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P54210 (PMA1_DUNAC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Plasma membrane ATPase
EC=3.6.3.6
Alternative name(s):
Proton pump
Gene names
Name:DHA1
OrganismDunaliella acidophila
Taxonomic identifier38272 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Chlorophyta › Chlorophyceae › Chlamydomonadales › Dunaliellaceae › Dunaliella

Protein attributes

Sequence length1103 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11031103Plasma membrane ATPase
PRO_0000046287

Regions

Transmembrane80 – 10021Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane266 – 28621Helical; Potential
Transmembrane306 – 32621Helical; Potential
Transmembrane643 – 66321Helical; Potential
Transmembrane690 – 71021Helical; Potential
Transmembrane734 – 75421Helical; Potential
Transmembrane845 – 86521Helical; Potential
Transmembrane881 – 90121Helical; Potential
Transmembrane944 – 96421Helical; Potential

Sites

Active site35814-aspartylphosphate intermediate By similarity
Metal binding6161Magnesium By similarity
Metal binding6201Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P54210 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 6F8BC2370D03DDC8

FASTA1,103119,791
        10         20         30         40         50         60 
MSGKERTEEN GAVKQDTKEQ VKKSADNGDK GVDEVDFAKI GLEDAFKYLN CSEHGLSGAE 

        70         80         90        100        110        120 
AEARLKQHGP NKLPDNSRNP VLVYFGYMWN PLAWAMEAAA IIAIALVDGA DFALIVGLLI 

       130        140        150        160        170        180 
INATISFVEE SNADKAIKAL SAALAPKAMA LRNGAMVTID AVDLVPGDVI LIRIGNVVPA 

       190        200        210        220        230        240 
DVKLLPEHGA DDYETPVQID QAALTGESLP AKKFTGNVAF SGSTVKQGER HAVVYATGVN 

       250        260        270        280        290        300 
TFFGRAAALI SGTHNVANIQ RVMNRIGGLC LITIGVWVVI EVPVQFAHYK HSCVAGKEGC 

       310        320        330        340        350        360 
PTLLNMLVIL VGAIPIAMPT VLSVTLALGA YKLAREGAIV TRMSAVEEMA GLDVLCSDKT 

       370        380        390        400        410        420 
GTLTLNKLSI DPSNVFPVGT MDIPEVMKFG ALSANIITEE PIDMVLWESY PEREKLKSEY 

       430        440        450        460        470        480 
KHTKYFPFNP NDKITIATVL EIATGRVFRV LKGSPQVVLA KAWNAQALDG PVNEKIKEYA 

       490        500        510        520        530        540 
GRGFRSLGIA MAEGDGKDGT KWEMLAVLPM FDPPRHDTKE TIERCMKQGI AVKMVTGDHL 

       550        560        570        580        590        600 
LIGKETAKML GMGTEMYPSE VLIKARNGDV EAPHGYKNYV AMVEACNGFA QVFPEHKFEI 

       610        620        630        640        650        660 
VEILQEAHHR VGMTGDGVND APALKKAHVG VAVADATDAA RGAADIVLTE PGLSTIVTAV 

       670        680        690        700        710        720 
IGARKIFKRM TTYAKYTISV TFRIAFTFGL LTVIYDWYFP TILIVILAVF NDGAMIALSK 

       730        740        750        760        770        780 
DRVVASVLPS TWNLATIFVP GFVYAMWLTL SSWALYQVAT HSTFFERMTP LPSLNTQHAT 

       790        800        810        820        830        840 
LISWCEDEIS SKLGVNPQDS LCTYPSYADQ LNECKGSVSL SSQVPGVPTI LDQCVTEQRY 

       850        860        870        880        890        900 
IRDALTRALI YTHLSVSGQA VVFVVRTSGF SLKEVAGVST YVAFALAQFG ATMFGIFGLG 

       910        920        930        940        950        960 
GYNKPRQNFD NCQFCDYSTH NRVLFFNSEV EPRAGTESVY TASVIGCGGY VIVAWIWAAL 

       970        980        990       1000       1010       1020 
FYTALDPLKW GLMWIMNDDG FRDRHAWRKS NHEAMERRSR EQLDNKEFAG PSGMVPANFS 

      1030       1040       1050       1060       1070       1080 
NPLGRASMSK PVSALLDRKS ASLVAINRSS MTVSHDPNHA LNIGRRSMIG RPSGPLGRNS 

      1090       1100 
NTGQSNPLNS SSVEIKPDAP NKV

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References

[1]"Primary structure and effect of pH on the expression of the plasma membrane H(+)-ATPase from Dunaliella acidophila and Dunaliella salina."
Weiss M., Pick U.
Plant Physiol. 112:1693-1702(1996) [PubMed: 8972605] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SAG 19.85.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U54690 mRNA. Translation: AAB49042.1.

3D structure databases

ProteinModelPortalP54210.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006534. ATPase_P-typ_PM_proton-efflux.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 3 hits.
PANTHERPTHR24093:SF61. PTHR24093:SF61. 1 hit.
PfamPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMA1_DUNAC
AccessionPrimary (citable) accession number: P54210
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 19, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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