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Protein

Glucose-6-phosphate isomerase, cytosolic

Gene

PGIC

Organism
Oenothera sinuata var. hirsuta (Mexican evening primrose) (Oenothera mexicana)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase, cytosolic (PGIC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Proton donorBy similarity1
Active sitei391By similarity1
Active sitei516By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, cytosolic (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGIC
OrganismiOenothera sinuata var. hirsuta (Mexican evening primrose) (Oenothera mexicana)
Taxonomic identifieri49758 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOnagroideaeOnagreaeOenothera

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805651 – 568Glucose-6-phosphate isomerase, cytosolicAdd BLAST568

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54243.
SMRiP54243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

P54243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPALISET EAWKDLKAHV EDIKRTHLRE LMGDTERCQS MMVEFDNIFL
60 70 80 90 100
DYSRQQASPD TINKLYKLAD AAHLKQKIDR MYNGDHINST ENRSVLHVAL
110 120 130 140 150
RAPRNSAICS DGKNVVPDVW NVLDKIKDFS ERVRNGSWVG ATGKELKDVI
160 170 180 190 200
AVGIGGSFLG PLFVHTALQT DPEASKNARG RELRFLANVD PIDAARNISG
210 220 230 240 250
LDPETTLVVV VSKTFTTAET MLNARTLREW ISSALGPSAV AKHMVAVSTN
260 270 280 290 300
LPLVEKFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFAVVEKFLQ
310 320 330 340 350
GAHNIDQHFS SAPFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL
360 370 380 390 400
APHIQQVSME SNGKGVSIDG LPLPFESGEI DFGEPGTNGQ HSFYQLIHQG
410 420 430 440 450
RVIPCDFIGV VKSQQPVYLK GEVVNNHDEL MSNFFAQPDA LAYGKTPEQL
460 470 480 490 500
KKENVSEHLI PHKTFTGNRP SVSILLPTLD AYRIGQLLAI YEHRVAVQGF
510 520 530 540 550
IWGINSFDQW GVELGKSLAT QVRKQLHASR VKGESVEGFN FSTKTLLTRY
560
LEATSDVPAA PSTLLPKI
Length:568
Mass (Da):62,685
Last modified:October 1, 1996 - v1
Checksum:iCC42B79C7592B928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89397 Genomic DNA. Translation: CAA61577.1.

Similar proteinsi

Entry informationi

Entry nameiG6PI_OENSH
AccessioniPrimary (citable) accession number: P54243
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families