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P54249

- ACHA_ERICO

UniProt

P54249 - ACHA_ERICO

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Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Erinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Hardly binds alpha-bungarotoxin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 661Confers toxin resistanceSequence Analysis
Sitei68 – 681Confers toxin resistanceSequence Analysis

GO - Molecular functioni

  1. extracellular ligand-gated ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:CHRNA1
OrganismiErinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
Taxonomic identifieri37316 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›84›84Acetylcholine receptor subunit alphaPRO_0000076971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi7 ↔ 21By similarity
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi71 ↔ 72Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Structurei

3D structure databases

ProteinModelPortaliP54249.
SMRiP54249. Positions 1-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P54249-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AIFKSYCEII VTHFPFDEQN CSMKLGTWTY DGSVVAINPE NDQPDLSNFM
60 70 80
ESGEWVIKEA RGWKHRVIYA CCPSTPYLDI TYHF
Length:84
Mass (Da):9,756
Last modified:October 1, 1996 - v1
Checksum:i439578668037047F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei84 – 841

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17016 mRNA. Translation: AAA61645.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17016 mRNA. Translation: AAA61645.1 .

3D structure databases

ProteinModelPortali P54249.
SMRi P54249. Positions 1-84.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.70.170.10. 1 hit.
InterProi IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
[Graphical view ]
SUPFAMi SSF63712. SSF63712. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The binding site of the nicotinic acetylcholine receptor in animal species resistant to alpha-bungarotoxin."
    Barchan D., Ovadia M., Kochva E., Fuchs S.
    Biochemistry 34:9172-9176(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiACHA_ERICO
AccessioniPrimary (citable) accession number: P54249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3