ID   CTHL5_BOVIN             Reviewed;         159 AA.
AC   P54229; A5PJ96; B9UKL6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=Cathelicidin-5;
DE   AltName: Full=Antibacterial peptide BMAP-28;
DE   AltName: Full=Myeloid antibacterial peptide 28;
DE   Flags: Precursor;
GN   Name=CATHL5; Synonyms=BMAP28;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   MEDLINE=97067059; PubMed=8910461; DOI=10.1074/jbc.271.45.28375;
RA   Skerlavaj B., Gennaro R., Bagella L., Merluzzi L., Risso A.,
RA   Zanetti M.;
RT   "Biological characterization of two novel cathelicidin-derived
RT   peptides and identification of structural requirements for their
RT   antimicrobial and cell lytic activities.";
RL   J. Biol. Chem. 271:28375-28381(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 44, Isolate 74, and Isolate JEW38;
RX   PubMed=19136450; DOI=10.1093/jhered/esn112;
RA   Gillenwaters E.N., Seabury C.M., Elliott J.S., Womack J.E.;
RT   "Sequence analysis and polymorphism discovery in 4 members of the
RT   bovine cathelicidin gene family.";
RL   J. Hered. 100:241-245(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   CHARACTERIZATION, AND MASS SPECTROMETRY.
RX   MEDLINE=96300243; PubMed=8706679;
RX   DOI=10.1111/j.1432-1033.1996.0769w.x;
RA   Storici P., Tossi A., Lenarcic B., Romeo D.;
RT   "Purification and structural characterization of bovine cathelicidins,
RT   precursors of antimicrobial peptides.";
RL   Eur. J. Biochem. 238:769-776(1996).
CC   -!- FUNCTION: Exerts a potent antimicrobial activity against Gram-
CC       negative and Gram-positive bacteria, including methicillin-
CC       resistant Staphylococcus aureus, and fungi.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=14414; Mass_error=1; Method=Electrospray;
CC       Range=30-159; Source=PubMed:8706679;
CC   -!- SIMILARITY: Belongs to the cathelicidin family.
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DR   EMBL; X97609; CAA66208.1; -; mRNA.
DR   EMBL; EU751296; ACI31918.1; -; Genomic_DNA.
DR   EMBL; EU751297; ACI31919.1; -; Genomic_DNA.
DR   EMBL; EU751302; ACI31924.1; -; Genomic_DNA.
DR   EMBL; BC142015; AAI42016.1; -; mRNA.
DR   IPI; IPI00710530; -.
DR   RefSeq; NP_776935.1; -.
DR   UniGene; Bt.15991; -.
DR   HSSP; P32196; 1KWI.
DR   SMR; P54229; 30-131.
DR   Ensembl; ENSBTAG00000020076; Bos taurus.
DR   GeneID; 282167; -.
DR   KEGG; bta:282167; -.
DR   HOVERGEN; P54229; -.
DR   OMA; P54229; QRSSDAN.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR001894; Cathelicidin.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   PANTHER; PTHR10206; Cathelicidin; 1.
DR   Pfam; PF00666; Cathelicidins; 1.
DR   ProDom; PD001838; Cathelicidin; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Disulfide bond;
KW   Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL        1     29       Potential.
FT   PROPEP       30    131
FT                                /FTId=PRO_0000004716.
FT   PEPTIDE     132    159       Cathelicidin-5.
FT                                /FTId=PRO_0000004717.
FT   MOD_RES      30     30       Pyrrolidone carboxylic acid.
FT   DISULFID     86     97       By similarity.
FT   DISULFID    108    125       By similarity.
SQ   SEQUENCE   159 AA;  17616 MW;  89B7CB46C5EEC367 CRC64;
     METQRASLSL GRWSLWLLLL GLALPSASAQ ALSYREAVLR AVDQLNEKSS EANLYRLLEL
     DPPPKEDDEN PNIPKPVSFR VKETVCPRTS QQSPEQCDFK ENGLLKECVG TVTLDQVGSN
     FDITCAVPQS VGGLRSLGRK ILRAWKKYGP IIVPIIRIG
//