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P54227 (STMN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stathmin
Alternative name(s):
Leukemia-associated gene protein
Leukemia-associated phosphoprotein p18
Metablastin
Oncoprotein 18
Short name=Op18
Phosphoprotein p19
Short name=pp19
Prosolin
Protein Pr22
pp17
Gene names
Name:Stmn1
Synonyms:Lag, Lap18, Pr22
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis By similarity. Involved in the control of the learned and innate fear. Ref.9

Subunit structure

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST. Ref.7

Subcellular location

Cytoplasmcytoskeleton.

Tissue specificity

Highly expressed in the lateral nucleus of the amygdala. Ref.9

Post-translational modification

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF Probable. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity. Ref.6

Disruption phenotype

Mice show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environments. Ref.9

Sequence similarities

Belongs to the stathmin family.

Contains 1 SLD (stathmin-like) domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cdkn1bP464142EBI-1006438,EBI-1005742

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 149148Stathmin
PRO_0000182390

Regions

Domain4 – 145142SLD
Coiled coil41 – 140100 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue91N6-acetyllysine By similarity
Modified residue161Phosphoserine; by PKA Ref.6 Ref.11 Ref.12
Modified residue251Phosphoserine; by CDK1, MAPK1 and MAPK3 Ref.6 Ref.8 Ref.11
Modified residue311Phosphoserine By similarity
Modified residue381Phosphoserine; by CDK1, MAPK1 and MAPK3 Ref.6 Ref.8
Modified residue631Phosphoserine; by PKA Ref.6
Modified residue1001N6-acetyllysine By similarity
Modified residue1191N6-acetyllysine Ref.13

Sequences

Sequence LengthMass (Da)Tools
P54227 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 616526E0A6667BDA

FASTA14917,274
        10         20         30         40         50         60 
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI QKKLEAAEER 

        70         80         90        100        110        120 
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 

       130        140 
ERLREKDKHV EEVRKNKESK DPADETEAD 

« Hide

References

« Hide 'large scale' references
[1]"Molecular diversity of the SCG10/stathmin gene family in the mouse."
Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N.
Genomics 18:360-373(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Erratum
Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N.
Genomics 21:298-298(1994)
[3]"Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control."
Hosoya H., Ishikawa K., Dohi N., Marunouchi T.
Cell Struct. Funct. 21:237-243(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland and Retina.
[5]Lubec G., Klug S., Yang J.W., Zigmond M.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 15-27, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Brain and Hippocampus.
[6]"Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2."
Beretta L., Dobransky T., Sobel A.
J. Biol. Chem. 268:20076-20084(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-16; SER-25; SER-38 AND SER-63.
[7]"Stathmin interaction with a putative kinase and coiled-coil-forming protein domains."
Maucuer A., Camonis J.H., Sobel A.
Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KIST.
Tissue: Embryo.
[8]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic brain.
[9]"Stathmin, a gene enriched in the amygdala, controls both learned and innate fear."
Shumyatsky G.P., Malleret G., Shin R.-M., Takizawa S., Tully K., Tsvetkov E., Zakharenko S.S., Joseph J., Vronskaya S., Yin D., Schubart U.K., Kandel E.R., Bolshakov V.Y.
Cell 123:697-709(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CONTROL OF FEAR, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[10]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
[11]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[12]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[13]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L20256 Genomic DNA. No translation available.
L20257 Genomic DNA. No translation available.
L20258 Genomic DNA. No translation available.
X94915 mRNA. Translation: CAA64401.1.
BC010581 mRNA. Translation: AAH10581.1.
BC031831 mRNA. Translation: AAH31831.1.
BC054396 mRNA. Translation: AAH54396.1.
PIRB48917.
RefSeqNP_062615.1. NM_019641.4.
UniGeneMm.378957.

3D structure databases

ProteinModelPortalP54227.
SMRP54227. Positions 6-141.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201092. 1 interaction.
IntActP54227. 2 interactions.

PTM databases

PhosphoSiteP54227.

2D gel databases

REPRODUCTION-2DPAGEP54227.
UCD-2DPAGEP54227.

Proteomic databases

PaxDbP54227.
PRIDEP54227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030636; ENSMUSP00000030636; ENSMUSG00000028832.
ENSMUST00000105868; ENSMUSP00000101494; ENSMUSG00000028832.
GeneID16765.
KEGGmmu:16765.
UCSCuc008vfc.2. mouse.

Organism-specific databases

CTD3925.
MGIMGI:96739. Stmn1.

Phylogenomic databases

eggNOGNOG75290.
HOGENOMHOG000013197.
HOVERGENHBG054037.
InParanoidP54227.
KOK04381.
OMAKEAVPEF.
OrthoDBEOG744TBN.
PhylomeDBP54227.
TreeFamTF326935.

Gene expression databases

BgeeP54227.
CleanExMM_STMN1.
GenevestigatorP54227.

Family and domain databases

InterProIPR000956. Stathmin_fam.
[Graphical view]
PANTHERPTHR10104. PTHR10104. 1 hit.
PfamPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFPIRSF002285. Stathmin. 1 hit.
PRINTSPR00345. STATHMIN.
SUPFAMSSF101494. SSF101494. 1 hit.
PROSITEPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTMN1. mouse.
NextBio290586.
PROP54227.
SOURCESearch...

Entry information

Entry nameSTMN1_MOUSE
AccessionPrimary (citable) accession number: P54227
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot