Reviewed, UniProtKB/Swiss-Prot P54202 (ADH2_EMENI)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase II
      Short name=ADH II

Gene names

Name:	alcB
ORF Names:	AN3741

Organism

Emericella nidulans (Aspergillus nidulans)

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Alcohol dehydrogenase 2		PRO_0000160720
Sites
	Metal binding	48	1	Zinc 1; catalytic By similarity
	Metal binding	74	1	Zinc 1; catalytic By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	110	1	Zinc 2 By similarity
	Metal binding	113	1	Zinc 2 By similarity
	Metal binding	121	1	Zinc 2 By similarity
	Metal binding	163	1	Zinc 1; catalytic By similarity
Experimental info
	Sequence conflict	295	1	A → R in CAA88034. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P54202-1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 0B65AC6CD0306663	FASTA	367	38,690
	10 20 30 40 50 60 MAAPEIPKKQ KAVIYDNPGT VSTKVVELDV PEPGDNEVLI NLTHSGVCHS DFGIMTNTWK 70 80 90 100 110 120 ILPFPTQPGQ VGGHEGVGKV VKLGAGAEAS GLKIGDRVGV KWISSACGQC PPCQDGADGL 130 140 150 160 170 180 CFNQKVSGYY TPGTFQQYVL GPAQYVTPIP DGLPSAEAAP LLCAGVTVYA SLKRSKAQPG 190 200 210 220 230 240 QWIVISGAGG GLGHLAVQIA AKGMGLRVIG VDHGSKEELV KASGAEHFVD ITKFPTGDKF 250 260 270 280 290 300 EAISSHVKSL TTKGLGAHAV IVCTASNIAY AQSLLFLRYN GTMVCVGIPE NEPQAIASAY 310 320 330 340 350 360 PGLFIQKHVH VTGSAVGNRN EAIETMEFAA RGVIKAHFRE EKMEALTEIF KEMEEGKLQG RVVLDLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The cloning and sequencing of the alcB gene, coding for alcohol dehydrogenase II, in Aspergillus nidulans." Hunter G.D., Jones I.G., Sealy-Lewis H.M. Curr. Genet. 29:122-129(1996) [PubMed: 8821658] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z48000 Genomic DNA. Translation: CAA88034.1. AACD01000061 Genomic DNA. Translation: EAA59949.1.
PIR	S62746.
RefSeq	XP_661345.1.
3D structure databases
HSSP	HSSP built from PDB template 1JVB based on UniProtKB P39462.
ModBase	Search...
Genome annotation databases
GeneID	2873163.
KEGG	ani:AN3741.2.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH2_EMENI

Accession

Primary (citable) accession number: P54202
Secondary accession number(s): Q5B6T9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	May 1, 2007
Last modified:	November 25, 2008
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)