Reviewed, UniProtKB/Swiss-Prot P54185 (OBA5_DROME)

Names and origin

Protein names

Recommended name:
    Putative odorant-binding protein A5
Alternative name(s):
    Antennal protein 5

Gene names

Name:	a5
ORF Names:	CG5430

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted Potential. Note: Secreted in the lumen of the sensilla Potential.
Tissue specificity	Cells at the bases of a few scattered sensilla on the posterior surface of the antenna.
Sequence similarities	Belongs to the phosphatidylethanolamine-binding protein family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ndae1	Q9VM32	1	EBI-127279,EBI-143399

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 210	191	Putative odorant-binding protein A5		PRO_0000023281
Experimental info
	Sequence conflict	13	1	F → W Ref.1
	Sequence conflict	105	1	W → R in AAC46472. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P54185-1 [UniParc]. Last modified October 18, 2001. Version 2. Checksum: 1DB9C0AFAD286719	FASTA	210	24,573
	10 20 30 40 50 60 MKLPALHLLF LGFICLARSQ DNDENVRRIM KEMEVIPEIL DEPPRELLRI KYDNTIDIEE 70 80 90 100 110 120 GKTYTPTELK FQPRLDWNAD PESFYTVLMI CPDAPNRENP MYRSWLHWLV VNVPGLDIMK 130 140 150 160 170 180 GQPISEYFGP LPPKDSGIQR YLILVYQQSD KLDFDEKKME LSNADGHSNF DVMKFTQKYE 190 200 210 MGSPVAGNIF QSRWDEYVPE LMKTLYGVSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Members of a family of Drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs." Pikielny C.W., Hasan G., Rouyer F., Rosbash M. Neuron 12:35-49(1994) [PubMed: 7545907] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Canton-S. Tissue: Antenna.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U05243 mRNA. Translation: AAC46472.1. AE014134 Genomic DNA. Translation: AAF51385.1.
RefSeq	NP_476998.1.
UniGene	Dm.2837
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:19357N.
IntAct	P54185. 2 interactions.
STRING	P54185.
Genome annotation databases
Ensembl	FBtr0077922; FBpp0077588; FBgn0011294; Drosophila melanogaster. [Genome view]
GeneID	33317.
KEGG	dme:Dmel_CG5430.
NMPDR	fig|7227.3.peg.227.
Organism-specific databases
CTD	33317.
FlyBase	FBgn0011294. a5.
Phylogenomic databases
HOGENOM	P54185.
OMA	MICPDAP
OrthoDB	EOG9DV5TZ
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-006835-MON.
Gene expression databases
GermOnline	CG5430. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001858. Phosphotidylethanolamine_bd_CS. IPR008914. PtdEtn-bd_prot_PEBP. [Graphical view]
Gene3D	G3DSA:3.90.280.10. PEBP. 1 hit.
Pfam	PF01161. PBP. 1 hit. [Graphical view]
PROSITE	PS01220. PBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	783004.

Entry information

Entry name

OBA5_DROME

Accession

Primary (citable) accession number: P54185
Secondary accession number(s): Q9VPZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 18, 2001
Last modified:	November 24, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project