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P54227

- STMN1_MOUSE

UniProt

P54227 - STMN1_MOUSE

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Protein
Stathmin
Gene
Stmn1, Lag, Lap18, Pr22
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis By similarity. Involved in the control of the learned and innate fear.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. axonogenesis Source: MGI
  2. microtubule depolymerization Source: Ensembl
  3. mitotic spindle organization Source: Ensembl
  4. negative regulation of microtubule polymerization Source: MGI
  5. positive regulation of cellular component movement Source: MGI
  6. response to virus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin
Alternative name(s):
Leukemia-associated gene protein
Leukemia-associated phosphoprotein p18
Metablastin
Oncoprotein 18
Short name:
Op18
Phosphoprotein p19
Short name:
pp19
Prosolin
Protein Pr22
pp17
Gene namesi
Name:Stmn1
Synonyms:Lag, Lap18, Pr22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:96739. Stmn1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. membrane Source: MGI
  4. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice show deficits in spike-timing-dependent long-term potentiation, exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environments.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 149148Stathmin
PRO_0000182390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei9 – 91N6-acetyllysine By similarity
Modified residuei16 – 161Phosphoserine; by PKA3 Publications
Modified residuei25 – 251Phosphoserine; by CDK1, MAPK1 and MAPK33 Publications
Modified residuei31 – 311Phosphoserine By similarity
Modified residuei38 – 381Phosphoserine; by CDK1, MAPK1 and MAPK32 Publications
Modified residuei63 – 631Phosphoserine; by PKA1 Publication
Modified residuei100 – 1001N6-acetyllysine By similarity
Modified residuei119 – 1191N6-acetyllysine1 Publication

Post-translational modificationi

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF Inferred. Phosphorylation at Ser-16 seems to be required for neuron polarization By similarity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP54227.
PaxDbiP54227.
PRIDEiP54227.

2D gel databases

REPRODUCTION-2DPAGEP54227.
UCD-2DPAGEP54227.

PTM databases

PhosphoSiteiP54227.

Expressioni

Tissue specificityi

Highly expressed in the lateral nucleus of the amygdala.1 Publication

Gene expression databases

BgeeiP54227.
CleanExiMM_STMN1.
GenevestigatoriP54227.

Interactioni

Subunit structurei

Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Cdkn1bP464142EBI-1006438,EBI-1005742

Protein-protein interaction databases

BioGridi201092. 1 interaction.
IntActiP54227. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP54227.
SMRiP54227. Positions 6-141.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 145142SLD
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 140100 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the stathmin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG75290.
HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiP54227.
KOiK04381.
OMAiREKDKHM.
OrthoDBiEOG744TBN.
PhylomeDBiP54227.
TreeFamiTF326935.

Family and domain databases

InterProiIPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54227-1 [UniParc]FASTAAdd to Basket

« Hide

MASSDIQVKE LEKRASGQAF ELILSPRSKE SVPDFPLSPP KKKDLSLEEI    50
QKKLEAAEER RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK 100
LTHKMEANKE NREAQMAAKL ERLREKDKHV EEVRKNKESK DPADETEAD 149
Length:149
Mass (Da):17,274
Last modified:January 23, 2007 - v2
Checksum:i616526E0A6667BDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20256 Genomic DNA. No translation available.
L20257 Genomic DNA. No translation available.
L20258 Genomic DNA. No translation available.
X94915 mRNA. Translation: CAA64401.1.
BC010581 mRNA. Translation: AAH10581.1.
BC031831 mRNA. Translation: AAH31831.1.
BC054396 mRNA. Translation: AAH54396.1.
CCDSiCCDS18772.1.
PIRiB48917.
RefSeqiNP_062615.1. NM_019641.4.
UniGeneiMm.378957.

Genome annotation databases

EnsembliENSMUST00000030636; ENSMUSP00000030636; ENSMUSG00000028832.
ENSMUST00000105868; ENSMUSP00000101494; ENSMUSG00000028832.
GeneIDi16765.
KEGGimmu:16765.
UCSCiuc008vfc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L20256 Genomic DNA. No translation available.
L20257 Genomic DNA. No translation available.
L20258 Genomic DNA. No translation available.
X94915 mRNA. Translation: CAA64401.1 .
BC010581 mRNA. Translation: AAH10581.1 .
BC031831 mRNA. Translation: AAH31831.1 .
BC054396 mRNA. Translation: AAH54396.1 .
CCDSi CCDS18772.1.
PIRi B48917.
RefSeqi NP_062615.1. NM_019641.4.
UniGenei Mm.378957.

3D structure databases

ProteinModelPortali P54227.
SMRi P54227. Positions 6-141.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201092. 1 interaction.
IntActi P54227. 2 interactions.

PTM databases

PhosphoSitei P54227.

2D gel databases

REPRODUCTION-2DPAGE P54227.
UCD-2DPAGE P54227.

Proteomic databases

MaxQBi P54227.
PaxDbi P54227.
PRIDEi P54227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030636 ; ENSMUSP00000030636 ; ENSMUSG00000028832 .
ENSMUST00000105868 ; ENSMUSP00000101494 ; ENSMUSG00000028832 .
GeneIDi 16765.
KEGGi mmu:16765.
UCSCi uc008vfc.2. mouse.

Organism-specific databases

CTDi 3925.
MGIi MGI:96739. Stmn1.

Phylogenomic databases

eggNOGi NOG75290.
HOGENOMi HOG000013197.
HOVERGENi HBG054037.
InParanoidi P54227.
KOi K04381.
OMAi REKDKHM.
OrthoDBi EOG744TBN.
PhylomeDBi P54227.
TreeFami TF326935.

Miscellaneous databases

ChiTaRSi STMN1. mouse.
NextBioi 290586.
PROi P54227.
SOURCEi Search...

Gene expression databases

Bgeei P54227.
CleanExi MM_STMN1.
Genevestigatori P54227.

Family and domain databases

InterProi IPR000956. Stathmin_fam.
[Graphical view ]
PANTHERi PTHR10104. PTHR10104. 1 hit.
Pfami PF00836. Stathmin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002285. Stathmin. 1 hit.
PRINTSi PR00345. STATHMIN.
SUPFAMi SSF101494. SSF101494. 1 hit.
PROSITEi PS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control."
    Hosoya H., Ishikawa K., Dohi N., Marunouchi T.
    Cell Struct. Funct. 21:237-243(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland and Retina.
  4. Lubec G., Klug S., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 15-27, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Hippocampus.
  5. "Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2."
    Beretta L., Dobransky T., Sobel A.
    J. Biol. Chem. 268:20076-20084(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-16; SER-25; SER-38 AND SER-63.
  6. "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains."
    Maucuer A., Camonis J.H., Sobel A.
    Proc. Natl. Acad. Sci. U.S.A. 92:3100-3104(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIST.
    Tissue: Embryo.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  8. Cited for: FUNCTION IN CONTROL OF FEAR, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  9. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  12. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSTMN1_MOUSE
AccessioniPrimary (citable) accession number: P54227
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi