Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SCO1 protein homolog

Gene

ypmQ

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for insertion of copper into the active site of cytochrome c oxidase. May play a role in copper homeostasis or redox signaling.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64CopperBy similarity1
Metal bindingi68CopperBy similarity1
Metal bindingi154CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU21750-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SCO1 protein homolog
Alternative name(s):
BsSco
Gene namesi
Name:ypmQ
Ordered Locus Names:BSU21750
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64C → S: Abolishes cytochrome c oxidase assembly. 1 Publication1
Mutagenesisi68C → S: Abolishes cytochrome c oxidase assembly. 1 Publication1
Mutagenesisi154H → A: Abolishes cytochrome c oxidase assembly. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
ChainiPRO_000017387519 – 193SCO1 protein homologAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi19N-palmitoyl cysteineCurated1
Lipidationi19S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP54178.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100011976.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 38Combined sources3
Beta strandi44 – 46Combined sources3
Helixi48 – 50Combined sources3
Beta strandi55 – 60Combined sources6
Helixi71 – 84Combined sources14
Beta strandi90 – 96Combined sources7
Turni98 – 100Combined sources3
Helixi103 – 110Combined sources8
Turni111 – 114Combined sources4
Helixi117 – 119Combined sources3
Beta strandi120 – 124Combined sources5
Helixi128 – 139Combined sources12
Beta strandi144 – 146Combined sources3
Turni149 – 152Combined sources4
Beta strandi157 – 161Combined sources5
Beta strandi165 – 176Combined sources12
Helixi179 – 189Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ON4NMR-A24-193[»]
1XZOX-ray1.70A/B22-193[»]
ProteinModelPortaliP54178.
SMRiP54178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54178.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 191ThioredoxinPROSITE-ProRule annotationAdd BLAST166

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108KF3. Bacteria.
COG1999. LUCA.
HOGENOMiHOG000089498.
InParanoidiP54178.
KOiK07152.
OMAiTICPIMT.
PhylomeDBiP54178.

Family and domain databases

CDDicd02968. SCO. 1 hit.
InterProiView protein in InterPro
IPR003782. SCO1/SenC.
IPR036249. Thioredoxin-like_sf.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiView protein in Pfam
PF02630. SCO1-SenC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIKGLTAG LIFLFLCACG GQQIKDPLNY EVEPFTFQNQ DGKNVSLESL
60 70 80 90 100
KGEVWLADFI FTNCETICPP MTAHMTDLQK KLKAENIDVR IISFSVDPEN
110 120 130 140 150
DKPKQLKKFA ANYPLSFDNW DFLTGYSQSE IEEFALKSFK AIVKKPEGED
160 170 180 190
QVIHQSSFYL VGPDGKVLKD YNGVENTPYD DIISDVKSAS TLK
Length:193
Mass (Da):21,718
Last modified:July 7, 2009 - v2
Checksum:iD2C57D908B4864D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85E → G in AAA96641 (PubMed:8969496).Curated1

Mass spectrometryi

Molecular mass is 21108±64.5 Da from positions 19 - 193. Determined by MALDI. The measured mass is closest to that of the mature protein with 2 palmitate moieties.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77246 Genomic DNA. Translation: AAA96641.1.
AL009126 Genomic DNA. Translation: CAB14093.2.
PIRiH69938.
RefSeqiNP_390058.2. NC_000964.3.
WP_003245947.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14093; CAB14093; BSU21750.
GeneIDi939098.
KEGGibsu:BSU21750.
PATRICifig|224308.179.peg.2376.

Similar proteinsi

Entry informationi

Entry nameiSCO1_BACSU
AccessioniPrimary (citable) accession number: P54178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: October 25, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families