P54256 (HAP1_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 69.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Huntingtin-associated protein 1 Short name=HAP-1 | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 629 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat. |
| Tissue specificity | In the brain, especially in the olfactory bulb and in the brain stem. No detectable expression in peripheral tissues such as lung, testis, spleen, and small intestine. |
| Sequence similarities | Contains 1 HAP1 N-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular response to growth factor stimulus Inferred from expression pattern. Source: RGD early endosome to late endosome transportTraceable author statement. Source: RGD positive regulation of neuron projection developmentInferred from direct assay. Source: RGD |
| Cellular component | axon terminus Inferred from direct assay. Source: RGD dendriteInferred from direct assay. Source: RGD early endosomeTraceable author statement. Source: RGD growth coneInferred from direct assay. Source: RGD late endosomeTraceable author statement. Source: RGD perinuclear region of cytoplasmInferred from direct assay. Source: RGD |
| Molecular function | protein binding Inferred from physical interaction. Source: RGD |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform B (identifier: P54256-1) Also known as: Long; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform A (identifier: P54256-2) Also known as: Short; The sequence of this isoform differs from the canonical sequence as follows: 579-629: DSPAPQQQTNMGGGIVEQQPIVPTQDSQRLEEDRATHSPSAREEEGPSGAT → GECSRRGHPPASGTSYRSSTL |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 629 | 629 | Huntingtin-associated protein 1 | PRO_0000083896 | |||||
Regions | |||||||||
| Domain | 80 – 404 | 325 | HAP1 N-terminal | ||||||
| Compositional bias | 220 – 529 | 310 | Glu-rich | ||||||
| Compositional bias | 220 – 237 | 18 | Poly-Glu | ||||||
| Compositional bias | 468 – 471 | 4 | Poly-Pro | ||||||
Natural variations | |||||||||
| Alternative sequence | 579 – 629 | 51 | DSPAP…PSGAT → GECSRRGHPPASGTSYRSST L in isoform A. | VSP_004280 | |||||
Sequences
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References
| [1] | "A huntingtin-associated protein enriched in brain with implications for pathology." Li X.-J., Li S.-H., Sharp A.H., Nucifora F.C. Jr., Schilling G., Lanahan A., Worley P., Snyder S.H., Ross C.A. Nature 378:398-402(1995) [PubMed: 7477378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B). Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U38370 mRNA. Translation: AAC52326.1. U38373 mRNA. Translation: AAC52327.1. |
| IPI | IPI00211805. IPI00231413. |
| PIR | S67492. S67495. |
| RefSeq | NP_077047.1. NM_024133.2. NP_817091.1. NM_177982.1. |
| UniGene | Rn.37430. |
3D structure databases | |
| ProteinModelPortal | P54256. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P54256. 4 interactions. |
| MINT | MINT-421542. |
| STRING | P54256. |
Proteomic databases | |
| PRIDE | P54256. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 29430. |
| KEGG | rno:29430. |
| UCSC | NM_024133. rat. |
Organism-specific databases | |
| CTD | 9001. |
| RGD | 68327. Hap1. |
Phylogenomic databases | |
| eggNOG | maNOG19164. |
| GeneTree | ENSGT00390000003132. |
| HOVERGEN | HBG031599. |
| InParanoid | P54256. |
Gene expression databases | |
| ArrayExpress | P54256. |
| Genevestigator | P54256. |
| GermOnline | ENSRNOG00000014819. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR006933. HAP1_N. [Graphical view] |
| KO | K04647. |
| Pfam | PF04849. HAP1_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 609148. |
Entry information
| Entry name | HAP1_RAT | ||||||||
| Accession | Primary (citable) accession number: P54256 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |