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Protein

Glucose-6-phosphate isomerase, cytosolic

Gene

PGIC

Organism
Oenothera mexicana (Mexican evening primrose)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei360 – 3601Proton donorBy similarity
Active sitei391 – 3911By similarity
Active sitei516 – 5161By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, cytosolic (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGIC
OrganismiOenothera mexicana (Mexican evening primrose)
Taxonomic identifieri49758 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOenothera

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Glucose-6-phosphate isomerase, cytosolicPRO_0000180565Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54243-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPALISET EAWKDLKAHV EDIKRTHLRE LMGDTERCQS MMVEFDNIFL
60 70 80 90 100
DYSRQQASPD TINKLYKLAD AAHLKQKIDR MYNGDHINST ENRSVLHVAL
110 120 130 140 150
RAPRNSAICS DGKNVVPDVW NVLDKIKDFS ERVRNGSWVG ATGKELKDVI
160 170 180 190 200
AVGIGGSFLG PLFVHTALQT DPEASKNARG RELRFLANVD PIDAARNISG
210 220 230 240 250
LDPETTLVVV VSKTFTTAET MLNARTLREW ISSALGPSAV AKHMVAVSTN
260 270 280 290 300
LPLVEKFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFAVVEKFLQ
310 320 330 340 350
GAHNIDQHFS SAPFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL
360 370 380 390 400
APHIQQVSME SNGKGVSIDG LPLPFESGEI DFGEPGTNGQ HSFYQLIHQG
410 420 430 440 450
RVIPCDFIGV VKSQQPVYLK GEVVNNHDEL MSNFFAQPDA LAYGKTPEQL
460 470 480 490 500
KKENVSEHLI PHKTFTGNRP SVSILLPTLD AYRIGQLLAI YEHRVAVQGF
510 520 530 540 550
IWGINSFDQW GVELGKSLAT QVRKQLHASR VKGESVEGFN FSTKTLLTRY
560
LEATSDVPAA PSTLLPKI
Length:568
Mass (Da):62,685
Last modified:October 1, 1996 - v1
Checksum:iCC42B79C7592B928
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89397 Genomic DNA. Translation: CAA61577.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89397 Genomic DNA. Translation: CAA61577.1.

3D structure databases

ProteinModelPortaliP54243.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogenetic relationships among the sections of Clarkia (Onagraceae) inferred from the nucleotide sequences of PgiC."
    Gottlieb L.D., Ford V.S.
    Syst. Bot. 21:1-18(1996)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Population from Rockdale TX.

Entry informationi

Entry nameiG6PI_OENME
AccessioniPrimary (citable) accession number: P54243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.