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P54114

- ALDH3_YEAST

UniProt

P54114 - ALDH3_YEAST

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Protein
Aldehyde dehydrogenase [NAD(P)+] 2
Gene
ALD3, ALD4, YMR169C, YM8520.18C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Involved in pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei169 – 1691Transition state stabilizer By similarity
Active sitei268 – 2681Proton acceptor By similarity
Active sitei302 – 3021Nucleophile By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: SGD

GO - Biological processi

  1. beta-alanine biosynthetic process Source: SGD
  2. pantothenate biosynthetic process Source: UniProtKB-KW
  3. polyamine catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13668.
YEAST:YMR169C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase [NAD(P)+] 2 (EC:1.2.1.3)
Gene namesi
Name:ALD3
Synonyms:ALD4
Ordered Locus Names:YMR169C
ORF Names:YM8520.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR169c.
SGDiS000004779. ALD3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Aldehyde dehydrogenase [NAD(P)+] 2
PRO_0000056440Add
BLAST

Proteomic databases

MaxQBiP54114.
PaxDbiP54114.
PeptideAtlasiP54114.

Expressioni

Inductioni

Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.1 Publication

Gene expression databases

GenevestigatoriP54114.

Interactioni

Protein-protein interaction databases

BioGridi35347. 13 interactions.
MINTiMINT-2781729.
STRINGi4932.YMR169C.

Structurei

3D structure databases

ProteinModelPortaliP54114.
SMRiP54114. Positions 23-492.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00740000115630.
HOGENOMiHOG000271505.
KOiK00129.
OMAiEVGTRIM.
OrthoDBiEOG7S226Z.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54114-1 [UniParc]FASTAAdd to Basket

« Hide

MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT    50
SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT 100
LAALETLDAG KPFHSNAKQD LAQIIELTRY YAGAVDKFNM GETIPLTFNK 150
FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ GALAAGNTVI IKPAENTSLS 200
LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK ISFTGSTKVG 250
GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ 300
ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS 350
STQYDRIKSY IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS 400
KLLRDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA 450
RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI GRESGDTGVD NYLQIKSVHV 500
DLSLDK 506
Length:506
Mass (Da):55,385
Last modified:October 1, 1996 - v1
Checksum:i11687E520B7E97DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49705 Genomic DNA. Translation: CAA89805.1.
BK006946 Genomic DNA. Translation: DAA10065.1.
PIRiS54527.
RefSeqiNP_013892.1. NM_001182673.1.

Genome annotation databases

EnsemblFungiiYMR169C; YMR169C; YMR169C.
GeneIDi855205.
KEGGisce:YMR169C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49705 Genomic DNA. Translation: CAA89805.1 .
BK006946 Genomic DNA. Translation: DAA10065.1 .
PIRi S54527.
RefSeqi NP_013892.1. NM_001182673.1.

3D structure databases

ProteinModelPortali P54114.
SMRi P54114. Positions 23-492.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35347. 13 interactions.
MINTi MINT-2781729.
STRINGi 4932.YMR169C.

Proteomic databases

MaxQBi P54114.
PaxDbi P54114.
PeptideAtlasi P54114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR169C ; YMR169C ; YMR169C .
GeneIDi 855205.
KEGGi sce:YMR169C.

Organism-specific databases

CYGDi YMR169c.
SGDi S000004779. ALD3.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00740000115630.
HOGENOMi HOG000271505.
KOi K00129.
OMAi EVGTRIM.
OrthoDBi EOG7S226Z.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-13668.
YEAST:YMR169C-MONOMER.

Miscellaneous databases

NextBioi 978699.

Gene expression databases

Genevestigatori P54114.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes."
    Navarro-Avino J.P., Prasad R., Miralles V.J., Benito R.M., Serrano R.
    Yeast 15:829-842(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, INDUCTION.
  4. "Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae."
    White W.H., Skatrud P.L., Xue Z., Toyn J.H.
    Genetics 163:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiALDH3_YEAST
AccessioniPrimary (citable) accession number: P54114
Secondary accession number(s): D6VZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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