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P54157 (BCSA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:bcsA
Ordered Locus Names:BSU22050
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Putative chalcone synthase
PRO_0000216091

Sites

Active site1441 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54157 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2C8779BD648925A4

FASTA36540,713
        10         20         30         40         50         60 
MAFILSIGTS LPAYNVNQEK AAEFARYMFQ HSFKDIDRLL SSFKNGQIHS RQFVKPIEWY 

        70         80         90        100        110        120 
KEGHSFEEKN QIYIEETLKH SRAAVRECLS HPEFFQEAIP YEKVEAVFFV SSTGLSTPSI 

       130        140        150        160        170        180 
EARLMNELPF SPYTKRIPIW GLGCAGGASG LARAAEYCKA YPEAFVLVIS AELCSLTFQP 

       190        200        210        220        230        240 
EDKTKSNLIG TSLFGDGIAA ALLCGEKADR RVSKLKLAPK IMDAQSVLMK QSEDVMGWDF 

       250        260        270        280        290        300 
TDQGFKVIFS RDIPTLVEKW LKTNVQIFLD KHKLSFHDIS VFLAHPGGKK VIDAYIKSLG 

       310        320        330        340        350        360 
LSSEKLSSAQ SILQKHGNMS SATILYVIKD HLQNGHKKEA ERGLIGALGP GFSSELLLFS 


WEKGA 

« Hide

References

« Hide 'large scale' references
[1]"Organization of the Bacillus subtilis 168 chromosome between kdg and the attachment site of the SP beta prophage: use of long accurate PCR and yeast artificial chromosomes for sequencing."
Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.
Microbiology 142:3005-3015(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]Saxild H.H., Christensen L., Nygaard P., Schou S.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77246 Genomic DNA. Translation: AAA96613.1.
AL009126 Genomic DNA. Translation: CAB14122.1.
X83878 Genomic DNA. No translation available.
PIRA69593.
RefSeqNP_390087.1. NC_000964.3.

3D structure databases

ProteinModelPortalP54157.
SMRP54157. Positions 2-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU22050.

Proteomic databases

PaxDbP54157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB14122; CAB14122; BSU22050.
GeneID939069.
KEGGbsu:BSU22050.
PATRIC18976217. VBIBacSub10457_2299.

Organism-specific databases

GenoListBSU22050. [Micado]

Phylogenomic databases

eggNOGCOG3424.
HOGENOMHOG000245461.
KOK16167.
OMAPGTLDHE.
OrthoDBEOG6BW4W3.
PhylomeDBP54157.

Enzyme and pathway databases

BioCycBSUB:BSU22050-MONOMER.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBCSA_BACSU
AccessionPrimary (citable) accession number: P54157
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList