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Protein

Proto-oncogene vav

Gene

Vav1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri515 – 564Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene vav
Alternative name(s):
p95
Gene namesi
Name:Vav1
Synonyms:Vav
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3951 Vav1

Subcellular locationi

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809821 – 843Proto-oncogene vavAdd BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei824PhosphotyrosineBy similarity1
Modified residuei842PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated by FYN. Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54100
PRIDEiP54100

PTM databases

PhosphoSitePlusiP54100

Interactioni

Subunit structurei

Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2 (By similarity). Interacts with HCK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK (By similarity). Interacts with ANKRD54. Interacts with CD6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064264

Structurei

3D structure databases

ProteinModelPortaliP54100
SMRiP54100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 119Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST119
Domaini194 – 373DHPROSITE-ProRule annotationAdd BLAST180
Domaini402 – 504PHPROSITE-ProRule annotationAdd BLAST103
Domaini590 – 658SH3 1PROSITE-ProRule annotationAdd BLAST69
Domaini669 – 763SH2PROSITE-ProRule annotationAdd BLAST95
Domaini780 – 840SH3 2PROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 99Leu-richAdd BLAST67

Domaini

The DH domain is involved in interaction with CCPG1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri515 – 564Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiKOG2996 Eukaryota
ENOG410XPH6 LUCA
HOVERGENiHBG018066
InParanoidiP54100
PhylomeDBiP54100

Family and domain databases

CDDicd00029 C1, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd10405 SH2_Vav1, 1 hit
cd11979 SH3_VAV1_1, 1 hit
cd11976 SH3_VAV1_2, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR003096 SM22_calponin
IPR028530 Vav1
IPR035879 VAV1_SH2
IPR035730 VAV1_SH3_1
IPR035729 VAV1_SH3_2
PANTHERiPTHR22826:SF112 PTHR22826:SF112, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P54100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL
60 70 80 90 100
LPHAINLREV NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF
110 120 130 140 150
DVQDFGKVIY TLSALSWTPI AQNKGIMPFP TEDSALGDED IYSGLSDQID
160 170 180 190 200
DTAEEDEDLY DCVENEEAEG DEIYEDLMRS ESVPTPPKMT EYDKRCCCLR
210 220 230 240 250
EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI EELLSVHTHF
260 270 280 290 300
LKELKDALSG PGATMLYQVF IKYKERFLVY GRYCSQVESA IKHLDQVATA
310 320 330 340 350
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDT
360 370 380 390 400
TEKENLRLAL DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY
410 420 430 440 450
GRPKIDGELK ITSVERRSKT DRYAFLLDKA LLICKRRGDS YDLKASVNLH
460 470 480 490 500
SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ GYELFFKTRE LKKKWMEQFE
510 520 530 540 550
MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF YQGYRCYRCR
560 570 580 590 600
APAHKECLGR VPPCGRQDFS GTMKKDKLHR RAQDKKRNEL GLPKMEVCQE
610 620 630 640 650
YYGIPPPPGA FGPFLRLNPG DIVELTKAEA EHTWWEGRNT ATNEVGWFPC
660 670 680 690 700
NRVRPYVHGP PQDLSVHLWY AGPMERAGAE GILTNRSDGT YLVRQRVKDT
710 720 730 740 750
AEFAISIKYN VEVKHIKIMT SEGLYRITEK KAFRGLPELV EFYQQNSLKD
760 770 780 790 800
CFKSLDTTLQ FPYKEPERRA INKPPVGSTK YFGTAKARYD FCARDRSELS
810 820 830 840
LKEGDIIKIL NKKGQQGWWR GEIYGRIGWF PSNYVEEDYS EYC
Length:843
Mass (Da):97,954
Last modified:October 1, 1996 - v1
Checksum:iC4A5CACD45FCB80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39476 mRNA Translation: AAA98606.1
UniGeneiRn.48861

Similar proteinsi

Entry informationi

Entry nameiVAV_RAT
AccessioniPrimary (citable) accession number: P54100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health