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P54198

- HIRA_HUMAN

UniProt

P54198 - HIRA_HUMAN

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Protein

Protein HIRA

Gene

HIRA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.3 Publications

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription corepressor activity Source: ProtInc

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. chromatin modification Source: UniProtKB-KW
  3. DNA replication-independent nucleosome assembly Source: UniProt
  4. gastrulation Source: Ensembl
  5. muscle cell differentiation Source: Ensembl
  6. osteoblast differentiation Source: Ensembl
  7. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  8. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
SignaLinkiP54198.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HIRA
Alternative name(s):
TUP1-like enhancer of split protein 1
Gene namesi
Name:HIRA
Synonyms:DGCR1, HIR, TUPLE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:4916. HIRA.

Subcellular locationi

Nucleus. NucleusPML body
Note: Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

GO - Cellular componenti

  1. nuclear chromatin Source: UniProt
  2. nucleoplasm Source: Reactome
  3. nucleus Source: ProtInc
  4. protein complex Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi449 – 45810Missing: Impairs binding to ASF1A. 1 Publication
Mutagenesisi458 – 4603RRR → AKK: Abrogates binding to ASF1A.
Mutagenesisi458 – 4603RRR → KKK: Impairs binding to ASF1A.
Mutagenesisi458 – 4592RR → AK: Impairs binding to ASF1A.
Mutagenesisi458 – 4581R → A: Impairs binding to ASF1A.
Mutagenesisi458 – 4581R → K: Impairs binding to ASF1A; when associated with K-460.
Mutagenesisi459 – 46810Missing: Abrogates binding to ASF1A. 1 Publication
Mutagenesisi459 – 4591R → A: Abrogates binding to ASF1A. 1 Publication
Mutagenesisi460 – 4601R → A: Abrogates binding to ASF1A. 1 Publication
Mutagenesisi460 – 4601R → K: Impairs binding to ASF1A; when associated with K-458. 1 Publication
Mutagenesisi461 – 4611I → D: Abrogates binding to ASF1A. 1 Publication
Mutagenesisi464 – 4641L → D: Impairs binding to ASF1A. 1 Publication
Mutagenesisi466 – 4661I → D: Impairs binding to ASF1A. 1 Publication
Mutagenesisi555 – 5551T → A: Impairs phosphorylation by CDK2. 1 Publication
Mutagenesisi628 – 6314KRKL → AAAA: Impairs binding to CCNA1 and phosphorylation by CDK2. 1 Publication

Organism-specific databases

Orphaneti567. 22q11.2 deletion syndrome.
PharmGKBiPA29293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10171017Protein HIRAPRO_0000051019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei549 – 5491Phosphoserine1 Publication
Modified residuei555 – 5551Phosphothreonine; by CDK21 Publication
Modified residuei557 – 5571Phosphoserine1 Publication
Modified residuei576 – 5761Phosphothreonine1 Publication
Modified residuei584 – 5841Phosphoserine1 Publication
Modified residuei586 – 5861Phosphothreonine3 Publications
Modified residuei610 – 6101Phosphoserine1 Publication
Modified residuei611 – 6111Phosphoserine1 Publication
Modified residuei612 – 6121Phosphoserine1 Publication
Modified residuei614 – 6141Phosphoserine1 Publication
Modified residuei661 – 6611Phosphoserine2 Publications
Modified residuei687 – 6871Phosphoserine1 Publication

Post-translational modificationi

Sumoylated.1 Publication
Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.5 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP54198.
PaxDbiP54198.
PeptideAtlasiP54198.
PRIDEiP54198.

PTM databases

PhosphoSiteiP54198.

Expressioni

Tissue specificityi

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.1 Publication

Developmental stagei

Expressed during embryogenesis.

Gene expression databases

BgeeiP54198.
CleanExiHS_HIRA.
ExpressionAtlasiP54198. baseline and differential.
GenevestigatoriP54198.

Organism-specific databases

HPAiCAB039243.
CAB039244.

Interactioni

Subunit structurei

Interacts with histone H3F3B, PAX3 and PAX7 (By similarity). Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 and histone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1.By similarity7 Publications

Protein-protein interaction databases

BioGridi113141. 22 interactions.
DIPiDIP-29240N.
IntActiP54198. 7 interactions.
MINTiMINT-3020150.
STRINGi9606.ENSP00000263208.

Structurei

Secondary structure

1
1017
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi450 – 4534Combined sources
Beta strandi459 – 4624Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I32X-ray2.70E/F425-472[»]
ProteinModelPortaliP54198.
SMRiP54198. Positions 16-365.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 5343WD 1Add
BLAST
Repeati68 – 10740WD 2Add
BLAST
Repeati129 – 16840WD 3Add
BLAST
Repeati172 – 21140WD 4Add
BLAST
Repeati220 – 26344WD 5Add
BLAST
Repeati266 – 32257WD 6Add
BLAST
Repeati326 – 36742WD 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni421 – 729309Interaction with CCNA1Add
BLAST
Regioni421 – 47959Interaction with ASF1AAdd
BLAST
Regioni439 – 47537Required for repression of histone gene transcriptionAdd
BLAST
Regioni593 – 826234Interaction with histone H2BAdd
BLAST
Regioni594 – 739146Interaction with PAX3By similarityAdd
BLAST
Regioni738 – 1017280Interaction with histone H4Add
BLAST
Regioni740 – 82889Interaction with PAX3By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi408 – 4125Poly-Gln
Compositional biasi640 – 6434Poly-Lys
Compositional biasi805 – 8084Poly-Val

Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00550000074919.
HOGENOMiHOG000007670.
HOVERGENiHBG005969.
InParanoidiP54198.
KOiK11293.
OMAiLEDIRKX.
PhylomeDBiP54198.
TreeFamiTF323161.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P54198-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLLKPTWVN HNGKPIFSVD IHPDGTKFAT GGQGQDSGKV VIWNMSPVLQ
60 70 80 90 100
EDDEKDENIP KMLCQMDNHL ACVNCVRWSN SGMYLASGGD DKLIMVWKRA
110 120 130 140 150
TYIGPSTVFG SSGKLANVEQ WRCVSILRNH SGDVMDVAWS PHDAWLASCS
160 170 180 190 200
VDNTVVIWNA VKFPEILATL RGHSGLVKGL TWDPVGKYIA SQADDRSLKV
210 220 230 240 250
WRTLDWQLET SITKPFDECG GTTHVLRLSW SPDGHYLVSA HAMNNSGPTA
260 270 280 290 300
QIIEREGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGSS AKPSCPYCCC
310 320 330 340 350
AVGSKDRSLS VWLTCLKRPL VVIHELFDKS IMDISWTLNG LGILVCSMDG
360 370 380 390 400
SVAFLDFSQD ELGDPLSEEE KSRIHQSTYG KSLAIMTEAQ LSTAVIENPE
410 420 430 440 450
MLKYQRRQQQ QQLDQKSAAT REMGSATSVA GVVNGESLED IRKNLLKKQV
460 470 480 490 500
ETRTADGRRR ITPLCIAQLD TGDFSTAFFN SIPLSGSLAG TMLSSHSSPQ
510 520 530 540 550
LLPLDSSTPN SFGASKPCTE PVVAASARPA GDSVNKDSMN ATSTPAALSP
560 570 580 590 600
SVLTTPSKIE PMKAFDSRFT ERSKATPGAP ALTSMTPTAV ERLKEQNLVK
610 620 630 640 650
ELRPRDLLES SSDSDEKVPL AKASSLSKRK LELEVETVEK KKKGRPRKDS
660 670 680 690 700
RLMPVSLSVQ SPAALTAEKE AMCLSAPALA LKLPIPSPQR AFTLQVSSDP
710 720 730 740 750
SMYIEVENEV TVVGGVKLSR LKCNREGKEW ETVLTSRILT AAGSCDVVCV
760 770 780 790 800
ACEKRMLSVF STCGRRLLSP ILLPSPISTL HCTGSYVMAL TAAATLSVWD
810 820 830 840 850
VHRQVVVVKE ESLHSILAGS DMTVSQILLT QHGIPVMNLS DGKAYCFNPS
860 870 880 890 900
LSTWNLVSDK QDSLAQCADF RSSLPSQDAM LCSGPLAIIQ GRTSNSGRQA
910 920 930 940 950
ARLFSVPHVV QQETTLAYLE NQVAAALTLQ SSHEYRHWLL VYARYLVNEG
960 970 980 990 1000
FEYRLREICK DLLGPVHYST GSQWESTVVG LRKRELLKEL LPVIGQNLRF
1010
QRLFTECQEQ LDILRDK
Length:1,017
Mass (Da):111,835
Last modified:February 21, 2006 - v2
Checksum:i475784B2FF9D16D6
GO
Isoform Short (identifier: P54198-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     593-799: Missing.

