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P54223

- BETA_RHIME

UniProt

P54223 - BETA_RHIME

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.1 PublicationUniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-244.
SMEL266834:GJF6-970-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:R00947
ORF Names:SMc00093
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Chromosome

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_0000205594Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMc00093.

Structurei

3D structure databases

ProteinModelPortaliP54223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiREMHCPR.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54223-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQADFVIIGS GSAGSALAYR LSEDGRNSVI VLEFGGSDVG PFIQMPAALA
60 70 80 90 100
WPMSMNRYNW GYLSEPEPNL NNRRITAPRG KVIGGSSSIN GMVYVRGHSE
110 120 130 140 150
DFNRWEELGA QGWAYADVLP YYKRMEHSHG GEEGWRGTDG PLHVQRGPVK
160 170 180 190 200
NPLFHAFIEA GKEAGFEVTE DYNGSKQEGF GLMEQTTWRG RRWSAASAYL
210 220 230 240 250
RPALKRPNVE LIRCFARKIV IENGRATGVE IERGGRIEVV KANREVIVSA
260 270 280 290 300
SSFNSPKLLM LSGIGPAAHL KEMGIDVKVD RPGVGQNLQD HMEFYFQQVS
310 320 330 340 350
TKPVSLYSWL PWFWQGVAGA QWLFFKRGLG ISNQFESCAF LRSAPGVKQP
360 370 380 390 400
DIQYHFLPVA ISYDGKAAAK SHGFQVHVGY NLSKSRGNVS LRSSDPKADP
410 420 430 440 450
VIRFNYMSHP EDWEKFRHCV RLTREIFGQK AFDLYRGPEI QPGEKVQTDE
460 470 480 490 500
EIDGFLREHL ESAYHPCGTC KMGAKDDPMA VVDPETRVIG VDGLRVADSS
510 520 530 540
IFPHITYGNL NAPSIMTGEK SADHILGRQP LARSNQEPWI NPRWAVSDR
Length:549
Mass (Da):61,291
Last modified:May 30, 2000 - v2
Checksum:i29BE064F40CB88F4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti267 – 2671A → R in AAC13369. (PubMed:9141699)Curated
Sequence conflicti417 – 4248RHCVRLTR → DLRAVTG in AAC13369. (PubMed:9141699)Curated
Sequence conflicti429 – 4291Q → E in AAC13369. (PubMed:9141699)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39940 Genomic DNA. Translation: AAC13369.1.
AL591688 Genomic DNA. Translation: CAC45519.1.
RefSeqiNP_385053.1. NC_003047.1.

Genome annotation databases

EnsemblBacteriaiCAC45519; CAC45519; SMc00093.
GeneIDi1232590.
KEGGisme:SMc00093.
PATRICi23631169. VBISinMel96828_2346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39940 Genomic DNA. Translation: AAC13369.1 .
AL591688 Genomic DNA. Translation: CAC45519.1 .
RefSeqi NP_385053.1. NC_003047.1.

3D structure databases

ProteinModelPortali P54223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266834.SMc00093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC45519 ; CAC45519 ; SMc00093 .
GeneIDi 1232590.
KEGGi sme:SMc00093.
PATRICi 23631169. VBISinMel96828_2346.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi REMHCPR.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci MetaCyc:MONOMER-244.
SMEL266834:GJF6-970-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34."
    Pocard J.A., Vincent N., Boncompagni E., Tombras Smith L., Poggi M.-C., Le Rudulier D.
    Microbiology 143:1369-1379(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
    Strain: 102F34.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiBETA_RHIME
AccessioniPrimary (citable) accession number: P54223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3