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Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Erinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Hardly binds alpha-bungarotoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Confers toxin resistanceSequence analysis1
Sitei68Confers toxin resistanceSequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:CHRNA1
OrganismiErinaceus concolor (Eastern European hedgehog) (Erinaceus roumanicus)
Taxonomic identifieri37316 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaInsectivoraErinaceidaeErinaceinaeErinaceus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000076971‹1 – ›84Acetylcholine receptor subunit alphaAdd BLAST›84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 21By similarity
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi71 ↔ 72Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Structurei

3D structure databases

ProteinModelPortaliP54249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
SUPFAMiSSF63712. SSF63712. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.

Sequencei

Sequence statusi: Fragment.

P54249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AIFKSYCEII VTHFPFDEQN CSMKLGTWTY DGSVVAINPE NDQPDLSNFM
60 70 80
ESGEWVIKEA RGWKHRVIYA CCPSTPYLDI TYHF
Length:84
Mass (Da):9,756
Last modified:October 1, 1996 - v1
Checksum:i439578668037047F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei841

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17016 mRNA. Translation: AAA61645.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17016 mRNA. Translation: AAA61645.1.

3D structure databases

ProteinModelPortaliP54249.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR018000. Neurotransmitter_ion_chnl_CS.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
SUPFAMiSSF63712. SSF63712. 1 hit.
PROSITEiView protein in PROSITE
PS00236. NEUROTR_ION_CHANNEL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACHA_ERICO
AccessioniPrimary (citable) accession number: P54249
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.