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P54119 (CDK1_AJECA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 1

Short name=CDK1
EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cell division protein kinase 1
Gene names
Name:CDC2
Synonyms:CDK1
OrganismAjellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifier5037 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeAjellomyces

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-181 activates it By similarity.

Subunit structure

Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Cyclin-dependent kinase 1
PRO_0000085718

Regions

Domain4 – 307304Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1481Proton acceptor By similarity
Binding site341ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1811Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
P54119 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 3B80A7F5BD4E748B

FASTA32436,824
        10         20         30         40         50         60 
MENYQKIEKI GEGTYGVVYK ARDLTHPNRI VALKKIRLEA EDEGVPSTAI REISLLKEMH 

        70         80         90        100        110        120 
DPNIVRLLNI VHADGHKLYL VFEFLDLDLK KYMEALPVSE GGRGKALPDG STLDMNRLGL 

       130        140        150        160        170        180 
GEAMVKKFMA QLVEGIRYCH SHRVLHRDLK PQNLLIDREG NLKLADFGLA RAFGVPLRTY 

       190        200        210        220        230        240 
THEVVTLWYR APEILLGGRQ YSTGVDMWSV GAIFAEMCTR KPLFPGDSEI DEIFKIFKLL 

       250        260        270        280        290        300 
GTPDENTWPG VTSFPDFKAS FPKWKREDTR KLVPGLERNG LDLLDAMLEY DPARRISAKQ 

       310        320 
ACMHPYFQAG SSAYSGRERL QPYP 

« Hide

References

[1]"The Histoplasma capsulatum cdc2 gene is transcriptionally regulated during the morphologic transition."
di Lallo G., Gargano S., Maresca B.
Gene 140:51-57(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 26032 / G217B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X74361 Genomic DNA. Translation: CAA52405.1.
PIRS36437.

3D structure databases

ProteinModelPortalP54119.
SMRP54119. Positions 1-308.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP54119.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.11.22. 221.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK1_AJECA
AccessionPrimary (citable) accession number: P54119
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families