Reviewed, UniProtKB/Swiss-Prot P54114 (ALDH3_YEAST)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase [NAD(P)+] 2
    EC=1.2.1.5

Gene names

Name:	ALD3
Synonyms:	ALD4
Ordered Locus Names:	YMR169C
ORF Names:	YM8520.18C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.
Miscellaneous	Present with 172 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	beta-alanine biosynthetic process Inferred from mutant phenotype. Source: SGD oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW polyamine catabolic process Inferred from genetic interaction. Source: SGD response to stress Inferred from expression pattern. Source: SGD
Molecular function	aldehyde dehydrogenase (NAD) activity Ref.2 Inferred from direct assay. Source: SGD aldehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Aldehyde dehydrogenase [NAD(P)+] 2		PRO_0000056440
Sites
	Active site	268	1	Proton acceptor By similarity
	Active site	302	1	Nucleophile By similarity
	Site	169	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54114-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 11687E520B7E97DD	FASTA	506	55,385
	10 20 30 40 50 60 MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT SFQAANEKDV 70 80 90 100 110 120 DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT LAALETLDAG KPFHSNAKQD 130 140 150 160 170 180 LAQIIELTRY YAGAVDKFNM GETIPLTFNK FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ 190 200 210 220 230 240 GALAAGNTVI IKPAENTSLS LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK 250 260 270 280 290 300 ISFTGSTKVG GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ 310 320 330 340 350 360 ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS STQYDRIKSY 370 380 390 400 410 420 IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS KLLRDEIFGP VVVVSKFTNY 430 440 450 460 470 480 DDALKLANDT CYGLASAVFT KDVKKAHMFA RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI 490 500 GRESGDTGVD NYLQIKSVHV DLSLDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. , Skelton J., Walsh S.V., Whitehead S., Barrell B.G. Nature 387:90-93(1997) [PubMed: 9169872] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes." Navarro-Avino J.P., Prasad R., Miralles V.J., Benito R.M., Serrano R. Yeast 15:829-842(1999) [PubMed: 10407263] [Abstract] Cited for: CHARACTERIZATION.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z49705 Genomic DNA. Translation: CAA89805.1.
PIR	S54527.
RefSeq	NP_013892.1.
3D structure databases
HSSP	HSSP built from PDB template 1O9J based on UniProtKB Q28399.
ModBase	Search...
Proteomic databases
PeptideAtlas	P54114.
Genome annotation databases
Ensembl	YMR169C. Saccharomyces cerevisiae. [Contig view]
GeneID	855205.
GenomeReviews	Gene locus YMR169C in contig Z71257_GR.
KEGG	sce:YMR169C.
NMPDR	fig|4932.3.peg.4942.
Organism-specific databases
CYGD	YMR169c.
SGD	S000004779. ALD3.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P54114.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-13668.
Gene expression databases
ArrayExpress	P54114.
GermOnline	YMR169C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P54114.
NextBio	978699.

Entry information

Entry name

ALDH3_YEAST

Accession

Primary (citable) accession number: P54114

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)