Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54227

- STMN1_MOUSE

UniProt

P54227 - STMN1_MOUSE

Protein

Stathmin

Gene

Stmn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis By similarity. Involved in the control of the learned and innate fear.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. axonogenesis Source: MGI
    2. microtubule depolymerization Source: Ensembl
    3. mitotic spindle organization Source: Ensembl
    4. negative regulation of microtubule polymerization Source: MGI
    5. positive regulation of cellular component movement Source: MGI
    6. response to virus Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stathmin
    Alternative name(s):
    Leukemia-associated gene protein
    Leukemia-associated phosphoprotein p18
    Metablastin
    Oncoprotein 18
    Short name:
    Op18
    Phosphoprotein p19
    Short name:
    pp19
    Prosolin
    Protein Pr22
    pp17
    Gene namesi
    Name:Stmn1
    Synonyms:Lag, Lap18, Pr22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:96739. Stmn1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. membrane Source: MGI
    4. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Disruption phenotypei

    Mice show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environments.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 149148StathminPRO_0000182390Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei9 – 91N6-acetyllysineBy similarity
    Modified residuei16 – 161Phosphoserine; by PKA3 Publications
    Modified residuei25 – 251Phosphoserine; by CDK1, MAPK1 and MAPK33 Publications
    Modified residuei31 – 311PhosphoserineBy similarity
    Modified residuei38 – 381Phosphoserine; by CDK1, MAPK1 and MAPK32 Publications
    Modified residuei63 – 631Phosphoserine; by PKA1 Publication
    Modified residuei100 – 1001N6-acetyllysineBy similarity
    Modified residuei119 – 1191N6-acetyllysine1 Publication

    Post-translational modificationi

    Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF Probable. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity.By similarityCurated

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP54227.
    PaxDbiP54227.
    PRIDEiP54227.

    2D gel databases

    REPRODUCTION-2DPAGEP54227.
    UCD-2DPAGEP54227.

    PTM databases

    PhosphoSiteiP54227.

    Expressioni

    Tissue specificityi

    Highly expressed in the lateral nucleus of the amygdala.1 Publication

    Gene expression databases

    BgeeiP54227.
    CleanExiMM_STMN1.
    GenevestigatoriP54227.

    Interactioni

    Subunit structurei

    Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cdkn1bP464142EBI-1006438,EBI-1005742

    Protein-protein interaction databases

    BioGridi201092. 1 interaction.
    IntActiP54227. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP54227.
    SMRiP54227. Positions 6-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 145142SLDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili41 – 140100Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the stathmin family.Curated
    Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG75290.
    HOGENOMiHOG000013197.
    HOVERGENiHBG054037.
    InParanoidiP54227.
    KOiK04381.
    OMAiREKDKHM.
    OrthoDBiEOG744TBN.
    PhylomeDBiP54227.
    TreeFamiTF326935.

    Family and domain databases

    InterProiIPR000956. Stathmin_fam.
    [Graphical view]
    PANTHERiPTHR10104. PTHR10104. 1 hit.
    PfamiPF00836. Stathmin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002285. Stathmin. 1 hit.
    PRINTSiPR00345. STATHMIN.
    SUPFAMiSSF101494. SSF101494. 1 hit.
    PROSITEiPS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54227-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI    50
    QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK 100
    LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD 149
    Length:149
    Mass (Da):17,274
    Last modified:January 23, 2007 - v2
    Checksum:i616526E0A6667BDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20256 Genomic DNA. No translation available.
    L20257 Genomic DNA. No translation available.
    L20258 Genomic DNA. No translation available.
    X94915 mRNA. Translation: CAA64401.1.
    BC010581 mRNA. Translation: AAH10581.1.
    BC031831 mRNA. Translation: AAH31831.1.
    BC054396 mRNA. Translation: AAH54396.1.
    CCDSiCCDS18772.1.
    PIRiB48917.
    RefSeqiNP_062615.1. NM_019641.4.
    UniGeneiMm.378957.

    Genome annotation databases

    EnsembliENSMUST00000030636; ENSMUSP00000030636; ENSMUSG00000028832.
    ENSMUST00000105868; ENSMUSP00000101494; ENSMUSG00000028832.
    GeneIDi16765.
    KEGGimmu:16765.
    UCSCiuc008vfc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L20256 Genomic DNA. No translation available.
    L20257 Genomic DNA. No translation available.
    L20258 Genomic DNA. No translation available.
    X94915 mRNA. Translation: CAA64401.1 .
    BC010581 mRNA. Translation: AAH10581.1 .
    BC031831 mRNA. Translation: AAH31831.1 .
    BC054396 mRNA. Translation: AAH54396.1 .
    CCDSi CCDS18772.1.
    PIRi B48917.
    RefSeqi NP_062615.1. NM_019641.4.
    UniGenei Mm.378957.

    3D structure databases

    ProteinModelPortali P54227.
    SMRi P54227. Positions 6-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201092. 1 interaction.
    IntActi P54227. 2 interactions.

    PTM databases

    PhosphoSitei P54227.

    2D gel databases

    REPRODUCTION-2DPAGE P54227.
    UCD-2DPAGE P54227.

    Proteomic databases

    MaxQBi P54227.
    PaxDbi P54227.
    PRIDEi P54227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030636 ; ENSMUSP00000030636 ; ENSMUSG00000028832 .
    ENSMUST00000105868 ; ENSMUSP00000101494 ; ENSMUSG00000028832 .
    GeneIDi 16765.
    KEGGi mmu:16765.
    UCSCi uc008vfc.2. mouse.

    Organism-specific databases

    CTDi 3925.
    MGIi MGI:96739. Stmn1.

    Phylogenomic databases

    eggNOGi NOG75290.
    HOGENOMi HOG000013197.
    HOVERGENi HBG054037.
    InParanoidi P54227.
    KOi K04381.
    OMAi REKDKHM.
    OrthoDBi EOG744TBN.
    PhylomeDBi P54227.
    TreeFami TF326935.

    Miscellaneous databases

    ChiTaRSi STMN1. mouse.
    NextBioi 290586.
    PROi P54227.
    SOURCEi Search...

    Gene expression databases

    Bgeei P54227.
    CleanExi MM_STMN1.
    Genevestigatori P54227.

    Family and domain databases

    InterProi IPR000956. Stathmin_fam.
    [Graphical view ]
    PANTHERi PTHR10104. PTHR10104. 1 hit.
    Pfami PF00836. Stathmin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002285. Stathmin. 1 hit.
    PRINTSi PR00345. STATHMIN.
    SUPFAMi SSF101494. SSF101494. 1 hit.
    PROSITEi PS00563. STATHMIN_1. 1 hit.
    PS01041. STATHMIN_2. 1 hit.
    PS51663. STATHMIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control."
      Hosoya H., Ishikawa K., Dohi N., Marunouchi T.
      Cell Struct. Funct. 21:237-243(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland and Retina.
    4. Lubec G., Klug S., Yang J.W., Zigmond M.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 15-27, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain and Hippocampus.
    5. "Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2."
      Beretta L., Dobransky T., Sobel A.
      J. Biol. Chem. 268:20076-20084(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-16; SER-25; SER-38 AND SER-63.
    6. "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains."
      Maucuer A., Camonis J.H., Sobel A.
      Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIST.
      Tissue: Embryo.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic brain.
    8. Cited for: FUNCTION IN CONTROL OF FEAR, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    9. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    12. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSTMN1_MOUSE
    AccessioniPrimary (citable) accession number: P54227
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3