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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciBSUB:BSU21680-MONOMER.
BRENDAi1.8.4.12. 658.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Synonyms:yppQ
Ordered Locus Names:BSU21680
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 143143Peptide methionine sulfoxide reductase MsrBPRO_0000140262Add
BLAST

Proteomic databases

PaxDbiP54155.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100011941.

Structurei

Secondary structure

1
143
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1110Combined sources
Helixi14 – 229Combined sources
Turni32 – 343Combined sources
Beta strandi39 – 446Combined sources
Turni45 – 473Combined sources
Beta strandi50 – 534Combined sources
Turni54 – 563Combined sources
Beta strandi60 – 645Combined sources
Beta strandi66 – 683Combined sources
Turni72 – 743Combined sources
Beta strandi75 – 806Combined sources
Beta strandi87 – 926Combined sources
Turni93 – 953Combined sources
Beta strandi98 – 1047Combined sources
Beta strandi108 – 1114Combined sources
Beta strandi113 – 1164Combined sources
Helixi118 – 1203Combined sources
Beta strandi121 – 1255Combined sources
Helixi126 – 1294Combined sources
Turni130 – 1334Combined sources
Helixi135 – 1406Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KZNNMR-A1-143[»]
3E0OX-ray2.60A/B/C/D/E/F1-143[»]
ProteinModelPortaliP54155.
SMRiP54155. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 126122MsrBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
InParanoidiP54155.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.
PhylomeDBiP54155.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNKEEKIK SLNRMQYEVT QNNGTEPPFQ NEYWDHKEEG LYVDIVSGKP
60 70 80 90 100
LFTSKDKFDS QCGWPSFTKP IEEEVEEKLD TSHGMIRTEV RSRTADSHLG
110 120 130 140
HVFNDGPGPN GLRYCINSAA LRFVPKHKLK EEGYESYLHL FNK
Length:143
Mass (Da):16,602
Last modified:October 1, 1996 - v1
Checksum:iEC29C9B017C68EED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77246 Genomic DNA. Translation: AAA96648.1.
AL009126 Genomic DNA. Translation: CAB14086.1.
PIRiF69940.
RefSeqiNP_390051.1. NC_000964.3.
WP_003230813.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14086; CAB14086; BSU21680.
GeneIDi939102.
KEGGibsu:BSU21680.
PATRICi18976141. VBIBacSub10457_2261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77246 Genomic DNA. Translation: AAA96648.1.
AL009126 Genomic DNA. Translation: CAB14086.1.
PIRiF69940.
RefSeqiNP_390051.1. NC_000964.3.
WP_003230813.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KZNNMR-A1-143[»]
3E0OX-ray2.60A/B/C/D/E/F1-143[»]
ProteinModelPortaliP54155.
SMRiP54155. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100011941.

Proteomic databases

PaxDbiP54155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14086; CAB14086; BSU21680.
GeneIDi939102.
KEGGibsu:BSU21680.
PATRICi18976141. VBIBacSub10457_2261.

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
InParanoidiP54155.
KOiK07305.
OMAiRMQYEVT.
OrthoDBiEOG6091JX.
PhylomeDBiP54155.

Enzyme and pathway databases

BioCyciBSUB:BSU21680-MONOMER.
BRENDAi1.8.4.12. 658.

Miscellaneous databases

EvolutionaryTraceiP54155.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization of the Bacillus subtilis 168 chromosome between kdg and the attachment site of the SP beta prophage: use of long accurate PCR and yeast artificial chromosomes for sequencing."
    Capuano V., Galleron N., Pujic P., Sorokin A., Ehrlich S.D.
    Microbiology 142:3005-3015(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Solution NMR structure of methionine sulfoxide reductase B using minimal constraint strategy; Northeast structural genomics target SR10."
    Northeast structural genomics consortium (NESG)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiMSRB_BACSU
AccessioniPrimary (citable) accession number: P54155
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.