPBIAS    468    471       Poly-Pro.
FT   VAR_SEQ     579    629       DSPAPQQQTNMGGGIVEQQPIVPTQDSQRLEEDRATHSPSA
FT                                REEEGPSGAT -> GECSRRGHPPASGTSYRSSTL (in
FT                                isoform A).
FT                                /FTId=VSP_004280.
SQ   SEQUENCE   629 AA;  70213 MW;  C23C5CB57520B574 CRC64;
     MRPKDQVQSS AGDGTGSGDP ATGTPTTQPA ADPAPEPSAE PKPAPAQGTG SGQKSGSRTK
     TGGSFCRSRI RGDSDAPWTR YIFQGPYGPR ATGLGTGRAE GIWKTPAAYI GRRPGVSGPE
     RAAFIRELQE ALCPNPLPRK KITEDDIKVM LYLLEEKERD LNTAARIGQS LVKQNSVLME
     ENNKLETMLG SAREEILHLR KQVNLRDDLL QLYSDSDDDE EDEEDEEEEE GEEEEREGQR
     DQDQQHDHPY GAPKPPPKAE TLHHCPQLEA LKQKLKLLEE ENDHLREEAS HLDNLEDKEQ
     MLILECVEQF SEASQQMAEL SEVLVLRLEG YERQQKEITQ LQAEITKLQQ RCQSYGAQTE
     KLQQQLASEK GVHPESLRAG SHMQDYGSRP RERQEDGKSH RQRSSMPAGS VTHYGYSVPL
     DALPSFPETL AEELRTSLRK FITDPAYFME RCDTRCREER KKEQGTMPPP PVQDLKPPED
     FEAPEELVPE EELGAIEEVG TAEDGPAEET EQASEETEAW EEVEPEVDEA TRMNVVVSAL
     EASGLGPSHL DMKYVLQQLS NWQDAHSKRQ QKQKVVPKDS PAPQQQTNMG GGIVEQQPIV
     PTQDSQRLEE DRATHSPSAR EEEGPSGAT
//