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Protein

Aldehyde dehydrogenase [NAD(P)+] 2

Gene

ALD3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic aldehyde dehydrogenase involved in ethanol oxidation. Involved in pantothenic acid production through the conversion of 3-aminopropanal to beta-alanine, an intermediate in pantothenic acid (vitamin B5) and coenzyme A (CoA) biosynthesis.1 Publication

Miscellaneous

Present with 172 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei169Transition state stabilizerBy similarity1
Active sitei268Proton acceptorPROSITE-ProRule annotation1
Active sitei302NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: SGD

GO - Biological processi

  • beta-alanine biosynthetic process Source: SGD
  • pantothenate biosynthetic process Source: UniProtKB-KW
  • polyamine catabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyciMetaCyc:YMR169C-MONOMER
YEAST:YMR169C-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase [NAD(P)+] 2 (EC:1.2.1.3)
Gene namesi
Name:ALD3
Synonyms:ALD4
Ordered Locus Names:YMR169C
ORF Names:YM8520.18C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR169C
SGDiS000004779 ALD3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564401 – 506Aldehyde dehydrogenase [NAD(P)+] 2Add BLAST506

Proteomic databases

MaxQBiP54114
PaxDbiP54114
PRIDEiP54114

PTM databases

iPTMnetiP54114

Expressioni

Inductioni

Expression is under the control of MSN2 and MSN4, and is induced during diauxic shift and osmotic stress.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi35347, 42 interactors
MINTiP54114
STRINGi4932.YMR169C

Structurei

3D structure databases

ProteinModelPortaliP54114
SMRiP54114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

GeneTreeiENSGT00910000145185
HOGENOMiHOG000271505
InParanoidiP54114
KOiK00129
OMAiIEQRDCG
OrthoDBiEOG092C1LLH

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P54114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
60 70 80 90 100
SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
110 120 130 140 150
LAALETLDAG KPFHSNAKQD LAQIIELTRY YAGAVDKFNM GETIPLTFNK
160 170 180 190 200
FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ GALAAGNTVI IKPAENTSLS
210 220 230 240 250
LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK ISFTGSTKVG
260 270 280 290 300
GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ
310 320 330 340 350
ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
360 370 380 390 400
STQYDRIKSY IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS
410 420 430 440 450
KLLRDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
460 470 480 490 500
RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI GRESGDTGVD NYLQIKSVHV

DLSLDK
Length:506
Mass (Da):55,385
Last modified:October 1, 1996 - v1
Checksum:i11687E520B7E97DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA Translation: CAA89805.1
BK006946 Genomic DNA Translation: DAA10065.1
PIRiS54527
RefSeqiNP_013892.1, NM_001182673.1

Genome annotation databases

EnsemblFungiiYMR169C; YMR169C; YMR169C
GeneIDi855205
KEGGisce:YMR169C

Similar proteinsi

Entry informationi

Entry nameiALDH3_YEAST
AccessioniPrimary (citable) accession number: P54114
Secondary accession number(s): D6VZZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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