Reviewed, UniProtKB/Swiss-Prot P54246 (ACR5_CAEEL)

Names and origin

Protein names

Recommended name:
    Acetylcholine receptor subunit alpha-type acr-5

Gene names

Name:	acr-5
ORF Names:	K03F8.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Possible acetylcholine receptor.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein By similarity. Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ligand-gated ionic channel (TC 1.A.9) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane
Molecular function	Ionic channel Receptor
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 548	532	Acetylcholine receptor subunit alpha-type acr-5		PRO_0000000402
Regions
	Transmembrane	324 – 344	21	Potential
	Transmembrane	357 – 377	21	Potential
	Transmembrane	392 – 412	21	Potential
	Transmembrane	437 – 457	21	Potential
Amino acid modifications
	Glycosylation	54	1	N-linked (GlcNAc...) Potential
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	77	1	N-linked (GlcNAc...) Potential
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P54246-1 [UniParc]. Last modified April 4, 2006. Version 3. Checksum: 307575BB2E35B40D	FASTA	548	64,476
	10 20 30 40 50 60 MLPNIILILL IRYCSCGAGS RVYEKYGKQV QLSPATTSSY REWYDSNREH STRNNTNVDD 70 80 90 100 110 120 FQTQLKKSLE NTTAAYNATF MQELIEERQR YLEKLNEGQF INDQRRLVEE LLDPNYYEKT 130 140 150 160 170 180 VHPKRDYTRP TRVNLSMSLY QILDVDEHMQ SIEVNVWMVQ HWYDEFLDWN PVDYGMINRT 190 200 210 220 230 240 IVPYHQIWIP DTYLYNSEEL EQKKTESLMN AQLETGHWNQ KKDGAKVQLM FPAIYKLSCR 250 260 270 280 290 300 MDVRWFPYDR QNYKTSFKPM KLLQQTIDYW PLSSTVNLGN MARNDEWEVI SFEFVRVEET 310 320 330 340 350 360 FKCCTAPWVM LYAHLVIRRK PLYYMINLVV PTSIITIVAV TGFFTPTSSS SERDEKLYLG 370 380 390 400 410 420 INTLLTMSVM MLMVCNQMPS TSTYVPLMSW YYIGIIMVIV VGTFLATGVL AIHGQKHYNK 430 440 450 460 470 480 PISDRIRKLI YNPVVEFFIL SPPTSLIDLW TEFGVISEQR HSTHLDPLLL QHMDPISHTT 490 500 510 520 530 540 RADPQHFFGS ISSQMCDLQS TYSYTARLAT ITRQYTQHAK MKALRKNQYR MSMDTSQARG VKKQKMQR

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00053 Genomic DNA. Translation: AAZ94293.1.
PIR	T16546.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P54246.
Genome annotation databases
Ensembl	K03F8.2; K03F8.2; K03F8.2; Caenorhabditis elegans. [Genome view]
UCSC	K03F8.2. c. elegans.
Organism-specific databases
WormBase	WBGene00000044. acr-5.
WormPep	K03F8.2. CE38967. [WorfDB]
Phylogenomic databases
HOGENOM	HBG385593.
InParanoid	P54246.
Gene expression databases
ArrayExpress	P54246.
Family and domain databases
InterPro	IPR006029. Neu_channel_TM. IPR006202. Neur_chan_lig_bd. IPR006201. Neur_channel. [Graphical view]
Gene3D	G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
PANTHER	PTHR18945. Neur_channel. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00252. NRIONCHANNEL.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACR5_CAEEL

Accession

Primary (citable) accession number: P54246
Secondary accession number(s): Q3Y417

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	April 4, 2006
Last modified:	December 15, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project