Show »
Length:810
Mass (Da):89,299
Checksum:iA169BFDCE4C8D4D7
GO

Sequence cautioni

The sequence CAA53044.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA54721.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA57436.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → G in CAA54721. (PubMed:7633437)Curated
Sequence conflicti889 – 8891I → N in CAA54721. (PubMed:7633437)Curated
Sequence conflicti889 – 8891I → N in CAA57436. (PubMed:7633437)Curated
Sequence conflicti889 – 8891I → N in CAA61979. (PubMed:8681138)Curated
Sequence conflicti990 – 9901L → M in CAA53044. (PubMed:8111380)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei593 – 799207Missing in isoform Short. 1 PublicationVSP_006772Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81844 mRNA. Translation: CAA57436.1. Different initiation.
X77633 mRNA. Translation: CAA54721.1. Different initiation.
X89887 mRNA. Translation: CAA61979.1.
X91501 Genomic DNA. Translation: CAA62800.1.
CR456503 mRNA. Translation: CAG30389.1.
BC032721 mRNA. Translation: AAH32721.1.
BC039835 mRNA. Translation: AAH39835.1.
X75296 mRNA. Translation: CAA53044.1. Different initiation.
CCDSiCCDS13759.1. [P54198-1]
PIRiI37465.
S45344.
RefSeqiNP_003316.3. NM_003325.3. [P54198-1]
UniGeneiHs.474206.

Genome annotation databases

EnsembliENST00000263208; ENSP00000263208; ENSG00000100084. [P54198-1]
ENST00000340170; ENSP00000345350; ENSG00000100084. [P54198-2]
GeneIDi7290.
KEGGihsa:7290.
UCSCiuc002zpf.1. human. [P54198-1]
uc010grn.1. human. [P54198-2]

Polymorphism databases

DMDMi88984228.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81844 mRNA. Translation: CAA57436.1 . Different initiation.
X77633 mRNA. Translation: CAA54721.1 . Different initiation.
X89887 mRNA. Translation: CAA61979.1 .
X91501 Genomic DNA. Translation: CAA62800.1 .
CR456503 mRNA. Translation: CAG30389.1 .
BC032721 mRNA. Translation: AAH32721.1 .
BC039835 mRNA. Translation: AAH39835.1 .
X75296 mRNA. Translation: CAA53044.1 . Different initiation.
CCDSi CCDS13759.1. [P54198-1 ]
PIRi I37465.
S45344.
RefSeqi NP_003316.3. NM_003325.3. [P54198-1 ]
UniGenei Hs.474206.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I32 X-ray 2.70 E/F 425-472 [» ]
ProteinModelPortali P54198.
SMRi P54198. Positions 16-365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113141. 22 interactions.
DIPi DIP-29240N.
IntActi P54198. 7 interactions.
MINTi MINT-3020150.
STRINGi 9606.ENSP00000263208.

PTM databases

PhosphoSitei P54198.

Polymorphism databases

DMDMi 88984228.

Proteomic databases

MaxQBi P54198.
PaxDbi P54198.
PeptideAtlasi P54198.
PRIDEi P54198.

Protocols and materials databases

DNASUi 7290.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263208 ; ENSP00000263208 ; ENSG00000100084 . [P54198-1 ]
ENST00000340170 ; ENSP00000345350 ; ENSG00000100084 . [P54198-2 ]
GeneIDi 7290.
KEGGi hsa:7290.
UCSCi uc002zpf.1. human. [P54198-1 ]
uc010grn.1. human. [P54198-2 ]

Organism-specific databases

CTDi 7290.
GeneCardsi GC22M019318.
HGNCi HGNC:4916. HIRA.
HPAi CAB039243.
CAB039244.
MIMi 600237. gene.
neXtProti NX_P54198.
Orphaneti 567. 22q11.2 deletion syndrome.
PharmGKBi PA29293.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00550000074919.
HOGENOMi HOG000007670.
HOVERGENi HBG005969.
InParanoidi P54198.
KOi K11293.
OMAi LEDIRKX.
PhylomeDBi P54198.
TreeFami TF323161.

Enzyme and pathway databases

Reactomei REACT_169121. Formation of Senescence-Associated Heterochromatin Foci (SAHF).
SignaLinki P54198.

