Reviewed, UniProtKB/Swiss-Prot P54242 (G6PI2_CLAXA)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase, cytosolic 2
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:

PGIC2

Organism

Clarkia xantiana

Taxonomic identifier

3938 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › Myrtales › Onagraceae › Clarkia

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 569	569	Glucose-6-phosphate isomerase, cytosolic 2		PRO_0000180562
Sites
	Active site	360	1	Proton donor By similarity
	Active site	391	1	By similarity
	Active site	516	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54242-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 775E889A06D5BEA2	FASTA	569	62,843
	10 20 30 40 50 60 MATPSLISET EAWKDLKAHL EGIKRTHLRE LMGDTERCQS MMVEFDNIFL DYSRQQASPD 70 80 90 100 110 120 TINKLYKLAE AAHLKQKIDR MYNGDHINST ENRSVLHVAL RAPRNSAICS DGKNVVPDVW 130 140 150 160 170 180 NVLDKIKDFS ERVRNGSWVG ATGKELKDVI AVGIGGSFLG PLFVHTALQT DPEASKNARG 190 200 210 220 230 240 RELRFLANVD PIDAARNISG LNPETTLVVV VSKTFTTAET MLNARTLREW ISSALGVSAV 250 260 270 280 290 300 AKHMVAVSTN LPLVEKFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFAVVEKFLQ 310 320 330 340 350 360 GAHSIDQHFS SAPFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL APHIQQVSME 370 380 390 400 410 420 SNGKGVSIDG LPLPFESGEI DFGEPGTNGQ HSFYQLIHQG RVIPCDFIGV VKSQQPVYLK 430 440 450 460 470 480 GEVVNNHDEL MSNFFAQPDA LAYGKTPEQL KKENVSEHLI PHKTFTGNRP SLSILLPTLD 490 500 510 520 530 540 AYRIGQLLAI YEHRVAVQGF VWGINSFDQW GVELGKSLAT QVRKQLHASR VKGEPVEEGF 550 560 NFSTKTLLTR YLEATSDVPA DPSTLLPKI

References

[1]	"The same duplication accounts for the PgiC genes in Clarkia xantiana and C. lewisii (Onagraceae)." Ford V.S., Thomas B.R., Gottlieb L.D. Syst. Bot. 20:147-160(1995) [Agricola: IND20466557] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phylogenetic relationships among the sections of Clarkia (Onagraceae) inferred from the nucleotide sequences of PgiC." Gottlieb L.D., Ford V.S. Syst. Bot. 21:1-18(1996) [Agricola: IND20535960] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Population LDG 7436.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X80667 Genomic DNA. Translation: CAA56694.1. X89387 Genomic DNA. Translation: CAA61567.1.
PIR	S57831.
3D structure databases
HSSP	HSSP built from PDB template 1GZD based on UniProtKB P08059.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.3.1.9. 1740.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI2_CLAXA

Accession

Primary (citable) accession number: P54242

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	October 13, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)