P54212 (CAH_DUNSA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase

Gene names

Name:

DCA

Organism

Dunaliella salina (Green alga)

Taxonomic identifier

3046 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Chlorophyta › Chlorophyceae › Chlamydomonadales › Dunaliellaceae › Dunaliella

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Induction	By salt stress.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Biological process	Stress response
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 589	589	Carbonic anhydrase		PRO_0000077445
Regions
	Region	258 – 259	2	Substrate binding By similarity
	Region	390 – 589	200	Catalytic
Sites
	Metal binding	418	1	Zinc; catalytic By similarity
	Metal binding	420	1	Zinc; catalytic By similarity
	Metal binding	440	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54212 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 0CC2A6F42C121171	FASTA	589	64,258
	10 20 30 40 50 60 MGSRRITLLG ALFAVLAVAI EGRTLLTHNL KAEAAETVDA VSSVVAGSAG RQLLVSEPHD 70 80 90 100 110 120 YNYEKVGFDW TGGVCVNTGT SKQSPINIET DSLAEESERL GTADDTSRLA LKGLLSSSYQ 130 140 150 160 170 180 LTSEVAINLE QDMQFSFNAP DEDLPQLTIG GVVHTFKPVQ IHFHHFASEH AIDGQLYPLE 190 200 210 220 230 240 AHMVMASQND GSDQLAVIGI MYKYGEEDPF LKRLQETAQS NGEAGDKNVE LNSFSINVAR 250 260 270 280 290 300 DLLPESDLTY YGYDGSLTTP GCDERVKWHV FKEARTVSVA QLKVFSEVTL AAHPEATVTN 310 320 330 340 350 360 NRVIQPLNGR KVYEYKGEPN DKYNYVQHGF DWRDNGLDSC AGDVQSPIDI VTSTLQAGSS 370 380 390 400 410 420 RSDVSSVNLM TLNTDAFTLT GNTVNIGQGM QINFGDPPAG DLPVIRIGTR DVTFRPLQVH 430 440 450 460 470 480 WHFFLSEHTV DGVHYPLEAH IVMKDNDNLG DSAGQLAVIG IMYKYGDADP FITDMQKRVS 490 500 510 520 530 540 DKIASGAITY GQSGVSLNNP DDPFNVNIKN NFLPSELGYA GYDGSLTTPP CSEIVKWHVF 550 560 570 580 LEPRTVSVEQ MEVFADVTLN SNPGATVTTN RMIQPLEGRT VYGYNGAAA

References

[1]	"A salt-resistant plasma membrane carbonic anhydrase is induced by salt in Dunaliella salina." Fisher M., Gokhman I., Pick U., Zamir A. J. Biol. Chem. 271:17718-17723(1996) [PubMed: 8663366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U53811 mRNA. Translation: AAC49378.1.
PIR	T08466.
3D structure databases
ProteinModelPortal	P54212.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	4.2.1.1. 2022.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 2 hits.
PANTHER	PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 2 hits. [Graphical view]
SMART	SM01057. Carb_anhydrase. 2 hits. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 2 hits.
PROSITE	PS00162. ALPHA_CA_1. 2 hits. PS51144. ALPHA_CA_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH_DUNSA

Accession

Primary (citable) accession number: P54212

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program