##gff-version 3 P54219 UniProtKB Chain 1 525 . . . ID=PRO_0000127510;Note=Chromaffin granule amine transporter P54219 UniProtKB Topological domain 1 21 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 22 42 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 43 138 . . . Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 139 158 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 159 167 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 168 188 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 189 197 . . . Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 198 218 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 219 227 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 228 250 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 251 256 . . . Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 257 279 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 280 299 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 300 319 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 320 335 . . . Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 336 360 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 361 365 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 366 386 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 387 397 . . . Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 398 418 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 419 422 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 423 443 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 444 448 . . . Note=Lumenal%2C vesicle;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Transmembrane 449 470 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Topological domain 471 525 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Region 503 525 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P54219 UniProtKB Glycosylation 58 58 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Glycosylation 87 87 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Glycosylation 104 104 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P54219 UniProtKB Alternative sequence 307 338 . . . ID=VSP_046304;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 P54219 UniProtKB Alternative sequence 445 525 . . . ID=VSP_046305;Note=In isoform 2. PSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRSPPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE->YSESGLPHGDPDVCNPEAHEGISSGGGQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:16326835;Dbxref=PMID:16326835 P54219 UniProtKB Natural variant 4 4 . . . ID=VAR_021856;Note=T->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs2270641,PMID:15489334,PMID:23337945 P54219 UniProtKB Natural variant 10 10 . . . ID=VAR_087305;Note=Found in a patient with bipolar disorder%3B has no significant effect on monoamine vesicular uptake. Q->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs150204882,PMID:23337945 P54219 UniProtKB Natural variant 11 11 . . . ID=VAR_052002;Note=R->Q;Dbxref=dbSNP:rs17092144 P54219 UniProtKB Natural variant 74 74 . . . ID=VAR_024632;Note=A->V;Dbxref=dbSNP:rs17215815 P54219 UniProtKB Natural variant 82 82 . . . ID=VAR_029149;Note=F->C;Dbxref=dbSNP:rs17215822 P54219 UniProtKB Natural variant 84 84 . . . ID=VAR_024633;Note=Found in patients with bipolar disorder%3B increases the vesicular uptake of noradrenaline and dopamine. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs17215801,PMID:23337945 P54219 UniProtKB Natural variant 98 98 . . . ID=VAR_020033;Note=S->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs2270637,PMID:23337945 P54219 UniProtKB Natural variant 101 101 . . . ID=VAR_024634;Note=Found in a patient with bipolar disorder%3B decreases the vesicular uptake of noradrenaline%2C dopamine and serotonin. A->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs17222218,PMID:23337945 P54219 UniProtKB Natural variant 136 136 . . . ID=VAR_012065;Note=Decreases the vesicular uptake of noradrenaline%2C dopamine and serotonin%3B may predispose carriers to a increased cortical response to negative stimuli and reduced threat-related amygdala reactivity. I->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs1390938,PMID:15489334,PMID:23337945 P54219 UniProtKB Natural variant 138 138 . . . ID=VAR_087306;Note=Found in patients with bipolar disorder%3B decreases the vesicular uptake of noradrenaline%2C dopamine and serotonin. R->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs148468662,PMID:23337945 P54219 UniProtKB Natural variant 140 140 . . . ID=VAR_029150;Note=G->R;Dbxref=dbSNP:rs17215808 P54219 UniProtKB Natural variant 164 164 . . . ID=VAR_024635;Note=I->M;Dbxref=dbSNP:rs17222092 P54219 UniProtKB Natural variant 202 202 . . . ID=VAR_029151;Note=I->T;Dbxref=dbSNP:rs17222120 P54219 UniProtKB Natural variant 249 249 . . . ID=VAR_024636;Note=V->I;Dbxref=dbSNP:rs17215759 P54219 UniProtKB Natural variant 392 392 . . . ID=VAR_024637;Note=Decreases the vesicular uptake of noradrenaline and dopamine. L->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23337945;Dbxref=dbSNP:rs17092104,PMID:23337945