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P54249 (ACHA_ERICO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylcholine receptor subunit alpha
Gene names
Name:CHRNA1
OrganismErinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
Taxonomic identifier37316 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus

Protein attributes

Sequence length84 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Hardly binds alpha-bungarotoxin.

Subunit structure

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Subcellular location

Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›84›84Acetylcholine receptor subunit alpha
PRO_0000076971

Sites

Site661Confers toxin resistance Potential
Site681Confers toxin resistance Potential

Amino acid modifications

Glycosylation201N-linked (GlcNAc...) Potential
Disulfide bond7 ↔ 21 By similarity
Disulfide bond71 ↔ 72Associated with receptor activation By similarity

Experimental info

Non-terminal residue11
Non-terminal residue841

Sequences

Sequence LengthMass (Da)Tools
P54249 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 439578668037047F

FASTA849,756
        10         20         30         40         50         60 
AIFKSYCEII VTHFPFDEQN CSMKLGTWTY DGSVVAINPE NDQPDLSNFM ESGEWVIKEA 

        70         80 
RGWKHRVIYA CCPSTPYLDI TYHF 

« Hide

References

[1]"The binding site of the nicotinic acetylcholine receptor in animal species resistant to alpha-bungarotoxin."
Barchan D., Ovadia M., Kochva E., Fuchs S.
Biochemistry 34:9172-9176(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U17016 mRNA. Translation: AAA61645.1.

3D structure databases

ProteinModelPortalP54249.
SMRP54249. Positions 1-84.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMSSF63712. SSF63712. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACHA_ERICO
AccessionPrimary (citable) accession number: P54249
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families