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Protein

Alcohol dehydrogenase 2

Gene

alcB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi74Zinc 1; catalyticBy similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi121Zinc 2By similarity1
Metal bindingi163Zinc 1; catalyticBy similarity1
Binding sitei212NADBy similarity1
Binding sitei216NADBy similarity1
Binding sitei361NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 193NADBy similarity7
Nucleotide bindingi286 – 288NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: AspGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • alcohol metabolic process Source: AspGD
  • ethanol metabolic process Source: GO_Central
  • NADH oxidation Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase II
Short name:
ADH II
Gene namesi
Name:alcB
ORF Names:AN3741
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607201 – 367Alcohol dehydrogenase 2Add BLAST367

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00004982

Structurei

3D structure databases

ProteinModelPortaliP54202
SMRiP54202
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685
InParanoidiP54202
KOiK13953
OMAiFNGTLVC
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P54202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEIPKKQ KAVIYDNPGT VSTKVVELDV PEPGDNEVLI NLTHSGVCHS
60 70 80 90 100
DFGIMTNTWK ILPFPTQPGQ VGGHEGVGKV VKLGAGAEAS GLKIGDRVGV
110 120 130 140 150
KWISSACGQC PPCQDGADGL CFNQKVSGYY TPGTFQQYVL GPAQYVTPIP
160 170 180 190 200
DGLPSAEAAP LLCAGVTVYA SLKRSKAQPG QWIVISGAGG GLGHLAVQIA
210 220 230 240 250
AKGMGLRVIG VDHGSKEELV KASGAEHFVD ITKFPTGDKF EAISSHVKSL
260 270 280 290 300
TTKGLGAHAV IVCTASNIAY AQSLLFLRYN GTMVCVGIPE NEPQAIASAY
310 320 330 340 350
PGLFIQKHVH VTGSAVGNRN EAIETMEFAA RGVIKAHFRE EKMEALTEIF
360
KEMEEGKLQG RVVLDLS
Length:367
Mass (Da):38,690
Last modified:May 1, 2007 - v2
Checksum:i0B65AC6CD0306663
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295A → R in CAA88034 (PubMed:8821658).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48000 Genomic DNA Translation: CAA88034.1
AACD01000061 Genomic DNA Translation: EAA59949.1
BN001302 Genomic DNA Translation: CBF75491.1
PIRiS62746
RefSeqiXP_661345.1, XM_656253.1

Genome annotation databases

EnsemblFungiiCADANIAT00004982; CADANIAP00004982; CADANIAG00004982
EAA59949; EAA59949; AN3741.2
GeneIDi2873163
KEGGiani:AN3741.2

Similar proteinsi

Entry informationi

Entry nameiADH2_EMENI
AccessioniPrimary (citable) accession number: P54202
Secondary accession number(s): C8V7A8, Q5B6T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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