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P54130

- FGF9_MOUSE

UniProt

P54130 - FGF9_MOUSE

Protein

Fibroblast growth factor 9

Gene

Fgf9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. cardiac left ventricle morphogenesis Source: DFLAT
    3. cardiac ventricle development Source: DFLAT
    4. cell-cell signaling Source: MGI
    5. chondrocyte differentiation Source: MGI
    6. embryonic digestive tract development Source: MGI
    7. embryonic limb morphogenesis Source: MGI
    8. embryonic skeletal system development Source: MGI
    9. fibroblast growth factor receptor signaling pathway Source: MGI
    10. inner ear morphogenesis Source: MGI
    11. lung-associated mesenchyme development Source: MGI
    12. lung development Source: MGI
    13. male gonad development Source: MGI
    14. male sex determination Source: MGI
    15. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    16. negative regulation of Wnt signaling pathway Source: MGI
    17. osteoblast differentiation Source: MGI
    18. positive regulation of canonical Wnt signaling pathway Source: MGI
    19. positive regulation of cardiac muscle cell proliferation Source: DFLAT
    20. positive regulation of cell division Source: UniProtKB-KW
    21. positive regulation of cell proliferation Source: MGI
    22. positive regulation of epithelial cell proliferation Source: MGI
    23. positive regulation of gene expression Source: MGI
    24. positive regulation of MAPK cascade Source: Ensembl
    25. positive regulation of mesenchymal cell proliferation Source: MGI
    26. positive regulation of smoothened signaling pathway Source: MGI
    27. positive regulation of transcription, DNA-templated Source: DFLAT
    28. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
    29. protein import into nucleus Source: MGI
    30. regulation of timing of cell differentiation Source: MGI
    31. vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_213224. FGFR3b ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 9
    Short name:
    FGF-9
    Alternative name(s):
    Glia-activating factor
    Short name:
    GAF
    HBGF-9
    Gene namesi
    Name:Fgf9
    Synonyms:Fgf-9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:104723. Fgf9.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 33By similarityPRO_0000008975
    Chaini4 – 208205Fibroblast growth factor 9PRO_0000008976Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP54130.

    PTM databases

    PhosphoSiteiP54130.

    Expressioni

    Gene expression databases

    ArrayExpressiP54130.
    CleanExiMM_FGF9.
    GenevestigatoriP54130.

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-6032N.

    Structurei

    3D structure databases

    ProteinModelPortaliP54130.
    SMRiP54130. Positions 52-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG269410.
    GeneTreeiENSGT00730000110261.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP54130.
    KOiK04358.
    OMAiGELYGSD.
    OrthoDBiEOG7992S1.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028251. FGF9.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF28. PTHR11486:SF28. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54130-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPLGEVGSY FGVQDAVPFG NVPVLPVDSP VLLSDHLGQS EAGGLPRGPA    50
    VTDLDHLKGI LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI 100
    AVGLVSIRGV DSGLYLGMNE KGELYGSEKL TQECVFREQF EENWYNTYSS 150
    NLYKHVDTGR RYYVALNKDG TPREGTRTKR HQKFTHFLPR PVDPDKVPEL 200
    YKDILSQS 208
    Length:208
    Mass (Da):23,414
    Last modified:October 3, 2012 - v2
    Checksum:i4A3CE894DFF643EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341S → N in AAC52529. (PubMed:8576175)Curated
    Sequence conflicti34 – 341S → N in AAD49222. (PubMed:10474167)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33535 mRNA. Translation: AAC52529.1.
    D38258 mRNA. Translation: BAA07410.1.
    S82023 mRNA. Translation: AAB36429.1.
    AF144626, AF144624, AF144625 Genomic DNA. Translation: AAD49222.1.
    AK158782 mRNA. Translation: BAE34661.1.
    AC125399 Genomic DNA. No translation available.
    AC154202 Genomic DNA. No translation available.
    CH466535 Genomic DNA. Translation: EDL36153.1.
    BC099872 mRNA. Translation: AAH99872.1.
    BC099873 mRNA. Translation: AAH99873.1.
    BC099874 mRNA. Translation: AAH99874.1.
    BC099875 mRNA. Translation: AAH99875.1.
    BC125237 mRNA. Translation: AAI25238.1.
    CCDSiCCDS27164.1.
    RefSeqiNP_038546.2. NM_013518.4.
    UniGeneiMm.8846.

    Genome annotation databases

    EnsembliENSMUST00000022545; ENSMUSP00000022545; ENSMUSG00000021974.
    GeneIDi14180.
    KEGGimmu:14180.
    UCSCiuc007udx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33535 mRNA. Translation: AAC52529.1 .
    D38258 mRNA. Translation: BAA07410.1 .
    S82023 mRNA. Translation: AAB36429.1 .
    AF144626 , AF144624 , AF144625 Genomic DNA. Translation: AAD49222.1 .
    AK158782 mRNA. Translation: BAE34661.1 .
    AC125399 Genomic DNA. No translation available.
    AC154202 Genomic DNA. No translation available.
    CH466535 Genomic DNA. Translation: EDL36153.1 .
    BC099872 mRNA. Translation: AAH99872.1 .
    BC099873 mRNA. Translation: AAH99873.1 .
    BC099874 mRNA. Translation: AAH99874.1 .
    BC099875 mRNA. Translation: AAH99875.1 .
    BC125237 mRNA. Translation: AAI25238.1 .
    CCDSi CCDS27164.1.
    RefSeqi NP_038546.2. NM_013518.4.
    UniGenei Mm.8846.

    3D structure databases

    ProteinModelPortali P54130.
    SMRi P54130. Positions 52-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6032N.

    PTM databases

    PhosphoSitei P54130.

    Proteomic databases

    PRIDEi P54130.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022545 ; ENSMUSP00000022545 ; ENSMUSG00000021974 .
    GeneIDi 14180.
    KEGGi mmu:14180.
    UCSCi uc007udx.2. mouse.

    Organism-specific databases

    CTDi 2254.
    MGIi MGI:104723. Fgf9.

    Phylogenomic databases

    eggNOGi NOG269410.
    GeneTreei ENSGT00730000110261.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P54130.
    KOi K04358.
    OMAi GELYGSD.
    OrthoDBi EOG7992S1.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_213224. FGFR3b ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285370.
    PROi P54130.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P54130.
    CleanExi MM_FGF9.
    Genevestigatori P54130.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028251. FGF9.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF28. PTHR11486:SF28. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and biological activity of mouse fibroblast growth factor-9."
      Santos-Ocampo S., Colvin J.S., Chellaiah A.T., Ornitz D.M.
      J. Biol. Chem. 271:1726-1731(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB.
    2. "Retinoic acid induces gene expression of fibroblast growth factor-9 during induction of neuronal differentiation of mouse embryonal carcinoma P19 cells."
      Seo M., Noguchi K.
      FEBS Lett. 370:231-235(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4."
      Hecht D., Zimmerman N., Bedford M., Avivi A., Yayon A.
      Growth Factors 12:223-233(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene."
      Colvin J.S., Feldman B., Nadeau J.H., Goldfarb M., Ornitz D.M.
      Dev. Dyn. 216:72-88(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Visual cortex.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiFGF9_MOUSE
    AccessioniPrimary (citable) accession number: P54130
    Secondary accession number(s): Q499I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3