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P54157

- BCSA_BACSU

UniProt

P54157 - BCSA_BACSU

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Protein

Putative chalcone synthase

Gene

bcsA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciBSUB:BSU22050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative chalcone synthase (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase
Gene namesi
Name:bcsA
Ordered Locus Names:BSU22050
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU22050. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Putative chalcone synthasePRO_0000216091Add
BLAST

Proteomic databases

PaxDbiP54157.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU22050.

Structurei

3D structure databases

ProteinModelPortaliP54157.
SMRiP54157. Positions 2-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiCOG3424.
HOGENOMiHOG000245461.
InParanoidiP54157.
KOiK16167.
OMAiPGTLDHE.
OrthoDBiEOG6BW4W3.
PhylomeDBiP54157.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54157-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFILSIGTS LPAYNVNQEK AAEFARYMFQ HSFKDIDRLL SSFKNGQIHS
60 70 80 90 100
RQFVKPIEWY KEGHSFEEKN QIYIEETLKH SRAAVRECLS HPEFFQEAIP
110 120 130 140 150
YEKVEAVFFV SSTGLSTPSI EARLMNELPF SPYTKRIPIW GLGCAGGASG
160 170 180 190 200
LARAAEYCKA YPEAFVLVIS AELCSLTFQP EDKTKSNLIG TSLFGDGIAA
210 220 230 240 250
ALLCGEKADR RVSKLKLAPK IMDAQSVLMK QSEDVMGWDF TDQGFKVIFS
260 270 280 290 300
RDIPTLVEKW LKTNVQIFLD KHKLSFHDIS VFLAHPGGKK VIDAYIKSLG
310 320 330 340 350
LSSEKLSSAQ SILQKHGNMS SATILYVIKD HLQNGHKKEA ERGLIGALGP
360
GFSSELLLFS WEKGA
Length:365
Mass (Da):40,713
Last modified:October 1, 1996 - v1
Checksum:i2C8779BD648925A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77246 Genomic DNA. Translation: AAA96613.1.
AL009126 Genomic DNA. Translation: CAB14122.1.
X83878 Genomic DNA. No translation available.
PIRiA69593.
RefSeqiNP_390087.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB14122; CAB14122; BSU22050.
GeneIDi939069.
KEGGibsu:BSU22050.
PATRICi18976217. VBIBacSub10457_2299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77246 Genomic DNA. Translation: AAA96613.1 .
AL009126 Genomic DNA. Translation: CAB14122.1 .
X83878 Genomic DNA. No translation available.
PIRi A69593.
RefSeqi NP_390087.1. NC_000964.3.

3D structure databases

ProteinModelPortali P54157.
SMRi P54157. Positions 2-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU22050.

Proteomic databases

PaxDbi P54157.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14122 ; CAB14122 ; BSU22050 .
GeneIDi 939069.
KEGGi bsu:BSU22050.
PATRICi 18976217. VBIBacSub10457_2299.

Organism-specific databases

GenoListi BSU22050. [Micado ]

Phylogenomic databases

eggNOGi COG3424.
HOGENOMi HOG000245461.
InParanoidi P54157.
KOi K16167.
OMAi PGTLDHE.
OrthoDBi EOG6BW4W3.
PhylomeDBi P54157.

Enzyme and pathway databases

BioCyci BSUB:BSU22050-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the Bacillus subtilis 168 chromosome between kdg and the attachment site of the SP beta prophage: use of long accurate PCR and yeast artificial chromosomes for sequencing."
    Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.
    Microbiology 142:3005-3015(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. Saxild H.H., Christensen L., Nygaard P., Schou S.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
    Strain: 168.

Entry informationi

Entry nameiBCSA_BACSU
AccessioniPrimary (citable) accession number: P54157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3