Stathmin - Mus musculus (Mouse)

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P54227 (STMN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 117. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Stathmin

Alternative name(s):
Leukemia-associated gene protein
Leukemia-associated phosphoprotein p18
Metablastin
Oncoprotein 18
Short name=Op18
Phosphoprotein p19
Short name=pp19
Prosolin
Protein Pr22
pp17

Gene names

Name:	Stmn1
Synonyms:	Lag, Lap18, Pr22

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis By similarity. Involved in the control of the learned and innate fear. Ref.8
Subunit structure	Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST. Ref.7
Subcellular location	Cytoplasm › cytoskeleton.
Tissue specificity	Highly expressed in the lateral nucleus of the amygdala. Ref.8
Post-translational modification	Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF Probable. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity. Ref.6
Disruption phenotype	Mice show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environments. Ref.8
Sequence similarities	Belongs to the stathmin family. Contains 1 SLD (stathmin-like) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Coiled coil
Molecular function	Developmental protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	axonogenesis Inferred from mutant phenotype PubMed 11839567. Source: MGI microtubule depolymerization Inferred from electronic annotation. Source: Compara mitotic spindle organization Inferred from electronic annotation. Source: Compara negative regulation of microtubule polymerization Inferred from direct assay PubMed 15652749. Source: MGI positive regulation of cellular component movement Inferred from genetic interaction PubMed 15652749. Source: MGI response to virus Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from direct assay PubMed 10712642. Source: MGI membrane Inferred from direct assay PubMed 10712642. Source: MGI microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cdkn1b	P46414	2	EBI-1006438,EBI-1005742

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 149

148

Stathmin

PRO_0000182390

Regions

Domain

4 – 145

142

SLD

Coiled coil

41 – 140

100

Potential

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

Phosphoserine; by PKA Ref.6 Ref.12

Modified residue

Phosphoserine; by CDK1, MAPK1 and MAPK3 Ref.6 Ref.9

Modified residue

Phosphoserine By similarity

Modified residue

Phosphoserine; by CDK1, MAPK1 and MAPK3 Ref.6 Ref.9 Ref.11

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphoserine; by PKA Ref.6 Ref.10

Modified residue

N6-acetyllysine By similarity

Modified residue

100

N6-acetyllysine By similarity

Modified residue

119

N6-acetyllysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P54227 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 616526E0A6667BDA
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FASTA

149

17,274

        10         20         30         40         50         60 
MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI QKKLEAAEER 

        70         80         90        100        110        120 
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL 

       130        140 
ERLREKDKHV EEVRKNKESK DPADETEAD

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular diversity of the SCG10/stathmin gene family in the mouse." Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N. Genomics 18:360-373(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Erratum Okazaki T., Yoshida B.N., Avraham K.B., Wang H., Wuenschell C.W., Jenkins N.A., Copeland N.G., Anderson D.J., Mori N. Genomics 21:298-298(1994)
[3]	"Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control." Hosoya H., Ishikawa K., Dohi N., Marunouchi T. Cell Struct. Funct. 21:237-243(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary gland and Retina.
[5]	Lubec G., Klug S., Yang J.W., Zigmond M. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 15-27, MASS SPECTROMETRY. Tissue: Brain and Hippocampus.
[6]	"Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2." Beretta L., Dobransky T., Sobel A. J. Biol. Chem. 268:20076-20084(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-16; SER-25; SER-38 AND SER-63.
[7]	"Stathmin interaction with a putative kinase and coiled-coil-forming protein domains." Maucuer A., Camonis J.H., Sobel A. Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KIST. Tissue: Embryo.
[8]	"Stathmin, a gene enriched in the amygdala, controls both learned and innate fear." Shumyatsky G.P., Malleret G., Shin R.-M., Takizawa S., Tully K., Tsvetkov E., Zakharenko S.S., Joseph J., Vronskaya S., Yin D., Schubart U.K., Kandel E.R., Bolshakov V.Y. Cell 123:697-709(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN CONTROL OF FEAR, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[9]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-38 AND SER-46, MASS SPECTROMETRY. Tissue: Brain cortex.
[10]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, MASS SPECTROMETRY. Tissue: Melanoma.
[11]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, MASS SPECTROMETRY. Tissue: Macrophage.
[12]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L20256 Genomic DNA. No translation available. L20257 Genomic DNA. No translation available. L20258 Genomic DNA. No translation available. X94915 mRNA. Translation: CAA64401.1. BC010581 mRNA. Translation: AAH10581.1. BC031831 mRNA. Translation: AAH31831.1. BC054396 mRNA. Translation: AAH54396.1.
IPI	IPI00551236.
PIR	B48917.
RefSeq	NP_062615.1. NM_019641.4.
UniGene	Mm.378957.
3D structure databases
ProteinModelPortal	P54227.
SMR	P54227. Positions 6-141.
ModBase	Search...
Protein-protein interaction databases
IntAct	P54227. 2 interactions.
PTM databases
PhosphoSite	P54227.
2D gel databases
REPRODUCTION-2DPAGE	P54227.
UCD-2DPAGE	P54227.
Proteomic databases
PaxDb	P54227.
PRIDE	P54227.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030636; ENSMUSP00000030636; ENSMUSG00000028832. ENSMUST00000105868; ENSMUSP00000101494; ENSMUSG00000028832.
GeneID	16765.
KEGG	mmu:16765.
Organism-specific databases
CTD	3925.
MGI	MGI:96739. Stmn1.
Phylogenomic databases
eggNOG	NOG75290.
HOGENOM	HOG000013197.
HOVERGEN	HBG054037.
InParanoid	P54227.
KO	K04381.
OMA	KEAVPEF.
OrthoDB	EOG46MBKT.
Gene expression databases
ArrayExpress	P54227.
Bgee	P54227.
CleanEx	MM_STMN1.
Genevestigator	P54227.
GermOnline	ENSMUSG00000028832. Mus musculus.
Family and domain databases
InterPro	IPR000956. Stathmin_fam. [Graphical view]
PANTHER	PTHR10104. PTHR10104. 1 hit.
Pfam	PF00836. Stathmin. 1 hit. [Graphical view]
PIRSF	PIRSF002285. Stathmin. 1 hit.
PRINTS	PR00345. STATHMIN.
SUPFAM	SSF101494. Stathmin. 1 hit.
PROSITE	PS00563. STATHMIN_1. 1 hit. PS01041. STATHMIN_2. 1 hit. PS51663. STATHMIN_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	STMN1. mouse.
NextBio	290586.
SOURCE	Search...

Entry information

Entry name

STMN1_MOUSE

Accession

Primary (citable) accession number: P54227

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents