Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54108

- CRIS3_HUMAN

UniProt

P54108 - CRIS3_HUMAN

Protein

Cysteine-rich secretory protein 3

Gene

CRISP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. defense response Source: UniProtKB
    2. innate immune response Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich secretory protein 3
    Short name:
    CRISP-3
    Alternative name(s):
    Specific granule protein of 28 kDa
    Short name:
    SGP28
    Gene namesi
    Name:CRISP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16904. CRISP3.

    Subcellular locationi

    Secreted
    Note: In neutrophils, localized in specific granules.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. proteinaceous extracellular matrix Source: UniProtKB
    5. specific granule Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880440.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 245225Cysteine-rich secretory protein 3PRO_0000006268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi191 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi194 ↔ 203PROSITE-ProRule annotation
    Disulfide bondi207 ↔ 240PROSITE-ProRule annotation
    Disulfide bondi216 ↔ 234PROSITE-ProRule annotation
    Disulfide bondi225 ↔ 238PROSITE-ProRule annotation
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP54108.
    PeptideAtlasiP54108.
    PRIDEiP54108.

    PTM databases

    PhosphoSiteiP54108.

    Expressioni

    Tissue specificityi

    Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.

    Gene expression databases

    ArrayExpressiP54108.
    BgeeiP54108.
    CleanExiHS_CRISP3.
    GenevestigatoriP54108.

    Organism-specific databases

    HPAiHPA054392.

    Interactioni

    Subunit structurei

    Interacts with A1BG.1 Publication

    Protein-protein interaction databases

    BioGridi115605. 1 interaction.
    STRINGi9606.ENSP00000263045.

    Structurei

    3D structure databases

    ProteinModelPortaliP54108.
    SMRiP54108. Positions 39-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 171129SCPAdd
    BLAST
    Domaini207 – 24034ShKTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 1 SCP domain.Curated
    Contains 1 ShKT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG312931.
    HOGENOMiHOG000236338.
    HOVERGENiHBG004184.
    InParanoidiP54108.
    OrthoDBiEOG7F7WB4.
    PhylomeDBiP54108.
    TreeFamiTF316148.

    Family and domain databases

    Gene3Di3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR013871. Cysteine_rich_secretory.
    IPR003582. ShKT_dom.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    PF08562. Crisp. 1 hit.
    [Graphical view]
    PRINTSiPR00837. V5TPXLIKE.
    SMARTiSM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    PROSITEiPS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    PS51670. SHKT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P54108-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR    50
    RAVSPPARNM LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL 100
    YMSSASSSWS QAIQSWFDEY NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV 150
    GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD 200
    GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC SNSIY 245
    Length:245
    Mass (Da):27,630
    Last modified:October 1, 1996 - v1
    Checksum:iB4DD79CB7AE9E5F9
    GO
    Isoform 2 (identifier: P54108-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKQILHPALETTAM

    Show »
    Length:258
    Mass (Da):29,065
    Checksum:i4371D621491B8427
    GO
    Isoform 3 (identifier: P54108-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MKQILHPALETTDPCSTGFVFPAM

    Show »
    Length:268
    Mass (Da):30,116
    Checksum:i4DA3F68D69A9953D
    GO

    Sequence cautioni

    The sequence AAH69580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH69602.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG36185.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA63984.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA64527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791Q → R in BAF85475. (PubMed:14702039)Curated
    Sequence conflicti130 – 1301K → R in BAD97100. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061S → P.2 Publications
    Corresponds to variant rs495335 [ dbSNP | Ensembl ].
    VAR_011718
    Natural varianti134 – 1341A → S.1 Publication
    Corresponds to variant rs1864312 [ dbSNP | Ensembl ].
    VAR_011719

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MKQILHPALETTAM in isoform 2. 2 PublicationsVSP_042758
    Alternative sequencei1 – 11M → MKQILHPALETTDPCSTGFV FPAM in isoform 3. 1 PublicationVSP_042759

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94323 mRNA. Translation: CAA63984.1. Different initiation.
    AK292786 mRNA. Translation: BAF85475.1.
    AK313387 mRNA. Translation: BAG36185.1. Different initiation.
    DB205467 mRNA. No translation available.
    AK223380 mRNA. Translation: BAD97100.1.
    AL121974, AL121950 Genomic DNA. Translation: CAI20517.1.
    AL121950, AL121974 Genomic DNA. Translation: CAI20995.1.
    BC069580 mRNA. Translation: AAH69580.1. Different initiation.
    BC069602 mRNA. Translation: AAH69602.1. Different initiation.
    BC101539 mRNA. Translation: AAI01540.1.
    X95240 mRNA. Translation: CAA64527.1. Different initiation.
    CCDSiCCDS4929.2. [P54108-2]
    CCDS55019.1. [P54108-3]
    PIRiS68691.
    RefSeqiNP_001177915.1. NM_001190986.1. [P54108-3]
    NP_006052.2. NM_006061.2. [P54108-2]
    UniGeneiHs.404466.

