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P54108 (CRIS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich secretory protein 3

Short name=CRISP-3
Alternative name(s):
Specific granule protein of 28 kDa
Short name=SGP28
Gene names
Name:CRISP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with A1BG. Ref.7

Subcellular location

Secreted. Note: In neutrophils, localized in specific granules.

Tissue specificity

Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.

Sequence similarities

Belongs to the CRISP family.

Contains 1 SCP domain.

Contains 1 ShKT domain.

Sequence caution

The sequence AAH69580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH69602.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAG36185.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA63984.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA64527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P54108-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P54108-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTAM
Isoform 3 (identifier: P54108-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTDPCSTGFVFPAM

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 245225Cysteine-rich secretory protein 3
PRO_0000006268

Regions

Domain43 – 171129SCP
Domain207 – 24034ShKT

Amino acid modifications

Glycosylation2391N-linked (GlcNAc...) Potential
Disulfide bond191 ↔ 198 By similarity
Disulfide bond194 ↔ 203 By similarity
Disulfide bond207 ↔ 240 By similarity
Disulfide bond216 ↔ 234 By similarity
Disulfide bond225 ↔ 238 By similarity

Natural variations

Alternative sequence11M → MKQILHPALETTAM in isoform 2.
VSP_042758
Alternative sequence11M → MKQILHPALETTDPCSTGFV FPAM in isoform 3.
VSP_042759
Natural variant1061S → P. Ref.2 Ref.5
Corresponds to variant rs495335 [ dbSNP | Ensembl ].
VAR_011718
Natural variant1341A → S. Ref.2
Corresponds to variant rs1864312 [ dbSNP | Ensembl ].
VAR_011719

Experimental info

Sequence conflict791Q → R in BAF85475. Ref.2
Sequence conflict1301K → R in BAD97100. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: B4DD79CB7AE9E5F9

FASTA24527,630
        10         20         30         40         50         60 
MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR RAVSPPARNM 

        70         80         90        100        110        120 
LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL YMSSASSSWS QAIQSWFDEY 

       130        140        150        160        170        180 
NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR 

       190        200        210        220        230        240 
LYVPYEQGAP CASCPDNCDD GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC 


SNSIY 

« Hide

Isoform 2 [UniParc].

Checksum: 4371D621491B8427
Show »

FASTA25829,065
Isoform 3 [UniParc].

Checksum: 4DA3F68D69A9953D
Show »

FASTA26830,116

References

« Hide 'large scale' references
[1]"SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein."
Kjeldsen L., Cowland J.B., Johnson A.H., Borregaard N.
FEBS Lett. 380:246-250(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-155 (ISOFORM 3), VARIANTS PRO-106 AND SER-134.
Tissue: Trachea.
[3]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Gastric mucosa.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-106.
Tissue: Placenta.
[6]"The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3."
Kraetzschmar J., Haendler B., Eberspaecher U., Roostermann D., Donner P., Schleuning W.-D.
Eur. J. Biochem. 236:827-836(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[7]"Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma."
Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L.
Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH A1BG.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94323 mRNA. Translation: CAA63984.1. Different initiation.
AK292786 mRNA. Translation: BAF85475.1.
AK313387 mRNA. Translation: BAG36185.1. Different initiation.
DB205467 mRNA. No translation available.
AK223380 mRNA. Translation: BAD97100.1.
AL121974, AL121950 Genomic DNA. Translation: CAI20517.1.
AL121950, AL121974 Genomic DNA. Translation: CAI20995.1.
BC069580 mRNA. Translation: AAH69580.1. Different initiation.
BC069602 mRNA. Translation: AAH69602.1. Different initiation.
BC101539 mRNA. Translation: AAI01540.1.
X95240 mRNA. Translation: CAA64527.1. Different initiation.
CCDSCCDS4929.2. [P54108-2]
CCDS55019.1. [P54108-3]
PIRS68691.
RefSeqNP_001177915.1. NM_001190986.1. [P54108-3]
NP_006052.2. NM_006061.2. [P54108-2]
UniGeneHs.404466.

3D structure databases

ProteinModelPortalP54108.
SMRP54108. Positions 39-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115605. 1 interaction.
STRING9606.ENSP00000263045.

PTM databases

PhosphoSiteP54108.

Polymorphism databases

DMDM1706135.

Proteomic databases

PaxDbP54108.
PeptideAtlasP54108.
PRIDEP54108.

Protocols and materials databases

DNASU10321.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263045; ENSP00000263045; ENSG00000096006. [P54108-2]
ENST00000393666; ENSP00000377274; ENSG00000096006. [P54108-1]
ENST00000433368; ENSP00000389026; ENSG00000096006. [P54108-3]
GeneID10321.
KEGGhsa:10321.
UCSCuc003ozs.3. human. [P54108-2]
uc021zai.1. human. [P54108-3]

Organism-specific databases

CTD10321.
GeneCardsGC06M049741.
H-InvDBHIX0032937.
HGNCHGNC:16904. CRISP3.
HPAHPA054392.
neXtProtNX_P54108.
PharmGKBPA134880440.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312931.
HOGENOMHOG000236338.
HOVERGENHBG004184.
InParanoidP54108.
OrthoDBEOG7F7WB4.
PhylomeDBP54108.
TreeFamTF316148.

Gene expression databases

ArrayExpressP54108.
BgeeP54108.
CleanExHS_CRISP3.
GenevestigatorP54108.

Family and domain databases

Gene3D3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSPR00837. V5TPXLIKE.
SMARTSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
PROSITEPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCRISP3.
GenomeRNAi10321.
NextBio39127.
PROP54108.

Entry information

Entry nameCRIS3_HUMAN
AccessionPrimary (citable) accession number: P54108
Secondary accession number(s): A8K9S1 expand/collapse secondary AC list , B2R8I8, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM