Reviewed, UniProtKB/Swiss-Prot P54151 (MSRA_BRANA)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase
    EC=1.8.4.11
Alternative name(s):
    Protein-methionine-S-oxide reductase
    Peptide-methionine (S)-S-oxide reductase
      Short name=Peptide Met(O) reductase

Gene names

Name:

PMSR

Organism

Brassica napus (Rape)

Taxonomic identifier

3708 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Brassica

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Peptide methionine sulfoxide reductase		PRO_0000138633
Natural variations
	Natural variant	4	1	I → L
	Natural variant	14	1	V → A
	Natural variant	24	1	A → S
	Natural variant	75	1	S → A
	Natural variant	129	1	T → S

Sequences

	Sequence		Length	Mass (Da)
	P54151-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 41F4440E41772788	FASTA	257	28,466
	10 20 30 40 50 60 MLSIVASPPV ISAVSLSKPL QSLAKAALSL SKRAKPTSPF PKTARSISVY KSPMNNLFTR 70 80 90 100 110 120 LGFGSRPQPD PAASSAIAQG PDDDVPSPGQ QFAQFGAGCF WGAELAYQRV PGVTKTEVGY 130 140 150 160 170 180 SHGFVDNPTY EDVCSETTGH NEIVRVQYDP KEVSFESLLD VFWKRHDPTT LNRQGNDVGT 190 200 210 220 230 240 RYRSGIYFYT DEQEKLAREA MEKQQKILNR KIVTEILPAT KFYRAENYHQ QYLAKGGRMG 250 LSQSAEKGCN DPIRCYG

References

[1]	"A seed-specific Brassica napus oleosin promoter interacts with a G-box-specific protein and may be bi-directional." Keddie J.S., Tsiantis M., Piffanelli P., Cella R., Hatzopoulos P., Murphy D.J. Plant Mol. Biol. 24:327-340(1994) [PubMed: 8111035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: cv. Jet neuf.
[2]	"Identification of a peptide methionine sulphoxide reductase gene in an oleosin promoter from Brassica napus." Sadanandom A.C., Piffanelli P., Knott T., Robinson C., Sharpe A., Lydiate D., Murphy D.J., Fairbairn D.J. Plant J. 10:235-242(1996) [PubMed: 8771781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-4; ALA-14; SER-24; ALA-75 AND SER-129. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94225 Genomic DNA. Translation: CAA63919.1. Z48619 mRNA. Translation: CAA88538.1. X91486 mRNA. Translation: CAA62760.1.
PIR	S55365. T47215.
3D structure databases
SMR	P54151. Positions 77-257.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.8.4.11. 393.
Family and domain databases
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_BRANA

Accession

Primary (citable) accession number: P54151

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)