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Protein

Aldehyde dehydrogenase [NAD(P)+] 2

Gene

ALD3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Involved in pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei169 – 1691Transition state stabilizerBy similarity
Active sitei268 – 2681Proton acceptorPROSITE-ProRule annotation
Active sitei302 – 3021NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: SGD

GO - Biological processi

  • beta-alanine biosynthetic process Source: SGD
  • pantothenate biosynthetic process Source: UniProtKB-KW
  • polyamine catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13668.
YEAST:YMR169C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase [NAD(P)+] 2 (EC:1.2.1.3)
Gene namesi
Name:ALD3
Synonyms:ALD4
Ordered Locus Names:YMR169C
ORF Names:YM8520.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XIII

Organism-specific databases

CYGDiYMR169c.
EuPathDBiFungiDB:YMR169C.
SGDiS000004779. ALD3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Aldehyde dehydrogenase [NAD(P)+] 2PRO_0000056440Add
BLAST

Proteomic databases

MaxQBiP54114.
PaxDbiP54114.
PeptideAtlasiP54114.

Expressioni

Inductioni

Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi35347. 14 interactions.
MINTiMINT-2781729.

Structurei

3D structure databases

ProteinModelPortaliP54114.
SMRiP54114. Positions 23-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00800000124121.
HOGENOMiHOG000271505.
InParanoidiP54114.
KOiK00129.
OMAiRKVCFTG.
OrthoDBiEOG7S226Z.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
60 70 80 90 100
SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
110 120 130 140 150
LAALETLDAG KPFHSNAKQD LAQIIELTRY YAGAVDKFNM GETIPLTFNK
160 170 180 190 200
FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ GALAAGNTVI IKPAENTSLS
210 220 230 240 250
LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK ISFTGSTKVG
260 270 280 290 300
GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ
310 320 330 340 350
ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
360 370 380 390 400
STQYDRIKSY IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS
410 420 430 440 450
KLLRDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
460 470 480 490 500
RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI GRESGDTGVD NYLQIKSVHV

DLSLDK
Length:506
Mass (Da):55,385
Last modified:October 1, 1996 - v1
Checksum:i11687E520B7E97DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89805.1.
BK006946 Genomic DNA. Translation: DAA10065.1.
PIRiS54527.
RefSeqiNP_013892.1. NM_001182673.1.

Genome annotation databases

EnsemblFungiiYMR169C; YMR169C; YMR169C.
GeneIDi855205.
KEGGisce:YMR169C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89805.1.
BK006946 Genomic DNA. Translation: DAA10065.1.
PIRiS54527.
RefSeqiNP_013892.1. NM_001182673.1.

3D structure databases

ProteinModelPortaliP54114.
SMRiP54114. Positions 23-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35347. 14 interactions.
MINTiMINT-2781729.

Proteomic databases

MaxQBiP54114.
PaxDbiP54114.
PeptideAtlasiP54114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR169C; YMR169C; YMR169C.
GeneIDi855205.
KEGGisce:YMR169C.

Organism-specific databases

CYGDiYMR169c.
EuPathDBiFungiDB:YMR169C.
SGDiS000004779. ALD3.

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00800000124121.
HOGENOMiHOG000271505.
InParanoidiP54114.
KOiK00129.
OMAiRKVCFTG.
OrthoDBiEOG7S226Z.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13668.
YEAST:YMR169C-MONOMER.

Miscellaneous databases

NextBioi978699.
PROiP54114.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes."
    Navarro-Avino J.P., Prasad R., Miralles V.J., Benito R.M., Serrano R.
    Yeast 15:829-842(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, INDUCTION.
  4. "Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae."
    White W.H., Skatrud P.L., Xue Z., Toyn J.H.
    Genetics 163:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiALDH3_YEAST
AccessioniPrimary (citable) accession number: P54114
Secondary accession number(s): D6VZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.