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Protein

Cysteine-rich secretory protein 1

Gene

CRISP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in sperm-egg fusion and maturation.

GO - Biological processi

  • fusion of sperm to egg plasma membrane Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124812-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein 1
Short name:
CRISP-1
Alternative name(s):
AEG-like protein
ARP
Acidic epididymal glycoprotein homolog
Gene namesi
Name:CRISP1
Synonyms:AEGL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:304. CRISP1.

Subcellular locationi


    Note: Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head.

GO - Cellular componenti

  • extracellular space Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi167.
OpenTargetsiENSG00000124812.
PharmGKBiPA24605.

Polymorphism and mutation databases

BioMutaiCRISP1.
DMDMi1706134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000626022 – 249Cysteine-rich secretory protein 1Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi195 ↔ 202PROSITE-ProRule annotation
Disulfide bondi198 ↔ 207PROSITE-ProRule annotation
Disulfide bondi211 ↔ 244PROSITE-ProRule annotation
Disulfide bondi220 ↔ 238PROSITE-ProRule annotation
Disulfide bondi229 ↔ 242PROSITE-ProRule annotation
Glycosylationi230N-linked (GlcNAc...)1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP54107.
PeptideAtlasiP54107.
PRIDEiP54107.

PTM databases

PhosphoSitePlusiP54107.

Expressioni

Tissue specificityi

Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma.

Gene expression databases

BgeeiENSG00000124812.
CleanExiHS_CRISP1.
ExpressionAtlasiP54107. baseline and differential.
GenevisibleiP54107. HS.

Organism-specific databases

HPAiHPA028445.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000338276.

Structurei

3D structure databases

ProteinModelPortaliP54107.
SMRiP54107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 175SCPAdd BLAST131
Domaini211 – 244ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 1 SCP domain.Curated
Contains 1 ShKT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiP54107.
KOiK19919.
OMAiWASSYLI.
OrthoDBiEOG091G0D4V.
PhylomeDBiP54107.
TreeFamiTF316148.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P54107-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIKHLLFLV AAACLLPMLS MKKKSARDQF NKLVTDLPNV QEEIVNIHNA
60 70 80 90 100
LRRRVVPPAS NMLKMSWSEE AAQNARIFSK YCDMTESNPL ERRLPNTFCG
110 120 130 140 150
ENMHMTSYPV SWSSVIGVWY SESTSFKHGE WTTTDDDITT DHYTQIVWAT
160 170 180 190 200
SYLIGCAIAS CRQQGSPRYL YVCHYCHEGN DPETKNEPYK TGVPCEACPS
210 220 230 240
NCEDKLCTNP CIYYDEYFDC DIQVHYLGCN HSTTILFCKA TCLCDTEIK
Length:249
Mass (Da):28,481
Last modified:October 1, 1996 - v1
Checksum:i85BED3DDEAD62A9C
GO
Isoform Short (identifier: P54107-2) [UniParc]FASTAAdd to basket
Also known as: CRISP-1 delta

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: E → D
     179-249: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,462
Checksum:i18739B2B6EBF7F84
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22K → E in AAB35899 (PubMed:8543280).Curated1
Sequence conflicti22K → E in BAA07483 (PubMed:8838800).Curated1
Sequence conflicti97T → A in AAB35899 (PubMed:8543280).Curated1
Sequence conflicti97T → A in BAA07483 (PubMed:8838800).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006027178E → D in isoform Short. 2 Publications1
Alternative sequenceiVSP_006028179 – 249Missing in isoform Short. 2 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95237 mRNA. Translation: CAA64524.1.
X95238 mRNA. Translation: CAA64525.1.
S80310 mRNA. Translation: AAB35899.1.
D38451 mRNA. Translation: BAA07483.1.
AB451334 mRNA. Translation: BAG70148.1.
AB451479 mRNA. Translation: BAG70293.1.
AL359458 Genomic DNA. Translation: CAC34980.1.
CCDSiCCDS4931.1. [P54107-1]
CCDS4932.1. [P54107-2]
PIRiS68681.
S68684.
RefSeqiNP_001122.2. NM_001131.2. [P54107-1]
NP_001192149.1. NM_001205220.1. [P54107-1]
NP_733758.1. NM_170609.1. [P54107-2]
UniGeneiHs.109620.

