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Reviewed, UniProtKB/Swiss-Prot P54227 (STMN1_MOUSE)

Last modified July 22, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Stathmin
Alternative name(s):
    Phosphoprotein p19
      Short name=pp19
    Leukemia-associated phosphoprotein p18
    Oncoprotein 18
      Short name=Op18
    pp17
    Prosolin
    Metablastin
    Protein Pr22
    Leukemia-associated gene protein
Gene names
Name: Stmn1
Synonyms: Lag, Lap18, Pr22
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length149 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis By similarity. Involved in the control of the learned and innate fear.

Subunit structure

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.

Subcellular location

Cytoplasm.

Tissue specificity

Highly expressed in the lateral nucleus of the amygdala.

Post-translational modification

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF Probable. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity.

Miscellaneous

Mice lacking Stmn1 show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environements.

Sequence similarities

Belongs to the stathmin family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Cdkn1bP464142EBI-1006438,EBI-1005742

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 149148Stathmin

Regions

Coiled coil41 – 140100 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue161Phosphoserine; by PKA
Modified residue251Phosphoserine; by CDC2 and MAPK
Modified residue281Phosphoserine By similarity
Modified residue381Phosphoserine; by CDC2
Modified residue461Phosphoserine
Modified residue631Phosphoserine; by PKA
Modified residue1461Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54227-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 616526E0A6667BDA

FASTA14917,274
        10         20         30         40         50         60 
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI QKKLEAAEER 

        70         80         90        100        110        120 
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 

       130        140 
ERLREKDKHV EEVRKNKESK DPADETEAD 

« Hide

References

« Hide 'large scale' references
[1]"Molecular diversity of the SCG10/stathmin gene family in the mouse."
Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N.
Genomics 18:360-373(1993) [PubMed: 8288240] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Erratum
Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N.
Genomics 21:298-298(1994)
[3]"Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control."
Hosoya H., Ishikawa K., Dohi N., Marunouchi T.
Cell Struct. Funct. 21:237-243(1996) [PubMed: 8906359] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland and Retina.
[5]Lubec G., Klug S., Yang J.W., Zigmond M.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 15-27, MASS SPECTROMETRY.
Tissue: Brain and Hippocampus.
[6]"Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2."
Beretta L., Dobransky T., Sobel A.
J. Biol. Chem. 268:20076-20084(1993) [PubMed: 8376365] [Abstract]
Cited for: PHOSPHORYLATION AT SER-16; SER-25; SER-38 AND SER-63.
[7]"Stathmin interaction with a putative kinase and coiled-coil-forming protein domains."
Maucuer A., Camonis J.H., Sobel A.
Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed: 7724523] [Abstract]
Cited for: INTERACTION WITH KIST.
Tissue: Embryo.
[8]"Stathmin, a gene enriched in the amygdala, controls both learned and innate fear."
Shumyatsky G.P., Malleret G., Shin R.-M., Takizawa S., Tully K., Tsvetkov E., Zakharenko S.S., Joseph J., Vronskaya S., Yin D., Schubart U.K., Kandel E.R., Bolshakov V.Y.
Cell 123:697-709(2005) [PubMed: 16286011] [Abstract]
Cited for: FUNCTION IN CONTROL OF FEAR, TISSUE SPECIFICITY.
[9]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed: 17114649] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-38 AND SER-46, MASS SPECTROMETRY.
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

L20256 Genomic DNA. No translation available.
L20257 Genomic DNA. No translation available.
L20258 Genomic DNA. No translation available.
X94915 mRNA. Translation: CAA64401.1.
BC010581 mRNA. Translation: AAH10581.1.
BC031831 mRNA. Translation: AAH31831.1.
BC054396 mRNA. Translation: AAH54396.1.
PIRB48917.
RefSeqNP_062615.1.
UniGeneMm.378957

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP54227.

PTM databases

PhosphoSiteP54227.

2-D gel databases

REPRODUCTION-2DPAGEP54227.

Genome annotation databases

EnsemblENSMUSG00000028832. Mus musculus. [Contig view]
GeneID16765.
KEGGmmu:16765.

Organism-specific databases

MGIMGI:96739. Stmn1.

Phylogenomic databases

HOGENOMP54227.
HOVERGENP54227.

Gene expression databases

ArrayExpressP54227.
CleanExMM_STMN1.
GermOnlineENSMUSG00000028832. Mus musculus.

Family and domain databases

InterProIPR000956. Stathmin.
[Graphical view]
PANTHERPTHR10104. Stathmin. 1 hit.
PfamPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFPIRSF002285. Stathmin. 1 hit.
PRINTSPR00345. STATHMIN.
PROSITEPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
[Graphical view]
ProDomP54227.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameSTMN1_MOUSE
AccessionPrimary (citable) accession number: P54227
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 22, 2008
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents