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P54108

- CRIS3_HUMAN

UniProt

P54108 - CRIS3_HUMAN

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Protein
Cysteine-rich secretory protein 3
Gene
CRISP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. defense response Source: UniProtKB
  2. innate immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 3
Short name:
CRISP-3
Alternative name(s):
Specific granule protein of 28 kDa
Short name:
SGP28
Gene namesi
Name:CRISP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:16904. CRISP3.

Subcellular locationi

Secreted
Note: In neutrophils, localized in specific granules.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProt
  4. proteinaceous extracellular matrix Source: UniProtKB
  5. specific granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 245225Cysteine-rich secretory protein 3
PRO_0000006268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi191 ↔ 198 By similarity
Disulfide bondi194 ↔ 203 By similarity
Disulfide bondi207 ↔ 240 By similarity
Disulfide bondi216 ↔ 234 By similarity
Disulfide bondi225 ↔ 238 By similarity
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54108.
PeptideAtlasiP54108.
PRIDEiP54108.

PTM databases

PhosphoSiteiP54108.

Expressioni

Tissue specificityi

Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.

Gene expression databases

ArrayExpressiP54108.
BgeeiP54108.
CleanExiHS_CRISP3.
GenevestigatoriP54108.

Organism-specific databases

HPAiHPA054392.

Interactioni

Subunit structurei

Interacts with A1BG.1 Publication

Protein-protein interaction databases

BioGridi115605. 1 interaction.
STRINGi9606.ENSP00000263045.

Structurei

3D structure databases

ProteinModelPortaliP54108.
SMRiP54108. Positions 39-245.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 171129SCP
Add
BLAST
Domaini207 – 24034ShKT
Add
BLAST

Sequence similaritiesi

Belongs to the CRISP family.
Contains 1 SCP domain.
Contains 1 ShKT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG312931.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiP54108.
OrthoDBiEOG7F7WB4.
PhylomeDBiP54108.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P54108-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR    50
RAVSPPARNM LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL 100
YMSSASSSWS QAIQSWFDEY NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV 150
GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD 200
GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC SNSIY 245
Length:245
Mass (Da):27,630
Last modified:October 1, 1996 - v1
Checksum:iB4DD79CB7AE9E5F9
GO
Isoform 2 (identifier: P54108-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTAM

Show »
Length:258
Mass (Da):29,065
Checksum:i4371D621491B8427
GO
Isoform 3 (identifier: P54108-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTDPCSTGFVFPAM

Show »
Length:268
Mass (Da):30,116
Checksum:i4DA3F68D69A9953D
GO

Sequence cautioni

The sequence AAH69580.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH69602.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAG36185.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA63984.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA64527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061S → P.2 Publications
Corresponds to variant rs495335 [ dbSNP | Ensembl ].
VAR_011718
Natural varianti134 – 1341A → S.1 Publication
Corresponds to variant rs1864312 [ dbSNP | Ensembl ].
VAR_011719

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MKQILHPALETTAM in isoform 2.
VSP_042758
Alternative sequencei1 – 11M → MKQILHPALETTDPCSTGFV FPAM in isoform 3.
VSP_042759

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791Q → R in BAF85475. 1 Publication
Sequence conflicti130 – 1301K → R in BAD97100. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94323 mRNA. Translation: CAA63984.1. Different initiation.
AK292786 mRNA. Translation: BAF85475.1.
AK313387 mRNA. Translation: BAG36185.1. Different initiation.
DB205467 mRNA. No translation available.
AK223380 mRNA. Translation: BAD97100.1.
AL121974, AL121950 Genomic DNA. Translation: CAI20517.1.
AL121950, AL121974 Genomic DNA. Translation: CAI20995.1.
BC069580 mRNA. Translation: AAH69580.1. Different initiation.
BC069602 mRNA. Translation: AAH69602.1. Different initiation.
BC101539 mRNA. Translation: AAI01540.1.
X95240 mRNA. Translation: CAA64527.1. Different initiation.
CCDSiCCDS4929.2. [P54108-2]
CCDS55019.1. [P54108-3]
PIRiS68691.
RefSeqiNP_001177915.1. NM_001190986.1. [P54108-3]
NP_006052.2. NM_006061.2. [P54108-2]
UniGeneiHs.404466.

