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P54211 (PMA1_DUNBI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Plasma membrane ATPase
EC=3.6.3.6
Alternative name(s):
Proton pump
Gene names
Name:PMA1
OrganismDunaliella bioculata (Green alga)
Taxonomic identifier13790 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Chlorophyta › Chlorophyceae › Chlamydomonadales › Dunaliellaceae › Dunaliella

Protein attributes

Sequence length1131 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11311131Plasma membrane ATPase
PRO_0000046288

Regions

Transmembrane77 – 9721Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane305 – 32521Helical; Potential
Transmembrane642 – 66221Helical; Potential
Transmembrane689 – 70921Helical; Potential
Transmembrane733 – 75321Helical; Potential
Transmembrane884 – 90421Helical; Potential
Transmembrane946 – 96621Helical; Potential

Sites

Active site35714-aspartylphosphate intermediate By similarity
Metal binding6151Magnesium By similarity
Metal binding6191Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P54211 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E493726BD5CD732D

FASTA1,131123,451
        10         20         30         40         50         60 
MADIKEGVEE GSVKVDMIKE PLTQGDTGVD EVDFAKITLD DAFKYLNCNK HGLSSAEAAA 

        70         80         90        100        110        120 
RLQQHGPNKL PDSSRNPVLV FLGYMWNPLA WAMEAAAIIS IALLDVADFV LIVGLLLINA 

       130        140        150        160        170        180 
IISFYEESNA DKAIKALTAA LAPKAMVVRD GAIVTIDAVN LVPGDVILIR LGNIVPADVK 

       190        200        210        220        230        240 
LLEEEGADEG EQEAPMQIDQ AALTGESLPA KKFTGDVAFS GSSIKQGERH AVVYATGVNT 

       250        260        270        280        290        300 
FFGRAAALIS GTNNVSNLQT VMNKMSAICI VTILLWVVVE LAVQFGHYSH ECVGGREGCP 

       310        320        330        340        350        360 
TLLNMLVVLV GGIPIAMPTV LSVTLALGAY KLAREGAIVT RMSAVEEMAG MDVLCSDKTG 

       370        380        390        400        410        420 
TLTLNKLSID KSMVVPVGNM GVDEIMRMGA LSANTVTEEP IDMVLWESYP DRETIKRDYK 

       430        440        450        460        470        480 
HTKYFPFNPN DKITIATCLE IATGRVFRVL KGSPQVVLAK AWNAAELDAT VNQKMVEFAN 

       490        500        510        520        530        540 
RGFRALGLAM ADGDGKDGTK WEMLALLPLF DPPRHDTKET IEHCQNQGIQ VKMITGDHLL 

       550        560        570        580        590        600 
IGKETAKMLG MGTEMFPSEV MIKARNGDAS QLHGYKNFVE MVETCNGFAQ VFPEHKFEIV 

       610        620        630        640        650        660 
KILQDSNHVV GMTGDGVNDA PALKKADVGV AVADATDAAR GAADIVLTEP GLSTIVTAVI 

       670        680        690        700        710        720 
GARKIFQRMT TYSKYTIAMT FRICFTFGLI TVIYDWYFPT ILIVIMAVFN DGAMIALSKD 

       730        740        750        760        770        780 
RVVASKTPNS WNITNIFIMG MVYGLYLTLS TWALYQTATK TTFFEDKTPL HSLNDQYSVL 

       790        800        810        820        830        840 
QPWCEDEVRA KLGQTIDPYA SLCESNSYAK QFDECEGYQK GSGVQVEDVP TLHAQCVTEQ 

       850        860        870        880        890        900 
RYLRGAMTRS LIYTQVSISG QALVFVVRTA GYSLMERAGT STYLAFFFAQ VGATLFGIFG 

       910        920        930        940        950        960 
LGGFEKPRHQ LEDCQFCDYS FHEPVDWFDS GIVPESGTES DFTASVIGCG GYVIVAWIWS 

       970        980        990       1000       1010       1020 
AIWYVLLDPI KWILFWILNE EGFRDTMSWR ESTKRSLDRR SKDDIGDKEF TGPSGMVPAN 

      1030       1040       1050       1060       1070       1080 
YSNPLGRASM SKPVSAVLDR KSASLVAINR NSMTVSQDPN RALNIGRRSM IGRPSGPVGR 

      1090       1100       1110       1120       1130 
TSMPLGRISR TSNTLSTGSK DGQIGRGSKP LNSSSAEIKP DKYDFASTIR E

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References

[1]"Primary structure of the plasma membrane H(+)-ATPase from the halotolerant alga Dunaliella bioculata."
Wolf A.H., Slayman C.W., Gradmann D.
Plant Mol. Biol. 28:657-666(1995) [PubMed: 7647298] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SAG 19-4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X73901 mRNA. Translation: CAA52107.1.
PIRS34213. S57807.

3D structure databases

ProteinModelPortalP54211.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006534. ATPase_P-typ_PM_proton-efflux.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 3 hits.
PANTHERPTHR24093:SF61. PTHR24093:SF61. 1 hit.
PfamPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMA1_DUNBI
AccessionPrimary (citable) accession number: P54211
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 19, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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