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P54105

- ICLN_HUMAN

UniProt

P54105 - ICLN_HUMAN

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Protein
Methylosome subunit pICln
Gene
CLNS1A, CLCI, ICLN
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.3 Publications

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. cell volume homeostasis Source: InterPro
  3. chloride transport Source: InterPro
  4. gene expression Source: Reactome
  5. ncRNA metabolic process Source: Reactome
  6. spliceosomal snRNP assembly Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11066. snRNP Assembly.

Protein family/group databases

TCDBi1.A.47.1.1. the nucleotide-sensitive anion-selective channel, icln (icln) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylosome subunit pICln
Alternative name(s):
Chloride channel, nucleotide sensitive 1A
Chloride conductance regulatory protein ICln
Short name:
I(Cln)
Chloride ion current inducer protein
Short name:
ClCI
Reticulocyte pICln
Gene namesi
Name:CLNS1A
Synonyms:CLCI, ICLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:2080. CLNS1A.

Subcellular locationi

Cytoplasmcytosol. Nucleus. Cytoplasmcytoskeleton
Note: A small fraction is also associated with the cytoskeleton.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytoskeleton Source: UniProtKB-SubCell
  3. cytosol Source: UniProtKB
  4. methylosome Source: UniProtKB
  5. nucleus Source: HPA
  6. pICln-Sm protein complex Source: UniProtKB
  7. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 237236Methylosome subunit pICln
PRO_0000185155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei102 – 1021Phosphoserine11 Publications
Modified residuei223 – 2231Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP54105.
PaxDbiP54105.
PeptideAtlasiP54105.
PRIDEiP54105.

PTM databases

PhosphoSiteiP54105.

Expressioni

Gene expression databases

ArrayExpressiP54105.
BgeeiP54105.
CleanExiHS_CLNS1A.
GenevestigatoriP54105.

Organism-specific databases

HPAiCAB017840.
HPA031707.
HPA031708.
HPA032045.

Interactioni

Subunit structurei

Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1 and WDR77/MEP50; may mediate SNRPD1 and SNRPD3 methylation. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with LSM10 and LSM11.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT5O147443EBI-724693,EBI-351098
SNRPBP146783EBI-724693,EBI-372458
SNRPD1P623146EBI-724693,EBI-372177
SNRPD2P623165EBI-724693,EBI-297993
SNRPD3P623186EBI-724693,EBI-372789
SNRPFP623064EBI-724693,EBI-356900

Protein-protein interaction databases

BioGridi107617. 75 interactions.
DIPiDIP-44185N.
IntActiP54105. 24 interactions.
MINTiMINT-5002627.
STRINGi9606.ENSP00000263309.

Structurei

3D structure databases

ProteinModelPortaliP54105.
SMRiP54105. Positions 18-135.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG316963.
HOGENOMiHOG000006913.
HOVERGENiHBG003108.
InParanoidiP54105.
KOiK05019.
OMAiQYHMAGV.
OrthoDBiEOG7H1JMG.
PhylomeDBiP54105.
TreeFamiTF315155.

Family and domain databases

InterProiIPR003521. ICln.
[Graphical view]
PANTHERiPTHR21399. PTHR21399. 1 hit.
PRINTSiPR01348. ICLNCHANNEL.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54105-1 [UniParc]FASTAAdd to Basket

« Hide

MSFLKSFPPP GPAEGLLRQQ PDTEAVLNGK GLGTGTLYIA ESRLSWLDGS    50
GLGFSLEYPT ISLHALSRDR SDCLGEHLYV MVNAKFEEES KEPVADEEEE 100
DSDDDVEPIT EFRFVPSDKS ALEAMFTAMC ECQALHPDPE DEDSDDYDGE 150
EYDVEAHEQG QGDIPTFYTY EEGLSHLTAE GQATLERLEG MLSQSVSSQY 200
NMAGVRTEDS IRDYEDGMEV DTTPTVAGQF EDADVDH 237
Length:237
Mass (Da):26,215
Last modified:October 1, 1996 - v1
Checksum:iAE9C09884A6FF158
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201Q → H.1 Publication
VAR_015736
Natural varianti218 – 2181M → T.1 Publication
VAR_015737

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91788 mRNA. Translation: CAA62902.1.
U17899 mRNA. Translation: AAC50111.1.
U53454 mRNA. Translation: AAB03316.1.
AF005422 mRNA. Translation: AAB61444.1.
AF026003 mRNA. Translation: AAB88806.1.
AF232708 Genomic DNA. Translation: AAF76861.1.
AF232224 Genomic DNA. Translation: AAF76858.1.
AF232225 Genomic DNA. Translation: AAF76859.1.
AK315259 mRNA. Translation: BAG37676.1.
BT019907 mRNA. Translation: AAV38710.1.
BC119634 mRNA. Translation: AAI19635.1.
BC119635 mRNA. Translation: AAI19636.1.
CCDSiCCDS8252.1.
PIRiJC4135.
RefSeqiNP_001284.1. NM_001293.2.
UniGeneiHs.430733.