Miscellaneous databases

ChiTaRSi HIRA. human.
EvolutionaryTracei P54198.
GeneWikii HIRA.
GenomeRNAii 7290.
NextBioi 28503.
PROi P54198.
SOURCEi Search...

Gene expression databases

Bgeei P54198.
CleanExi HS_HIRA.
ExpressionAtlasi P54198. baseline and differential.
Genevestigatori P54198.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR011494. Hira.
IPR019015. HIRA_B_motif.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF07569. Hira. 1 hit.
PF09453. HIRA_B. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view ]
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region."
    Lamour V., Lecluse Y., Desmaze C., Spector M., Bodescot M., Aurias A., Osley M.A., Lipinski M.
    Hum. Mol. Genet. 4:791-799(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: Brain.
  2. "Structural organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22."
    Lorain S., Demczuk S., Lamour V., Toth S., Aurias A., Roe B.A., Lipinski M.
    Genome Res. 6:43-50(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM LONG).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Eye and Lymph.
  5. "Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease."
    Halford S., Wadey R., Roberts C., Daw S.C.M., Whiting J.A., O'Donnell H., Dunham I., Bentley D., Lindsay E., Baldini A., Francis F., Lehrach H., Williamson R., Wilson D.I., Goodship J., Cross I., Burn J., Scambler P.J.
    Hum. Mol. Genet. 2:2099-2107(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-1017 (ISOFORM SHORT).
    Tissue: Fetal brain.
  6. "The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients."
    Wilming L.G., Snoeren C.A.S., van Rijswijk A., Grosveld F., Meijers C.
    Hum. Mol. Genet. 6:247-258(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA."
    Lorain S., Quivy J.-P., Monier-Gavelle F., Scamps C., Lecluse Y., Almouzni G., Lipinski M.
    Mol. Cell. Biol. 18:5546-5556(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIRIP3; HISTONE H2B; HISTONE H4 AND NFU1, SUBCELLULAR LOCATION.
  8. "HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression."
    Hall C., Nelson D.M., Ye X., Baker K., DeCaprio J.A., Seeholzer S., Lipinski M., Adams P.D.
    Mol. Cell. Biol. 21:1854-1865(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CCNA1, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-555 AND SER-687, MUTAGENESIS OF THR-555 AND 628-LYS--LEU-631.
  9. "Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity."
    Nelson D.M., Ye X., Hall C., Santos H., Ma T., Kao G.D., Yen T.J., Harper J.W., Adams P.D.
    Mol. Cell. Biol. 22:7459-7472(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. Cited for: INTERACTION WITH ASF1A.
  11. "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."
    Tagami H., Ray-Gallet D., Almouzni G., Nakatani Y.
    Cell 116:51-61(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH ASF1A; CABIN1; HISTONE H3.3 AND UBN1.
  12. "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA."
    Zhang R., Poustovoitov M.V., Ye X., Santos H.A., Chen W., Daganzo S.M., Erzberger J.P., Serebriiskii I.G., Canutescu A.A., Dunbrack R.L., Pehrson J.R., Berger J.M., Kaufman P.D., Adams P.D.
    Dev. Cell 8:19-30(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ASF1A, SUBCELLULAR LOCATION.
  13. "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
    Gocke C.B., Yu H., Kang J.
    J. Biol. Chem. 280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.
  14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584 AND THR-586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells."
    Banumathy G., Somaiah N., Zhang R., Tang Y., Hoffmann J., Andrake M., Ceulemans H., Schultz D., Marmorstein R., Adams P.D.
    Mol. Cell. Biol. 29:758-770(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBN1.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549; SER-557; THR-576 AND THR-586, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-586 AND SER-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610; SER-611; SER-612; SER-614 AND SER-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly."
    Tang Y., Poustovoitov M.V., Zhao K., Garfinkel M., Canutescu A., Dunbrack R., Adams P.D., Marmorstein R.
    Nat. Struct. Mol. Biol. 13:921-929(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 425-472 IN COMPLEX WITH ASF1A, MUTAGENESIS OF 449-GLN--ARG-458; 459-ARG--GLN-468; ARG-459; ARG-460; ILE-461; LEU-464 AND ILE-466.

Entry informationi

Entry nameiHIRA_HUMAN
AccessioniPrimary (citable) accession number: P54198
Secondary accession number(s): Q05BU9, Q8IXN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3