    Genome annotation databases

    EnsembliENST00000263045; ENSP00000263045; ENSG00000096006. [P54108-2]
    ENST00000433368; ENSP00000389026; ENSG00000096006. [P54108-3]
    GeneIDi10321.
    KEGGihsa:10321.
    UCSCiuc003ozs.3. human. [P54108-2]
    uc021zai.1. human. [P54108-3]

    Polymorphism databases

    DMDMi1706135.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94323 mRNA. Translation: CAA63984.1 . Different initiation.
    AK292786 mRNA. Translation: BAF85475.1 .
    AK313387 mRNA. Translation: BAG36185.1 . Different initiation.
    DB205467 mRNA. No translation available.
    AK223380 mRNA. Translation: BAD97100.1 .
    AL121974 , AL121950 Genomic DNA. Translation: CAI20517.1 .
    AL121950 , AL121974 Genomic DNA. Translation: CAI20995.1 .
    BC069580 mRNA. Translation: AAH69580.1 . Different initiation.
    BC069602 mRNA. Translation: AAH69602.1 . Different initiation.
    BC101539 mRNA. Translation: AAI01540.1 .
    X95240 mRNA. Translation: CAA64527.1 . Different initiation.
    CCDSi CCDS4929.2. [P54108-2 ]
    CCDS55019.1. [P54108-3 ]
    PIRi S68691.
    RefSeqi NP_001177915.1. NM_001190986.1. [P54108-3 ]
    NP_006052.2. NM_006061.2. [P54108-2 ]
    UniGenei Hs.404466.

    3D structure databases

    ProteinModelPortali P54108.
    SMRi P54108. Positions 39-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115605. 1 interaction.
    STRINGi 9606.ENSP00000263045.

    PTM databases

    PhosphoSitei P54108.

    Polymorphism databases

    DMDMi 1706135.

    Proteomic databases

    PaxDbi P54108.
    PeptideAtlasi P54108.
    PRIDEi P54108.

    Protocols and materials databases

    DNASUi 10321.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263045 ; ENSP00000263045 ; ENSG00000096006 . [P54108-2 ]
    ENST00000433368 ; ENSP00000389026 ; ENSG00000096006 . [P54108-3 ]
    GeneIDi 10321.
    KEGGi hsa:10321.
    UCSCi uc003ozs.3. human. [P54108-2 ]
    uc021zai.1. human. [P54108-3 ]

    Organism-specific databases

    CTDi 10321.
    GeneCardsi GC06M049741.
    H-InvDB HIX0032937.
    HGNCi HGNC:16904. CRISP3.
    HPAi HPA054392.
    neXtProti NX_P54108.
    PharmGKBi PA134880440.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312931.
    HOGENOMi HOG000236338.
    HOVERGENi HBG004184.
    InParanoidi P54108.
    OrthoDBi EOG7F7WB4.
    PhylomeDBi P54108.
    TreeFami TF316148.

    Miscellaneous databases

    GeneWikii CRISP3.
    GenomeRNAii 10321.
    NextBioi 39127.
    PROi P54108.

    Gene expression databases

    ArrayExpressi P54108.
    Bgeei P54108.
    CleanExi HS_CRISP3.
    Genevestigatori P54108.

    Family and domain databases

    Gene3Di 3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR013871. Cysteine_rich_secretory.
    IPR003582. ShKT_dom.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    PF08562. Crisp. 1 hit.
    [Graphical view ]
    PRINTSi PR00837. V5TPXLIKE.
    SMARTi SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    PROSITEi PS01009. CRISP_1. 1 hit.
    PS01010. CRISP_2. 1 hit.
    PS51670. SHKT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein."
      Kjeldsen L., Cowland J.B., Johnson A.H., Borregaard N.
      FEBS Lett. 380:246-250(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-155 (ISOFORM 3), VARIANTS PRO-106 AND SER-134.
      Tissue: Trachea.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Gastric mucosa.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-106.
      Tissue: Placenta.
    6. "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3."
      Kraetzschmar J., Haendler B., Eberspaecher U., Roostermann D., Donner P., Schleuning W.-D.
      Eur. J. Biochem. 236:827-836(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    7. "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma."
      Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L.
      Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH A1BG.

    Entry informationi

    Entry nameiCRIS3_HUMAN
    AccessioniPrimary (citable) accession number: P54108
    Secondary accession number(s): A8K9S1
    , B2R8I8, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3