Genome annotation databases

EnsembliENST00000329411; ENSP00000331317; ENSG00000124812. [P54107-2]
ENST00000335847; ENSP00000338276; ENSG00000124812. [P54107-1]
ENST00000505118; ENSP00000427589; ENSG00000124812. [P54107-1]
ENST00000507853; ENSP00000425020; ENSG00000124812. [P54107-2]
GeneIDi167.
KEGGihsa:167.
UCSCiuc003ozw.3. human. [P54107-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95237 mRNA. Translation: CAA64524.1.
X95238 mRNA. Translation: CAA64525.1.
S80310 mRNA. Translation: AAB35899.1.
D38451 mRNA. Translation: BAA07483.1.
AB451334 mRNA. Translation: BAG70148.1.
AB451479 mRNA. Translation: BAG70293.1.
AL359458 Genomic DNA. Translation: CAC34980.1.
CCDSiCCDS4931.1. [P54107-1]
CCDS4932.1. [P54107-2]
PIRiS68681.
S68684.
RefSeqiNP_001122.2. NM_001131.2. [P54107-1]
NP_001192149.1. NM_001205220.1. [P54107-1]
NP_733758.1. NM_170609.1. [P54107-2]
UniGeneiHs.109620.

3D structure databases

ProteinModelPortaliP54107.
SMRiP54107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338276.

PTM databases

PhosphoSitePlusiP54107.

Polymorphism and mutation databases

BioMutaiCRISP1.
DMDMi1706134.

Proteomic databases

PaxDbiP54107.
PeptideAtlasiP54107.
PRIDEiP54107.

Protocols and materials databases

DNASUi167.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329411; ENSP00000331317; ENSG00000124812. [P54107-2]
ENST00000335847; ENSP00000338276; ENSG00000124812. [P54107-1]
ENST00000505118; ENSP00000427589; ENSG00000124812. [P54107-1]
ENST00000507853; ENSP00000425020; ENSG00000124812. [P54107-2]
GeneIDi167.
KEGGihsa:167.
UCSCiuc003ozw.3. human. [P54107-1]

Organism-specific databases

CTDi167.
DisGeNETi167.
GeneCardsiCRISP1.
HGNCiHGNC:304. CRISP1.
HPAiHPA028445.
MIMi601193. gene.
neXtProtiNX_P54107.
OpenTargetsiENSG00000124812.
PharmGKBiPA24605.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017. Eukaryota.
COG2340. LUCA.
GeneTreeiENSGT00760000119004.
HOGENOMiHOG000236338.
HOVERGENiHBG004184.
InParanoidiP54107.
KOiK19919.
OMAiWASSYLI.
OrthoDBiEOG091G0D4V.
PhylomeDBiP54107.
TreeFamiTF316148.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124812-MONOMER.

Miscellaneous databases

GeneWikiiCRISP1.
GenomeRNAii167.
PROiP54107.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124812.
CleanExiHS_CRISP1.
ExpressionAtlasiP54107. baseline and differential.
GenevisibleiP54107. HS.

Family and domain databases

Gene3Di3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR013871. Cysteine_rich_secretory.
IPR003582. ShKT_dom.
IPR002413. V5_allergen.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF08562. Crisp. 1 hit.
[Graphical view]
PRINTSiPR00838. V5ALLERGEN.
PR00837. V5TPXLIKE.
SMARTiSM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
PROSITEiPS01009. CRISP_1. 1 hit.
PS01010. CRISP_2. 1 hit.
PS51670. SHKT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIS1_HUMAN
AccessioniPrimary (citable) accession number: P54107
Secondary accession number(s): B5BU98
, O00698, Q13248, Q14082, Q96SF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.