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P54249

- ACHA_ERICO

UniProt

P54249 - ACHA_ERICO

Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Erinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Hardly binds alpha-bungarotoxin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei66 – 661Confers toxin resistanceSequence Analysis
    Sitei68 – 681Confers toxin resistanceSequence Analysis

    GO - Molecular functioni

    1. extracellular ligand-gated ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylcholine receptor subunit alpha
    Gene namesi
    Name:CHRNA1
    OrganismiErinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
    Taxonomic identifieri37316 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›84›84Acetylcholine receptor subunit alphaPRO_0000076971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 21By similarity
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi71 ↔ 72Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP54249.
    SMRiP54249. Positions 1-84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane

    Family and domain databases

    Gene3Di2.70.170.10. 1 hit.
    InterProiIPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    [Graphical view]
    SUPFAMiSSF63712. SSF63712. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P54249-1 [UniParc]FASTAAdd to Basket

    « Hide

    AIFKSYCEII VTHFPFDEQN CSMKLGTWTY DGSVVAINPE NDQPDLSNFM   50
    ESGEWVIKEA RGWKHRVIYA CCPSTPYLDI TYHF 84
    Length:84
    Mass (Da):9,756
    Last modified:October 1, 1996 - v1
    Checksum:i439578668037047F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei84 – 841

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17016 mRNA. Translation: AAA61645.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17016 mRNA. Translation: AAA61645.1 .

    3D structure databases

    ProteinModelPortali P54249.
    SMRi P54249. Positions 1-84.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.70.170.10. 1 hit.
    InterProi IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63712. SSF63712. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The binding site of the nicotinic acetylcholine receptor in animal species resistant to alpha-bungarotoxin."
      Barchan D., Ovadia M., Kochva E., Fuchs S.
      Biochemistry 34:9172-9176(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiACHA_ERICO
    AccessioniPrimary (citable) accession number: P54249
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3