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Protein

Cysteine-rich secretory protein 3

Gene

CRISP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • defense response Source: UniProtKB
  • innate immune response Source: UniProtKB
  • neutrophil degranulation Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 3
Short name:
CRISP-3
Alternative name(s):
Specific granule protein of 28 kDa
Short name:
SGP28
Gene namesi
Name:CRISP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000096006.11
HGNCiHGNC:16904 CRISP3
neXtProtiNX_P54108

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10321
OpenTargetsiENSG00000096006
PharmGKBiPA134880440

Polymorphism and mutation databases

BioMutaiCRISP3
DMDMi1706135

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000626821 – 245Cysteine-rich secretory protein 3Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi191 ↔ 198PROSITE-ProRule annotation
Disulfide bondi194 ↔ 203PROSITE-ProRule annotation
Disulfide bondi207 ↔ 240PROSITE-ProRule annotation
Disulfide bondi216 ↔ 234PROSITE-ProRule annotation
Disulfide bondi225 ↔ 238PROSITE-ProRule annotation
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54108
PeptideAtlasiP54108
PRIDEiP54108
ProteomicsDBi56646
56647 [P54108-2]
56648 [P54108-3]
TopDownProteomicsiP54108-1 [P54108-1]

PTM databases

iPTMnetiP54108
PhosphoSitePlusiP54108

Expressioni

Tissue specificityi

Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.

Gene expression databases

BgeeiENSG00000096006
CleanExiHS_CRISP3
ExpressionAtlasiP54108 baseline and differential
GenevisibleiP54108 HS

Organism-specific databases

HPAiHPA054392

Interactioni

Subunit structurei

Interacts with A1BG.1 Publication

Protein-protein interaction databases

BioGridi115605, 1 interactor
STRINGi9606.ENSP00000389026

Structurei

3D structure databases

ProteinModelPortaliP54108
SMRiP54108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 171SCPAdd BLAST129
Domaini207 – 240ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000236338
HOVERGENiHBG004184
InParanoidiP54108
KOiK19919
PhylomeDBiP54108
TreeFamiTF316148

Family and domain databases

CDDicd05383 SCP_CRISP, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P54108-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR EIVNKHNELR
60 70 80 90 100
RAVSPPARNM LKMEWNKEAA ANAQKWANQC NYRHSNPKDR MTSLKCGENL
110 120 130 140 150
YMSSASSSWS QAIQSWFDEY NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV
160 170 180 190 200
GCGNAYCPNQ KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD
210 220 230 240
GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC SNSIY
Length:245
Mass (Da):27,630
Last modified:October 1, 1996 - v1
Checksum:iB4DD79CB7AE9E5F9
GO
Isoform 2 (identifier: P54108-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTAM

Show »
Length:258
Mass (Da):29,065
Checksum:i4371D621491B8427
GO
Isoform 3 (identifier: P54108-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKQILHPALETTDPCSTGFVFPAM

Show »
Length:268
Mass (Da):30,116
Checksum:i4DA3F68D69A9953D
GO

Sequence cautioni

The sequence AAH69580 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH69602 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG36185 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA63984 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA64527 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79Q → R in BAF85475 (PubMed:14702039).Curated1
Sequence conflicti130K → R in BAD97100 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011718106S → P2 PublicationsCorresponds to variant dbSNP:rs495335Ensembl.1
Natural variantiVAR_011719134A → S1 PublicationCorresponds to variant dbSNP:rs1864312Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427581M → MKQILHPALETTAM in isoform 2. 2 Publications1
Alternative sequenceiVSP_0427591M → MKQILHPALETTDPCSTGFV FPAM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94323 mRNA Translation: CAA63984.1 Different initiation.
AK292786 mRNA Translation: BAF85475.1
AK313387 mRNA Translation: BAG36185.1 Different initiation.
DB205467 mRNA No translation available.
AK223380 mRNA Translation: BAD97100.1
AL121950 Genomic DNA No translation available.
AL121974 Genomic DNA No translation available.
BC069580 mRNA Translation: AAH69580.1 Different initiation.
BC069602 mRNA Translation: AAH69602.1 Different initiation.
BC101539 mRNA Translation: AAI01540.1
X95240 mRNA Translation: CAA64527.1 Different initiation.
CCDSiCCDS4929.2 [P54108-2]
CCDS55019.1 [P54108-3]
PIRiS68691
RefSeqiNP_001177915.1, NM_001190986.2 [P54108-3]
NP_006052.2, NM_006061.3 [P54108-2]
UniGeneiHs.404466

Genome annotation databases

EnsembliENST00000263045; ENSP00000263045; ENSG00000096006 [P54108-2]
ENST00000433368; ENSP00000389026; ENSG00000096006 [P54108-3]
GeneIDi10321
KEGGihsa:10321
UCSCiuc003ozs.5 human [P54108-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCRIS3_HUMAN
AccessioniPrimary (citable) accession number: P54108
Secondary accession number(s): A8K9S1
, B2R8I8, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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