Genome annotation databases

EnsembliENST00000263045; ENSP00000263045; ENSG00000096006. [P54108-2]
ENST00000393666; ENSP00000377274; ENSG00000096006. [P54108-1]
ENST00000433368; ENSP00000389026; ENSG00000096006. [P54108-3]
GeneIDi10321.
KEGGihsa:10321.
UCSCiuc003ozs.3. human. [P54108-2]
uc021zai.1. human. [P54108-3]

Polymorphism databases

DMDMi1706135.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94323 mRNA. Translation: CAA63984.1 . Different initiation.
AK292786 mRNA. Translation: BAF85475.1 .
AK313387 mRNA. Translation: BAG36185.1 . Different initiation.
DB205467 mRNA. No translation available.
AK223380 mRNA. Translation: BAD97100.1 .
AL121974 , AL121950 Genomic DNA. Translation: CAI20517.1 .
AL121950 , AL121974 Genomic DNA. Translation: CAI20995.1 .
BC069580 mRNA. Translation: AAH69580.1 . Different initiation.
BC069602 mRNA. Translation: AAH69602.1 . Different initiation.
BC101539 mRNA. Translation: AAI01540.1 .
X95240 mRNA. Translation: CAA64527.1 . Different initiation.
CCDSi CCDS4929.2. [P54108-2 ]
CCDS55019.1. [P54108-3 ]
PIRi S68691.
RefSeqi NP_001177915.1. NM_001190986.1. [P54108-3 ]
NP_006052.2. NM_006061.2. [P54108-2 ]
UniGenei Hs.404466.

3D structure databases

ProteinModelPortali P54108.
SMRi P54108. Positions 39-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115605. 1 interaction.
STRINGi 9606.ENSP00000263045.

PTM databases

PhosphoSitei P54108.

Polymorphism databases

DMDMi 1706135.

Proteomic databases

PaxDbi P54108.
PeptideAtlasi P54108.
PRIDEi P54108.

Protocols and materials databases

DNASUi 10321.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263045 ; ENSP00000263045 ; ENSG00000096006 . [P54108-2 ]
ENST00000393666 ; ENSP00000377274 ; ENSG00000096006 . [P54108-1 ]
ENST00000433368 ; ENSP00000389026 ; ENSG00000096006 . [P54108-3 ]
GeneIDi 10321.
KEGGi hsa:10321.
UCSCi uc003ozs.3. human. [P54108-2 ]
uc021zai.1. human. [P54108-3 ]

Organism-specific databases

CTDi 10321.
GeneCardsi GC06M049741.
H-InvDB HIX0032937.
HGNCi HGNC:16904. CRISP3.
HPAi HPA054392.
neXtProti NX_P54108.
PharmGKBi PA134880440.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312931.
HOGENOMi HOG000236338.
HOVERGENi HBG004184.
InParanoidi P54108.
OrthoDBi EOG7F7WB4.
PhylomeDBi P54108.
TreeFami TF316148.

Miscellaneous databases

GeneWikii CRISP3.
GenomeRNAii 10321.
NextBioi 39127.
PROi P54108.

Gene expression databases

ArrayExpressi P54108.
Bgeei P54108.
CleanExi HS_CRISP3.
Genevestigatori P54108.

Family and domain databases

Gene3Di 3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view ]
PRINTSi PR00837. V5TPXLIKE.
SMARTi SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
PROSITEi PS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis-specific gene product and a rodent sperm-coating glycoprotein."
    Kjeldsen L., Cowland J.B., Johnson A.H., Borregaard N.
    FEBS Lett. 380:246-250(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF 1-155 (ISOFORM 3), VARIANTS PRO-106 AND SER-134.
    Tissue: Trachea.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Gastric mucosa.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PRO-106.
    Tissue: Placenta.
  6. "The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3."
    Kraetzschmar J., Haendler B., Eberspaecher U., Roostermann D., Donner P., Schleuning W.-D.
    Eur. J. Biochem. 236:827-836(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  7. "Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma."
    Udby L., Sorensen O.E., Pass J., Johnsen A.H., Behrendt N., Borregaard N., Kjeldsen L.
    Biochemistry 43:12877-12886(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH A1BG.

Entry informationi

Entry nameiCRIS3_HUMAN
AccessioniPrimary (citable) accession number: P54108
Secondary accession number(s): A8K9S1
, B2R8I8, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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