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Protein

Endochitinase 2

Gene

CTS2

Organism
Coccidioides posadasii (strain C735) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be associated with endosporulation.

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Endochitinase 2 (EC:3.2.1.14)
Gene namesi
Name:CTS2
ORF Names:CPC735_058480
OrganismiCoccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic identifieri222929 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000009084 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CPC735_058480.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001192823 – 826Endochitinase 2Add BLAST804
PropeptideiPRO_0000252289827 – 855Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi826GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi222929.XP_003066623.1.

Structurei

3D structure databases

ProteinModelPortaliP54197.
SMRiP54197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 800Ser/Thr-richAdd BLAST455

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4701. Eukaryota.
ENOG4111GPA. LUCA.
KOiK01183.
OrthoDBiEOG092C4MM9.

Family and domain databases

InterProiView protein in InterPro
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPTNILAAF IAVSSLFIQS LALNPYAKSN LAVYWGQGAG QNRLSYFCEK
60 70 80 90 100
TSFDIIVVGF INVFPDQGPA GWPGSNFGNQ CADSYYYTKN GTKTKLLDGC
110 120 130 140 150
YQIKEDLPKC KALGKTILLS LGGGAVHDFY EVKSEESALN FADFLWGAFG
160 170 180 190 200
PLTPDWTGPR PFGEASVDGF DFDIEKGSNF GYSIMVRRLR ELFLQDPLNR
210 220 230 240 250
YYISAAPQCI MPDKYLSHAI SNSAFDFIFI QFYNNPSCSA KRWVTNPKSV
260 270 280 290 300
TYTVDDWVKY IRKSGNPLAK LFIGLPASKS AAAKEDYLTP GEATKIVSTY
310 320 330 340 350
MAKYPSTFGG MMVWEATASE NNKLGGLPYA DIMKEVLLRC DPDPPTSTVT
360 370 380 390 400
STTSASTSTQ TSSQSTTMET KTLSASTTPS SPSTVSPSST MQTTSTGSTS
410 420 430 440 450
IETVTTRSQE PPSTTISTRS ASTEPVTTRS QEPPSTTIST RSASTETVTT
460 470 480 490 500
RSQEPPSTTI STWSASTETS TSSQDSPSTT ISTKSAPTGT VTTRSQDLPS
510 520 530 540 550
TTISTRSPET ETETATTKSQ GSPSITLSTR SSSAETVSTR SQHSSSTTIS
560 570 580 590 600
TKSAPTETGT TSEHSTSMPV STRSASTETV ITRSQNSDSQ SMTVSTRSPS
610 620 630 640 650
TESITTRSQG SPSETFSTKS VPVDTISTEL PSQTPTTIIT GTPSDPVSAP
660 670 680 690 700
TTTVPPNPTL TLAPSSSTTE DRTTITTIIT TSYVTVCPTG FTTVTITYTT
710 720 730 740 750
TYCPETASLT PTQPPIPGAP APPPDGWTTI VTVCPQCAPT PTTVTLTVPT
760 770 780 790 800
RSAFLPARTE TRPVVTVVPV PENPIKNVKP SESGDFVTVT TAAPATVTKT
810 820 830 840 850
LEYNNPVDSD VNVQPTGGSS PVEFEGSAMT VRSMDVVAKA LITAGAAVLG

LFLGL
Length:855
Mass (Da):90,609
Last modified:October 3, 2006 - v2
Checksum:iA53628680FE0CA9D
GO

Sequence cautioni

The sequence AAA92642 differs from that shown. Reason: Frameshift at position 847.Curated
The sequence EER24478 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41662 Genomic DNA. Translation: AAA92642.1. Frameshift.
ACFW01000049 Genomic DNA. Translation: EER24478.1. Sequence problems.
RefSeqiXP_003066623.1. XM_003066577.1.
UniGeneiCpo.2425.

Genome annotation databases

EnsemblFungiiEER24478; EER24478; CPC735_058480.
GeneIDi9692093.
KEGGicpw:CPC735_058480.

Similar proteinsi

Entry informationi

Entry nameiCHI2_COCP7
AccessioniPrimary (citable) accession number: P54197
Secondary accession number(s): C5PIX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2006
Last modified: May 10, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families