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Protein

Mitochondrial peptide methionine sulfoxide reductase

Gene

MSRA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BRENDAi1.8.4.11. 908.
ReactomeiR-BTA-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial peptide methionine sulfoxide reductase (EC:1.8.4.11)
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Protein-methionine-S-oxide reductase
Gene namesi
Name:MSRA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2007622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionBy similarityAdd BLAST20
ChainiPRO_000013862521 – 233Mitochondrial peptide methionine sulfoxide reductaseAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-acetyllysine; alternateBy similarity1
Modified residuei104N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP54149.
PeptideAtlasiP54149.
PRIDEiP54149.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021632.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028825.

Chemistry databases

BindingDBiP54149.

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni31 – 33Combined sources3
Turni49 – 51Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi64 – 72Combined sources9
Helixi73 – 81Combined sources9
Beta strandi86 – 97Combined sources12
Helixi103 – 107Combined sources5
Beta strandi114 – 121Combined sources8
Turni123 – 125Combined sources3
Helixi128 – 137Combined sources10
Beta strandi144 – 147Combined sources4
Beta strandi150 – 152Combined sources3
Helixi153 – 155Combined sources3
Beta strandi157 – 159Combined sources3
Helixi164 – 183Combined sources20
Helixi204 – 206Combined sources3
Helixi209 – 212Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FVAX-ray1.70A/B13-229[»]
1FVGX-ray1.60A21-219[»]
ProteinModelPortaliP54149.
SMRiP54149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP54149.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1635. Eukaryota.
COG0225. LUCA.
GeneTreeiENSGT00390000003823.
HOVERGENiHBG006401.
InParanoidiP54149.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiEOG091G0MD8.
TreeFamiTF353884.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSATRRALQ LFHSLFPIPR MGDSAAKIVS PQEALPGRKE PLVVAAKHHV
60 70 80 90 100
NGNRTVEPFP EGTQMAVFGM GCFWGAERKF WTLKGVYSTQ VGFAGGYTPN
110 120 130 140 150
PTYKEVCSGK TGHAEVVRVV FQPEHISFEE LLKVFWENHD PTQGMRQGND
160 170 180 190 200
HGSQYRSAIY PTSAEHVGAA LKSKEDYQKV LSEHGFGLIT TDIREGQTFY
210 220 230
YAEDYHQQYL SKDPDGYCGL GGTGVSCPLG IKK
Length:233
Mass (Da):25,818
Last modified:May 30, 2006 - v2
Checksum:iDA09151E42FB6C08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → V in AAC48539 (PubMed:8700890).Curated1
Sequence conflicti125H → R in AAX09061 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37150 mRNA. Translation: AAC48539.1.
BT021044 mRNA. Translation: AAX09061.1.
BC102980 mRNA. Translation: AAI02981.1.
RefSeqiNP_776539.1. NM_174114.2.
UniGeneiBt.4655.

Genome annotation databases

EnsembliENSBTAT00000028825; ENSBTAP00000028825; ENSBTAG00000021632.
GeneIDi281312.
KEGGibta:281312.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37150 mRNA. Translation: AAC48539.1.
BT021044 mRNA. Translation: AAX09061.1.
BC102980 mRNA. Translation: AAI02981.1.
RefSeqiNP_776539.1. NM_174114.2.
UniGeneiBt.4655.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FVAX-ray1.70A/B13-229[»]
1FVGX-ray1.60A21-219[»]
ProteinModelPortaliP54149.
SMRiP54149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028825.

Chemistry databases

BindingDBiP54149.
ChEMBLiCHEMBL2007622.

Proteomic databases

PaxDbiP54149.
PeptideAtlasiP54149.
PRIDEiP54149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028825; ENSBTAP00000028825; ENSBTAG00000021632.
GeneIDi281312.
KEGGibta:281312.

Organism-specific databases

CTDi4482.

Phylogenomic databases

eggNOGiKOG1635. Eukaryota.
COG0225. LUCA.
GeneTreeiENSGT00390000003823.
HOVERGENiHBG006401.
InParanoidiP54149.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiEOG091G0MD8.
TreeFamiTF353884.

Enzyme and pathway databases

BRENDAi1.8.4.11. 908.
ReactomeiR-BTA-5676934. Protein repair.

Miscellaneous databases

EvolutionaryTraceiP54149.

Gene expression databases

BgeeiENSBTAG00000021632.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_BOVIN
AccessioniPrimary (citable) accession number: P54149
Secondary accession number(s): Q3ZC16, Q5E976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2006
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.