P54130 (FGF9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 9
Short name=FGF-9

Alternative name(s):
Glia-activating factor
Short name=GAF
HBGF-9

Gene names

Name:	Fgf9
Synonyms:	Fgf-9

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Subunit structure	Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Secreted
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from direct assay PubMed 16778080. Source: MGI cardiac left ventricle morphogenesis Traceable author statement PubMed 20299672. Source: DFLAT cell-cell signaling Inferred from mutant phenotype PubMed 15328018. Source: MGI chondrocyte differentiation Inferred from mutant phenotype PubMed 17544391. Source: MGI embryonic digestive tract development Inferred from mutant phenotype PubMed 16308329. Source: MGI embryonic limb morphogenesis Inferred from mutant phenotype PubMed 17576930. Source: MGI embryonic skeletal system development Inferred from mutant phenotype PubMed 17544391. Source: MGI fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 15229180PubMed 16308329. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 15328018. Source: MGI lung-associated mesenchyme development Inferred from mutant phenotype PubMed 18533146. Source: MGI male gonad development Inferred from mutant phenotype PubMed 15229180PubMed 16540514. Source: MGI male sex determination Inferred from mutant phenotype PubMed 16700629. Source: MGI negative regulation of Wnt receptor signaling pathway Inferred from genetic interaction PubMed 16700629. Source: MGI osteoblast differentiation Inferred from mutant phenotype PubMed 17544391. Source: MGI positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 18533146. Source: MGI positive regulation of cardiac muscle cell proliferation Traceable author statement PubMed 20299672. Source: DFLAT positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of epithelial cell proliferation Inferred from direct assay PubMed 16308329PubMed 16540513. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from direct assay PubMed 16308329PubMed 16540513PubMed 18231602. Source: MGI positive regulation of smoothened signaling pathway Inferred from direct assay PubMed 16540513. Source: MGI positive regulation of transcription, DNA-dependent Traceable author statement PubMed 20299672. Source: DFLAT positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 17544391. Source: MGI protein import into nucleus Inferred from mutant phenotype PubMed 15229180. Source: MGI regulation of timing of cell differentiation Inferred from mutant phenotype PubMed 17544391. Source: MGI vasculogenesis involved in coronary vascular morphogenesis Traceable author statement PubMed 20299672. Source: DFLAT
Cellular_component	basement membrane Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 3	3	By similarity		PRO_0000008975
	Chain	4 – 208	205	Fibroblast growth factor 9		PRO_0000008976
Amino acid modifications
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	34	1	S → N in AAC52529. Ref.1
	Sequence conflict	34	1	S → N in AAD49222. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P54130 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 4A3CE894DFF643EB	FASTA	208	23,414
	10 20 30 40 50 60 MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 70 80 90 100 110 120 LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 130 140 150 160 170 180 KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 190 200 HQKFTHFLPR PVDPDKVPEL YKDILSQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and biological activity of mouse fibroblast growth factor-9." Santos-Ocampo S., Colvin J.S., Chellaiah A.T., Ornitz D.M. J. Biol. Chem. 271:1726-1731(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: FVB.
[2]	"Retinoic acid induces gene expression of fibroblast growth factor-9 during induction of neuronal differentiation of mouse embryonal carcinoma P19 cells." Seo M., Noguchi K. FEBS Lett. 370:231-235(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4." Hecht D., Zimmerman N., Bedford M., Avivi A., Yayon A. Growth Factors 12:223-233(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene." Colvin J.S., Feldman B., Nadeau J.H., Goldfarb M., Ornitz D.M. Dev. Dyn. 216:72-88(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Visual cortex.
[6]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[7]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33535 mRNA. Translation: AAC52529.1. D38258 mRNA. Translation: BAA07410.1. S82023 mRNA. Translation: AAB36429.1. AF144626, AF144624, AF144625 Genomic DNA. Translation: AAD49222.1. AK158782 mRNA. Translation: BAE34661.1. AC125399 Genomic DNA. No translation available. AC154202 Genomic DNA. No translation available. CH466535 Genomic DNA. Translation: EDL36153.1. BC099872 mRNA. Translation: AAH99872.1. BC099873 mRNA. Translation: AAH99873.1. BC099874 mRNA. Translation: AAH99874.1. BC099875 mRNA. Translation: AAH99875.1. BC125237 mRNA. Translation: AAI25238.1.
IPI	IPI00132271. IPI00775813.
RefSeq	NP_038546.2. NM_013518.4.
UniGene	Mm.8846.
3D structure databases
ProteinModelPortal	P54130.
SMR	P54130. Positions 52-208.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6032N.
PTM databases
PhosphoSite	P54130.
Proteomic databases
PRIDE	P54130.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022545; ENSMUSP00000022545; ENSMUSG00000021974.
GeneID	14180.
KEGG	mmu:14180.
Organism-specific databases
CTD	2254.
MGI	MGI:104723. Fgf9.
Phylogenomic databases
eggNOG	NOG269410.
GeneTree	ENSGT00700000104323.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	P54130.
KO	K04358.
OMA	GTKSRRH.
OrthoDB	EOG46WZ9V.
Gene expression databases
CleanEx	MM_FGF9.
Genevestigator	P54130.
GermOnline	ENSMUSG00000021974. Mus musculus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285370.
SOURCE	Search...

Entry information

Entry name

FGF9_MOUSE

Accession

Primary (citable) accession number: P54130
Secondary accession number(s): Q499I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program