Reviewed, UniProtKB/Swiss-Prot P54227 (STMN1_MOUSE)

Names and origin

Protein names

Recommended name:
    Stathmin
Alternative name(s):
    Phosphoprotein p19
      Short name=pp19
    Leukemia-associated phosphoprotein p18
    Oncoprotein 18
      Short name=Op18
    pp17
    Prosolin
    Metablastin
    Protein Pr22
    Leukemia-associated gene protein

Gene names

Name:	Stmn1
Synonyms:	Lag, Lap18, Pr22

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis By similarity. Involved in the control of the learned and innate fear.
Subunit structure	Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
Subcellular location	Cytoplasm.
Tissue specificity	Highly expressed in the lateral nucleus of the amygdala.
Post-translational modification	Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF Probable. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity.
Miscellaneous	Mice lacking Stmn1 show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environements.
Sequence similarities	Belongs to the stathmin family.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cytoplasm Microtubule
Domain	Coiled coil
Molecular function	Developmental protein
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	axonogenesis Inferred from mutant phenotype. Source: MGI negative regulation of microtubule polymerization Inferred from direct assay. Source: MGI positive regulation of cell motion Inferred from genetic interaction. Source: MGI
Cellular component	cytoplasm Inferred from direct assay. Source: MGI
Molecular function	protein binding Ref.7 Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cdkn1b	P46414	2	EBI-1006438,EBI-1005742

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 149	148	Stathmin
Regions
	Coiled coil	41 – 140	100	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	16	1	Phosphoserine; by PKA
	Modified residue	25	1	Phosphoserine; by CDC2 and MAPK
	Modified residue	28	1	Phosphoserine By similarity
	Modified residue	38	1	Phosphoserine; by CDC2
	Modified residue	46	1	Phosphoserine
	Modified residue	63	1	Phosphoserine; by PKA
	Modified residue	146	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54227-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 616526E0A6667BDA	FASTA	149	17,274
	10 20 30 40 50 60 MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI QKKLEAAEER 70 80 90 100 110 120 RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 130 140 ERLREKDKHV EEVRKNKESK DPADETEAD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular diversity of the SCG10/stathmin gene family in the mouse." Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N. Genomics 18:360-373(1993) [PubMed: 8288240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Erratum Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N. Genomics 21:298-298(1994)
[3]	"Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control." Hosoya H., Ishikawa K., Dohi N., Marunouchi T. Cell Struct. Funct. 21:237-243(1996) [PubMed: 8906359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary gland and Retina.
[5]	Lubec G., Klug S., Yang J.W., Zigmond M. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 15-27, MASS SPECTROMETRY. Tissue: Brain and Hippocampus.
[6]	"Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2." Beretta L., Dobransky T., Sobel A. J. Biol. Chem. 268:20076-20084(1993) [PubMed: 8376365] [Abstract] Cited for: PHOSPHORYLATION AT SER-16; SER-25; SER-38 AND SER-63.
[7]	"Stathmin interaction with a putative kinase and coiled-coil-forming protein domains." Maucuer A., Camonis J.H., Sobel A. Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed: 7724523] [Abstract] Cited for: INTERACTION WITH KIST. Tissue: Embryo.
[8]	"Stathmin, a gene enriched in the amygdala, controls both learned and innate fear." Shumyatsky G.P., Malleret G., Shin R.-M., Takizawa S., Tully K., Tsvetkov E., Zakharenko S.S., Joseph J., Vronskaya S., Yin D., Schubart U.K., Kandel E.R., Bolshakov V.Y. Cell 123:697-709(2005) [PubMed: 16286011] [Abstract] Cited for: FUNCTION IN CONTROL OF FEAR, TISSUE SPECIFICITY.
[9]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-38 AND SER-46, MASS SPECTROMETRY. Tissue: Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L20256 Genomic DNA. No translation available. L20257 Genomic DNA. No translation available. L20258 Genomic DNA. No translation available. X94915 mRNA. Translation: CAA64401.1. BC010581 mRNA. Translation: AAH10581.1. BC031831 mRNA. Translation: AAH31831.1. BC054396 mRNA. Translation: AAH54396.1.
PIR	B48917.
RefSeq	NP_062615.1.
UniGene	Mm.378957
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P54227.
PTM databases
PhosphoSite	P54227.
2-D gel databases
REPRODUCTION-2DPAGE	P54227.
Genome annotation databases
Ensembl	ENSMUSG00000028832. Mus musculus. [Contig view]
GeneID	16765.
KEGG	mmu:16765.
Organism-specific databases
MGI	MGI:96739. Stmn1.
Phylogenomic databases
HOGENOM	P54227.
HOVERGEN	P54227.
Gene expression databases
ArrayExpress	P54227.
CleanEx	MM_STMN1.
GermOnline	ENSMUSG00000028832. Mus musculus.
Family and domain databases
InterPro	IPR000956. Stathmin. [Graphical view]
PANTHER	PTHR10104. Stathmin. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. [Graphical view]
ProDom	P54227. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

STMN1_MOUSE

Accession

Primary (citable) accession number: P54227

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	July 22, 2008
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)