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Protein

Alcohol dehydrogenase 2

Gene

alcB

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi74Zinc 1; catalyticBy similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi121Zinc 2By similarity1
Metal bindingi163Zinc 1; catalyticBy similarity1
Binding sitei212NADBy similarity1
Binding sitei216NADBy similarity1
Binding sitei361NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 193NADBy similarity7
Nucleotide bindingi286 – 288NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: AspGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • alcohol metabolic process Source: AspGD
  • ethanol metabolic process Source: GO_Central
  • NADH oxidation Source: GO_Central

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase II
Short name:
ADH II
Gene namesi
Name:alcB
ORF Names:AN3741
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607201 – 367Alcohol dehydrogenase 2Add BLAST367

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54202.
SMRiP54202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiP54202.
KOiK13953.
OMAiPCRRGDF.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P54202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPEIPKKQ KAVIYDNPGT VSTKVVELDV PEPGDNEVLI NLTHSGVCHS
60 70 80 90 100
DFGIMTNTWK ILPFPTQPGQ VGGHEGVGKV VKLGAGAEAS GLKIGDRVGV
110 120 130 140 150
KWISSACGQC PPCQDGADGL CFNQKVSGYY TPGTFQQYVL GPAQYVTPIP
160 170 180 190 200
DGLPSAEAAP LLCAGVTVYA SLKRSKAQPG QWIVISGAGG GLGHLAVQIA
210 220 230 240 250
AKGMGLRVIG VDHGSKEELV KASGAEHFVD ITKFPTGDKF EAISSHVKSL
260 270 280 290 300
TTKGLGAHAV IVCTASNIAY AQSLLFLRYN GTMVCVGIPE NEPQAIASAY
310 320 330 340 350
PGLFIQKHVH VTGSAVGNRN EAIETMEFAA RGVIKAHFRE EKMEALTEIF
360
KEMEEGKLQG RVVLDLS
Length:367
Mass (Da):38,690
Last modified:May 1, 2007 - v2
Checksum:i0B65AC6CD0306663
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti295A → R in CAA88034 (PubMed:8821658).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48000 Genomic DNA. Translation: CAA88034.1.
AACD01000061 Genomic DNA. Translation: EAA59949.1.
BN001302 Genomic DNA. Translation: CBF75491.1.
PIRiS62746.
RefSeqiXP_661345.1. XM_656253.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004982; CADANIAP00004982; CADANIAG00004982.
EAA59949; EAA59949; AN3741.2.
GeneIDi2873163.
KEGGiani:AN3741.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48000 Genomic DNA. Translation: CAA88034.1.
AACD01000061 Genomic DNA. Translation: EAA59949.1.
BN001302 Genomic DNA. Translation: CBF75491.1.
PIRiS62746.
RefSeqiXP_661345.1. XM_656253.1.

3D structure databases

ProteinModelPortaliP54202.
SMRiP54202.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00004982; CADANIAP00004982; CADANIAG00004982.
EAA59949; EAA59949; AN3741.2.
GeneIDi2873163.
KEGGiani:AN3741.2.

Phylogenomic databases

HOGENOMiHOG000294685.
InParanoidiP54202.
KOiK13953.
OMAiPCRRGDF.
OrthoDBiEOG092C2Q8E.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_EMENI
AccessioniPrimary (citable) accession number: P54202
Secondary accession number(s): C8V7A8, Q5B6T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 1, 2007
Last modified: March 15, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.