Genome annotation databases

EnsembliENST00000525428; ENSP00000433919; ENSG00000074201.
ENST00000528364; ENSP00000434311; ENSG00000074201.
GeneIDi1207.
KEGGihsa:1207.
UCSCiuc001oyk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91788 mRNA. Translation: CAA62902.1 .
U17899 mRNA. Translation: AAC50111.1 .
U53454 mRNA. Translation: AAB03316.1 .
AF005422 mRNA. Translation: AAB61444.1 .
AF026003 mRNA. Translation: AAB88806.1 .
AF232708 Genomic DNA. Translation: AAF76861.1 .
AF232224 Genomic DNA. Translation: AAF76858.1 .
AF232225 Genomic DNA. Translation: AAF76859.1 .
AK315259 mRNA. Translation: BAG37676.1 .
BT019907 mRNA. Translation: AAV38710.1 .
BC119634 mRNA. Translation: AAI19635.1 .
BC119635 mRNA. Translation: AAI19636.1 .
CCDSi CCDS8252.1.
PIRi JC4135.
RefSeqi NP_001284.1. NM_001293.2.
UniGenei Hs.430733.

3D structure databases

ProteinModelPortali P54105.
SMRi P54105. Positions 18-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107617. 75 interactions.
DIPi DIP-44185N.
IntActi P54105. 24 interactions.
MINTi MINT-5002627.
STRINGi 9606.ENSP00000263309.

Protein family/group databases

TCDBi 1.A.47.1.1. the nucleotide-sensitive anion-selective channel, icln (icln) family.

PTM databases

PhosphoSitei P54105.

Proteomic databases

MaxQBi P54105.
PaxDbi P54105.
PeptideAtlasi P54105.
PRIDEi P54105.

Protocols and materials databases

DNASUi 1207.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000525428 ; ENSP00000433919 ; ENSG00000074201 .
ENST00000528364 ; ENSP00000434311 ; ENSG00000074201 .
GeneIDi 1207.
KEGGi hsa:1207.
UCSCi uc001oyk.3. human.

Organism-specific databases

CTDi 1207.
GeneCardsi GC11M077225.
HGNCi HGNC:2080. CLNS1A.
HPAi CAB017840.
HPA031707.
HPA031708.
HPA032045.
MIMi 602158. gene.
neXtProti NX_P54105.
PharmGKBi PA26607.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG316963.
HOGENOMi HOG000006913.
HOVERGENi HBG003108.
InParanoidi P54105.
KOi K05019.
OMAi QYHMAGV.
OrthoDBi EOG7H1JMG.
PhylomeDBi P54105.
TreeFami TF315155.

Enzyme and pathway databases

Reactomei REACT_11066. snRNP Assembly.

Miscellaneous databases

GeneWikii CLNS1A.
GenomeRNAii 1207.
NextBioi 4973.
PROi P54105.
SOURCEi Search...

Gene expression databases

ArrayExpressi P54105.
Bgeei P54105.
CleanExi HS_CLNS1A.
Genevestigatori P54105.

Family and domain databases

InterProi IPR003521. ICln.
[Graphical view ]
PANTHERi PTHR21399. PTHR21399. 1 hit.
PRINTSi PR01348. ICLNCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The ubiquitously expressed pICln protein forms homomeric complexes in vitro."
    Buyse G., de Greef C., Raeymaekers L., Droogmans G., Nilius B., Eggermont J.
    Biochem. Biophys. Res. Commun. 218:822-827(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium."
    Anquita J., Chalfant M.L., Civan M.M., Coca-Prados M.
    Biochem. Biophys. Res. Commun. 208:89-95(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ocular ciliary epithelium.
  3. "Colocalization of CLCI and CLCN3 to human 4q32 and mouse 8: the candidate region for tottering (tg)."
    Lamb F.S., Mathews K., Mills K., Barna T., Pruessner J., Kresnicka L.S., Schutte B.C.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Molecular cloning and expression of a chloride channel-associated protein pI(Cln) in human young red blood cells: association with actin."
    Schwartz R.S., Rybicki A.C., Nagel R.L.
    Biochem. J. 327:609-616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Chloride ion current inducer protein in human lens epithelium."
    Rae J.L., Shepard A.R.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lens epithelium.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-20 AND THR-218.
    Tissue: Colon cancer and Kidney.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.
  8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. Bienvenut W.V., Calvo F., Zebisch A., Kolch W.
    Submitted (OCT-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-43; 86-113 AND 188-237, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, PHOSPHORYLATION AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma and Colon carcinoma.
  11. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 19-113 AND 188-237, PHOSPHORYLATION AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  12. "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins."
    Pu W.T., Krapivinsky G.B., Krapivinsky L., Clapham D.E.
    Mol. Cell. Biol. 19:4113-4120(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SNRNP BIOGENESIS.
  13. "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln."
    Meister G., Eggert C., Buehler D., Brahms H., Kambach C., Fischer U.
    Curr. Biol. 11:1990-1994(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE METHYLOSOME COMPLEX.
  14. "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins."
    Friesen W.J., Paushkin S., Wyce A., Massenet S., Pesiridis G.S., Van Duyne G., Rappsilber J., Mann M., Dreyfuss G.
    Mol. Cell. Biol. 21:8289-8300(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN METHYLOSOME.
  15. "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."
    Azzouz T.N., Pillai R.S., Dapp C., Chari A., Meister G., Kambach C., Fischer U., Schuemperli D.
    J. Biol. Chem. 280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LSM10; LSM11 AND SNRPB.
  16. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line."
    Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.
    Electrophoresis 28:2027-2034(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Prostate cancer.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  19. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
    Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
    Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN THE METHYLOSOME COMPLEX, IDENTIFICATION IN 6S PICLN-SM COMPLEX, SUBCELLULAR LOCATION.
  20. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102 AND THR-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  24. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  26. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  27. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  28. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  29. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiICLN_HUMAN
AccessioniPrimary (citable) accession number: P54105
Secondary accession number(s): B2RCS9
, Q0VDK6, Q9NRD2, Q9NRD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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