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P54130 (FGF9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 9

Short name=FGF-9
Alternative name(s):
Glia-activating factor
Short name=GAF
HBGF-9
Gene names
Name:Fgf9
Synonyms:Fgf-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Subunit structure

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentSecreted
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from direct assay PubMed 16778080. Source: MGI

cardiac left ventricle morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

cardiac ventricle development

Traceable author statement PubMed 20299672. Source: DFLAT

cell-cell signaling

Inferred from mutant phenotype PubMed 15328018. Source: MGI

chondrocyte differentiation

Inferred from mutant phenotype PubMed 17544391. Source: MGI

embryonic digestive tract development

Inferred from mutant phenotype PubMed 16308329. Source: MGI

embryonic limb morphogenesis

Inferred from mutant phenotype PubMed 17576930. Source: MGI

embryonic skeletal system development

Inferred from mutant phenotype PubMed 17544391. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 15229180PubMed 16308329. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 15328018. Source: MGI

lung development

Inferred from direct assay PubMed 16540513. Source: MGI

lung-associated mesenchyme development

Inferred from mutant phenotype PubMed 18533146. Source: MGI

male gonad development

Inferred from mutant phenotype PubMed 15229180PubMed 16540514. Source: MGI

male sex determination

Inferred from mutant phenotype PubMed 16700629. Source: MGI

negative regulation of Wnt signaling pathway

Inferred from genetic interaction PubMed 16700629. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 16308329. Source: MGI

osteoblast differentiation

Inferred from mutant phenotype PubMed 17544391. Source: MGI

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 18533146. Source: MGI

positive regulation of cardiac muscle cell proliferation

Traceable author statement PubMed 20299672. Source: DFLAT

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from direct assay PubMed 16185683. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 16308329PubMed 16540513. Source: MGI

positive regulation of gene expression

Inferred from direct assay PubMed 9847236. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from direct assay PubMed 16308329PubMed 16540513PubMed 18231602. Source: MGI

positive regulation of smoothened signaling pathway

Inferred from direct assay PubMed 16540513. Source: MGI

positive regulation of transcription, DNA-templated

Traceable author statement PubMed 20299672. Source: DFLAT

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 17544391. Source: MGI

protein import into nucleus

Inferred from mutant phenotype PubMed 15229180. Source: MGI

regulation of timing of cell differentiation

Inferred from mutant phenotype PubMed 17544391. Source: MGI

vasculogenesis involved in coronary vascular morphogenesis

Traceable author statement PubMed 20299672. Source: DFLAT

   Cellular_componentbasement membrane

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 33 By similarity
PRO_0000008975
Chain4 – 208205Fibroblast growth factor 9
PRO_0000008976

Amino acid modifications

Glycosylation791N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict341S → N in AAC52529. Ref.1
Sequence conflict341S → N in AAD49222. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P54130 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 4A3CE894DFF643EB

FASTA20823,414
        10         20         30         40         50         60 
MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA VTDLDHLKGI 

        70         80         90        100        110        120 
LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE 

       130        140        150        160        170        180 
KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RYYVALNKDG TPREGTRTKR 

       190        200 
HQKFTHFLPR PVDPDKVPEL YKDILSQS 

« Hide

References

« Hide 'large scale' references
[1]"Expression and biological activity of mouse fibroblast growth factor-9."
Santos-Ocampo S., Colvin J.S., Chellaiah A.T., Ornitz D.M.
J. Biol. Chem. 271:1726-1731(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB.
[2]"Retinoic acid induces gene expression of fibroblast growth factor-9 during induction of neuronal differentiation of mouse embryonal carcinoma P19 cells."
Seo M., Noguchi K.
FEBS Lett. 370:231-235(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4."
Hecht D., Zimmerman N., Bedford M., Avivi A., Yayon A.
Growth Factors 12:223-233(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene."
Colvin J.S., Feldman B., Nadeau J.H., Goldfarb M., Ornitz D.M.
Dev. Dyn. 216:72-88(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Visual cortex.
[6]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[7]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33535 mRNA. Translation: AAC52529.1.
D38258 mRNA. Translation: BAA07410.1.
S82023 mRNA. Translation: AAB36429.1.
AF144626, AF144624, AF144625 Genomic DNA. Translation: AAD49222.1.
AK158782 mRNA. Translation: BAE34661.1.
AC125399 Genomic DNA. No translation available.
AC154202 Genomic DNA. No translation available.
CH466535 Genomic DNA. Translation: EDL36153.1.
BC099872 mRNA. Translation: AAH99872.1.
BC099873 mRNA. Translation: AAH99873.1.
BC099874 mRNA. Translation: AAH99874.1.
BC099875 mRNA. Translation: AAH99875.1.
BC125237 mRNA. Translation: AAI25238.1.
CCDSCCDS27164.1.
RefSeqNP_038546.2. NM_013518.4.
UniGeneMm.8846.

3D structure databases

ProteinModelPortalP54130.
SMRP54130. Positions 52-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6032N.

PTM databases

PhosphoSiteP54130.

Proteomic databases

PRIDEP54130.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022545; ENSMUSP00000022545; ENSMUSG00000021974.
GeneID14180.
KEGGmmu:14180.
UCSCuc007udx.2. mouse.

Organism-specific databases

CTD2254.
MGIMGI:104723. Fgf9.

Phylogenomic databases

eggNOGNOG269410.
GeneTreeENSGT00730000110261.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP54130.
KOK04358.
OMAGELYGSD.
OrthoDBEOG7992S1.
TreeFamTF317805.

Gene expression databases

ArrayExpressP54130.
CleanExMM_FGF9.
GenevestigatorP54130.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028251. FGF9.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF28. PTHR11486:SF28. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285370.
PROP54130.
SOURCESearch...

Entry information

Entry nameFGF9_MOUSE
AccessionPrimary (citable) accession number: P54130
Secondary accession number(s): Q499I9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot