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P54216 (ALF1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase 1

EC=4.1.2.13
Alternative name(s):
Aldolase CE-1
Short name=CE1
Gene names
Name:aldo-1
ORF Names:T05D4.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Tissue specificity

Ubiquitous.

Developmental stage

All stages of development.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself3EBI-327260,EBI-327260

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Fructose-bisphosphate aldolase 1
PRO_0000216928

Sites

Active site1891Proton acceptor By similarity
Active site2311Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site561Substrate By similarity
Binding site1471Substrate By similarity
Site3661Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Experimental info

Sequence conflict172 – 1732GS → A in CAB03291. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P54216 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 5B9F91D486FFAEB5

FASTA36639,240
        10         20         30         40         50         60 
MASYSQFLTK AQEDELRSIA NAIVTPGKGI LAADESTGSM DKRLNSIGLE NTEENRRKYR 

        70         80         90        100        110        120 
QLLFTAGADL NKYISGVIMF HETFYQKTDD GKPFTALLQE QGIIPGIKVD KGVVPMAGTI 

       130        140        150        160        170        180 
GEGTTQGLDD LNARCAQYKK DGAQFAKWRC VHKISSTTPS VTALKEIASN LGSRYASICQ 

       190        200        210        220        230        240 
QNGLVPIVEP EILPDGEHCL ARGQKITETV LSYVYHALNE HHVFLEGTLL KPNMVTSGQS 

       250        260        270        280        290        300 
FTGEKPSNAD IGLATVTALQ RGVPSAVPGV VFLSGGQSEE DATLNLNAIN QVSGKKPWAL 

       310        320        330        340        350        360 
TFSYGRALQA SCLAKWAGKD ENIAAAQEVL LHRAQVNSLA SVGKYTGDAS ADAAASQSLF 


VANHSY 

« Hide

References

« Hide 'large scale' references
[1]"Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes."
Inoue T., Yatsuki H., Kusakabe T., Joh K., Hori K.
Arch. Biochem. Biophys. 339:226-234(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83738 mRNA. Translation: BAA12091.1.
Z81115 Genomic DNA. Translation: CAB03291.1.
PIRT24514.
RefSeqNP_741281.1. NM_171235.3.
UniGeneCel.6851.

3D structure databases

ProteinModelPortalP54216.
SMRP54216. Positions 8-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41956. 1 interaction.
DIPDIP-25939N.
IntActP54216. 1 interaction.
MINTMINT-1094145.

Proteomic databases

PaxDbP54216.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID176788.
KEGGcel:CELE_T05D4.1.
UCSCT05D4.1.1. c. elegans.

Organism-specific databases

CTD176788.
WormBaseT05D4.1; CE16341; WBGene00011474; aldo-1.

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000220876.
InParanoidP54216.
KOK01623.
PhylomeDBP54216.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio894008.

Entry information

Entry nameALF1_CAEEL
AccessionPrimary (citable) accession number: P54216
Secondary accession number(s): O45747
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase