Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 9

Gene

Fgf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • cardiac left ventricle morphogenesis Source: DFLAT
  • cardiac ventricle development Source: DFLAT
  • cell-cell signaling Source: MGI
  • chondrocyte differentiation Source: MGI
  • embryonic digestive tract development Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • eye development Source: CACAO
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • inner ear morphogenesis Source: MGI
  • lung-associated mesenchyme development Source: MGI
  • lung development Source: MGI
  • male gonad development Source: MGI
  • male sex determination Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • osteoblast differentiation Source: MGI
  • positive regulation of activin receptor signaling pathway Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cardiac muscle cell proliferation Source: MGI
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of smoothened signaling pathway Source: MGI
  • positive regulation of transcription, DNA-templated Source: DFLAT
  • positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
  • positive regulation of vascular smooth muscle cell proliferation Source: Ensembl
  • protein import into nucleus Source: MGI
  • regulation of timing of cell differentiation Source: MGI
  • vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 9
Short name:
FGF-9
Alternative name(s):
Glia-activating factor
Short name:
GAF
HBGF-9
Gene namesi
Name:Fgf9
Synonyms:Fgf-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104723 Fgf9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000089751 – 3By similarity3
ChainiPRO_00000089764 – 208Fibroblast growth factor 9Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP54130
PRIDEiP54130

PTM databases

PhosphoSitePlusiP54130

Expressioni

Gene expression databases

BgeeiENSMUSG00000021974
CleanExiMM_FGF9
ExpressionAtlasiP54130 baseline and differential
GenevisibleiP54130 MM

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199654, 1 interactor
DIPiDIP-6032N
STRINGi10090.ENSMUSP00000022545

Structurei

3D structure databases

ProteinModelPortaliP54130
SMRiP54130
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP54130
KOiK04358
OMAiNLYKHGE
OrthoDBiEOG091G0NAY
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028251 FGF9
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF28 PTHR11486:SF28, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA
60 70 80 90 100
VTDLDHLKGI LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI
110 120 130 140 150
AVGLVSIRGV DSGLYLGMNE KGELYGSEKL TQECVFREQF EENWYNTYSS
160 170 180 190 200
NLYKHVDTGR RYYVALNKDG TPREGTRTKR HQKFTHFLPR PVDPDKVPEL

YKDILSQS
Length:208
Mass (Da):23,414
Last modified:October 3, 2012 - v2
Checksum:i4A3CE894DFF643EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34S → N in AAC52529 (PubMed:8576175).Curated1
Sequence conflicti34S → N in AAD49222 (PubMed:10474167).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33535 mRNA Translation: AAC52529.1
D38258 mRNA Translation: BAA07410.1
S82023 mRNA Translation: AAB36429.1
AF144626, AF144624, AF144625 Genomic DNA Translation: AAD49222.1
AK158782 mRNA Translation: BAE34661.1
AC125399 Genomic DNA No translation available.
AC154202 Genomic DNA No translation available.
CH466535 Genomic DNA Translation: EDL36153.1
BC099872 mRNA Translation: AAH99872.1
BC099873 mRNA Translation: AAH99873.1
BC099874 mRNA Translation: AAH99874.1
BC099875 mRNA Translation: AAH99875.1
BC125237 mRNA Translation: AAI25238.1
CCDSiCCDS27164.1
RefSeqiNP_038546.2, NM_013518.4
UniGeneiMm.8846

Genome annotation databases

EnsembliENSMUST00000022545; ENSMUSP00000022545; ENSMUSG00000021974
GeneIDi14180
KEGGimmu:14180
UCSCiuc007udx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFGF9_MOUSE
AccessioniPrimary (citable) accession number: P54130
Secondary accession number(s): Q499I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health